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Q3UN00 (Q3UN00_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
P2X purinoceptor RuleBase RU000681
Gene names
Name:P2rx7 Ensembl ENSMUSP00000112440 MGI 1339957
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the P2X receptor family. RuleBase RU000681

Ontologies

Keywords
   Biological processIon transport
Transport
   Molecular functionIon channel RuleBase RU000681
Receptor RuleBase RU000681
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNAD transport

Inferred from mutant phenotype PubMed 17803959. Source: MGI

T cell homeostasis

Inferred from mutant phenotype PubMed 16116196. Source: MGI

T cell proliferation

Inferred from mutant phenotype PubMed 15914561. Source: MGI

activation of MAPK activity

Inferred from mutant phenotype PubMed 17306762. Source: MGI

bleb assembly

Inferred from mutant phenotype PubMed 17135244. Source: MGI

calcium ion transport

Inferred from mutant phenotype PubMed 12370338. Source: MGI

cation transport

Inferred from mutant phenotype PubMed 12677010. Source: MGI

cell death

Inferred from direct assay PubMed 18097031. Source: MGI

cell morphogenesis

Inferred from mutant phenotype PubMed 12055263. Source: MGI

cell volume homeostasis

Inferred from direct assay PubMed 18097031. Source: MGI

cellular response to extracellular stimulus

Inferred from mutant phenotype PubMed 18082965. Source: MGI

ceramide biosynthetic process

Inferred from direct assay PubMed 16325464. Source: MGI

collagen metabolic process

Inferred from mutant phenotype PubMed 16969386. Source: MGI

cytolysis

Inferred from direct assay PubMed 16116196PubMed 18097031. Source: MGI

defense response to Gram-positive bacterium

Inferred from mutant phenotype PubMed 11544318. Source: MGI

gene expression

Inferred from mutant phenotype PubMed 18519738. Source: MGI

homeostasis of number of cells within a tissue

Inferred from mutant phenotype PubMed 16969386. Source: MGI

inflammatory response

Inferred from mutant phenotype PubMed 12055263PubMed 16969386. Source: MGI

membrane budding

Inferred from mutant phenotype PubMed 15905573. Source: MGI

membrane protein ectodomain proteolysis

Inferred from mutant phenotype PubMed 17286969. Source: MGI

mitochondrion organization

Inferred from direct assay PubMed 16325464. Source: MGI

multicellular organismal protein catabolic process

Inferred from direct assay PubMed 11489964. Source: MGI

negative regulation of MAPK cascade

Inferred from direct assay PubMed 11489964. Source: MGI

negative regulation of bone resorption

Inferred from mutant phenotype PubMed 12677010. Source: MGI

phagolysosome assembly

Inferred from mutant phenotype PubMed 11544318. Source: MGI

phospholipid transfer to membrane

Inferred from mutant phenotype PubMed 12370338. Source: MGI

phospholipid translocation

Inferred from direct assay PubMed 18097031. Source: MGI

plasma membrane organization

Inferred from direct assay PubMed 18097031. Source: MGI

pore complex assembly

Inferred from mutant phenotype PubMed 12370338PubMed 15937334PubMed 16269410. Source: MGI

positive regulation of MAPK cascade

Inferred from mutant phenotype PubMed 15937334. Source: MGI

positive regulation of T cell mediated cytotoxicity

Inferred from mutant phenotype PubMed 14761980. Source: MGI

positive regulation of apoptotic process

Inferred from mutant phenotype PubMed 16325464PubMed 16969386. Source: MGI

positive regulation of bone mineralization

Inferred from mutant phenotype PubMed 12677010PubMed 18519738. Source: MGI

positive regulation of catalytic activity

Inferred from mutant phenotype PubMed 14761980. Source: MGI

positive regulation of cytokine secretion

Inferred from mutant phenotype PubMed 18490713. Source: MGI

positive regulation of gamma-aminobutyric acid secretion

Inferred from mutant phenotype PubMed 15640761. Source: MGI

positive regulation of glutamate secretion

Inferred from mutant phenotype PubMed 15640761PubMed 17306762. Source: MGI

positive regulation of interleukin-1 alpha secretion

Inferred from mutant phenotype PubMed 18490713. Source: MGI

positive regulation of interleukin-1 beta production

Inferred from mutant phenotype PubMed 11016935. Source: MGI

positive regulation of interleukin-1 beta secretion

Inferred from mutant phenotype PubMed 11016935PubMed 15905573PubMed 18490713. Source: MGI

