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Q3UP75

- UD3A1_MOUSE

UniProt

Q3UP75 - UD3A1_MOUSE

Protein

UDP-glucuronosyltransferase 3A1

Gene

Ugt3a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.By similarity

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: MGI
    2. UDP-glycosyltransferase activity Source: MGI

    GO - Biological processi

    1. cellular response to genistein Source: MGI

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 3A1 (EC:2.4.1.17)
    Short name:
    UDPGT 3A1
    Gene namesi
    Name:Ugt3a1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:2146055. Ugt3a1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. UDP-N-acetylglucosamine transferase complex Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 523501UDP-glucuronosyltransferase 3A1PRO_0000299151Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi70 – 701N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ3UP75.
    PaxDbiQ3UP75.
    PRIDEiQ3UP75.

    PTM databases

    PhosphoSiteiQ3UP75.

    Expressioni

    Tissue specificityi

    Highly expressed in kidney, while it is expressed at low levels in liver. Not detected in other tissues examined.1 Publication

    Gene expression databases

    ArrayExpressiQ3UP75.
    BgeeiQ3UP75.
    GenevestigatoriQ3UP75.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1863680.
    STRINGi10090.ENSMUSP00000022861.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3UP75.
    SMRiQ3UP75. Positions 277-438.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 487465ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini509 – 52315CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei488 – 50821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    GeneTreeiENSGT00560000076760.
    HOGENOMiHOG000220831.
    HOVERGENiHBG106370.
    InParanoidiQ3UP75.
    OMAiSIMETIQ.
    OrthoDBiEOG7GBFWS.
    PhylomeDBiQ3UP75.
    TreeFamiTF315472.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3UP75-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAHRSWLLV SFFLLEVLLL EAAKILTIST LSASHYILMN RVSQILQGGG    50
    HDVIKLLYEG GDIPDFRKEN SSYQVINWRL PEDQQKTFEN RWHRLIDEYA 100
    YGRSKYHTLL KIHQYFADLC SHLLSRKDIM ELLQKENFDL VLLDSMDLCS 150
    FLIVEKLGKR FVSFLPFQFS YMDFGLPNAP LSYAPVYGSG LTDQMDFWGR 200
    VKNILMFFHF TKKRRDIFSQ YGNTVQEHFA EGSQPVLSDL LLKAELWFVN 250
    SDFALDFARP LFPNTVYVGG LLDKPVQPIP QDLEDFISQF GDSGFVLVAL 300
    GSVVSMIQSK EIIKEMNSAF AHLPQGVLWT CKSSHWPKDV SLAPNVKIMD 350
    WLPQIDLLAH PSIRLFVTHG GMNSVMEAVH HGVPMVGIPF FGDQPENMVR 400
    VEAKNLGVSI QLQTLKAESF LLTMKEVIED QRYKTAAMAS KVIRQSHPLT 450
    PAQRLVGWID HILQTGGAAH LKPYAFQQPW HEQYMLDVFL FLLGLTLGTL 500
    WLSVKVLVAV TRYLSISRKV KQA 523
    Length:523
    Mass (Da):59,698
    Last modified:October 11, 2005 - v1
    Checksum:i8DE48C64EEFFDFCF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti301 – 3011G → D in AAH25940. (PubMed:15489334)Curated
    Sequence conflicti445 – 4451Q → N in AAH25940. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK143745 mRNA. Translation: BAE25522.1.
    BC025940 mRNA. Translation: AAH25940.1.
    CCDSiCCDS27374.1.
    RefSeqiNP_997099.2. NM_207216.2.
    UniGeneiMm.482274.

    Genome annotation databases

    EnsembliENSMUST00000022861; ENSMUSP00000022861; ENSMUSG00000072664.
    GeneIDi105887.
    KEGGimmu:105887.
    UCSCiuc007vfk.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK143745 mRNA. Translation: BAE25522.1 .
    BC025940 mRNA. Translation: AAH25940.1 .
    CCDSi CCDS27374.1.
    RefSeqi NP_997099.2. NM_207216.2.
    UniGenei Mm.482274.

    3D structure databases

    ProteinModelPortali Q3UP75.
    SMRi Q3UP75. Positions 277-438.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1863680.
    STRINGi 10090.ENSMUSP00000022861.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    PTM databases

    PhosphoSitei Q3UP75.

    Proteomic databases

    MaxQBi Q3UP75.
    PaxDbi Q3UP75.
    PRIDEi Q3UP75.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022861 ; ENSMUSP00000022861 ; ENSMUSG00000072664 .
    GeneIDi 105887.
    KEGGi mmu:105887.
    UCSCi uc007vfk.2. mouse.

    Organism-specific databases

    CTDi 133688.
    MGIi MGI:2146055. Ugt3a1.

    Phylogenomic databases

    eggNOGi COG1819.
    GeneTreei ENSGT00560000076760.
    HOGENOMi HOG000220831.
    HOVERGENi HBG106370.
    InParanoidi Q3UP75.
    OMAi SIMETIQ.
    OrthoDBi EOG7GBFWS.
    PhylomeDBi Q3UP75.
    TreeFami TF315472.

    Miscellaneous databases

    NextBioi 357954.
    PROi Q3UP75.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3UP75.
    Bgeei Q3UP75.
    Genevestigatori Q3UP75.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Spleen.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.
    3. "Tissue- and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice."
      Buckley D.B., Klaassen C.D.
      Drug Metab. Dispos. 35:121-127(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiUD3A1_MOUSE
    AccessioniPrimary (citable) accession number: Q3UP75
    Secondary accession number(s): Q8R0Y5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3