ID   Q3UNI8_MOUSE            Unreviewed;       118 AA.
AC   Q3UNI8;
DT   11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT   11-OCT-2005, sequence version 1.
DT   27-MAR-2024, entry version 133.
DE   RecName: Full=D-dopachrome decarboxylase {ECO:0000256|ARBA:ARBA00038884};
DE            EC=4.1.1.84 {ECO:0000256|ARBA:ARBA00038884};
GN   Name=Ddt {ECO:0000313|EMBL:CCP38007.1, ECO:0000313|MGI:MGI:1298381};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE25759.1};
RN   [1] {ECO:0000313|EMBL:BAE25759.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA   Carninci P., Hayashizaki Y.;
RT   "High-efficiency full-length cDNA cloning.";
RL   Methods Enzymol. 303:19-44(1999).
RN   [2] {ECO:0000313|EMBL:BAE25759.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11042159; DOI=10.1101/gr.145100;
RA   Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA   Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT   "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT   full-length cDNA libraries for rapid discovery of new genes.";
RL   Genome Res. 10:1617-1630(2000).
RN   [3] {ECO:0000313|EMBL:BAE25759.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11076861; DOI=10.1101/gr.152600;
RA   Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA   Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA   Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA   Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA   Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA   Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA   Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT   "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT   pipeline with 384 multicapillary sequencer.";
RL   Genome Res. 10:1757-1771(2000).
RN   [4] {ECO:0000313|EMBL:BAE25759.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11217851; DOI=10.1038/35055500;
RG   The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT   "Functional annotation of a full-length mouse cDNA collection.";
RL   Nature 409:685-690(2001).
RN   [5] {ECO:0000313|EMBL:BAE25759.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12466851; DOI=10.1038/nature01266;
RG   The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT   "Analysis of the mouse transcriptome based on functional annotation of
RT   60,770 full-length cDNAs.";
RL   Nature 420:563-573(2002).
RN   [6] {ECO:0000313|EMBL:BAE25759.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
RA   Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
RA   Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
RA   Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
RA   Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:BAE25759.1}
RP   NUCLEOTIDE SEQUENCE.
RG   The FANTOM Consortium;
RG   Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT   "The Transcriptional Landscape of the Mammalian Genome.";
RL   Science 309:1559-1563(2005).
RN   [8] {ECO:0000313|EMBL:BAE25759.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=16141073; DOI=10.1126/science.1112009;
RG   RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT   "Antisense Transcription in the Mammalian Transcriptome.";
RL   Science 309:1564-1566(2005).
RN   [9] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [10] {ECO:0007829|PubMed:23806337}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA   Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA   Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT   "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT   pathways.";
RL   Mol. Cell 50:919-930(2013).
RN   [11] {ECO:0000313|EMBL:CCP38007.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=N.A. {ECO:0000313|EMBL:CCP38007.1};
RX   PubMed=25941635; DOI=10.1016/j.mgene.2015.02.005;
RA   Premzl M.;
RT   "Initial description of primate-specific cystine-knot Prometheus genes and
RT   differential gene expansions of D-dopachrome tautomerase genes.";
RL   Meta Gene 4:118-128(2015).
RN   [12] {ECO:0000313|EMBL:CCP38007.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=N.A. {ECO:0000313|EMBL:CCP38007.1};
RX   PubMed=26862561; DOI=10.1016/j.dib.2015.11.056;
RA   Premzl M.;
RT   "Curated eutherian third party data gene data sets.";
RL   Data Brief 6:208-213(2016).
RN   [13] {ECO:0000313|EMBL:CCP38007.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=N.A. {ECO:0000313|EMBL:CCP38007.1};
RX   DOI=10.1016/j.genrep.2019.100414;
RA   Premzl M.;
RT   "Eutherian third-party data gene collections.";
RL   Gene Rep 16:100414-100414(2019).
CC   -!- FUNCTION: Tautomerization of D-dopachrome with decarboxylation to give
CC       5,6-dihydroxyindole (DHI). {ECO:0000256|ARBA:ARBA00037460}.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000256|ARBA:ARBA00011233}.
CC   -!- SIMILARITY: Belongs to the MIF family. {ECO:0000256|ARBA:ARBA00005851}.
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DR   EMBL; AK144193; BAE25759.1; -; mRNA.
DR   EMBL; HF564802; CCP38007.1; -; Genomic_DNA.
DR   RefSeq; NP_034157.1; NM_010027.1.
DR   AlphaFoldDB; Q3UNI8; -.
DR   SMR; Q3UNI8; -.
DR   SwissPalm; Q3UNI8; -.
DR   MaxQB; Q3UNI8; -.
DR   DNASU; 13202; -.
DR   GeneID; 13202; -.
DR   KEGG; mmu:13202; -.
DR   AGR; MGI:1298381; -.
DR   CTD; 1652; -.
DR   MGI; MGI:1298381; Ddt.
DR   VEuPathDB; HostDB:ENSMUSG00000001666; -.
DR   OMA; PDRINIR; -.
DR   OrthoDB; 5383722at2759; -.
DR   BioGRID-ORCS; 13202; 1 hit in 76 CRISPR screens.
DR   ChiTaRS; Ddt; mouse.
DR   ExpressionAtlas; Q3UNI8; baseline and differential.
DR   GO; GO:0033981; F:D-dopachrome decarboxylase activity; IEA:Ensembl.
DR   GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.429.10; Macrophage Migration Inhibitory Factor; 1.
DR   InterPro; IPR001398; Macrophage_inhib_fac.
DR   InterPro; IPR019829; Macrophage_inhib_fac_CS.
DR   InterPro; IPR014347; Tautomerase/MIF_sf.
DR   PANTHER; PTHR11954; D-DOPACHROME DECARBOXYLASE; 1.
DR   PANTHER; PTHR11954:SF22; D-DOPACHROME DECARBOXYLASE; 1.
DR   Pfam; PF01187; MIF; 1.
DR   SUPFAM; SSF55331; Tautomerase/MIF; 1.
DR   PROSITE; PS01158; MIF; 1.
PE   1: Evidence at protein level;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Melanin biosynthesis {ECO:0000256|ARBA:ARBA00023101}.
SQ   SEQUENCE   118 AA;  13077 MW;  0440692D5413FC81 CRC64;
     MPFVELETNL PASRIPAGLE NRLCAATATI LDKPEDRVSV TIRPGMTLLM NKSTEPCAHL
     LVSSIGVVGT AEQNRTHSAS FFKFLTEELS LDQDRIVIRF FPLEAWQIGK KGTVMTFL
//