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Q3UN00

- Q3UN00_MOUSE

UniProt

Q3UN00 - Q3UN00_MOUSE

Protein

P2X purinoceptor

Gene

P2rx7

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: MGI
    2. channel activity Source: MGI
    3. extracellular ATP-gated cation channel activity Source: MGI
    4. lipopolysaccharide binding Source: MGI
    5. protein binding Source: MGI
    6. purinergic nucleotide receptor activity Source: RefGenome
    7. receptor activity Source: MGI

    GO - Biological processi

    1. activation of MAPK activity Source: MGI
    2. bleb assembly Source: MGI
    3. calcium ion transport Source: MGI
    4. cation transport Source: MGI
    5. cell morphogenesis Source: MGI
    6. cellular response to extracellular stimulus Source: MGI
    7. cell volume homeostasis Source: MGI
    8. ceramide biosynthetic process Source: MGI
    9. collagen metabolic process Source: MGI
    10. cytolysis Source: MGI
    11. defense response to Gram-positive bacterium Source: MGI
    12. extrinsic apoptotic signaling pathway Source: MGI
    13. gene expression Source: MGI
    14. homeostasis of number of cells within a tissue Source: MGI
    15. inflammatory response Source: MGI
    16. membrane budding Source: MGI
    17. membrane protein ectodomain proteolysis Source: MGI
    18. mitochondrion organization Source: MGI
    19. multicellular organismal protein catabolic process Source: MGI
    20. NAD transport Source: MGI
    21. negative regulation of bone resorption Source: MGI
    22. negative regulation of MAPK cascade Source: MGI
    23. phagolysosome assembly Source: MGI
    24. phospholipid transfer to membrane Source: MGI
    25. phospholipid translocation Source: MGI
    26. plasma membrane organization Source: MGI
    27. pore complex assembly Source: MGI
    28. positive regulation of apoptotic process Source: MGI
    29. positive regulation of bone mineralization Source: MGI
    30. positive regulation of catalytic activity Source: MGI
    31. positive regulation of cytokine secretion Source: MGI
    32. positive regulation of gamma-aminobutyric acid secretion Source: MGI
    33. positive regulation of glutamate secretion Source: MGI
    34. positive regulation of interleukin-1 alpha secretion Source: MGI
    35. positive regulation of interleukin-1 beta production Source: MGI
    36. positive regulation of interleukin-1 beta secretion Source: MGI
    37. positive regulation of interleukin-6 production Source: MGI
    38. positive regulation of lymphocyte apoptotic process Source: MGI
    39. positive regulation of MAPK cascade Source: MGI
    40. positive regulation of mitochondrial depolarization Source: MGI
    41. positive regulation of ossification Source: MGI
    42. positive regulation of prostaglandin secretion Source: MGI
    43. positive regulation of protein phosphorylation Source: MGI
    44. positive regulation of protein secretion Source: MGI
    45. positive regulation of T cell mediated cytotoxicity Source: MGI
    46. programmed cell death Source: MGI
    47. protein oligomerization Source: MGI
    48. protein phosphorylation Source: MGI
    49. protein processing Source: MGI
    50. purinergic nucleotide receptor signaling pathway Source: GOC
    51. reactive oxygen species metabolic process Source: MGI
    52. release of sequestered calcium ion into cytosol Source: MGI
    53. response to ATP Source: MGI
    54. response to bacterium Source: MGI
    55. response to calcium ion Source: MGI
    56. response to drug Source: MGI
    57. response to electrical stimulus Source: MGI
    58. response to fluid shear stress Source: MGI
    59. response to lipopolysaccharide Source: MGI
    60. response to mechanical stimulus Source: MGI
    61. response to organic cyclic compound Source: MGI
    62. response to organic substance Source: MGI
    63. response to zinc ion Source: MGI
    64. skeletal system morphogenesis Source: MGI
    65. synaptic vesicle exocytosis Source: MGI
    66. T cell homeostasis Source: MGI
    67. T cell proliferation Source: MGI
    68. transmembrane transport Source: GOC

    Keywords - Molecular functioni

    Ion channelUniRule annotation, ReceptorUniRule annotation

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    P2X purinoceptorUniRule annotation
    Gene namesi
    Name:P2rx7Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1339957. P2rx7.

