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Q3UQ28

- PXDN_MOUSE

UniProt

Q3UQ28 - PXDN_MOUSE

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Protein
Peroxidasin homolog
Gene
Pxdn, Kiaa0230
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Displays low peroxidase activity and is likely to participate in H2O2 metabolism and peroxidative reactions in the cardiovascular system By similarity. Plays a role in extracellular matrix formation.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Binds 1 calcium ion per subunit By similarity.
Binds 1 heme B (iron-protoporphyrin IX) group covalently per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei823 – 8231Heme (covalent; via 2 links) By similarity
Active sitei824 – 8241Proton acceptor By similarity
Metal bindingi825 – 8251Calcium By similarity
Metal bindingi904 – 9041Calcium By similarity
Metal bindingi906 – 9061Calcium; via carbonyl oxygen By similarity
Metal bindingi908 – 9081Calcium By similarity
Metal bindingi910 – 9101Calcium By similarity
Sitei974 – 9741Transition state stabilizer By similarity
Binding sitei977 – 9771Heme (covalent; via 2 links) By similarity
Metal bindingi1071 – 10711Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: Ensembl
  2. heme binding Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
  4. peroxidase activity Source: UniProtKB

GO - Biological processi

  1. extracellular matrix organization Source: UniProtKB
  2. hydrogen peroxide catabolic process Source: UniProtKB
  3. oxidation-reduction process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Calcium, Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidasin homolog (EC:1.11.1.7)
Gene namesi
Name:Pxdn
Synonyms:Kiaa0230
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1916925. Pxdn.

Subcellular locationi

Secretedextracellular spaceextracellular matrix
Note: Enriched in the peritubular space of fibrotic kidneys.1 Publication

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. extracellular matrix Source: UniProtKB
  3. extracellular space Source: UniProtKB
  4. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 14751452Peroxidasin homolog
PRO_0000319620Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi264 ↔ 314 By similarity
Disulfide bondi360 ↔ 409 By similarity
Disulfide bondi451 ↔ 499 By similarity
Disulfide bondi543 ↔ 591 By similarity
Glycosylationi637 – 6371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi696 – 6961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi716 – 7161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi728 – 7281N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi729 ↔ 745 By similarity
Disulfide bondi844 ↔ 854 By similarity
Disulfide bondi848 ↔ 872 By similarity
Disulfide bondi956 ↔ 967 By similarity
Modified residuei1173 – 11731Phosphotyrosine By similarity
Disulfide bondi1174 ↔ 1231 By similarity
Glycosylationi1175 – 11751N-linked (GlcNAc...) Reviewed prediction
Modified residuei1177 – 11771Phosphoserine By similarity
Disulfide bondi1272 ↔ 1298 By similarity
Glycosylationi1277 – 12771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1364 – 13641N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ3UQ28.
PaxDbiQ3UQ28.
PRIDEiQ3UQ28.

PTM databases

PhosphoSiteiQ3UQ28.

Expressioni

Tissue specificityi

Highly expressed in the cardiovascular system.1 Publication

Developmental stagei

Expressed in all embryonic tissues at 10 dpc. Detected at 7 dpc.2 Publications

Gene expression databases

ArrayExpressiQ3UQ28.
BgeeiQ3UQ28.
CleanExiMM_PXDN.
GenevestigatoriQ3UQ28.

Interactioni

Protein-protein interaction databases

BioGridi213608. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ3UQ28.
SMRiQ3UQ28. Positions 27-673, 735-1311.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 6037LRRNT
Add
BLAST
Repeati84 – 10522LRR 1
Add
BLAST
Repeati108 – 12922LRR 2
Add
BLAST
Repeati132 – 15322LRR 3
Add
BLAST
Repeati156 – 17722LRR 4
Add
BLAST
Domaini189 – 24254LRRCT
Add
BLAST
Domaini243 – 32987Ig-like C2-type 1
Add
BLAST
Domaini339 – 42587Ig-like C2-type 2
Add
BLAST
Domaini430 – 51788Ig-like C2-type 3
Add
BLAST
Domaini518 – 60790Ig-like C2-type 4
Add
BLAST
Domaini1409 – 146759VWFC
Add
BLAST

Sequence similaritiesi

Contains 1 LRRCT domain.
Contains 1 LRRNT domain.
Contains 1 VWFC domain.

