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Q3UQ41

- TM11A_MOUSE

UniProt

Q3UQ41 - TM11A_MOUSE

Protein

Transmembrane protease serine 11A

Gene

Tmprss11a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei198 – 1981Charge relay systemBy similarity
    Active sitei243 – 2431Charge relay systemBy similarity
    Active sitei339 – 3391Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Cell cycle

    Protein family/group databases

    MEROPSiS01.292.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protease serine 11A (EC:3.4.21.-)
    Alternative name(s):
    Airway trypsin-like protease 1
    Serine protease DESC3
    Short name:
    DESC-3
    Gene namesi
    Name:Tmprss11a
    Synonyms:Desc3, Gm7, Hatl1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:2684853. Tmprss11a.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: InterPro
    2. integral component of plasma membrane Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 389389Transmembrane protease serine 11APRO_0000299318Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi183 ↔ 199PROSITE-ProRule annotation
    Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi308 ↔ 324PROSITE-ProRule annotation
    Disulfide bondi335 ↔ 364PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ3UQ41.
    PRIDEiQ3UQ41.

    PTM databases

    PhosphoSiteiQ3UQ41.

    Expressioni

    Gene expression databases

    BgeeiQ3UQ41.
    CleanExiMM_TMPRSS11A.
    GenevestigatoriQ3UQ41.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000098634.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3UQ41.
    SMRiQ3UQ41. Positions 158-389.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini45 – 389345ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 148118SEAPROSITE-ProRule annotationAdd
    BLAST
    Domaini158 – 388231Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
    Contains 1 SEA domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5640.
    GeneTreeiENSGT00720000108393.
    HOGENOMiHOG000251823.
    HOVERGENiHBG013304.
    InParanoidiQ3UQ41.
    KOiK09750.
    OMAiVYITGFG.
    OrthoDBiEOG75B84T.
    PhylomeDBiQ3UQ41.
    TreeFamiTF351684.

    Family and domain databases

    Gene3Di3.30.70.960. 1 hit.
    InterProiIPR017329. Pept_S1A_HAT/DESC1.
    IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR000082. SEA_dom.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF01390. SEA. 1 hit.
    PF00089. Trypsin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    SSF82671. SSF82671. 1 hit.
    PROSITEiPS50024. SEA. 1 hit.
    PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3UQ41-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVAGYGTHN RDLKQWMVTL LSALSLMMVV VTIGLLALFL VFDIQVNSNS    50
    GQKSSNQLKD LQETNENLVD EIFIDSALNN RYIKNHVVGL TPEEDDTKAD 100
    IVMVFQPPAT GRRTVGKKTH HSILDQKTRN ARALPADVSL VQVKDCGKRA 150
    IPLIANRIVS GNPAAKGAWP WQVSLQRSNI HQCGGTLIGN MWVVTAAHCF 200
    RTNSNPRQWT LSFGTTINPP LMKRDVRRII MHERYRPPAR DHDIALVQFS 250
    PRVTFSDEVR RICLPEPSAS FPPNSTVYIT GFGALYYGGE SQNELREARV 300
    QIISNDICKK RHVYGNEIKR GMFCAGFLEG NYDACRGDSG GPLVIRDNKD 350
    TWYLIGIVSW GDNCGQKNKP GVYTQVTYYR HWIASKTGL 389
    Length:389
    Mass (Da):43,605
    Last modified:October 11, 2005 - v1
    Checksum:i1203DE9DADE964F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK142820 mRNA. Translation: BAE25202.1.
    CCDSiCCDS51531.1.
    RefSeqiNP_001028405.1. NM_001033233.2.
    UniGeneiMm.249106.

    Genome annotation databases

    EnsembliENSMUST00000101073; ENSMUSP00000098634; ENSMUSG00000072845.
    GeneIDi194597.
    KEGGimmu:194597.
    UCSCiuc008xxq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK142820 mRNA. Translation: BAE25202.1 .
    CCDSi CCDS51531.1.
    RefSeqi NP_001028405.1. NM_001033233.2.
    UniGenei Mm.249106.

    3D structure databases

    ProteinModelPortali Q3UQ41.
    SMRi Q3UQ41. Positions 158-389.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000098634.

    Protein family/group databases

    MEROPSi S01.292.

    PTM databases

    PhosphoSitei Q3UQ41.

    Proteomic databases

    PaxDbi Q3UQ41.
    PRIDEi Q3UQ41.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000101073 ; ENSMUSP00000098634 ; ENSMUSG00000072845 .
    GeneIDi 194597.
    KEGGi mmu:194597.
    UCSCi uc008xxq.1. mouse.

    Organism-specific databases

    CTDi 339967.
    MGIi MGI:2684853. Tmprss11a.

    Phylogenomic databases

    eggNOGi COG5640.
    GeneTreei ENSGT00720000108393.
    HOGENOMi HOG000251823.
    HOVERGENi HBG013304.
    InParanoidi Q3UQ41.
    KOi K09750.
    OMAi VYITGFG.
    OrthoDBi EOG75B84T.
    PhylomeDBi Q3UQ41.
    TreeFami TF351684.

    Miscellaneous databases

    NextBioi 371615.
    PROi Q3UQ41.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3UQ41.
    CleanExi MM_TMPRSS11A.
    Genevestigatori Q3UQ41.

    Family and domain databases

    Gene3Di 3.30.70.960. 1 hit.
    InterProi IPR017329. Pept_S1A_HAT/DESC1.
    IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR000082. SEA_dom.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF01390. SEA. 1 hit.
    PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037941. TMPRSS11ABCDE. 1 hit.
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    SSF82671. SSF82671. 1 hit.
    PROSITEi PS50024. SEA. 1 hit.
    PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head.
    2. "Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes."
      Hobson J.P., Netzel-Arnett S., Szabo R., Rehault S.M., Church F.C., Strickland D.K., Lawrence D.A., Antalis T.M., Bugge T.H.
      J. Biol. Chem. 279:46981-46994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    3. "ECRG1, a novel candidate of tumor suppressor gene in the esophageal carcinoma, triggers a senescent program in NIH3T3 cells."
      Zhao N., Huang G., Guo L., Lu S.-H.
      Exp. Biol. Med. 231:84-90(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE FUNCTION.

    Entry informationi

    Entry nameiTM11A_MOUSE
    AccessioniPrimary (citable) accession number: Q3UQ41
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3