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Protein

Ras GTPase-activating-like protein IQGAP2

Gene

Iqgap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Enzyme and pathway databases

ReactomeiR-MMU-5626467. RHO GTPases activate IQGAPs.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras GTPase-activating-like protein IQGAP2
Gene namesi
Name:Iqgap2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2449975. Iqgap2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 15751574Ras GTPase-activating-like protein IQGAP2PRO_0000354074Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161PhosphoserineCombined sources
Modified residuei356 – 3561PhosphothreonineBy similarity
Modified residuei599 – 5991PhosphoserineBy similarity
Modified residuei782 – 7821PhosphothreonineBy similarity
Modified residuei881 – 8811PhosphothreonineCombined sources
Modified residuei1002 – 10021PhosphothreonineBy similarity
Modified residuei1269 – 12691PhosphothreonineBy similarity
Modified residuei1279 – 12791PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3UQ44.
MaxQBiQ3UQ44.
PaxDbiQ3UQ44.
PRIDEiQ3UQ44.

PTM databases

iPTMnetiQ3UQ44.
PhosphoSiteiQ3UQ44.

Expressioni

Gene expression databases

BgeeiQ3UQ44.
GenevisibleiQ3UQ44. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi243818. 1 interaction.
STRINGi10090.ENSMUSP00000067685.

Structurei

3D structure databases

ProteinModelPortaliQ3UQ44.
SMRiQ3UQ44. Positions 23-207, 875-1252, 1477-1571.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 156116CHPROSITE-ProRule annotationAdd
BLAST
Domaini594 – 62734WWPROSITE-ProRule annotationAdd
BLAST
Domaini690 – 71930IQ 1PROSITE-ProRule annotationAdd
BLAST
Domaini720 – 74930IQ 2PROSITE-ProRule annotationAdd
BLAST
Domaini750 – 77930IQ 3PROSITE-ProRule annotationAdd
BLAST
Domaini917 – 1150234Ras-GAPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
Contains 3 IQ domains.PROSITE-ProRule annotation
Contains 1 Ras-GAP domain.PROSITE-ProRule annotation
Contains 1 WW domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2128. Eukaryota.
COG5261. LUCA.
GeneTreeiENSGT00600000084379.
HOGENOMiHOG000004842.
HOVERGENiHBG052143.
InParanoidiQ3UQ44.
KOiK05767.
OMAiKGGEMQI.
OrthoDBiEOG7FNC6M.
PhylomeDBiQ3UQ44.
TreeFamiTF313078.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
1.10.506.10. 2 hits.
InterProiIPR001715. CH-domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR000593. RasGAP_C.
IPR023152. RasGAP_CS.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF00612. IQ. 2 hits.
PF00616. RasGAP. 1 hit.
PF03836. RasGAP_C. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00015. IQ. 3 hits.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48350. SSF48350. 2 hits.
PROSITEiPS50021. CH. 1 hit.
PS50096. IQ. 3 hits.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UQ44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHEELPSLQ RPRYGSIVDD ERLSAEEMDE RRRQNIAYEY LCHLEEAKRW
60 70 80 90 100
MEVCLVEELP PTTELEEGLR NGVYLAKLAK FFAPKMVSEK KIYDVEQTRY
110 120 130 140 150
KKSGLHFRHT DNTVQWLRAM EAIGLPKIFY PETTDVYDRK NIPRMIYCIH
160 170 180 190 200
ALSLYLFKLG IAPQIQDLLG KVDFTEEEIS NMRKELEKYG IQMPAFSKIG
210 220 230 240 250
GILANELSVD EAALHAAVIA INEAIEKGVA KQTIITLRNP NAVLTCVDDS
260 270 280 290 300
LSQEYQKELW EAKKKKEESA KLKNSCISEE ERDAYEELLT QAEIQSNIST
310 320 330 340 350
VNRMAAVDHI NAVLQEGDPE NTLLALKKPE AQLPAVYPFA AVMYQNELFN
360 370 380 390 400
LQKQNTSNYL AHEELLIAVE MLSAVALLNQ ALESSDLVAV QNQLRSPTIG
410 420 430 440 450
FNNLDEAHVD RYADALLSVK QEALSQGQDT LSWNEIQNCI DMINNQIQEE
460 470 480 490 500
NDRMVVLGYI NEAIDAGNPL KTLDTLLLPT ANIRDVDPDC AQHYQDVLFY
510 520 530 540 550
TKSQKLGDPK NVSKVLWLDE IQQAINEANV DENRAKQWVT LVVDVNECLD
560 570 580 590 600
RKQSDHILTA LKSSPSNIHN ILPECANKYY DTLVKAKESK TDNESSEGSW
610 620 630 640 650
VTLNVQEKYN YYYNTDSKEG SWVPPELCLS KESWLTGEEI EDIVEEVTSD
660 670 680 690 700
YIREKLWSAS EDLLVRFEAT TLGPALREEF EARKAFLYEQ TESVVKIQAF
710 720 730 740 750
WKGFKQRQEY LHRQQVFAGN VDSVVKIQSW FRMVTARKSY LSRLRYFEDH
760 770 780 790 800
KNEIVKIQSL LRASKARDDY KALVGSENPP LTVIRKFVYL LDQSDLDFQE
810 820 830 840 850
ELEVARLREE VVTKIRANQQ LEKDLNLMDI KIGLLVKNRI TLEDVISHRK
860 870 880 890 900
KLNKKKGGEI EILNNTDNKG IKSLSKERRK TLETYQQLFY LLQTKPSYLA
910 920 930 940 950
KLIFQMPQNK STKFMDTVIF TLYNYASNQR EEYLLLKLFK TALEEEIKSK
960 970 980 990 1000
VDQVQDIVTG NPTVIKMVVS FNRGARGQNT LRQLLAPVVK EIIEDKALVI
1010 1020 1030 1040 1050
NTNPVEVYKA WVNQLETQTG EASKLPYDVT TEQALTYPEV KNKLEASIEN
1060 1070 1080 1090 1100
LRKVTDKVLG SIISSLDLLP YGLRYIAKVL KNSIREKFPD ATEEELLKIV
1110 1120 1130 1140 1150
GNLLYYRYMN PAIVAPDGFD IIDMTAGGQI NSNQRRNLGS VAKVLQHAAS
1160 1170 1180 1190 1200
NKLFEGENEH LSSMNNYLSE TYQEFRKYFQ EACDVPEPEE KFNMDKYTDL
1210 1220 1230 1240 1250
VTVSKPVIYI SIEEIINTHL LLLEHQDAIA TEKSDLLNEL LESLGEVPTV
1260 1270 1280 1290 1300
ESFLGEGAVD PNDPNKENTL NQLSKTEISL SLTSKYDVKD GEAVDGRSLM
1310 1320 1330 1340 1350
IKTKKLIIDV TRNQPGSTLT EILETPATGQ QELEHAKDME SRAVVDSRTP
1360 1370 1380 1390 1400
EEGKQSQAVI EDARLPLEQK KRKIQRNLRT LEQTGHVSSK NKYQDILNEI
1410 1420 1430 1440 1450
AKDIRNQRIH RKLRKAELSK LQQTLNALNK KAAFYEDQIN YYDTYIKTCV
1460 1470 1480 1490 1500
DNLKRKNSRR SIKLDGKAEP KGTKRVKPVR YTAAKLHDKG VLLGIDDLQT
1510 1520 1530 1540 1550
NQFKNVMFDI IATEDMGIFD VRSKFLGVEM EKVQLNIQDL LQMQYEGVAV
1560 1570
MKMFDKVKVN VNLLIYLLNK KFYGK
Length:1,575
Mass (Da):180,528
Last modified:November 25, 2008 - v2
Checksum:i5EF176042E4D158F
GO