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiNOG262194.
GeneTreeiENSGT00550000074325.
HOGENOMiHOG000016084.
HOVERGENiHBG108312.
InParanoidiQ3UQ28.
OMAiEPVITWN.
OrthoDBiEOG7D2FD6.
TreeFamiTF314316.

Family and domain databases

Gene3Di1.10.640.10. 2 hits.
2.60.40.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR001007. VWF_C.
[Graphical view]
PfamiPF03098. An_peroxidase. 1 hit.
PF07679. I-set. 4 hits.
PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SMARTiSM00408. IGc2. 4 hits.
SM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50835. IG_LIKE. 4 hits.
PS51450. LRR. 5 hits.
PS50292. PEROXIDASE_3. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UQ28-1 [UniParc]FASTAAdd to Basket

« Hide

MAVRPTRRCL LALLLCFAWW AMAVVASKQG AGCPSRCLCF RTTVRCMHLL     50
LEAVPAVAPQ TSILDLRFNR IREIQPGAFR RLRSLNTLLL NNNQIKKIPN 100
GAFEDLENLK YLYLYKNEIQ SIDRQAFKGL ASLEQLYLHF NQIETLDPES 150
FQHLPKLERL FLHNNRITHL VPGTFSQLES MKRLRLDSNA LHCDCEILWL 200
ADLLKTYAQS GNAQAAATCE YPRRIQGRSV ATITPEELNC ERPRITSEPQ 250
DADVTSGNTV YFTCRAEGNP KPEIIWLRNN NELSMKTDSR LNLLDDGTLM 300
IQNTQEADEG VYQCMAKNVA GEAKTQEVTL RYLGSPARPT FVIQPQNTEV 350
LVGESVTLEC SATGHPLPQI TWTRGDRTPL PIDPRVNITP SGGLYIQNVA 400
QSDSGEYTCF ASNSVDSIHA TAFIIVQALP QFTVTPQSRV VIEGQTVDFQ 450
CAAKGHPQPV IAWTKGGSQL SVDRRHLVLS SGTLRISGVA LHDQGQYECQ 500
AVNIIGSQKV VAHLTVQPRV TPVFASIPSD MTVEVGTNVQ LPCSSQGEPE 550
PAITWNKDGV QVTESGKFHI SPEGFLTIND VGTADAGRYE CVARNTIGYA 600
SVSMVLSVNV PDVSRNGDPY VATSIVEAIA TVDRAINSTR THLFDSRPRS 650
PNDLLALFRY PRDPYTVGQA RAGEIFERTL QLIQEHVQHG LMVDLNGTSY 700
HYNDLVSPQY LSLIANLSGC TAHRRVNNCS DMCFHQKYRT HDGTCNNLQH 750
PMWGASLTAF ERLLKAVYEN GFNTPRGINS QRQYNGHVLP MPRLVSTTLI 800
GTEVITPDEQ FTHMLMQWGQ FLDHDLDSTV VALSQARFSD GQHCSSVCSN 850
DPPCFSVMIP PNDPRVRSGA RCMFFVRSSP VCGSGMTSLL MNSVYPREQI 900
NQLTSYIDAS NVYGSTDHEA RSIRDLASHR GLLRQGIVQR SGKPLLPFAT 950
GPPTECMRDE NESPIPCFLA GDHRANEQLG LTSMHTLWFR EHNRIAAELL 1000
KLNPHWDGDT VYHETRKIVG AEIQHITYRH WLPKILGEVG MKMLGEYRGY 1050
DPSVNAGIFN AFATAAFRFG HTLINPLLYR LDENFEPIPQ GHVPLHKAFF 1100
SPFRIVNEGG IDPLLRGLFG VAGKMRIPSQ LLNTELTERL FSMAHTVALD 1150
LAAINIQRGR DHGIPPYHDY RVYCNLSAAY TFEDLKNEIK SPVIREKLQR 1200
LYGSTLNIDL FPALMVEDLV PGSRLGPTLM CLLSTQFRRL RDGDRLWYEN 1250
PGVFSPAQLT QLKQTSLARI LCDNSDNITR VQQDVFRVAE FPHGYSSCED 1300
IPRVDLRVWQ DCCEDCRTRG QFNAFSYHFR GRRSLEFSYE DDKPTKRARW 1350
RKALSVKHGK HLSNATSATH EHLEGPATND LKEFVLEMQK IITDLRKQIN 1400
SLESRLSTTE CVDDSGESHG GNTKWKKDPC TVCECKNGQI TCFVEACQPA 1450
ACPQPVKVEG ACCPVCLKNT AEEKP 1475
Length:1,475
Mass (Da):165,103
Last modified:July 27, 2011 - v2
Checksum:i7F49A5B0D4CDBEB6
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti549 – 5491P → Q in BAE25216. 1 Publication
Sequence conflicti1298 – 12981C → R in AAI12914. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK142872 mRNA. Translation: BAE25216.1.
AC159626 Genomic DNA. No translation available.
AC165078 Genomic DNA. No translation available.
BC112913 mRNA. Translation: AAI12914.1.
CCDSiCCDS25856.1.
RefSeqiNP_852060.2. NM_181395.2.
UniGeneiMm.251774.

