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Protein

Transmembrane protease serine 11A

Gene

Tmprss11a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei198 – 1981Charge relay systemBy similarity
Active sitei243 – 2431Charge relay systemBy similarity
Active sitei339 – 3391Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Cell cycle

Protein family/group databases

MEROPSiS01.292.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protease serine 11A (EC:3.4.21.-)
Alternative name(s):
Airway trypsin-like protease 1
Serine protease DESC3
Short name:
DESC-3
Gene namesi
Name:Tmprss11a
Synonyms:Desc3, Gm7, Hatl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:2684853. Tmprss11a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei24 – 4421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini45 – 389345ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular region Source: InterPro
  2. integral component of plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Transmembrane protease serine 11APRO_0000299318Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi183 ↔ 199PROSITE-ProRule annotation
Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi308 ↔ 324PROSITE-ProRule annotation
Disulfide bondi335 ↔ 364PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ3UQ41.
PRIDEiQ3UQ41.

PTM databases

PhosphoSiteiQ3UQ41.

Expressioni

Gene expression databases

BgeeiQ3UQ41.
CleanExiMM_TMPRSS11A.
GenevestigatoriQ3UQ41.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098634.

Structurei

3D structure databases

ProteinModelPortaliQ3UQ41.
SMRiQ3UQ41. Positions 158-389.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 148118SEAPROSITE-ProRule annotationAdd
BLAST
Domaini158 – 388231Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000251823.
HOVERGENiHBG013304.
InParanoidiQ3UQ41.
KOiK09750.
OMAiVYITGFG.
OrthoDBiEOG75B84T.
PhylomeDBiQ3UQ41.
TreeFamiTF351684.

Family and domain databases

Gene3Di3.30.70.960. 1 hit.
InterProiIPR017329. Pept_S1A_HAT/DESC1.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEiPS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UQ41-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEVAGYGTHN RDLKQWMVTL LSALSLMMVV VTIGLLALFL VFDIQVNSNS
60 70 80 90 100
GQKSSNQLKD LQETNENLVD EIFIDSALNN RYIKNHVVGL TPEEDDTKAD
110 120 130 140 150
IVMVFQPPAT GRRTVGKKTH HSILDQKTRN ARALPADVSL VQVKDCGKRA
160 170 180 190 200
IPLIANRIVS GNPAAKGAWP WQVSLQRSNI HQCGGTLIGN MWVVTAAHCF
210 220 230 240 250
RTNSNPRQWT LSFGTTINPP LMKRDVRRII MHERYRPPAR DHDIALVQFS
260 270 280 290 300
PRVTFSDEVR RICLPEPSAS FPPNSTVYIT GFGALYYGGE SQNELREARV
310 320 330 340 350
QIISNDICKK RHVYGNEIKR GMFCAGFLEG NYDACRGDSG GPLVIRDNKD
360 370 380
TWYLIGIVSW GDNCGQKNKP GVYTQVTYYR HWIASKTGL
Length:389
Mass (Da):43,605
Last modified:October 11, 2005 - v1
Checksum:i1203DE9DADE964F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK142820 mRNA. Translation: BAE25202.1.
CCDSiCCDS51531.1.
RefSeqiNP_001028405.1. NM_001033233.2.
UniGeneiMm.249106.

Genome annotation databases

EnsembliENSMUST00000101073; ENSMUSP00000098634; ENSMUSG00000072845.
GeneIDi194597.
KEGGimmu:194597.
UCSCiuc008xxq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK142820 mRNA. Translation: BAE25202.1.
CCDSiCCDS51531.1.
RefSeqiNP_001028405.1. NM_001033233.2.
UniGeneiMm.249106.

3D structure databases

ProteinModelPortaliQ3UQ41.
SMRiQ3UQ41. Positions 158-389.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098634.

Protein family/group databases

MEROPSiS01.292.

PTM databases

PhosphoSiteiQ3UQ41.

Proteomic databases

PaxDbiQ3UQ41.
PRIDEiQ3UQ41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101073; ENSMUSP00000098634; ENSMUSG00000072845.
GeneIDi194597.
KEGGimmu:194597.
UCSCiuc008xxq.1. mouse.

Organism-specific databases

CTDi339967.
MGIiMGI:2684853. Tmprss11a.

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000251823.
HOVERGENiHBG013304.
InParanoidiQ3UQ41.
KOiK09750.
OMAiVYITGFG.
OrthoDBiEOG75B84T.
PhylomeDBiQ3UQ41.
TreeFamiTF351684.

Miscellaneous databases

NextBioi371615.
PROiQ3UQ41.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UQ41.
CleanExiMM_TMPRSS11A.
GenevestigatoriQ3UQ41.

Family and domain databases

Gene3Di3.30.70.960. 1 hit.
InterProiIPR017329. Pept_S1A_HAT/DESC1.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEiPS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  2. "Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes."
    Hobson J.P., Netzel-Arnett S., Szabo R., Rehault S.M., Church F.C., Strickland D.K., Lawrence D.A., Antalis T.M., Bugge T.H.
    J. Biol. Chem. 279:46981-46994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  3. "ECRG1, a novel candidate of tumor suppressor gene in the esophageal carcinoma, triggers a senescent program in NIH3T3 cells."
    Zhao N., Huang G., Guo L., Lu S.-H.
    Exp. Biol. Med. 231:84-90(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE FUNCTION.

Entry informationi

Entry nameiTM11A_MOUSE
AccessioniPrimary (citable) accession number: Q3UQ41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 11, 2005
Last modified: January 7, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.