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Protein

Oxytocin receptor

Gene

Oxtr

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Oxytocin receptorUniRule annotation
Gene namesi
Name:OxtrImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:109147. Oxtr.

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei35 – 56HelicalUniRule annotationAdd BLAST22
Transmembranei68 – 86HelicalUniRule annotationAdd BLAST19
Transmembranei106 – 127HelicalUniRule annotationAdd BLAST22
Transmembranei147 – 167HelicalUniRule annotationAdd BLAST21
Transmembranei192 – 215HelicalUniRule annotationAdd BLAST24
Transmembranei267 – 289HelicalUniRule annotationAdd BLAST23
Transmembranei301 – 323HelicalUniRule annotationAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

GlycoproteinUniRule annotation

Proteomic databases

PaxDbiQ3UPP9.

Structurei

3D structure databases

ProteinModelPortaliQ3UPP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 320G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST273

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG105710.

Family and domain databases

CDDicd15387. 7tmA_OT_R. 1 hit.
InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
PANTHERiPTHR24241:SF101. PTHR24241:SF101. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q3UPP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GSIELDLGSG VPPGAEGNLT AGPPRRNEAL ARVEVAVLCL ILFLALSGNA
60 70 80 90 100
CVLLALRTTR HKHSRLFFFM KHLSIADLVV AVFQVLPQLL WDITFRFYGP
110 120 130 140 150
DLLCRLVKYL QVVGMFASTY LLLVMSLDRC LAICQPLRSL RRRTDRLAVL
160 170 180 190 200
ATWLGCLVAS VPQVHIFSLR EVADGVFDCW AVFIQPWGPK AYVTWITLAV
210 220 230 240 250
YIVPVIVLAA CYGLISFKIW QNLRLKTAAA AAAAEGSDAA GGAGRAALAR
260 270 280 290 300
VSSVKLISKA KIRTVKMTFI IVLAFIVCWT PFFFVQMWSV WDVNAPKEAS
310 320 330 340 350
AFIIAMLLAS LNSCCNPWIY MLFTGHLFHE LVQRFLCCSA RYLKGSRPGE
360 370 380
TSISKKSNSS TFVLSRRSSS QRSCSQPSSA
Length:380
Mass (Da):41,890
Last modified:October 11, 2005 - v1
Checksum:iA3863B9D77C78D32
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK143340 mRNA. Translation: BAE25346.1.
UniGeneiMm.333310.

Similar proteinsi

Entry informationi

Entry nameiQ3UPP9_MOUSE
AccessioniPrimary (citable) accession number: Q3UPP9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: August 30, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)