Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Aquaporin 2

Gene

Aqp2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

PorinImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Aquaporin 2Imported
Gene namesi
Name:Aqp2Imported
ORF Names:mCG_18397Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1096865. Aqp2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3524HelicalSequence analysisAdd
BLAST
Transmembranei41 – 6222HelicalSequence analysisAdd
BLAST
Transmembranei83 – 10725HelicalSequence analysisAdd
BLAST
Transmembranei127 – 14923HelicalSequence analysisAdd
BLAST
Transmembranei161 – 18020HelicalSequence analysisAdd
BLAST
Transmembranei202 – 22423HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000023013.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023752.

Family & Domainsi

Sequence similaritiesi

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00760000119223.
HOVERGENiHBG000312.
KOiK09865.
OMAiCTEFLAT.
OrthoDBiEOG091G166T.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UQD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWELRSIAFS RAVLAEFLAT LLFVFFGLGS ALQWASSPPS VLQIAVAFGL
60 70 80 90 100
GIGTLVQALG HVSGAHINPA VTVACLVGCH VSFLRAAFYV AAQLLGAVAG
110 120 130 140 150
AAILHEITPV EIRGDLAVNA LHNNATAGQA VTVELFLTMQ LVLCIFASTD
160 170 180 190 200
ERRSDNLGSP ALSIGFSVTL GHLLGIYFTG CSMNPARSLA PAVVTGKFDD
210 220 230 240 250
HWVFWIGPLV GAVIGSLLYN YLLFPSTKSL QERLAVLKGL EPDTDWEERE
260 270
VRRRQSVELH SPQSLPRGSK A
Length:271
Mass (Da):28,965
Last modified:October 11, 2005 - v1
Checksum:i41601C37BFD11CBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK142567 mRNA. Translation: BAE25108.1.
CH466550 Genomic DNA. Translation: EDL04125.1.
RefSeqiNP_033829.3. NM_009699.3.
UniGeneiMm.20206.

Genome annotation databases

GeneIDi11827.
KEGGimmu:11827.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK142567 mRNA. Translation: BAE25108.1.
CH466550 Genomic DNA. Translation: EDL04125.1.
RefSeqiNP_033829.3. NM_009699.3.
UniGeneiMm.20206.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023752.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11827.
KEGGimmu:11827.

Organism-specific databases

CTDi359.
MGIiMGI:1096865. Aqp2.

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00760000119223.
HOVERGENiHBG000312.
KOiK09865.
OMAiCTEFLAT.
OrthoDBiEOG091G166T.

Miscellaneous databases

ChiTaRSiAqp2. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023013.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ3UQD4_MOUSE
AccessioniPrimary (citable) accession number: Q3UQD4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.