Iqgap2

Functionⁱ

Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.

GO - Molecular functionⁱ

actin filament binding Source: MGI
Arp2/3 complex binding Source: MGI
calmodulin binding Source: MGI
phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
Rac GTPase binding Source: MGI
Rho GTPase binding Source: MGI

Complete GO annotation...

GO - Biological processⁱ

Arp2/3 complex-mediated actin nucleation Source: MGI
regulation of GTPase activity Source: InterPro
thrombin-activated receptor signaling pathway Source: MGI

Complete GO annotation...

Keywordsⁱ

Molecular function	Calmodulin-binding

Molecular function

Calmodulin-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5626467. RHO GTPases activate IQGAPs. R-MMU-6798695. Neutrophil degranulation.

Reactomeⁱ

R-MMU-5626467. RHO GTPases activate IQGAPs.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras GTPase-activating-like protein IQGAP2
Gene namesⁱ	Name:Iqgap2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 13

Organism-specific databases

MGIⁱ	MGI:2449975. Iqgap2.

Subcellular locationⁱ

GO - Cellular componentⁱ

cell surface Source: MGI
cytoplasm Source: MGI
extracellular exosome Source: MGI
filamentous actin Source: Ensembl
filopodium Source: MGI
lamellipodium Source: MGI
microtubule Source: MGI
microvillus
Source: MGI
Inferred from direct assayⁱ
- 18604197

Complete GO annotation...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000354074	1 – 1575	Ras GTPase-activating-like protein IQGAP2Add BLAST		1575

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	16	PhosphoserineCombined sources	1
Modified residueⁱ	356	PhosphothreonineBy similarity	1
Modified residueⁱ	595	PhosphoserineBy similarity	1
Modified residueⁱ	599	PhosphoserineBy similarity	1
Modified residueⁱ	782	PhosphothreonineBy similarity	1
Modified residueⁱ	881	PhosphothreonineCombined sources	1
Modified residueⁱ	1002	PhosphothreonineBy similarity	1
Modified residueⁱ	1269	PhosphothreonineBy similarity	1
Modified residueⁱ	1279	PhosphoserineBy similarity	1
Modified residueⁱ	1461	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q3UQ44.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q3UQ44.
PaxDbⁱ	Q3UQ44.
PeptideAtlas More...PeptideAtlasⁱ	Q3UQ44.
PRIDEⁱ	Q3UQ44.

PTM databases

iPTMnetⁱ	Q3UQ44.
PhosphoSitePlusⁱ	Q3UQ44.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000021676.
Genevisibleⁱ	Q3UQ44. MM.

Interactionⁱ

GO - Molecular functionⁱ

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	243818. 2 interactors.
STRINGⁱ	10090.ENSMUSP00000067685.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3UQ44.
SMRⁱ	Q3UQ44.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	41 – 156	Calponin-homologyPROSITE-ProRule annotationAdd BLAST	116
Domainⁱ	594 – 627	WWPROSITE-ProRule annotationAdd BLAST	34
Domainⁱ	690 – 719	IQ 1PROSITE-ProRule annotationAdd BLAST	30
Domainⁱ	720 – 749	IQ 2PROSITE-ProRule annotationAdd BLAST	30
Domainⁱ	750 – 779	IQ 3PROSITE-ProRule annotationAdd BLAST	30
Domainⁱ	917 – 1150	Ras-GAPPROSITE-ProRule annotationAdd BLAST	234

