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Q3UNN8

- PLD5_MOUSE

UniProt

Q3UNN8 - PLD5_MOUSE

Protein

Inactive phospholipase D5

Gene

Pld5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. catalytic activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inactive phospholipase D5
    Short name:
    Inactive PLD 5
    Alternative name(s):
    Inactive choline phosphatase 5
    Inactive phosphatidylcholine-hydrolyzing phospholipase D5
    Gene namesi
    Name:Pld5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2442056. Pld5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 536536Inactive phospholipase D5PRO_0000288607Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ3UNN8.

    PTM databases

    PhosphoSiteiQ3UNN8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ3UNN8.
    BgeeiQ3UNN8.
    CleanExiMM_PLD5.
    GenevestigatoriQ3UNN8.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3UNN8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6868CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini90 – 536447ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei69 – 8921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini215 – 24228PLD phosphodiesterase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini434 – 46027PLD phosphodiesterase 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the phospholipase D family.Curated
    Contains 2 PLD phosphodiesterase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG70733.
    GeneTreeiENSGT00390000009798.
    HOGENOMiHOG000293407.
    HOVERGENiHBG108266.
    InParanoidiQ3UNN8.
    KOiK16861.
    OMAiHTFPRLN.
    OrthoDBiEOG70KGP9.
    PhylomeDBiQ3UNN8.
    TreeFamiTF313378.

    Family and domain databases

    InterProiIPR001736. PLipase_D/transphosphatidylase.
    [Graphical view]
    SMARTiSM00155. PLDc. 2 hits.
    [Graphical view]
    PROSITEiPS50035. PLD. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3UNN8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEIRQHEWLS ASPHEGFEQM RLKSRPKEPS PSLTRVGANF YSSVKQQDYS    50
    ASVWLRRKDK LEHSQQKCIV IFALVCCFAV LVALIFSAVD IMGEDEDGLS 100
    EKNCQNKCRI ALVENIPEGL NYSEDAPFHL PLFQGWMNLL NMAKKSVDIV 150
    SSHWDLNHTH PAACQGQRLF EKLLQLTSQN IEVKLVSDVT ADSKVLEALK 200
    LKGAEVTYMN MTAYNKGRLQ SSFWIVDKQH VYIGSAGLDW RSLGQMKELG 250
    VIFYNCSCLV LDLQRIFALY SSLKFKSRVP QTWSKRLYGV YDNEKKLQLQ 300
    LNETKSQAFV SNSPKLFCPK NRSFDIDAIY SVIDDAKQYV YIAVTDYLPI 350
    SSTSSKRTYW PDLDGKIREA LVLRSVKVRL LISFWKETDP LTFNFISSLK 400
    AICTEIANCS LKVKFFDLER ENACATKEQK NQTFPKLNRN KYMVTDGAAY 450
    IGNFDWVGND FTQNAGTGLV INQADVRDNR SIIKQLKDVF ERDWYSPYAK 500
    SIQPTKQPNC SSLSKLKSPS KQPAMANATG REPLSV 536
    Length:536
    Mass (Da):61,066
    Last modified:October 11, 2005 - v1
    Checksum:i6A9D11644CF0FBBF
    GO
    Isoform 2 (identifier: Q3UNN8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-91: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:445
    Mass (Da):50,616
    Checksum:i203DA401107D2E6E
    GO
    Isoform 3 (identifier: Q3UNN8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-208: Missing.

    Show »
    Length:328
    Mass (Da):37,523
    Checksum:i36B745F4E372D86E
    GO

    Sequence cautioni

    The sequence AAI00429.1 differs from that shown. Reason: Erroneous termination at position 456. Translated as Trp.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 208208Missing in isoform 3. 1 PublicationVSP_025728Add
    BLAST
    Alternative sequencei1 – 9191Missing in isoform 2. 1 PublicationVSP_025729Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK136851 mRNA. Translation: BAE23146.1.
    AK136888 mRNA. Translation: BAE23156.1.
    AK144116 mRNA. Translation: BAE25709.1.
    BC100428 mRNA. Translation: AAI00429.1. Sequence problems.
    CCDSiCCDS15552.1. [Q3UNN8-1]
    RefSeqiNP_001182745.1. NM_001195816.1.
    NP_795890.2. NM_176916.4. [Q3UNN8-1]
    XP_006496962.1. XM_006496899.1. [Q3UNN8-3]
    XP_006496963.1. XM_006496900.1. [Q3UNN8-3]
    UniGeneiMm.338001.

    Genome annotation databases

    EnsembliENSMUST00000065967; ENSMUSP00000069326; ENSMUSG00000055214. [Q3UNN8-1]
    GeneIDi319455.
    KEGGimmu:319455.
    UCSCiuc007dtw.1. mouse. [Q3UNN8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK136851 mRNA. Translation: BAE23146.1 .
    AK136888 mRNA. Translation: BAE23156.1 .
    AK144116 mRNA. Translation: BAE25709.1 .
    BC100428 mRNA. Translation: AAI00429.1 . Sequence problems.
    CCDSi CCDS15552.1. [Q3UNN8-1 ]
    RefSeqi NP_001182745.1. NM_001195816.1.
    NP_795890.2. NM_176916.4. [Q3UNN8-1 ]
    XP_006496962.1. XM_006496899.1. [Q3UNN8-3 ]
    XP_006496963.1. XM_006496900.1. [Q3UNN8-3 ]
    UniGenei Mm.338001.

    3D structure databases

    ProteinModelPortali Q3UNN8.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q3UNN8.

    Proteomic databases

    PRIDEi Q3UNN8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000065967 ; ENSMUSP00000069326 ; ENSMUSG00000055214 . [Q3UNN8-1 ]
    GeneIDi 319455.
    KEGGi mmu:319455.
    UCSCi uc007dtw.1. mouse. [Q3UNN8-1 ]

    Organism-specific databases

    CTDi 200150.
    MGIi MGI:2442056. Pld5.

    Phylogenomic databases

    eggNOGi NOG70733.
    GeneTreei ENSGT00390000009798.
    HOGENOMi HOG000293407.
    HOVERGENi HBG108266.
    InParanoidi Q3UNN8.
    KOi K16861.
    OMAi HTFPRLN.
    OrthoDBi EOG70KGP9.
    PhylomeDBi Q3UNN8.
    TreeFami TF313378.

    Miscellaneous databases

    NextBioi 394760.
    PROi Q3UNN8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3UNN8.
    Bgeei Q3UNN8.
    CleanExi MM_PLD5.
    Genevestigatori Q3UNN8.

    Family and domain databases

    InterProi IPR001736. PLipase_D/transphosphatidylase.
    [Graphical view ]
    SMARTi SM00155. PLDc. 2 hits.
    [Graphical view ]
    PROSITEi PS50035. PLD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Strain: C57BL/6J.
      Tissue: Diencephalon.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Pituitary.

    Entry informationi

    Entry nameiPLD5_MOUSE
    AccessioniPrimary (citable) accession number: Q3UNN8
    Secondary accession number(s): Q3UVW3, Q497Q7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3