Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q3UQ44 (IQGA2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras GTPase-activating-like protein IQGAP2
Gene names
Name:Iqgap2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length1575 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.

Sequence similarities

Contains 1 CH (calponin-homology) domain.

Contains 3 IQ domains.

Contains 1 Ras-GAP domain.

Contains 1 WW domain.

Sequence caution

The sequence AK147360 differs from that shown. Reason: Frameshift at position 408.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 15751574Ras GTPase-activating-like protein IQGAP2
PRO_0000354074

Regions

Domain41 – 156116CH
Domain594 – 62734WW
Domain690 – 71930IQ 1
Domain720 – 74930IQ 2
Domain750 – 77930IQ 3
Domain917 – 1150234Ras-GAP

Amino acid modifications

Modified residue161Phosphoserine Ref.2 Ref.3
Modified residue13891Phosphoserine Ref.4

Experimental info

Sequence conflict12751K → R in BAE25199. Ref.1
Sequence conflict14471K → E in BAE25199. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q3UQ44 [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: 5EF176042E4D158F

FASTA1,575180,528
        10         20         30         40         50         60 
MPHEELPSLQ RPRYGSIVDD ERLSAEEMDE RRRQNIAYEY LCHLEEAKRW MEVCLVEELP 

        70         80         90        100        110        120 
PTTELEEGLR NGVYLAKLAK FFAPKMVSEK KIYDVEQTRY KKSGLHFRHT DNTVQWLRAM 

       130        140        150        160        170        180 
EAIGLPKIFY PETTDVYDRK NIPRMIYCIH ALSLYLFKLG IAPQIQDLLG KVDFTEEEIS 

       190        200        210        220        230        240 
NMRKELEKYG IQMPAFSKIG GILANELSVD EAALHAAVIA INEAIEKGVA KQTIITLRNP 

       250        260        270        280        290        300 
NAVLTCVDDS LSQEYQKELW EAKKKKEESA KLKNSCISEE ERDAYEELLT QAEIQSNIST 

       310        320        330        340        350        360 
VNRMAAVDHI NAVLQEGDPE NTLLALKKPE AQLPAVYPFA AVMYQNELFN LQKQNTSNYL 

       370        380        390        400        410        420 
AHEELLIAVE MLSAVALLNQ ALESSDLVAV QNQLRSPTIG FNNLDEAHVD RYADALLSVK 

       430        440        450        460        470        480 
QEALSQGQDT LSWNEIQNCI DMINNQIQEE NDRMVVLGYI NEAIDAGNPL KTLDTLLLPT 

       490        500        510        520        530        540 
ANIRDVDPDC AQHYQDVLFY TKSQKLGDPK NVSKVLWLDE IQQAINEANV DENRAKQWVT 

       550        560        570        580        590        600 
LVVDVNECLD RKQSDHILTA LKSSPSNIHN ILPECANKYY DTLVKAKESK TDNESSEGSW 

       610        620        630        640        650        660 
VTLNVQEKYN YYYNTDSKEG SWVPPELCLS KESWLTGEEI EDIVEEVTSD YIREKLWSAS 

       670        680        690        700        710        720 
EDLLVRFEAT TLGPALREEF EARKAFLYEQ TESVVKIQAF WKGFKQRQEY LHRQQVFAGN 

       730        740        750        760        770        780 
VDSVVKIQSW FRMVTARKSY LSRLRYFEDH KNEIVKIQSL LRASKARDDY KALVGSENPP 

       790        800        810        820        830        840 
LTVIRKFVYL LDQSDLDFQE ELEVARLREE VVTKIRANQQ LEKDLNLMDI KIGLLVKNRI 

       850        860        870        880        890        900 
TLEDVISHRK KLNKKKGGEI EILNNTDNKG IKSLSKERRK TLETYQQLFY LLQTKPSYLA 

       910        920        930        940        950        960 
KLIFQMPQNK STKFMDTVIF TLYNYASNQR EEYLLLKLFK TALEEEIKSK VDQVQDIVTG 

       970        980        990       1000       1010       1020 
NPTVIKMVVS FNRGARGQNT LRQLLAPVVK EIIEDKALVI NTNPVEVYKA WVNQLETQTG 

