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Q3UNN8 (PLD5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inactive phospholipase D5

Short name=Inactive PLD 5
Alternative name(s):
Inactive choline phosphatase 5
Inactive phosphatidylcholine-hydrolyzing phospholipase D5
Gene names
Name:Pld5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length536 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the phospholipase D family.

Contains 2 PLD phosphodiesterase domains.

Caution

In contrast to other members of the family, it lacks the conserved active sites, suggesting that it has no phospholipase activity.

Sequence caution

The sequence AAI00429.1 differs from that shown. Reason: Erroneous termination at position 456. Translated as Trp.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainRepeat
Transmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncatalytic activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q3UNN8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q3UNN8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q3UNN8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-208: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 536536Inactive phospholipase D5
PRO_0000288607

Regions

Topological domain1 – 6868Cytoplasmic Potential
Transmembrane69 – 8921Helical; Potential
Topological domain90 – 536447Extracellular Potential
Domain215 – 24228PLD phosphodiesterase 1
Domain434 – 46027PLD phosphodiesterase 2

Amino acid modifications

Glycosylation1211N-linked (GlcNAc...) Potential
Glycosylation3021N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 208208Missing in isoform 3.
VSP_025728
Alternative sequence1 – 9191Missing in isoform 2.
VSP_025729

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 6A9D11644CF0FBBF

FASTA53661,066
        10         20         30         40         50         60 
MEIRQHEWLS ASPHEGFEQM RLKSRPKEPS PSLTRVGANF YSSVKQQDYS ASVWLRRKDK 

        70         80         90        100        110        120 
LEHSQQKCIV IFALVCCFAV LVALIFSAVD IMGEDEDGLS EKNCQNKCRI ALVENIPEGL 

       130        140        150        160        170        180 
NYSEDAPFHL PLFQGWMNLL NMAKKSVDIV SSHWDLNHTH PAACQGQRLF EKLLQLTSQN 

       190        200        210        220        230        240 
IEVKLVSDVT ADSKVLEALK LKGAEVTYMN MTAYNKGRLQ SSFWIVDKQH VYIGSAGLDW 

       250        260        270        280        290        300 
RSLGQMKELG VIFYNCSCLV LDLQRIFALY SSLKFKSRVP QTWSKRLYGV YDNEKKLQLQ 

       310        320        330        340        350        360 
LNETKSQAFV SNSPKLFCPK NRSFDIDAIY SVIDDAKQYV YIAVTDYLPI SSTSSKRTYW 

       370        380        390        400        410        420 
PDLDGKIREA LVLRSVKVRL LISFWKETDP LTFNFISSLK AICTEIANCS LKVKFFDLER 

       430        440        450        460        470        480 
ENACATKEQK NQTFPKLNRN KYMVTDGAAY IGNFDWVGND FTQNAGTGLV INQADVRDNR 

       490        500        510        520        530 
SIIKQLKDVF ERDWYSPYAK SIQPTKQPNC SSLSKLKSPS KQPAMANATG REPLSV 

« Hide

Isoform 2 [UniParc].

Checksum: 203DA401107D2E6E
Show »

FASTA44550,616
Isoform 3 [UniParc].

Checksum: 36B745F4E372D86E
Show »

FASTA32837,523

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Strain: C57BL/6J.
Tissue: Diencephalon.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Pituitary.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK136851 mRNA. Translation: BAE23146.1.
AK136888 mRNA. Translation: BAE23156.1.
AK144116 mRNA. Translation: BAE25709.1.
BC100428 mRNA. Translation: AAI00429.1. Sequence problems.
CCDSCCDS15552.1. [Q3UNN8-1]
RefSeqNP_001182745.1. NM_001195816.1.
NP_795890.2. NM_176916.4. [Q3UNN8-1]
XP_006496962.1. XM_006496899.1. [Q3UNN8-3]
XP_006496963.1. XM_006496900.1. [Q3UNN8-3]
UniGeneMm.338001.

3D structure databases

ProteinModelPortalQ3UNN8.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ3UNN8.

Proteomic databases

PRIDEQ3UNN8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000065967; ENSMUSP00000069326; ENSMUSG00000055214. [Q3UNN8-1]
GeneID319455.
KEGGmmu:319455.
UCSCuc007dtw.1. mouse. [Q3UNN8-1]

Organism-specific databases

CTD200150.
MGIMGI:2442056. Pld5.

Phylogenomic databases

eggNOGNOG70733.
GeneTreeENSGT00390000009798.
HOGENOMHOG000293407.
HOVERGENHBG108266.
InParanoidQ3UNN8.
KOK16861.
OMAHTFPRLN.
OrthoDBEOG70KGP9.
PhylomeDBQ3UNN8.
TreeFamTF313378.

Gene expression databases

ArrayExpressQ3UNN8.
BgeeQ3UNN8.
CleanExMM_PLD5.
GenevestigatorQ3UNN8.

Family and domain databases

InterProIPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
SMARTSM00155. PLDc. 2 hits.
[Graphical view]
PROSITEPS50035. PLD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio394760.
PROQ3UNN8.
SOURCESearch...

Entry information

Entry namePLD5_MOUSE
AccessionPrimary (citable) accession number: Q3UNN8
Secondary accession number(s): Q3UVW3, Q497Q7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2005
Last modified: July 9, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot