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Protein

Transcription factor CP2-like protein 1

Gene

Tfcp2l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional suppressor. May suppress UBP1-mediated transcriptional activation. Required for normal duct development in the salivary gland and kidney.2 Publications

GO - Molecular functioni

GO - Biological processi

  • cell morphogenesis Source: MGI
  • cytoplasm organization Source: MGI
  • determination of adult lifespan Source: MGI
  • epithelial cell maturation Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of growth Source: MGI
  • salivary gland development Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor CP2-like protein 1
Alternative name(s):
CP2-related transcriptional repressor 1
Short name:
CRTR-1
Gene namesi
Name:Tfcp2l1
Synonyms:Crtr1, Tcfcp2l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2444691. Tfcp2l1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • membrane Source: MGI
  • nucleus Source: MGI
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Approximately half of the mutant mice die before weaning and show growth retardation during early postnatal stages. Mice display defects in the morphology of the submandibular ducts, abnormalities in the maturation of renal tubules and abnormal composition of saliva and urine.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 479479Transcription factor CP2-like protein 1PRO_0000228007Add
BLAST

Proteomic databases

PaxDbiQ3UNW5.
PeptideAtlasiQ3UNW5.
PRIDEiQ3UNW5.

PTM databases

iPTMnetiQ3UNW5.
PhosphoSiteiQ3UNW5.

Expressioni

Tissue specificityi

Highly expressed in placenta, testis, small intestine, kidney and stomach. Low levels of expression in lung, mesenteric lymph nodes, muscle, ovary, and thymus. No expression was detected in brain, heart, liver, and spleen. Expressed in eccrine glands in the palm.2 Publications

Developmental stagei

Expressed at low levels in 10.5- and 11.5-dpc embryos. Expression was not detected at 12.5- and 13.5-dpc. Highly expressed in the epithelial monolayer lining in a subset of tubules of embryonic kidney cortex. Low levels of expression were detected in 16.5-dpc embryonic intestine, limb, lung, and skin. No expression was detected in the brain. Expression is regulated in at least two distinct sites, the pluripotent cells of the developing embryo and the epithelial cells lining the embryonic kidney distal convoluted tubules. Expressed in the ducts of submandibular and sublingual glands, isolated submandibular gland, parotid and lachrymal glands and nasal gland in E16 embryos. At birth, the expression is detected in minor nasal glands in the olfactory epithelium, ducts of the mammary gland, male reproductive system, endolymphatic sac and lung. Expressed during renal development; first detected in the ureteric epithelium, at the distal end of the S-shaped body in nephron and subsequently in all nephric tubule, with expression localizing to more distal regions in the nephron during the maturation of the kidney.2 Publications

Gene expression databases

BgeeiENSMUSG00000026380.
CleanExiMM_TCFCP2L1.
GenevisibleiQ3UNW5. MM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EsrrbQ615394EBI-5691372,EBI-2312731

Protein-protein interaction databases

BioGridi219895. 91 interactions.
IntActiQ3UNW5. 137 interactions.
STRINGi10090.ENSMUSP00000027629.

Structurei

3D structure databases

ProteinModelPortaliQ3UNW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5252Mediate transcriptional repressionAdd
BLAST

Sequence similaritiesi

Belongs to the grh/CP2 family. CP2 subfamily.Curated

Phylogenomic databases

eggNOGiKOG4091. Eukaryota.
ENOG410XNZ6. LUCA.
GeneTreeiENSGT00760000119235.
HOGENOMiHOG000230625.
HOVERGENiHBG053805.
InParanoidiQ3UNW5.
KOiK09275.
OMAiDVAYQVN.
OrthoDBiEOG091G0YV2.
PhylomeDBiQ3UNW5.
TreeFamiTF314132.