      1030       1040       1050       1060       1070       1080 
EASKLPYDVT TEQALTYPEV KNKLEASIEN LRKVTDKVLG SIISSLDLLP YGLRYIAKVL 

      1090       1100       1110       1120       1130       1140 
KNSIREKFPD ATEEELLKIV GNLLYYRYMN PAIVAPDGFD IIDMTAGGQI NSNQRRNLGS 

      1150       1160       1170       1180       1190       1200 
VAKVLQHAAS NKLFEGENEH LSSMNNYLSE TYQEFRKYFQ EACDVPEPEE KFNMDKYTDL 

      1210       1220       1230       1240       1250       1260 
VTVSKPVIYI SIEEIINTHL LLLEHQDAIA TEKSDLLNEL LESLGEVPTV ESFLGEGAVD 

      1270       1280       1290       1300       1310       1320 
PNDPNKENTL NQLSKTEISL SLTSKYDVKD GEAVDGRSLM IKTKKLIIDV TRNQPGSTLT 

      1330       1340       1350       1360       1370       1380 
EILETPATGQ QELEHAKDME SRAVVDSRTP EEGKQSQAVI EDARLPLEQK KRKIQRNLRT 

      1390       1400       1410       1420       1430       1440 
LEQTGHVSSK NKYQDILNEI AKDIRNQRIH RKLRKAELSK LQQTLNALNK KAAFYEDQIN 

      1450       1460       1470       1480       1490       1500 
YYDTYIKTCV DNLKRKNSRR SIKLDGKAEP KGTKRVKPVR YTAAKLHDKG VLLGIDDLQT 

      1510       1520       1530       1540       1550       1560 
NQFKNVMFDI IATEDMGIFD VRSKFLGVEM EKVQLNIQDL LQMQYEGVAV MKMFDKVKVN 

      1570 
VNLLIYLLNK KFYGK

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Head.
[2]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, MASS SPECTROMETRY.
Tissue: Liver.
[3]"Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, MASS SPECTROMETRY.
Tissue: Liver.
[4]"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry."
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M.
J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1389, MASS SPECTROMETRY.
Tissue: Melanoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK142813 mRNA. Translation: BAE25199.1.
AK147360 mRNA. No translation available.
IPIIPI00406193.
RefSeqNP_081987.1. NM_027711.1.
UniGeneMm.38878.

3D structure databases

HSSPHSSP built from PDB template 1NF1 based on UniProtKB P21359.
ProteinModelPortalQ3UQ44.
SMRQ3UQ44. Positions 23-207, 875-1252, 1477-1571.
ModBaseSearch...

PTM databases

PhosphoSiteQ3UQ44.

Proteomic databases

PaxDbQ3UQ44.
PRIDEQ3UQ44.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000068603; ENSMUSP00000067685; ENSMUSG00000021676.
GeneID544963.
KEGGmmu:544963.
UCSCuc007rmo.1. mouse.

Organism-specific databases

CTD10788.
MGIMGI:2449975. Iqgap2.

Phylogenomic databases

eggNOGCOG5261.
GeneTreeENSGT00600000084379.
HOGENOMHOG000004842.
HOVERGENHBG052143.
InParanoidQ3UQ44.
KOK05767.
OMAPEEMKHS.
OrthoDBEOG4P8FH6.

Gene expression databases

ArrayExpressQ3UQ44.
BgeeQ3UQ44.
GenevestigatorQ3UQ44.

Family and domain databases

Gene3D1.10.418.10. 1 hit.
1.10.506.10. 2 hits.
InterProIPR001715. CH-domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR001936. RasGAP.
IPR000593. RasGAP_C.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
IPR001202. WW_dom.
[Graphical view]
PfamPF00307. CH. 1 hit.
PF00612. IQ. 2 hits.
PF00616. RasGAP. 1 hit.
PF03836. RasGAP_C. 1 hit.
[Graphical view]
SMARTSM00033. CH. 1 hit.
SM00015. IQ. 3 hits.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMSSF47576. Calponin-homology. 1 hit.
SSF48350. Rho_GAP. 1 hit.
PROSITEPS50021. CH. 1 hit.
PS50096. IQ. 3 hits.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIQGAP2. mouse.
NextBio412173.
SOURCESearch...

Entry information

Entry nameIQGA2_MOUSE
AccessionPrimary (citable) accession number: Q3UQ44
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: May 1, 2013
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents