Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q3UQ41 (TM11A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protease serine 11A

EC=3.4.21.-
Alternative name(s):
Airway trypsin-like protease 1
Serine protease DESC3
Short name=DESC-3
Gene names
Name:Tmprss11a
Synonyms:Desc3, Gm7, Hatl1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest. Ref.3

Subcellular location

Membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Contains 1 SEA domain.

Ontologies

Keywords
   Biological processCell cycle
   Cellular componentMembrane
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: InterPro

integral component of plasma membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 389389Transmembrane protease serine 11A
PRO_0000299318

Regions

Topological domain1 – 2323Cytoplasmic Potential
Transmembrane24 – 4421Helical; Signal-anchor for type II membrane protein; Potential
Topological domain45 – 389345Extracellular Potential
Domain31 – 148118SEA
Domain158 – 388231Peptidase S1

Sites

Active site1981Charge relay system By similarity
Active site2431Charge relay system By similarity
Active site3391Charge relay system By similarity

Amino acid modifications

Glycosylation2741N-linked (GlcNAc...) Potential
Disulfide bond183 ↔ 199 By similarity
Disulfide bond308 ↔ 324 By similarity
Disulfide bond335 ↔ 364 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3UQ41 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 1203DE9DADE964F9

FASTA38943,605
        10         20         30         40         50         60 
MEVAGYGTHN RDLKQWMVTL LSALSLMMVV VTIGLLALFL VFDIQVNSNS GQKSSNQLKD 

        70         80         90        100        110        120 
LQETNENLVD EIFIDSALNN RYIKNHVVGL TPEEDDTKAD IVMVFQPPAT GRRTVGKKTH 

       130        140        150        160        170        180 
HSILDQKTRN ARALPADVSL VQVKDCGKRA IPLIANRIVS GNPAAKGAWP WQVSLQRSNI 

       190        200        210        220        230        240 
HQCGGTLIGN MWVVTAAHCF RTNSNPRQWT LSFGTTINPP LMKRDVRRII MHERYRPPAR 

       250        260        270        280        290        300 
DHDIALVQFS PRVTFSDEVR RICLPEPSAS FPPNSTVYIT GFGALYYGGE SQNELREARV 

       310        320        330        340        350        360 
QIISNDICKK RHVYGNEIKR GMFCAGFLEG NYDACRGDSG GPLVIRDNKD TWYLIGIVSW 

       370        380 
GDNCGQKNKP GVYTQVTYYR HWIASKTGL 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Head.
[2]"Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes."
Hobson J.P., Netzel-Arnett S., Szabo R., Rehault S.M., Church F.C., Strickland D.K., Lawrence D.A., Antalis T.M., Bugge T.H.
J. Biol. Chem. 279:46981-46994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]"ECRG1, a novel candidate of tumor suppressor gene in the esophageal carcinoma, triggers a senescent program in NIH3T3 cells."
Zhao N., Huang G., Guo L., Lu S.-H.
Exp. Biol. Med. 231:84-90(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: POSSIBLE FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK142820 mRNA. Translation: BAE25202.1.
CCDSCCDS51531.1.
RefSeqNP_001028405.1. NM_001033233.2.
UniGeneMm.249106.

3D structure databases

ProteinModelPortalQ3UQ41.
SMRQ3UQ41. Positions 158-389.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000098634.

Protein family/group databases

MEROPSS01.292.

PTM databases

PhosphoSiteQ3UQ41.

Proteomic databases

PaxDbQ3UQ41.
PRIDEQ3UQ41.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000101073; ENSMUSP00000098634; ENSMUSG00000072845.
GeneID194597.
KEGGmmu:194597.
UCSCuc008xxq.1. mouse.

Organism-specific databases

CTD339967.
MGIMGI:2684853. Tmprss11a.

Phylogenomic databases

eggNOGCOG5640.
GeneTreeENSGT00720000108393.
HOGENOMHOG000251823.
HOVERGENHBG013304.
InParanoidQ3UQ41.
KOK09750.
OMAVYITGFG.
OrthoDBEOG75B84T.
PhylomeDBQ3UQ41.
TreeFamTF351684.

Gene expression databases

BgeeQ3UQ41.
CleanExMM_TMPRSS11A.
GenevestigatorQ3UQ41.

Family and domain databases

Gene3D3.30.70.960. 1 hit.
InterProIPR017329. Pept_S1A_HAT/DESC1.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFPIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEPS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio371615.
PROQ3UQ41.
SOURCESearch...

Entry information

Entry nameTM11A_MOUSE
AccessionPrimary (citable) accession number: Q3UQ41
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 11, 2005
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot