Q3UN00 (Q3UN00_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
P2X purinoceptor RuleBase RU000681

Gene names

Name:

P2rx7 Ensembl ENSMUSP00000112440 MGI 1339957

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	431 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Homo- or heteropolymers By similarity. RuleBase RU000681
Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU000681.
Sequence similarities	Belongs to the P2X receptor family. RuleBase RU000681

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU000681
Molecular function	Ion channel RuleBase RU000681 Receptor RuleBase RU000681
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	NAD transport Inferred from mutant phenotype PubMed 17803959. Source: MGI T cell homeostasis Inferred from mutant phenotype PubMed 16116196. Source: MGI T cell proliferation Inferred from mutant phenotype PubMed 15914561. Source: MGI activation of MAPK activity Inferred from mutant phenotype PubMed 17306762. Source: MGI bleb assembly Inferred from mutant phenotype PubMed 17135244. Source: MGI cell morphogenesis Inferred from mutant phenotype PubMed 12055263. Source: MGI cell volume homeostasis Inferred from direct assay PubMed 18097031. Source: MGI cellular response to extracellular stimulus Inferred from mutant phenotype PubMed 18082965. Source: MGI ceramide biosynthetic process Inferred from direct assay PubMed 16325464. Source: MGI collagen metabolic process Inferred from mutant phenotype PubMed 16969386. Source: MGI cytolysis Inferred from direct assay PubMed 16116196PubMed 18097031. Source: MGI defense response to Gram-positive bacterium Inferred from mutant phenotype PubMed 11544318. Source: MGI homeostasis of number of cells within a tissue Inferred from mutant phenotype PubMed 16969386. Source: MGI inflammatory response Inferred from mutant phenotype PubMed 12055263PubMed 16969386. Source: MGI membrane budding Inferred from mutant phenotype PubMed 15905573. Source: MGI membrane protein ectodomain proteolysis Inferred from mutant phenotype PubMed 17286969. Source: MGI mitochondrion organization Inferred from direct assay PubMed 16325464. Source: MGI multicellular organismal protein catabolic process Inferred from direct assay PubMed 11489964. Source: MGI negative regulation of MAPK cascade Inferred from direct assay PubMed 11489964. Source: MGI negative regulation of bone resorption Inferred from mutant phenotype PubMed 12677010. Source: MGI phagolysosome assembly Inferred from mutant phenotype PubMed 11544318. Source: MGI phospholipid transfer to membrane Inferred from mutant phenotype PubMed 12370338. Source: MGI phospholipid translocation Inferred from direct assay PubMed 18097031. Source: MGI plasma membrane organization Inferred from direct assay PubMed 18097031. Source: MGI pore complex assembly Inferred from mutant phenotype PubMed 12370338PubMed 15937334PubMed 16269410. Source: MGI positive regulation of T cell mediated cytotoxicity Inferred from mutant phenotype PubMed 14761980. Source: MGI positive regulation of apoptotic process Inferred from mutant phenotype PubMed 16325464PubMed 16493071PubMed 16969386. Source: MGI positive regulation of bone mineralization Inferred from mutant phenotype PubMed 12677010PubMed 18519738. Source: MGI positive regulation of gamma-aminobutyric acid secretion Inferred from mutant phenotype PubMed 15640761. Source: MGI positive regulation of glutamate secretion Inferred from mutant phenotype PubMed 15640761PubMed 17306762. Source: MGI positive regulation of interleukin-1 alpha secretion Inferred from mutant phenotype PubMed 18490713. Source: MGI positive regulation of interleukin-1 beta secretion Inferred from mutant phenotype PubMed 11016935PubMed 15905573PubMed 18490713. Source: MGI positive regulation of interleukin-6 production Inferred from mutant phenotype PubMed 11016935. Source: MGI positive regulation of mitochondrial depolarization Inferred from mutant phenotype PubMed 16198349. Source: MGI positive regulation of prostaglandin secretion Inferred from mutant phenotype PubMed 16269410. Source: MGI protein oligomerization Inferred from direct assay PubMed 15713258. Source: MGI protein processing Inferred from mutant phenotype PubMed 11016935. Source: MGI reactive oxygen species metabolic process Inferred from mutant phenotype PubMed 17448897. Source: MGI release of sequestered calcium ion into cytosol Inferred from mutant phenotype PubMed 18082965. Source: MGI response to ATP Inferred from direct assay PubMed 15240711PubMed 15713258. Source: MGI response to calcium ion Inferred from direct assay PubMed 15240711. Source: MGI response to drug Inferred from mutant phenotype PubMed 18082965. Source: MGI response to electrical stimulus Inferred from mutant phenotype PubMed 15640761. Source: MGI response to fluid shear stress Inferred from mutant phenotype PubMed 16269410. Source: MGI response to lipopolysaccharide Inferred from direct assay PubMed 15240711. Source: MGI response to mechanical stimulus Inferred from mutant phenotype PubMed 16269410. Source: MGI response to zinc ion Inferred from mutant phenotype PubMed 15978588PubMed 18082965. Source: MGI skeletal system morphogenesis Inferred from mutant phenotype PubMed 18519738. Source: MGI synaptic vesicle exocytosis Inferred from mutant phenotype PubMed 15713258. Source: MGI
Cellular_component	cell-cell junction Inferred from direct assay PubMed 15331634. Source: MGI external side of plasma membrane Inferred from direct assay PubMed 17286969. Source: MGI integral to plasma membrane Inferred from mutant phenotype PubMed 12677010. Source: MGI neuromuscular junction Inferred from direct assay PubMed 15713258. Source: MGI neuronal cell body Inferred from direct assay PubMed 15964665PubMed 15978588. Source: MGI
Molecular_function	ATP binding Inferred from mutant phenotype PubMed 12677010. Source: MGI extracellular ATP-gated cation channel activity Inferred from mutant phenotype PubMed 12677010PubMed 15713258. Source: MGI lipopolysaccharide binding Inferred from direct assay PubMed 11489964. Source: MGI purinergic nucleotide receptor activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q3UN00 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 7935E3F02AF82FA0	FASTA	431	49,368
	10 20 30 40 50 60 MPACCSWNDV LQYETNKVTR IQSTNYGTVK WVLHMIVFSY ISFALVSDKL YQRKEPVISS 70 80 90 100 110 120 VHTKVKGIAE VTENVTEGGV TKLGHSIFDT ADYTFPLQGN SFFVMTNYVK SEGQVQTLCP 130 140 150 160 170 180 EYPRRGAQCS SDRRCKKGWM DPQSKGIQTG RCVPYDKTRK TCEVSAWCPT EEEKEAPRPA 190 200 210 220 230 240 LLRSAENFTV LIKNNIHFPG HNYTTRNILP TMNGSCTFHK TWDPQCSIFR LGDIFQEAGE 250 260 270 280 290 300 NFTEVAVQGG IMGIEIYWDC NLDSWSHHCR PRYSFRRLDD KNTDESFVPG YNFRYAKYYK 310 320 330 340 350 360 ENNVEKRTLI KAFGIRFDIL VFGTGGKFDI IQLVVYIGST LSYFGLATVC IDLLINTYSS 370 380 390 400 410 420 AFCRSGVYPY CKCCEPCTVN EYYYRKKCES IMEPKPTLKY VSFVDEPHIR MVDQQLLGKS 430 LQVVKGQEVP T