    Subcellular locationi

    GO - Cellular componenti

    1. cell-cell junction Source: MGI
    2. external side of plasma membrane Source: MGI
    3. integral component of nuclear inner membrane Source: RefGenome
    4. integral component of plasma membrane Source: MGI
    5. membrane Source: MGI
    6. neuromuscular junction Source: MGI
    7. neuronal cell body Source: MGI
    8. plasma membrane Source: MGI
    9. synapse Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ3UN00.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the P2X receptor family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000016028.
    HOGENOMiHOG000232042.
    HOVERGENiHBG053086.
    KOiK05220.

    Family and domain databases

    Gene3Di2.60.490.10. 1 hit.
    InterProiIPR003050. P2X7_purnocptor.
    IPR027309. P2X_extracellular_dom.
    IPR001429. P2X_purnocptor.
    [Graphical view]
    PANTHERiPTHR10125. PTHR10125. 1 hit.
    PTHR10125:SF13. PTHR10125:SF13. 1 hit.
    PfamiPF00864. P2X_receptor. 1 hit.
    [Graphical view]
    PRINTSiPR01314. P2X7RECEPTOR.
    PR01307. P2XRECEPTOR.
    TIGRFAMsiTIGR00863. P2X. 1 hit.
    PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3UN00-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPACCSWNDV LQYETNKVTR IQSTNYGTVK WVLHMIVFSY ISFALVSDKL    50
    YQRKEPVISS VHTKVKGIAE VTENVTEGGV TKLGHSIFDT ADYTFPLQGN 100
    SFFVMTNYVK SEGQVQTLCP EYPRRGAQCS SDRRCKKGWM DPQSKGIQTG 150
    RCVPYDKTRK TCEVSAWCPT EEEKEAPRPA LLRSAENFTV LIKNNIHFPG 200
    HNYTTRNILP TMNGSCTFHK TWDPQCSIFR LGDIFQEAGE NFTEVAVQGG 250
    IMGIEIYWDC NLDSWSHHCR PRYSFRRLDD KNTDESFVPG YNFRYAKYYK 300
    ENNVEKRTLI KAFGIRFDIL VFGTGGKFDI IQLVVYIGST LSYFGLATVC 350
    IDLLINTYSS AFCRSGVYPY CKCCEPCTVN EYYYRKKCES IMEPKPTLKY 400
    VSFVDEPHIR MVDQQLLGKS LQVVKGQEVP T 431
    Length:431
    Mass (Da):49,368
    Last modified:October 11, 2005 - v1
    Checksum:i7935E3F02AF82FA0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC114632 Genomic DNA. No translation available.
    AK144585 mRNA. Translation: BAE25948.1.
    RefSeqiNP_001033928.1. NM_001038839.2.
    NP_001033976.1. NM_001038887.1.
    UniGeneiMm.42026.

    Genome annotation databases

    EnsembliENSMUST00000121489; ENSMUSP00000112440; ENSMUSG00000029468.
    GeneIDi18439.
    KEGGimmu:18439.
    UCSCiuc008zlp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC114632 Genomic DNA. No translation available.
    AK144585 mRNA. Translation: BAE25948.1 .
    RefSeqi NP_001033928.1. NM_001038839.2.
    NP_001033976.1. NM_001038887.1.
    UniGenei Mm.42026.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000121489 ; ENSMUSP00000112440 ; ENSMUSG00000029468 .
    GeneIDi 18439.
    KEGGi mmu:18439.
    UCSCi uc008zlp.1. mouse.

    Organism-specific databases

    CTDi 5027.
    MGIi MGI:1339957. P2rx7.

    Phylogenomic databases

    GeneTreei ENSGT00390000016028.
    HOGENOMi HOG000232042.
    HOVERGENi HBG053086.
    KOi K05220.

    Miscellaneous databases

    NextBioi 294114.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q3UN00.

    Family and domain databases

    Gene3Di 2.60.490.10. 1 hit.
    InterProi IPR003050. P2X7_purnocptor.
    IPR027309. P2X_extracellular_dom.
    IPR001429. P2X_purnocptor.
    [Graphical view ]
    PANTHERi PTHR10125. PTHR10125. 1 hit.
    PTHR10125:SF13. PTHR10125:SF13. 1 hit.
    Pfami PF00864. P2X_receptor. 1 hit.
    [Graphical view ]
    PRINTSi PR01314. P2X7RECEPTOR.
    PR01307. P2XRECEPTOR.
    TIGRFAMsi TIGR00863. P2X. 1 hit.
    PROSITEi PS01212. P2X_RECEPTOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: LungImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: LungImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: LungImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: LungImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: LungImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: LungImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: LungImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: LungImported.
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    10. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ3UN00_MOUSE
    AccessioniPrimary (citable) accession number: Q3UN00
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3