Sequence cautioni

The sequence AK147360 differs from that shown. Reason: Frameshift at position 408. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1275 – 12751K → R in BAE25199 (PubMed:16141072).Curated
Sequence conflicti1447 – 14471K → E in BAE25199 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK142813 mRNA. Translation: BAE25199.1.
AK147360 mRNA. No translation available.
CCDSiCCDS36753.1.
RefSeqiNP_081987.1. NM_027711.1.
UniGeneiMm.38878.

Genome annotation databases

EnsembliENSMUST00000068603; ENSMUSP00000067685; ENSMUSG00000021676.
GeneIDi544963.
KEGGimmu:544963.
UCSCiuc007rmo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK142813 mRNA. Translation: BAE25199.1.
AK147360 mRNA. No translation available.
CCDSiCCDS36753.1.
RefSeqiNP_081987.1. NM_027711.1.
UniGeneiMm.38878.

3D structure databases

ProteinModelPortaliQ3UQ44.
SMRiQ3UQ44. Positions 23-207, 875-1252, 1477-1571.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi243818. 1 interaction.
STRINGi10090.ENSMUSP00000067685.

PTM databases

iPTMnetiQ3UQ44.
PhosphoSiteiQ3UQ44.

Proteomic databases

EPDiQ3UQ44.
MaxQBiQ3UQ44.
PaxDbiQ3UQ44.
PRIDEiQ3UQ44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068603; ENSMUSP00000067685; ENSMUSG00000021676.
GeneIDi544963.
KEGGimmu:544963.
UCSCiuc007rmo.1. mouse.

Organism-specific databases

CTDi10788.
MGIiMGI:2449975. Iqgap2.

Phylogenomic databases

eggNOGiKOG2128. Eukaryota.
COG5261. LUCA.
GeneTreeiENSGT00600000084379.
HOGENOMiHOG000004842.
HOVERGENiHBG052143.
InParanoidiQ3UQ44.
KOiK05767.
OMAiKGGEMQI.
OrthoDBiEOG7FNC6M.
PhylomeDBiQ3UQ44.
TreeFamiTF313078.

Enzyme and pathway databases

ReactomeiR-MMU-5626467. RHO GTPases activate IQGAPs.

Miscellaneous databases

ChiTaRSiIqgap2. mouse.
NextBioi412173.
PROiQ3UQ44.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UQ44.
GenevisibleiQ3UQ44. MM.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
1.10.506.10. 2 hits.
InterProiIPR001715. CH-domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR000593. RasGAP_C.
IPR023152. RasGAP_CS.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF00612. IQ. 2 hits.
PF00616. RasGAP. 1 hit.
PF03836. RasGAP_C. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00015. IQ. 3 hits.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48350. SSF48350. 2 hits.
PROSITEiPS50021. CH. 1 hit.
PS50096. IQ. 3 hits.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  3. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16 AND THR-881, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiIQGA2_MOUSE
AccessioniPrimary (citable) accession number: Q3UQ44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: March 16, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.