Q3UP61 (Q3UP61_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein EMBL BAE25536.1

Gene names

Name:	Dlg1 MGI 107231
Synonyms:	Dlgh1 MGI 107231

Organism

Mus musculus (Mouse) EMBL BAE25536.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	872 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 SH3 domain. SAAS SAAS011511 Contains 1 guanylate kinase-like domain. SAAS SAAS011511

Ontologies

Keywords
Domain	SH3 domain SAAS SAAS008145
Gene Ontology (GO)
Biological process	actin filament organization Inferred from sequence or structural similarity. Source: UniProtKB cell-cell adhesion Inferred from sequence or structural similarity. Source: UniProtKB cortical actin cytoskeleton organization Inferred from sequence or structural similarity. Source: UniProtKB endothelial cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of mitotic cell cycle Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	basolateral plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	phosphatase binding Inferred from sequence or structural similarity. Source: UniProtKB protein kinase binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q3UP61 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 0CD78C2BD8691DD1	FASTA	872	96,790
	10 20 30 40 50 60 MPVRKQDTQR ALHLLEEYRS KLSQTEDRQL RSSIERVINI FQSNLFQALI DIQEFYEVTL 70 80 90 100 110 120 LDNPKCVDHS KQCEPVQPVT TWEIASLPST AVTSETLPGS LGPPVEKYRY QDEEVLPPEH 130 140 150 160 170 180 ISPQVTNEVL GPELVHVSEK NLSEIENVHG FVSHSHISPI KANPPPVLVN TDSLETPTYV 190 200 210 220 230 240 NGTDADYGYE EITLERGNSG LGFSIAGGTD NPHIGDDSSI FITKIITGGA AAQDGRLRVN 250 260 270 280 290 300 DCILRVNEAD VRDVTHSKAV EALKEAGSIV RLYVKRRKPA SEKIMEIKLI KGPKGLGFSI 310 320 330 340 350 360 AGGVGNQHIP GDNSIYVTKI IEGGAAHKDG KLQIGDKLLA VNSVCLEEVT HEEAVTALKN 370 380 390 400 410 420 TSDFVYLKVA KPTSMYINDG YAPPDITNSS SQSVDNHVSP SSCLGQTPTS PARYSPISKA 430 440 450 460 470 480 VLGDDEITRE PRKVVLHRGS TGLGFNIVGG EDGEGIFISF ILAGGPADLS GELRKGDRII 490 500 510 520 530 540 SVNSVDLRAA SHEQAAAALK NAGQAVTIVA QYRPEEYSRF EAKIHDLREQ MMNSSVSSGS 550 560 570 580 590 600 GSLRTSQKRS LYVRALFDYD KTKDSGLPSQ GLNFRFGDIL HVINASDDEW WQARQVTPDG 610 620 630 640 650 660 ESDEVGVIPS KRRVEKKERA RLKTVKFNSK TRGDKGEIPD DMGSKGLKHV TSNASDSESS 670 680 690 700 710 720 YRGQEEYVLS YEPVNQQEVN YTRPVIILGP MKDRVNDDLI SEFPDKFGSC VPHTTRPKRD 730 740 750 760 770 780 YEVDGRDYHF VTSREQMEKD IQEHKFIEAG QYNNHLYGTS VQSVRAVAEK GKHCILDVSG 790 800 810 820 830 840 NAIKRLQIAQ LYPISIFIKP KSMENIMEMN KRLTEEQARK TFERAMKLEQ EFTEHFTAIV 850 860 870 QGDTLEDIYN QVKQIIEEQS GPYIWVPAKE KL

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed: 10349636] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE25536.1. Tissue: Spleen EMBL BAE25536.1.
[2]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed: 16141073] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE25536.1. Tissue: Spleen EMBL BAE25536.1.
[3]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE25536.1. Tissue: Spleen EMBL BAE25536.1.
[4]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE25536.1. Tissue: Spleen EMBL BAE25536.1.
[5]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE25536.1. Tissue: Spleen EMBL BAE25536.1.
[6]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed: 11042159] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE25536.1. Tissue: Spleen EMBL BAE25536.1.
[7]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed: 11076861] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE25536.1. Tissue: Spleen EMBL BAE25536.1.
[8]	Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE25536.1. Tissue: Spleen EMBL BAE25536.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK143780 mRNA. Translation: BAE25536.1.
IPI	IPI00408668.
UniGene	Mm.382.
3D structure databases
ProteinModelPortal	Q3UP61.
SMR	Q3UP61. Positions 4-63, 189-278, 283-372, 430-510, 551-872.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q3UP61. 1 interaction.
STRING	Q3UP61.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG107814.
Gene expression databases
ArrayExpress	Q3UP61.
Genevestigator	Q3UP61.
Family and domain databases
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR004172. L27. IPR015143. L27_1. IPR016313. M-assoc_guanylate_kinase. IPR019590. MAGUK_PEST_N. IPR001478. PDZ/DHR/GLGF. IPR019583. PDZ_assoc. IPR011511. SH3_2. IPR001452. SH3_domain. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. PF09058. L27_1. 1 hit. PF10608. MAGUK_N_PEST. 1 hit. PF00595. PDZ. 3 hits. PF10600. PDZ_assoc. 1 hit. PF07653. SH3_2. 1 hit. [Graphical view]
PIRSF	PIRSF001741. MAGUK_DLGH. 1 hit.
SMART	SM00072. GuKc. 1 hit. SM00569. L27. 1 hit. SM00228. PDZ. 3 hits. SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF50156. PDZ. 3 hits. SSF50044. SH3. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. PS51022. L27. 1 hit. PS50106. PDZ. 3 hits. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q3UP61_MOUSE

Accession

Primary (citable) accession number: Q3UP61

Entry history

Integrated into UniProtKB/TrEMBL:	October 11, 2005
Last sequence update:	October 11, 2005
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)