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Protein

Beta-1,3-N-acetylglucosaminyltransferase

Gene

Mfng

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor.UniRule annotation

Cofactori

Mn2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei70 – 701SubstrateUniRule annotation
Binding sitei143 – 1431SubstrateUniRule annotation
Active sitei232 – 2321UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • pattern specification process Source: InterPro
  • positive regulation of Notch signaling pathway Source: MGI
  • positive regulation of protein binding Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,3-N-acetylglucosaminyltransferaseUniRule annotation (EC:2.4.1.222UniRule annotation)
Alternative name(s):
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferaseUniRule annotation
Gene namesi
Name:MfngImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1095404. Mfng.

Subcellular locationi

  • Golgi apparatus membrane UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatusUniRule annotation, MembraneUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiQ3UPI0.

Expressioni

Gene expression databases

BgeeiQ3UPI0.
ExpressionAtlasiQ3UPI0. baseline and differential.
GenevisibleiQ3UPI0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018313.

Structurei

3D structure databases

ProteinModelPortaliQ3UPI0.
SMRiQ3UPI0. Positions 50-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 31 family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000009913.
HOVERGENiHBG007986.
KOiK05948.
OMAiLRWFCHV.
PhylomeDBiQ3UPI0.

Family and domain databases

InterProiIPR017374. Fringe.
IPR003378. Fringe-like.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF02434. Fringe. 1 hit.
[Graphical view]
PIRSFiPIRSF038073. B-acetylgalactosaminyltfrase. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3UPI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHCRLFRGMA GALFTLLCVG LLSLRYHSSL SQRMIQGALR LNQRNPGPLE
60 70 80 90 100
LQLGDIFIAV KTTWAFHRSR LDLLLDTWVS RIRQQTFIFT DSPDERLQER
110 120 130 140 150
LGPHLVVTNC SAEHSHPALS CKMAAEFDAF LVSGLRWFCH VDDDNYVNPK
160 170 180 190 200
ALLQLLKTFP QDRDVYVGKP SLNRPIHASE LQSKNRTKLV RFWFATGGAG
210 220 230 240 250
FCINRQLALK MVPWASGSHF VDTSALIRLP DDCTVGYIIE CKLGGRLQPS
260 270 280 290 300
PLFHSHLETL QLLGAAQLPE QVTLSYGVFE GKLNVIKLPG PFSHEEDPSR
310 320
FRSLHCLLYP DTPWCPLLAA P
Length:321
Mass (Da):36,200
Last modified:October 11, 2005 - v1
Checksum:i76EBCEC2314C50CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK143523 mRNA. Translation: BAE25415.1.
RefSeqiNP_032621.1. NM_008595.2.
UniGeneiMm.149235.

Genome annotation databases

GeneIDi17305.
KEGGimmu:17305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK143523 mRNA. Translation: BAE25415.1.
RefSeqiNP_032621.1. NM_008595.2.
UniGeneiMm.149235.

3D structure databases

ProteinModelPortaliQ3UPI0.
SMRiQ3UPI0. Positions 50-318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018313.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Proteomic databases

PRIDEiQ3UPI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17305.
KEGGimmu:17305.

Organism-specific databases

CTDi4242.
MGIiMGI:1095404. Mfng.

Phylogenomic databases

GeneTreeiENSGT00390000009913.
HOVERGENiHBG007986.
KOiK05948.
OMAiLRWFCHV.
PhylomeDBiQ3UPI0.

Miscellaneous databases

NextBioi291848.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UPI0.
ExpressionAtlasiQ3UPI0. baseline and differential.
GenevisibleiQ3UPI0. MM.

Family and domain databases

InterProiIPR017374. Fringe.
IPR003378. Fringe-like.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF02434. Fringe. 1 hit.
[Graphical view]
PIRSFiPIRSF038073. B-acetylgalactosaminyltfrase. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Whole bodyImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Whole bodyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Whole bodyImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Whole bodyImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Whole bodyImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Whole bodyImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Whole bodyImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Whole bodyImported.

Entry informationi

Entry nameiQ3UPI0_MOUSE
AccessioniPrimary (citable) accession number: Q3UPI0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: June 24, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.