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Protein

Phospholipid phosphatase 5

Gene

Plpp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol (By similarity).By similarity

Catalytic activityi

A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid phosphatase 5By similarity (EC:3.1.3.4)
Alternative name(s):
Phosphatidic acid phosphatase type 2 domain-containing protein 1B
Gene namesi
Name:Plpp5By similarity
Synonyms:Ppapdc1, Ppapdc1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1919160. Plpp5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Transmembranei206 – 223HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002869461 – 260Phospholipid phosphatase 5Add BLAST260

Proteomic databases

PaxDbiQ3UMZ3.
PRIDEiQ3UMZ3.

PTM databases

PhosphoSitePlusiQ3UMZ3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031570.
ExpressionAtlasiQ3UMZ3. baseline and differential.
GenevisibleiQ3UMZ3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067035.

Structurei

3D structure databases

ProteinModelPortaliQ3UMZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni104 – 112Phosphatase sequence motif IBy similarity9
Regioni145 – 148Phosphatase sequence motif IIBy similarity4
Regioni197 – 207Phosphatase sequence motif IIIBy similarityAdd BLAST11

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3030. Eukaryota.
COG0671. LUCA.
GeneTreeiENSGT00510000046723.
HOGENOMiHOG000215098.
HOVERGENiHBG056764.
InParanoidiQ3UMZ3.
OMAiEMWLYKF.
OrthoDBiEOG091G0O0I.
PhylomeDBiQ3UMZ3.
TreeFamiTF323722.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
IPR032462. PPAPDC1B.
[Graphical view]
PANTHERiPTHR10165:SF87. PTHR10165:SF87. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UMZ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTAALGAEL GVRVLLFVAF LVTELLPPFQ RRIQPEELWL YRNPYVEAEY
60 70 80 90 100
FPTGRMFVIA FLTPLSLIFL AKFLRKADAT DSKQACLAAS LALALNGVFT
110 120 130 140 150
NIIKLIVGRP RPDFFYRCFP DGLAHSDLTC TGDEDVVNEG RKSFPSGHSS
160 170 180 190 200
FAFAGLAFAS FYLAGKLHCF TPQGRGKSWR LCAFLSPLLF AAVIALSRTC
210 220 230 240 250
DYKHHWQDVL VGSMIGMTFA YVCYRQYYPP LTDVECHKPF QDKHKLPSSQ
260
KPSELHHLEI
Length:260
Mass (Da):29,223
Last modified:October 11, 2005 - v1
Checksum:i5065F56EC3CCD554
GO
Isoform 2 (identifier: Q3UMZ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     208-226: DVLVGSMIGMTFAYVCYRQ → GWYKDMHRCSQLFMRVLGI
     227-260: Missing.

Note: No experimental confirmation available.
Show »
Length:226
Mass (Da):25,386
Checksum:iE611F54B40720DAF
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025243208 – 226DVLVG…VCYRQ → GWYKDMHRCSQLFMRVLGI in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_025244227 – 260Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144593 mRNA. Translation: BAE25955.1.
BC099489 mRNA. Translation: AAH99489.1.
CCDSiCCDS40306.1. [Q3UMZ3-1]
CCDS80868.1. [Q3UMZ3-2]
RefSeqiNP_082276.1. NM_028000.1. [Q3UMZ3-1]
UniGeneiMm.385055.

Genome annotation databases

EnsembliENSMUST00000068916; ENSMUSP00000067035; ENSMUSG00000031570. [Q3UMZ3-1]
ENSMUST00000139836; ENSMUSP00000122437; ENSMUSG00000031570. [Q3UMZ3-2]
GeneIDi71910.
KEGGimmu:71910.
UCSCiuc009lgr.1. mouse. [Q3UMZ3-1]
uc009lgs.1. mouse. [Q3UMZ3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144593 mRNA. Translation: BAE25955.1.
BC099489 mRNA. Translation: AAH99489.1.
CCDSiCCDS40306.1. [Q3UMZ3-1]
CCDS80868.1. [Q3UMZ3-2]
RefSeqiNP_082276.1. NM_028000.1. [Q3UMZ3-1]
UniGeneiMm.385055.

3D structure databases

ProteinModelPortaliQ3UMZ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067035.

PTM databases

PhosphoSitePlusiQ3UMZ3.

Proteomic databases

PaxDbiQ3UMZ3.
PRIDEiQ3UMZ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068916; ENSMUSP00000067035; ENSMUSG00000031570. [Q3UMZ3-1]
ENSMUST00000139836; ENSMUSP00000122437; ENSMUSG00000031570. [Q3UMZ3-2]
GeneIDi71910.
KEGGimmu:71910.
UCSCiuc009lgr.1. mouse. [Q3UMZ3-1]
uc009lgs.1. mouse. [Q3UMZ3-2]

Organism-specific databases

CTDi84513.
MGIiMGI:1919160. Plpp5.

Phylogenomic databases

eggNOGiKOG3030. Eukaryota.
COG0671. LUCA.
GeneTreeiENSGT00510000046723.
HOGENOMiHOG000215098.
HOVERGENiHBG056764.
InParanoidiQ3UMZ3.
OMAiEMWLYKF.
OrthoDBiEOG091G0O0I.
PhylomeDBiQ3UMZ3.
TreeFamiTF323722.

Miscellaneous databases

ChiTaRSiPpapdc1b. mouse.
PROiQ3UMZ3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031570.
ExpressionAtlasiQ3UMZ3. baseline and differential.
GenevisibleiQ3UMZ3. MM.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
IPR032462. PPAPDC1B.
[Graphical view]
PANTHERiPTHR10165:SF87. PTHR10165:SF87. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLPP5_MOUSE
AccessioniPrimary (citable) accession number: Q3UMZ3
Secondary accession number(s): Q4KL19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.