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Protein

UDP-glucuronosyltransferase 3A1

Gene

Ugt3a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).By similarity

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  • glucuronosyltransferase activity Source: MGI
  • UDP-glycosyltransferase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-156588 Glucuronidation

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 3A1 (EC:2.4.1.17)
Short name:
UDPGT 3A1
Gene namesi
Name:Ugt3a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2146055 Ugt3a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 487ExtracellularSequence analysisAdd BLAST465
Transmembranei488 – 508HelicalSequence analysisAdd BLAST21
Topological domaini509 – 523CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000029915123 – 523UDP-glucuronosyltransferase 3A1Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ3UP75
PaxDbiQ3UP75
PeptideAtlasiQ3UP75
PRIDEiQ3UP75

PTM databases

iPTMnetiQ3UP75
PhosphoSitePlusiQ3UP75
SwissPalmiQ3UP75

Expressioni

Tissue specificityi

Highly expressed in kidney, while it is expressed at low levels in liver. Not detected in other tissues examined.1 Publication

Gene expression databases

BgeeiENSMUSG00000072664
ExpressionAtlasiQ3UP75 baseline and differential
GenevisibleiQ3UP75 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022861

Structurei

3D structure databases

ProteinModelPortaliQ3UP75
SMRiQ3UP75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00760000118949
HOGENOMiHOG000220831
HOVERGENiHBG106370
InParanoidiQ3UP75
OMAiDLVIVEM
OrthoDBiEOG091G06JC
PhylomeDBiQ3UP75
TreeFamiTF315472

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UP75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAHRSWLLV SFFLLEVLLL EAAKILTIST LSASHYILMN RVSQILQGGG
60 70 80 90 100
HDVIKLLYEG GDIPDFRKEN SSYQVINWRL PEDQQKTFEN RWHRLIDEYA
110 120 130 140 150
YGRSKYHTLL KIHQYFADLC SHLLSRKDIM ELLQKENFDL VLLDSMDLCS
160 170 180 190 200
FLIVEKLGKR FVSFLPFQFS YMDFGLPNAP LSYAPVYGSG LTDQMDFWGR
210 220 230 240 250
VKNILMFFHF TKKRRDIFSQ YGNTVQEHFA EGSQPVLSDL LLKAELWFVN
260 270 280 290 300
SDFALDFARP LFPNTVYVGG LLDKPVQPIP QDLEDFISQF GDSGFVLVAL
310 320 330 340 350
GSVVSMIQSK EIIKEMNSAF AHLPQGVLWT CKSSHWPKDV SLAPNVKIMD
360 370 380 390 400
WLPQIDLLAH PSIRLFVTHG GMNSVMEAVH HGVPMVGIPF FGDQPENMVR
410 420 430 440 450
VEAKNLGVSI QLQTLKAESF LLTMKEVIED QRYKTAAMAS KVIRQSHPLT
460 470 480 490 500
PAQRLVGWID HILQTGGAAH LKPYAFQQPW HEQYMLDVFL FLLGLTLGTL
510 520
WLSVKVLVAV TRYLSISRKV KQA
Length:523
Mass (Da):59,698
Last modified:October 11, 2005 - v1
Checksum:i8DE48C64EEFFDFCF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti301G → D in AAH25940 (PubMed:15489334).Curated1
Sequence conflicti445Q → N in AAH25940 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK143745 mRNA Translation: BAE25522.1
BC025940 mRNA Translation: AAH25940.1
CCDSiCCDS27374.1
RefSeqiNP_997099.2, NM_207216.2
UniGeneiMm.482274

Genome annotation databases

EnsembliENSMUST00000022861; ENSMUSP00000022861; ENSMUSG00000072664
GeneIDi105887
KEGGimmu:105887
UCSCiuc007vfk.2 mouse

Similar proteinsi

Entry informationi

Entry nameiUD3A1_MOUSE
AccessioniPrimary (citable) accession number: Q3UP75
Secondary accession number(s): Q8R0Y5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 11, 2005
Last modified: June 20, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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