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Protein

Probable G-protein coupled receptor 162

Gene

Gpr162

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 162
Gene namesi
Name:Gpr162
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1315214. Gpr162.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717ExtracellularSequence analysisAdd
BLAST
Transmembranei18 – 3821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini39 – 4911CytoplasmicSequence analysisAdd
BLAST
Transmembranei50 – 7021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini71 – 9121ExtracellularSequence analysisAdd
BLAST
Transmembranei92 – 11221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini113 – 13321CytoplasmicSequence analysisAdd
BLAST
Transmembranei134 – 15421Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini155 – 17420ExtracellularSequence analysisAdd
BLAST
Transmembranei175 – 19521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini196 – 27580CytoplasmicSequence analysisAdd
BLAST
Transmembranei276 – 29621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini297 – 3037ExtracellularSequence analysis
Transmembranei304 – 32421Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini325 – 588264CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 588588Probable G-protein coupled receptor 162PRO_0000069648Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence analysis
Modified residuei413 – 4131PhosphoserineCombined sources
Modified residuei435 – 4351PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ3UN16.
PaxDbiQ3UN16.
PRIDEiQ3UN16.

PTM databases

iPTMnetiQ3UN16.
PhosphoSiteiQ3UN16.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038390.
CleanExiMM_GPR162.
GenevisibleiQ3UN16. MM.

Structurei

3D structure databases

ProteinModelPortaliQ3UN16.
SMRiQ3UN16. Positions 15-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFBH. Eukaryota.
ENOG410XST7. LUCA.
GeneTreeiENSGT00390000017213.
HOGENOMiHOG000231123.
HOVERGENiHBG080132.
InParanoidiQ3UN16.
KOiK08440.
OMAiGDGRICK.
OrthoDBiEOG091G02R9.
PhylomeDBiQ3UN16.
TreeFamiTF330832.

Family and domain databases

InterProiIPR022347. GCR_153/162.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR022348. GPR162.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01991. GPR153GPR162.
PR01993. GPR162.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UN16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGGLGAEE ASLRSNALSW LACGLLALLA NAWIILSISA KQQKHKPLEL
60 70 80 90 100
LLCFLAGTHI LMAAVPLTTF AVVQLRRQAS SDYDWNESIC KVFVSTYYTL
110 120 130 140 150
ALATCFTVAS LSYHRMWMVR WPVNYRLSNA KKQALHAVMG IWMVSFILST
160 170 180 190 200
LPSIGWHNNG ERYYARGCQF IVSKIGLGFG VCFSLLLLGG IVMGLVCVAI
210 220 230 240 250
TFYQTLWARP RRARQARRAG GSVGTKAGGL GGLGTRPAFE VPAIVVEDTR
260 270 280 290 300
GKRRSSLDGS ESAKTSLQVT NLVSAIVFLY DSLTGVPILV VSFFSLKSDS
310 320 330 340 350
APPWMVLAVL WCSMAQTLLL PSFIWSCERY RADVRTVWEQ CVAIMSEDDG
360 370 380 390 400
DDDGTCDDYT DGRVCKIRFD ANGATGSGSR DPTQVKLLPG RHMLFPPLER
410 420 430 440 450
VHYLQVPLSR RLSHDETNIF STPRAPGSFL HKWSSSDDIR ILPAQSRALG
460 470 480 490 500
GPPEYLGQRH RLEDEEDEEE AEGGGLASLR QFLESGVLGS GGGPPRGPGF
510 520 530 540 550
FREEITTFID ETPLPSPTAS PGPSPRRPRP LGFSPRRLSL GSPDSRAVGL
560 570 580
PLGLSAGRRC SLTGSEGSSR AWGRPWGPGN PIFPQLTL
Length:588
Mass (Da):64,148
Last modified:November 22, 2005 - v2
Checksum:iC51E3BD59BF82D70
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti346 – 3461S → Y in BAE25932 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002397 Genomic DNA. Translation: AAC36011.1.
AK134941 mRNA. Translation: BAE22348.1.
AK144354 mRNA. Translation: BAE25846.1.
AK144543 mRNA. Translation: BAE25932.1.
BC031437 mRNA. Translation: AAH31437.1.
CCDSiCCDS20534.1.
RefSeqiNP_038561.1. NM_013533.3.
XP_006505618.1. XM_006505555.2.
XP_006505619.1. XM_006505556.2.
XP_006505620.1. XM_006505557.2.
XP_011239517.1. XM_011241215.1.
UniGeneiMm.2514.

Genome annotation databases

EnsembliENSMUST00000046893; ENSMUSP00000038536; ENSMUSG00000038390.
ENSMUST00000204667; ENSMUSP00000145267; ENSMUSG00000038390.
GeneIDi14788.
KEGGimmu:14788.
UCSCiuc009dsg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002397 Genomic DNA. Translation: AAC36011.1.
AK134941 mRNA. Translation: BAE22348.1.
AK144354 mRNA. Translation: BAE25846.1.
AK144543 mRNA. Translation: BAE25932.1.
BC031437 mRNA. Translation: AAH31437.1.
CCDSiCCDS20534.1.
RefSeqiNP_038561.1. NM_013533.3.
XP_006505618.1. XM_006505555.2.
XP_006505619.1. XM_006505556.2.
XP_006505620.1. XM_006505557.2.
XP_011239517.1. XM_011241215.1.
UniGeneiMm.2514.

3D structure databases

ProteinModelPortaliQ3UN16.
SMRiQ3UN16. Positions 15-161.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ3UN16.
PhosphoSiteiQ3UN16.

Proteomic databases

MaxQBiQ3UN16.
PaxDbiQ3UN16.
PRIDEiQ3UN16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046893; ENSMUSP00000038536; ENSMUSG00000038390.
ENSMUST00000204667; ENSMUSP00000145267; ENSMUSG00000038390.
GeneIDi14788.
KEGGimmu:14788.
UCSCiuc009dsg.1. mouse.

Organism-specific databases

CTDi27239.
MGIiMGI:1315214. Gpr162.

Phylogenomic databases

eggNOGiENOG410IFBH. Eukaryota.
ENOG410XST7. LUCA.
GeneTreeiENSGT00390000017213.
HOGENOMiHOG000231123.
HOVERGENiHBG080132.
InParanoidiQ3UN16.
KOiK08440.
OMAiGDGRICK.
OrthoDBiEOG091G02R9.
PhylomeDBiQ3UN16.
TreeFamiTF330832.

Miscellaneous databases

PROiQ3UN16.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038390.
CleanExiMM_GPR162.
GenevisibleiQ3UN16. MM.

Family and domain databases

InterProiIPR022347. GCR_153/162.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR022348. GPR162.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01991. GPR153GPR162.
PR01993. GPR162.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP162_MOUSE
AccessioniPrimary (citable) accession number: Q3UN16
Secondary accession number(s): O88835
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: September 7, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.