Family and domain databases

InterProiIPR007604. CP2.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF04516. CP2. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3UNW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFWHTQPEH YNQHNSGSYL RDVLALPIFK QEEPQLSPEN GARLPPLQYV
60 70 80 90 100
LCAATSPAVK LHEETLTYLN QGQSYEIRLL ENRKLGDFQD LNTKYVKSII
110 120 130 140 150
RVVFHDRRLQ YTEYQQLEGW RWSRPGDRIL DIDIPLSVGI LDPRASPTQL
160 170 180 190 200
NAVEFLWDPS KRASAFIQVH CISTEFTPRK HGGEKGVPFR VQIDTFKQNE
210 220 230 240 250
SGDYSEHLHS ASCQIKVFKP KGADRKQKTD REKMEKRTAQ EKEKYQPSYE
260 270 280 290 300
TTILTECSPW PDVPYQANNT PSPSYNGSPN SFGLREGNSS PNHPVEPLPL
310 320 330 340 350
GSDHLLPSAS IQDAQQWLHR NRFSQFCWLF ASFSGADLLK MSRDDLVQVC
360 370 380 390 400
GPADGIRLFN AIKGRNVRPK MTIYVCQELE QNQLPLPQKQ DDSGDNSLCV
410 420 430 440 450
YHAIFLEELT TLELTEKIAS LYSIPPQHIH RVYRQGPAGI HVVVSNEMVQ
460 470
NFQDESCFIL STLKAESNDG YHIILKCGL
Length:479
Mass (Da):54,737
Last modified:July 11, 2012 - v2
Checksum:i4765C41F5ECCB8C6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601K → R in AAK01150 (PubMed:11073954).Curated
Sequence conflicti195 – 1951T → A in AAK01150 (PubMed:11073954).Curated
Sequence conflicti201 – 21212SGDYS…LHSAS → KWGLLGASTLLPA in AAK01150 (PubMed:11073954).CuratedAdd
BLAST
Sequence conflicti217 – 2171V → G in AAK01150 (PubMed:11073954).Curated
Sequence conflicti220 – 2278PKGADRKQ → AQGELIGNK in AAK01150 (PubMed:11073954).Curated
Sequence conflicti269 – 2702NT → TP in AAK01150 (PubMed:11073954).Curated
Sequence conflicti288 – 2881N → T in AAK01150 (PubMed:11073954).Curated
Sequence conflicti292 – 2921N → I in AAK01150 (PubMed:11073954).Curated
Sequence conflicti465 – 4651Missing in BAE25632 (PubMed:16141072).Curated
Sequence conflicti468 – 4681N → S in AAK01150 (PubMed:11073954).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311309 mRNA. Translation: AAK01150.1.
AK143960 mRNA. Translation: BAE25632.1.
AC109271 Genomic DNA. No translation available.
AC109294 Genomic DNA. No translation available.
CH466520 Genomic DNA. Translation: EDL39825.1.
BC116663 mRNA. Translation: AAI16664.1.
CCDSiCCDS35691.1.
RefSeqiNP_076244.2. NM_023755.2.
UniGeneiMm.24621.

Genome annotation databases

EnsembliENSMUST00000027629; ENSMUSP00000027629; ENSMUSG00000026380.
GeneIDi81879.
KEGGimmu:81879.
UCSCiuc007cil.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311309 mRNA. Translation: AAK01150.1.
AK143960 mRNA. Translation: BAE25632.1.
AC109271 Genomic DNA. No translation available.
AC109294 Genomic DNA. No translation available.
CH466520 Genomic DNA. Translation: EDL39825.1.
BC116663 mRNA. Translation: AAI16664.1.
CCDSiCCDS35691.1.
RefSeqiNP_076244.2. NM_023755.2.
UniGeneiMm.24621.

3D structure databases

ProteinModelPortaliQ3UNW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219895. 91 interactions.
IntActiQ3UNW5. 137 interactions.
STRINGi10090.ENSMUSP00000027629.

PTM databases

iPTMnetiQ3UNW5.
PhosphoSiteiQ3UNW5.

Proteomic databases

PaxDbiQ3UNW5.
PeptideAtlasiQ3UNW5.
PRIDEiQ3UNW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027629; ENSMUSP00000027629; ENSMUSG00000026380.
GeneIDi81879.
KEGGimmu:81879.
UCSCiuc007cil.1. mouse.

Organism-specific databases

CTDi29842.
MGIiMGI:2444691. Tfcp2l1.

Phylogenomic databases

eggNOGiKOG4091. Eukaryota.
ENOG410XNZ6. LUCA.
GeneTreeiENSGT00760000119235.
HOGENOMiHOG000230625.
HOVERGENiHBG053805.
InParanoidiQ3UNW5.
KOiK09275.
OMAiDVAYQVN.
OrthoDBiEOG091G0YV2.
PhylomeDBiQ3UNW5.
TreeFamiTF314132.

Miscellaneous databases

PROiQ3UNW5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026380.
CleanExiMM_TCFCP2L1.
GenevisibleiQ3UNW5. MM.

Family and domain databases

InterProiIPR007604. CP2.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF04516. CP2. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTF2L1_MOUSE
AccessioniPrimary (citable) accession number: Q3UNW5
Secondary accession number(s): Q14AW3, Q99PF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 11, 2012
Last modified: September 7, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.