Insrr

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: InterPro
transmembrane receptor protein tyrosine kinase activity Source: InterPro

GO - Biological processⁱ

cellular response to alkaline pH Source: InterPro
transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Putative uncharacterized proteinImported
Gene namesⁱ	Name:InsrrImported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:1346037. Insrr.

Subcellular locationⁱ

GO - Cellular componentⁱ

integral component of plasma membrane Source: InterPro

Complete GO annotation...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	Sequence analysisAdd BLAST		23
ChainⁱPRO_5004230133	24 – 709	Sequence analysisAdd BLAST		686

Proteomic databases

PaxDbⁱ	Q3UQC8.
PeptideAtlas More...PeptideAtlasⁱ	Q3UQC8.

Expressionⁱ

Gene expression databases

Genevisibleⁱ	Q3UQC8. MM.

Genevisibleⁱ

Q3UQC8. MM.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	483 – 603	Fibronectin type-IIIInterPro annotationAdd BLAST		121
Domainⁱ	607 – 707	Fibronectin type-IIIInterPro annotationAdd BLAST		101

Keywords - Domainⁱ

SignalSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG1095. Eukaryota. KOG4258. Eukaryota. COG0515. LUCA.
HOVERGENⁱ	HBG006134.
KEGG Orthology (KO) More...KOⁱ	K05086.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00063. FN3. 2 hits.
Gene3Dⁱ	2.60.40.10. 2 hits. 3.80.20.20. 2 hits.
InterProⁱ	View protein in InterPro IPR003961. FN3_dom. IPR006211. Furin-like_Cys-rich_dom. IPR006212. Furin_repeat. IPR009030. Growth_fac_rcpt_. IPR013783. Ig-like_fold. IPR028792. INSRR. IPR032675. L_dom-like. IPR000494. Rcpt_L-dom.
PANTHERⁱ	PTHR24416:SF380. PTHR24416:SF380. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00757. Furin-like. 1 hit. PF01030. Recep_L_domain. 2 hits.
SMARTⁱ	View protein in SMART SM00261. FU. 1 hit.
SUPFAMⁱ	SSF49265. SSF49265. 2 hits. SSF52058. SSF52058. 3 hits. SSF57184. SSF57184. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50853. FN3. 2 hits.

Sequenceⁱ

Sequence statusⁱ: Fragment.

Q3UQC8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAVPALWPWG VHLLMSLLSL GSGLDTLEVC PSLDIRSEVT ELRRLENCSV 
        60         70         80         90        100
VEGHLQILLM FAATGEDFRG LSFPRLTQVT DYLLLFRVYG LESLRDLFPN 
       110        120        130        140        150
LTVIRGTRLF LGYALIIFEM PHLRDVGLPS LGAVLRGAVR VEKNQELCHL 
       160        170        180        190        200
STIDWGLLQP APGTNHIVGN KLGEECADVC PGVLGAAGEP CSRTTFSGRT 
       210        220        230        240        250
DYRCWTSSHC QKVCPCPRGM ACTAGGDCCH SECLGGCSQP EDPRACVACR 
       260        270        280        290        300
HLYFQGVCLR ACPPGTYQYE SWRCVTAELC AHLREVPGLA TTFGIYEGSC 
       310        320        330        340        350
LAQCPPGFTR NGSGIFCHKC EGLCPKECKV GTKTIDSVQA TQDLVGCTHV 
       360        370        380        390        400
EGNLILNLRQ GYNLEPELQR NLGLVETITG FLKIKHSFAL VTLGFFKNLK 
       410        420        430        440        450
LIRGDSMVDG NYTLYVLDNQ NLQQLGSWVT AGLTIPVGKI YFAFNPRLCL 
       460        470        480        490        500
EHIYQLEEVT GTRGRQSKAE INPRTNGDRA ACQTRTLRFV FNLTEEDRIL 
       510        520        530        540        550
LRWERYEPLE ARDLLSFIVY YKESPFQNAT EHVGPDACGT QSWNLLDVEL 
       560        570        580        590        600
PLSRTQEPGV TLAPLKPWTQ YAVFVRAITL TTAEDSPHQG AQSPIVYLRT 
       610        620        630        640        650
LPAAPTVPQD VISTSNSSSH LLVRWKPPVQ RNGNITYYLV LWQRLAEDGD 
       660        670        680        690        700
LYINDYCHRG LRLPTSSHDT RFDREDPALE AEPEQGCCPC QHSPPGQALP 

ALEAQEVTF

Length:709

Mass (Da):78,686

Last modified:October 11, 2005 - v1

Checksum:ⁱD7CE7B699AAD89EF

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	709	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK142578 mRNA. Translation: BAE25114.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_035962.2. NM_011832.2.
UniGeneⁱ	Mm.42041.

Genome annotation databases

GeneIDⁱ	23920.
KEGGⁱ	mmu:23920.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK142578 mRNA. Translation: BAE25114.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_035962.2. NM_011832.2.
UniGeneⁱ	Mm.42041.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PaxDbⁱ	Q3UQC8.
PeptideAtlas More...PeptideAtlasⁱ	Q3UQC8.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	23920.
KEGGⁱ	mmu:23920.

Organism-specific databases

CTDⁱ	3645.
MGIⁱ	MGI:1346037. Insrr.

Phylogenomic databases

eggNOGⁱ	KOG1095. Eukaryota. KOG4258. Eukaryota. COG0515. LUCA.
HOVERGENⁱ	HBG006134.
KEGG Orthology (KO) More...KOⁱ	K05086.

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Genevisibleⁱ	Q3UQC8. MM.

Genevisibleⁱ

Q3UQC8. MM.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00063. FN3. 2 hits.
Gene3Dⁱ	2.60.40.10. 2 hits. 3.80.20.20. 2 hits.
InterProⁱ	View protein in InterPro IPR003961. FN3_dom. IPR006211. Furin-like_Cys-rich_dom. IPR006212. Furin_repeat. IPR009030. Growth_fac_rcpt_. IPR013783. Ig-like_fold. IPR028792. INSRR. IPR032675. L_dom-like. IPR000494. Rcpt_L-dom.
PANTHERⁱ	PTHR24416:SF380. PTHR24416:SF380. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00757. Furin-like. 1 hit. PF01030. Recep_L_domain. 2 hits.
SMARTⁱ	View protein in SMART SM00261. FU. 1 hit.
SUPFAMⁱ	SSF49265. SSF49265. 2 hits. SSF52058. SSF52058. 3 hits. SSF57184. SSF57184. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50853. FN3. 2 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q3UQC8_MOUSE
Accessionⁱ	Q3UQC8Primary (citable) accession number: Q3UQC8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 11, 2005
	Last sequence update:	October 11, 2005
	Last modified:	July 5, 2017
	This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB - Q3UQC8 (Q3UQC8_MOUSE)

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Putative uncharacterized protein

Select a section on the left to see content.

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Proteomic databases

Expressionⁱ

Gene expression databases

Family & Domainsⁱ

Domains and Repeats

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Experimental Info

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3UQC8 (Q3UQC8_MOUSE)

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Putative uncharacterized protein

Insrr

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