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Q3UNN8

- PLD5_MOUSE

UniProt

Q3UNN8 - PLD5_MOUSE

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Protein

Inactive phospholipase D5

Gene

Pld5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. catalytic activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive phospholipase D5
Short name:
Inactive PLD 5
Alternative name(s):
Inactive choline phosphatase 5
Inactive phosphatidylcholine-hydrolyzing phospholipase D5
Gene namesi
Name:Pld5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2442056. Pld5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6868CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei69 – 8921HelicalSequence AnalysisAdd
BLAST
Topological domaini90 – 536447ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 536536Inactive phospholipase D5PRO_0000288607Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ3UNN8.

PTM databases

PhosphoSiteiQ3UNN8.

Expressioni

Gene expression databases

BgeeiQ3UNN8.
CleanExiMM_PLD5.
ExpressionAtlasiQ3UNN8. baseline.
GenevestigatoriQ3UNN8.

Structurei

3D structure databases

ProteinModelPortaliQ3UNN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini215 – 24228PLD phosphodiesterase 1PROSITE-ProRule annotationAdd
BLAST
Domaini434 – 46027PLD phosphodiesterase 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the phospholipase D family.Curated
Contains 2 PLD phosphodiesterase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG70733.
GeneTreeiENSGT00390000009798.
HOGENOMiHOG000293407.
HOVERGENiHBG108266.
InParanoidiQ3UNN8.
KOiK16861.
OMAiHTFPRLN.
OrthoDBiEOG70KGP9.
PhylomeDBiQ3UNN8.
TreeFamiTF313378.

Family and domain databases

InterProiIPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
PROSITEiPS50035. PLD. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3UNN8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIRQHEWLS ASPHEGFEQM RLKSRPKEPS PSLTRVGANF YSSVKQQDYS
60 70 80 90 100
ASVWLRRKDK LEHSQQKCIV IFALVCCFAV LVALIFSAVD IMGEDEDGLS
110 120 130 140 150
EKNCQNKCRI ALVENIPEGL NYSEDAPFHL PLFQGWMNLL NMAKKSVDIV
160 170 180 190 200
SSHWDLNHTH PAACQGQRLF EKLLQLTSQN IEVKLVSDVT ADSKVLEALK
210 220 230 240 250
LKGAEVTYMN MTAYNKGRLQ SSFWIVDKQH VYIGSAGLDW RSLGQMKELG
260 270 280 290 300
VIFYNCSCLV LDLQRIFALY SSLKFKSRVP QTWSKRLYGV YDNEKKLQLQ
310 320 330 340 350
LNETKSQAFV SNSPKLFCPK NRSFDIDAIY SVIDDAKQYV YIAVTDYLPI
360 370 380 390 400
SSTSSKRTYW PDLDGKIREA LVLRSVKVRL LISFWKETDP LTFNFISSLK
410 420 430 440 450
AICTEIANCS LKVKFFDLER ENACATKEQK NQTFPKLNRN KYMVTDGAAY
460 470 480 490 500
IGNFDWVGND FTQNAGTGLV INQADVRDNR SIIKQLKDVF ERDWYSPYAK
510 520 530
SIQPTKQPNC SSLSKLKSPS KQPAMANATG REPLSV
Length:536
Mass (Da):61,066
Last modified:October 11, 2005 - v1
Checksum:i6A9D11644CF0FBBF
GO
Isoform 2 (identifier: Q3UNN8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: Missing.

Note: No experimental confirmation available.

Show »
Length:445
Mass (Da):50,616
Checksum:i203DA401107D2E6E
GO
Isoform 3 (identifier: Q3UNN8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-208: Missing.

Show »
Length:328
Mass (Da):37,523
Checksum:i36B745F4E372D86E
GO

Sequence cautioni

The sequence AAI00429.1 differs from that shown. Reason: Erroneous termination at position 456. Translated as Trp.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 208208Missing in isoform 3. 1 PublicationVSP_025728Add
BLAST
Alternative sequencei1 – 9191Missing in isoform 2. 1 PublicationVSP_025729Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136851 mRNA. Translation: BAE23146.1.
AK136888 mRNA. Translation: BAE23156.1.
AK144116 mRNA. Translation: BAE25709.1.
BC100428 mRNA. Translation: AAI00429.1. Sequence problems.
CCDSiCCDS15552.1. [Q3UNN8-1]
RefSeqiNP_001182745.1. NM_001195816.1.
NP_795890.2. NM_176916.4. [Q3UNN8-1]
XP_006496962.1. XM_006496899.1. [Q3UNN8-3]
XP_006496963.1. XM_006496900.1. [Q3UNN8-3]
UniGeneiMm.338001.

Genome annotation databases

EnsembliENSMUST00000065967; ENSMUSP00000069326; ENSMUSG00000055214. [Q3UNN8-1]
GeneIDi319455.
KEGGimmu:319455.
UCSCiuc007dtw.1. mouse. [Q3UNN8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136851 mRNA. Translation: BAE23146.1 .
AK136888 mRNA. Translation: BAE23156.1 .
AK144116 mRNA. Translation: BAE25709.1 .
BC100428 mRNA. Translation: AAI00429.1 . Sequence problems.
CCDSi CCDS15552.1. [Q3UNN8-1 ]
RefSeqi NP_001182745.1. NM_001195816.1.
NP_795890.2. NM_176916.4. [Q3UNN8-1 ]
XP_006496962.1. XM_006496899.1. [Q3UNN8-3 ]
XP_006496963.1. XM_006496900.1. [Q3UNN8-3 ]
UniGenei Mm.338001.

3D structure databases

ProteinModelPortali Q3UNN8.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q3UNN8.

Proteomic databases

PRIDEi Q3UNN8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000065967 ; ENSMUSP00000069326 ; ENSMUSG00000055214 . [Q3UNN8-1 ]
GeneIDi 319455.
KEGGi mmu:319455.
UCSCi uc007dtw.1. mouse. [Q3UNN8-1 ]

Organism-specific databases

CTDi 200150.
MGIi MGI:2442056. Pld5.

Phylogenomic databases

eggNOGi NOG70733.
GeneTreei ENSGT00390000009798.
HOGENOMi HOG000293407.
HOVERGENi HBG108266.
InParanoidi Q3UNN8.
KOi K16861.
OMAi HTFPRLN.
OrthoDBi EOG70KGP9.
PhylomeDBi Q3UNN8.
TreeFami TF313378.

Miscellaneous databases

NextBioi 394760.
PROi Q3UNN8.
SOURCEi Search...

Gene expression databases

Bgeei Q3UNN8.
CleanExi MM_PLD5.
ExpressionAtlasi Q3UNN8. baseline.
Genevestigatori Q3UNN8.

Family and domain databases

InterProi IPR001736. PLipase_D/transphosphatidylase.
[Graphical view ]
SMARTi SM00155. PLDc. 2 hits.
[Graphical view ]
PROSITEi PS50035. PLD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Strain: C57BL/6J.
    Tissue: Diencephalon.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Pituitary.

Entry informationi

Entry nameiPLD5_MOUSE
AccessioniPrimary (citable) accession number: Q3UNN8
Secondary accession number(s): Q3UVW3, Q497Q7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2005
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3