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Lung EMBL BAE25948.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Lung EMBL BAE25948.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Lung EMBL BAE25948.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Tissue: Lung EMBL BAE25948.1.
[5]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Tissue: Lung EMBL BAE25948.1.
[6]	Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Lung EMBL BAE25948.1.
[7]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Tissue: Lung EMBL BAE25948.1.
[8]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Lung EMBL BAE25948.1.
[9]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000112440.
[10]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000112440.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC114632 Genomic DNA. No translation available. AK144585 mRNA. Translation: BAE25948.1.
IPI	IPI00720113.
RefSeq	NP_001033928.1. NM_001038839.1. NP_001033976.1. NM_001038887.1. NP_035157.2. NM_011027.2.
UniGene	Mm.42026.
3D structure databases
SMR	Q3UN00. Positions 35-355.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000121489; ENSMUSP00000112440; ENSMUSG00000029468.
GeneID	18439.
KEGG	mmu:18439.
UCSC	uc008zlp.1. mouse.
Organism-specific databases
CTD	5027.
MGI	MGI:1339957. P2rx7.
Phylogenomic databases
GeneTree	ENSGT00390000016028.
HOGENOM	HOG000232042.
HOVERGEN	HBG053086.
KO	K05220.
Gene expression databases
Genevestigator	Q3UN00.
Family and domain databases
Gene3D	2.60.490.10. 1 hit.
InterPro	IPR003050. P2X7_purnocptor. IPR027309. P2X_extracellular_dom. IPR001429. P2X_purnocptor. [Graphical view]
PANTHER	PTHR10125. PTHR10125. 1 hit. PTHR10125:SF13. PTHR10125:SF13. 1 hit.
Pfam	PF00864. P2X_receptor. 1 hit. [Graphical view]
PRINTS	PR01314. P2X7RECEPTOR. PR01307. P2XRECEPTOR.
TIGRFAMs	TIGR00863. P2X. 1 hit.
PROSITE	PS01212. P2X_RECEPTOR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	294114.
SOURCE	Search...

Entry information

Entry name

Q3UN00_MOUSE

Accession

Primary (citable) accession number: Q3UN00

Entry history

Integrated into UniProtKB/TrEMBL:	October 11, 2005
Last sequence update:	October 11, 2005
Last modified:	May 1, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)