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Protein
Submitted name:

Aquaporin 2

Gene

Aqp2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPorinImported
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Aquaporin 2Imported
Gene namesi
Name:Aqp2Imported
ORF Names:mCG_18397Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1096865. Aqp2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 35HelicalSequence analysisAdd BLAST24
Transmembranei41 – 62HelicalSequence analysisAdd BLAST22
Transmembranei83 – 107HelicalSequence analysisAdd BLAST25
Transmembranei127 – 149HelicalSequence analysisAdd BLAST23
Transmembranei161 – 180HelicalSequence analysisAdd BLAST20
Transmembranei202 – 224HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000023013.

Family & Domainsi

Sequence similaritiesi

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
HOVERGENiHBG000312.
KOiK09865.
OMAiLLGIHYT.
OrthoDBiEOG091G166T.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiView protein in InterPro
IPR023271. Aquaporin-like.
IPR034294. Aquaporin_transptr.
IPR000425. MIP.
IPR022357. MIP_CS.
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiView protein in Pfam
PF00230. MIP. 1 hit.
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiView protein in PROSITE
PS00221. MIP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3UQD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWELRSIAFS RAVLAEFLAT LLFVFFGLGS ALQWASSPPS VLQIAVAFGL
60 70 80 90 100
GIGTLVQALG HVSGAHINPA VTVACLVGCH VSFLRAAFYV AAQLLGAVAG
110 120 130 140 150
AAILHEITPV EIRGDLAVNA LHNNATAGQA VTVELFLTMQ LVLCIFASTD
160 170 180 190 200
ERRSDNLGSP ALSIGFSVTL GHLLGIYFTG CSMNPARSLA PAVVTGKFDD
210 220 230 240 250
HWVFWIGPLV GAVIGSLLYN YLLFPSTKSL QERLAVLKGL EPDTDWEERE
260 270
VRRRQSVELH SPQSLPRGSK A
Length:271
Mass (Da):28,965
Last modified:October 11, 2005 - v1
Checksum:i41601C37BFD11CBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK142567 mRNA. Translation: BAE25108.1.
CH466550 Genomic DNA. Translation: EDL04125.1.
RefSeqiNP_033829.3. NM_009699.3.
UniGeneiMm.20206.

Genome annotation databases

GeneIDi11827.
KEGGimmu:11827.

Similar proteinsi

Entry informationi

Entry nameiQ3UQD4_MOUSE
AccessioniPrimary (citable) accession number: Q3UQD4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: October 25, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)