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG2128. Eukaryota. COG5261. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00600000084379.
HOGENOMⁱ	HOG000004842.
HOVERGENⁱ	HBG052143.
InParanoidⁱ	Q3UQ44.
KEGG Orthology (KO) More...KOⁱ	K05767.
OMAⁱ	VIYISIE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00ET.
PhylomeDBⁱ	Q3UQ44.
TreeFamⁱ	TF313078.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00014. CH. 1 hit.
Gene3Dⁱ	1.10.418.10. 1 hit.
InterProⁱ	View protein in InterPro IPR001715. CH-domain. IPR000048. IQ_motif_EF-hand-BS. IPR000593. RasGAP_C. IPR023152. RasGAP_CS. IPR001936. RasGAP_dom. IPR008936. Rho_GTPase_activation_prot. IPR001202. WW_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00307. CH. 1 hit. PF00612. IQ. 2 hits. PF00616. RasGAP. 1 hit. PF03836. RasGAP_C. 1 hit.
SMARTⁱ	View protein in SMART SM00033. CH. 1 hit. SM00015. IQ. 3 hits. SM00323. RasGAP. 1 hit.
SUPFAMⁱ	SSF47576. SSF47576. 1 hit. SSF48350. SSF48350. 2 hits.
PROSITEⁱ	View protein in PROSITE PS50021. CH. 1 hit. PS50096. IQ. 3 hits. PS00509. RAS_GTPASE_ACTIV_1. 1 hit. PS50018. RAS_GTPASE_ACTIV_2. 1 hit. PS01159. WW_DOMAIN_1. 1 hit. PS50020. WW_DOMAIN_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q3UQ44-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPHEELPSLQ RPRYGSIVDD ERLSAEEMDE RRRQNIAYEY LCHLEEAKRW 
        60         70         80         90        100
MEVCLVEELP PTTELEEGLR NGVYLAKLAK FFAPKMVSEK KIYDVEQTRY 
       110        120        130        140        150
KKSGLHFRHT DNTVQWLRAM EAIGLPKIFY PETTDVYDRK NIPRMIYCIH 
       160        170        180        190        200
ALSLYLFKLG IAPQIQDLLG KVDFTEEEIS NMRKELEKYG IQMPAFSKIG 
       210        220        230        240        250
GILANELSVD EAALHAAVIA INEAIEKGVA KQTIITLRNP NAVLTCVDDS 
       260        270        280        290        300
LSQEYQKELW EAKKKKEESA KLKNSCISEE ERDAYEELLT QAEIQSNIST 
       310        320        330        340        350
VNRMAAVDHI NAVLQEGDPE NTLLALKKPE AQLPAVYPFA AVMYQNELFN 
       360        370        380        390        400
LQKQNTSNYL AHEELLIAVE MLSAVALLNQ ALESSDLVAV QNQLRSPTIG 
       410        420        430        440        450
FNNLDEAHVD RYADALLSVK QEALSQGQDT LSWNEIQNCI DMINNQIQEE 
       460        470        480        490        500
NDRMVVLGYI NEAIDAGNPL KTLDTLLLPT ANIRDVDPDC AQHYQDVLFY 
       510        520        530        540        550
TKSQKLGDPK NVSKVLWLDE IQQAINEANV DENRAKQWVT LVVDVNECLD 
       560        570        580        590        600
RKQSDHILTA LKSSPSNIHN ILPECANKYY DTLVKAKESK TDNESSEGSW 
       610        620        630        640        650
VTLNVQEKYN YYYNTDSKEG SWVPPELCLS KESWLTGEEI EDIVEEVTSD 
       660        670        680        690        700
YIREKLWSAS EDLLVRFEAT TLGPALREEF EARKAFLYEQ TESVVKIQAF 
       710        720        730        740        750
WKGFKQRQEY LHRQQVFAGN VDSVVKIQSW FRMVTARKSY LSRLRYFEDH 
       760        770        780        790        800
KNEIVKIQSL LRASKARDDY KALVGSENPP LTVIRKFVYL LDQSDLDFQE 
       810        820        830        840        850
ELEVARLREE VVTKIRANQQ LEKDLNLMDI KIGLLVKNRI TLEDVISHRK 
       860        870        880        890        900
KLNKKKGGEI EILNNTDNKG IKSLSKERRK TLETYQQLFY LLQTKPSYLA 
       910        920        930        940        950
KLIFQMPQNK STKFMDTVIF TLYNYASNQR EEYLLLKLFK TALEEEIKSK 
       960        970        980        990       1000
VDQVQDIVTG NPTVIKMVVS FNRGARGQNT LRQLLAPVVK EIIEDKALVI 
      1010       1020       1030       1040       1050
NTNPVEVYKA WVNQLETQTG EASKLPYDVT TEQALTYPEV KNKLEASIEN 
      1060       1070       1080       1090       1100
LRKVTDKVLG SIISSLDLLP YGLRYIAKVL KNSIREKFPD ATEEELLKIV 
      1110       1120       1130       1140       1150
GNLLYYRYMN PAIVAPDGFD IIDMTAGGQI NSNQRRNLGS VAKVLQHAAS 
      1160       1170       1180       1190       1200
NKLFEGENEH LSSMNNYLSE TYQEFRKYFQ EACDVPEPEE KFNMDKYTDL 
      1210       1220       1230       1240       1250
VTVSKPVIYI SIEEIINTHL LLLEHQDAIA TEKSDLLNEL LESLGEVPTV 
      1260       1270       1280       1290       1300
ESFLGEGAVD PNDPNKENTL NQLSKTEISL SLTSKYDVKD GEAVDGRSLM 
      1310       1320       1330       1340       1350
IKTKKLIIDV TRNQPGSTLT EILETPATGQ QELEHAKDME SRAVVDSRTP 
      1360       1370       1380       1390       1400
EEGKQSQAVI EDARLPLEQK KRKIQRNLRT LEQTGHVSSK NKYQDILNEI 
      1410       1420       1430       1440       1450
AKDIRNQRIH RKLRKAELSK LQQTLNALNK KAAFYEDQIN YYDTYIKTCV 
      1460       1470       1480       1490       1500
DNLKRKNSRR SIKLDGKAEP KGTKRVKPVR YTAAKLHDKG VLLGIDDLQT 
      1510       1520       1530       1540       1550
NQFKNVMFDI IATEDMGIFD VRSKFLGVEM EKVQLNIQDL LQMQYEGVAV 
      1560       1570 
MKMFDKVKVN VNLLIYLLNK KFYGK