positive regulation of interleukin-6 production

Inferred from mutant phenotype PubMed 11016935. Source: MGI

positive regulation of lymphocyte apoptotic process

Inferred from mutant phenotype PubMed 16493071. Source: MGI

positive regulation of mitochondrial depolarization

Inferred from mutant phenotype PubMed 16198349. Source: MGI

positive regulation of ossification

Inferred from mutant phenotype PubMed 16269410PubMed 18519738. Source: MGI

positive regulation of prostaglandin secretion

Inferred from mutant phenotype PubMed 16269410. Source: MGI

positive regulation of protein phosphorylation

Inferred from mutant phenotype PubMed 15937334PubMed 17448897. Source: MGI

positive regulation of protein secretion

Inferred from direct assay PubMed 15240711. Source: MGI

protein oligomerization

Inferred from direct assay PubMed 15713258. Source: MGI

protein phosphorylation

Inferred from mutant phenotype PubMed 17306762. Source: MGI

protein processing

Inferred from mutant phenotype PubMed 11016935. Source: MGI

purinergic nucleotide receptor signaling pathway

Inferred from Biological aspect of Ancestor. Source: GOC

reactive oxygen species metabolic process

Inferred from mutant phenotype PubMed 17448897. Source: MGI

release of sequestered calcium ion into cytosol

Inferred from mutant phenotype PubMed 18082965. Source: MGI

response to ATP

Inferred from direct assay PubMed 15240711PubMed 15713258. Source: MGI

response to bacterium

Inferred from mutant phenotype PubMed 10395640. Source: MGI

response to calcium ion

Inferred from direct assay PubMed 15240711. Source: MGI

response to drug

Inferred from mutant phenotype PubMed 18082965. Source: MGI

response to electrical stimulus

Inferred from mutant phenotype PubMed 15640761. Source: MGI

response to fluid shear stress

Inferred from mutant phenotype PubMed 16269410. Source: MGI

response to lipopolysaccharide

Inferred from direct assay PubMed 15240711. Source: MGI

response to mechanical stimulus

Inferred from mutant phenotype PubMed 16269410. Source: MGI

response to organic cyclic compound

Inferred from direct assay PubMed 15240711. Source: MGI

response to organic substance

Inferred from mutant phenotype PubMed 16116196PubMed 16455971PubMed 17286969. Source: MGI

response to zinc ion

Inferred from mutant phenotype PubMed 15978588PubMed 18082965. Source: MGI

skeletal system morphogenesis

Inferred from mutant phenotype PubMed 18519738. Source: MGI

synaptic vesicle exocytosis

Inferred from mutant phenotype PubMed 15713258. Source: MGI

transmembrane transport

Inferred from mutant phenotype PubMed 18519738. Source: GOC

   Cellular_componentcell-cell junction

Inferred from direct assay PubMed 15331634. Source: MGI

external side of plasma membrane

Inferred from direct assay PubMed 17286969. Source: MGI

integral component of plasma membrane

Inferred from mutant phenotype PubMed 12677010. Source: MGI

membrane

Inferred from direct assay PubMed 15713258. Source: MGI

neuromuscular junction

Inferred from direct assay PubMed 15713258. Source: MGI

neuronal cell body

Inferred from direct assay PubMed 15964665PubMed 15978588. Source: MGI

plasma membrane

Inferred from direct assay PubMed 15331634. Source: MGI

synapse

Inferred from direct assay PubMed 18082965. Source: MGI

   Molecular_functionATP binding

Inferred from mutant phenotype PubMed 12677010. Source: MGI

channel activity

Inferred from mutant phenotype PubMed 18519738. Source: MGI

extracellular ATP-gated cation channel activity

Inferred from mutant phenotype PubMed 12677010PubMed 15713258. Source: MGI

lipopolysaccharide binding

Inferred from direct assay PubMed 11489964. Source: MGI

purinergic nucleotide receptor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

receptor activity

Inferred from mutant phenotype PubMed 12677010. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q3UN00 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 7935E3F02AF82FA0

FASTA43149,368
        10         20         30         40         50         60 
MPACCSWNDV LQYETNKVTR IQSTNYGTVK WVLHMIVFSY ISFALVSDKL YQRKEPVISS 

        70         80         90        100        110        120 
VHTKVKGIAE VTENVTEGGV TKLGHSIFDT ADYTFPLQGN SFFVMTNYVK SEGQVQTLCP 

       130        140        150        160        170        180 
EYPRRGAQCS SDRRCKKGWM DPQSKGIQTG RCVPYDKTRK TCEVSAWCPT EEEKEAPRPA 

       190        200        210        220        230        240 
LLRSAENFTV LIKNNIHFPG HNYTTRNILP TMNGSCTFHK TWDPQCSIFR LGDIFQEAGE 

       250        260        270        280        290        300 
NFTEVAVQGG IMGIEIYWDC NLDSWSHHCR PRYSFRRLDD KNTDESFVPG YNFRYAKYYK 

       310        320        330        340        350        360 
ENNVEKRTLI KAFGIRFDIL VFGTGGKFDI IQLVVYIGST LSYFGLATVC IDLLINTYSS 

       370        380        390        400        410        420 
AFCRSGVYPY CKCCEPCTVN EYYYRKKCES IMEPKPTLKY VSFVDEPHIR MVDQQLLGKS 

       430 
LQVVKGQEVP T 

« Hide

References

« Hide 'large scale' references
[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Lung EMBL BAE25948.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Lung EMBL BAE25948.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Lung EMBL BAE25948.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Lung EMBL BAE25948.1.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Lung EMBL BAE25948.1.
[6]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Lung EMBL BAE25948.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Lung EMBL BAE25948.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Lung EMBL BAE25948.1.
[9]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000112440.
[10]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000112440.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC114632 Genomic DNA. No translation available.
AK144585 mRNA. Translation: BAE25948.1.
RefSeqNP_001033928.1. NM_001038839.2.
NP_001033976.1. NM_001038887.1.
UniGeneMm.42026.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000121489; ENSMUSP00000112440; ENSMUSG00000029468.
GeneID18439.
KEGGmmu:18439.
UCSCuc008zlp.1. mouse.

Organism-specific databases

CTD5027.
MGIMGI:1339957. P2rx7.

Phylogenomic databases

GeneTreeENSGT00390000016028.
HOGENOMHOG000232042.
HOVERGENHBG053086.
KOK05220.

Gene expression databases

GenevestigatorQ3UN00.

Family and domain databases

Gene3D2.60.490.10. 1 hit.
InterProIPR003050. P2X7_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF13. PTHR10125:SF13. 1 hit.
PfamPF00864. P2X_receptor. 1 hit.
[Graphical view]
PRINTSPR01314. P2X7RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsTIGR00863. P2X. 1 hit.
PROSITEPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio294114.
SOURCESearch...

Entry information

Entry nameQ3UN00_MOUSE
AccessionPrimary (citable) accession number: Q3UN00
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)