Genome annotation databases

EnsembliENSMUST00000122328; ENSMUSP00000113703; ENSMUSG00000020674.
GeneIDi69675.
KEGGimmu:69675.
UCSCiuc007ngl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK142872 mRNA. Translation: BAE25216.1 .
AC159626 Genomic DNA. No translation available.
AC165078 Genomic DNA. No translation available.
BC112913 mRNA. Translation: AAI12914.1 .
CCDSi CCDS25856.1.
RefSeqi NP_852060.2. NM_181395.2.
UniGenei Mm.251774.

3D structure databases

ProteinModelPortali Q3UQ28.
SMRi Q3UQ28. Positions 27-673, 735-1311.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 213608. 1 interaction.

PTM databases

PhosphoSitei Q3UQ28.

Proteomic databases

MaxQBi Q3UQ28.
PaxDbi Q3UQ28.
PRIDEi Q3UQ28.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000122328 ; ENSMUSP00000113703 ; ENSMUSG00000020674 .
GeneIDi 69675.
KEGGi mmu:69675.
UCSCi uc007ngl.2. mouse.

Organism-specific databases

CTDi 7837.
MGIi MGI:1916925. Pxdn.
Rougei Search...

Phylogenomic databases

eggNOGi NOG262194.
GeneTreei ENSGT00550000074325.
HOGENOMi HOG000016084.
HOVERGENi HBG108312.
InParanoidi Q3UQ28.
OMAi EPVITWN.
OrthoDBi EOG7D2FD6.
TreeFami TF314316.

Miscellaneous databases

NextBioi 330062.
PROi Q3UQ28.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q3UQ28.
Bgeei Q3UQ28.
CleanExi MM_PXDN.
Genevestigatori Q3UQ28.

Family and domain databases

Gene3Di 1.10.640.10. 2 hits.
2.60.40.10. 4 hits.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF03098. An_peroxidase. 1 hit.
PF07679. I-set. 4 hits.
PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view ]
PRINTSi PR00457. ANPEROXIDASE.
SMARTi SM00408. IGc2. 4 hits.
SM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF48113. SSF48113. 1 hit.
PROSITEi PS50835. IG_LIKE. 4 hits.
PS51450. LRR. 5 hits.
PS50292. PEROXIDASE_3. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 370-1475.
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Identification and characterization of VPO1, a new animal heme-containing peroxidase."
    Cheng G., Salerno J.C., Cao Z., Pagano P.J., Lambeth J.D.
    Free Radic. Biol. Med. 45:1682-1694(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  5. "Peroxidasin is secreted and incorporated into the extracellular matrix of myofibroblasts and fibrotic kidney."
    Peterfi Z., Donko A., Orient A., Sum A., Prokai A., Molnar B., Vereb Z., Rajnavolgyi E., Kovacs K.J., Muller V., Szabo A.J., Geiszt M.
    Am. J. Pathol. 175:725-735(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. "Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo."
    Homma S., Shimada T., Hikake T., Yaginuma H.
    Gene Expr. Patterns 9:1-26(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiPXDN_MOUSE
AccessioniPrimary (citable) accession number: Q3UQ28
Secondary accession number(s): A4FU83, E9QNQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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