Length:1,575

Mass (Da):180,528

Last modified:November 25, 2008 - v2

Checksum:ⁱ5EF176042E4D158F

GO

Sequence cautionⁱ

The sequence AK147360 differs from that shown. Reason: Frameshift at position 408.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	1275	K → R in BAE25199 (PubMed:16141072).Curated		1
Sequence conflictⁱ	1447	K → E in BAE25199 (PubMed:16141072).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK142813 mRNA. Translation: BAE25199.1. AK147360 mRNA. No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS36753.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_081987.1. NM_027711.1.
UniGeneⁱ	Mm.38878.

Genome annotation databases

Ensemblⁱ	ENSMUST00000068603; ENSMUSP00000067685; ENSMUSG00000021676.
GeneIDⁱ	544963.
KEGGⁱ	mmu:544963.
UCSC genome browser More...UCSCⁱ	uc007rmo.1. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK142813 mRNA. Translation: BAE25199.1. AK147360 mRNA. No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS36753.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_081987.1. NM_027711.1.
UniGeneⁱ	Mm.38878.

3D structure databases

ProteinModelPortalⁱ	Q3UQ44.
SMRⁱ	Q3UQ44.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	243818. 2 interactors.
STRINGⁱ	10090.ENSMUSP00000067685.

PTM databases

iPTMnetⁱ	Q3UQ44.
PhosphoSitePlusⁱ	Q3UQ44.

Proteomic databases

EPDⁱ	Q3UQ44.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q3UQ44.
PaxDbⁱ	Q3UQ44.
PeptideAtlas More...PeptideAtlasⁱ	Q3UQ44.
PRIDEⁱ	Q3UQ44.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000068603; ENSMUSP00000067685; ENSMUSG00000021676.
GeneIDⁱ	544963.
KEGGⁱ	mmu:544963.
UCSC genome browser More...UCSCⁱ	uc007rmo.1. mouse.

Organism-specific databases

CTDⁱ	10788.
MGIⁱ	MGI:2449975. Iqgap2.

Phylogenomic databases

eggNOGⁱ	KOG2128. Eukaryota. COG5261. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00600000084379.
HOGENOMⁱ	HOG000004842.
HOVERGENⁱ	HBG052143.
InParanoidⁱ	Q3UQ44.
KEGG Orthology (KO) More...KOⁱ	K05767.
OMAⁱ	VIYISIE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00ET.
PhylomeDBⁱ	Q3UQ44.
TreeFamⁱ	TF313078.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5626467. RHO GTPases activate IQGAPs. R-MMU-6798695. Neutrophil degranulation.

Reactomeⁱ

R-MMU-5626467. RHO GTPases activate IQGAPs.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSⁱ	Iqgap2. mouse.
Protein Ontology More...PROⁱ	PR:Q3UQ44.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000021676.
Genevisibleⁱ	Q3UQ44. MM.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00014. CH. 1 hit.
Gene3Dⁱ	1.10.418.10. 1 hit.
InterProⁱ	View protein in InterPro IPR001715. CH-domain. IPR000048. IQ_motif_EF-hand-BS. IPR000593. RasGAP_C. IPR023152. RasGAP_CS. IPR001936. RasGAP_dom. IPR008936. Rho_GTPase_activation_prot. IPR001202. WW_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00307. CH. 1 hit. PF00612. IQ. 2 hits. PF00616. RasGAP. 1 hit. PF03836. RasGAP_C. 1 hit.
SMARTⁱ	View protein in SMART SM00033. CH. 1 hit. SM00015. IQ. 3 hits. SM00323. RasGAP. 1 hit.
SUPFAMⁱ	SSF47576. SSF47576. 1 hit. SSF48350. SSF48350. 2 hits.
PROSITEⁱ	View protein in PROSITE PS50021. CH. 1 hit. PS50096. IQ. 3 hits. PS00509. RAS_GTPASE_ACTIV_1. 1 hit. PS50018. RAS_GTPASE_ACTIV_2. 1 hit. PS01159. WW_DOMAIN_1. 1 hit. PS50020. WW_DOMAIN_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IQGA2_MOUSE
Accessionⁱ	Q3UQ44Primary (citable) accession number: Q3UQ44
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 25, 2008
	Last sequence update:	November 25, 2008
	Last modified:	July 5, 2017
	This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3UQ44 (IQGA2_MOUSE)

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Ras GTPase-activating-like protein IQGAP2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