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UniProtKB - Q3UMY5 (EMAL4_MOUSE)

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Protein

Echinoderm microtubule-associated protein-like 4

Gene

Eml4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.By similarity

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

  • negative regulation of microtubule depolymerization Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Echinoderm microtubule-associated protein-like 4
Short name:
EMAP-4
Gene namesi
Name:Eml4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1926048. Eml4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002843921 – 988Echinoderm microtubule-associated protein-like 4Add BLAST988

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei7PhosphoserineBy similarity1
Modified residuei13PhosphoserineBy similarity1
Modified residuei16PhosphoserineBy similarity1
Modified residuei61PhosphoserineBy similarity1
Modified residuei79PhosphoserineCombined sources1
Modified residuei96PhosphothreonineBy similarity1
Modified residuei144PhosphoserineCombined sources1
Modified residuei146PhosphoserineCombined sources1
Modified residuei171PhosphoserineBy similarity1
Modified residuei200PhosphoserineBy similarity1
Modified residuei201PhosphothreonineBy similarity1
Modified residuei237PhosphotyrosineBy similarity1
Modified residuei248PhosphothreonineBy similarity1
Modified residuei906PhosphoserineBy similarity1
Modified residuei908PhosphoserineCombined sources1
Modified residuei914PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ3UMY5.
MaxQBiQ3UMY5.
PaxDbiQ3UMY5.
PeptideAtlasiQ3UMY5.
PRIDEiQ3UMY5.

PTM databases

iPTMnetiQ3UMY5.
PhosphoSitePlusiQ3UMY5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032624.
CleanExiMM_EML4.

Interactioni

GO - Molecular functioni

Complete GO annotation...

Protein-protein interaction databases

BioGridi219641. 1 interactor.
STRINGi10090.ENSMUSP00000094528.

Structurei

3D structure databases

ProteinModelPortaliQ3UMY5.
SMRiQ3UMY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati318 – 367WD 1Add BLAST50
Repeati372 – 415WD 2Add BLAST44
Repeati418 – 459WD 3Add BLAST42
Repeati465 – 503WD 4Add BLAST39
Repeati518 – 557WD 5Add BLAST40
Repeati601 – 640WD 6Add BLAST40
Repeati684 – 723WD 7Add BLAST40
Repeati730 – 769WD 8Add BLAST40
Repeati843 – 883WD 9Add BLAST41

Sequence similaritiesi

Belongs to the WD repeat EMAP family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410KDGE. Eukaryota.
COG2319. LUCA.
HOGENOMiHOG000294061.
HOVERGENiHBG051470.
InParanoidiQ3UMY5.
KOiK15420.
PhylomeDBiQ3UMY5.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiView protein in InterPro
IPR005108. HELP.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF03451. HELP. 1 hit.
PF00400. WD40. 5 hits.
SMARTiView protein in SMART
SM00320. WD40. 9 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF50998. SSF50998. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 3 hits.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UMY5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGFAGSLDD SISAASTSDV QDRLSALESR VQQQEDEITV LKAALADVLR 
        60         70         80         90        100
RLAISEDHVA SVKKSMPSKG QPSLREAISM SCITNGSGIS RKQNHTSSVS 
       110        120        130        140        150
IARKETLSSA AKSGTEKKKE KPQGQREKKE DSHSNDQSPQ IRASPSPQPS 
       160        170        180        190        200
SQPLQINRQT PESKSSAPIK SIKRPPTAEK SHNSWENSDD SRNKLMKTVS 
       210        220        230        240        250
TSKLISKVIK NADKHKDVIV NQAKMSTREK NSQEGEYIKM FMRGRPITMF 
       260        270        280        290        300
IPSDVDNYDD IRTELPPEKL KLEWVYGYRG KDCRANVYLL PTGEIVYFIA 
       310        320        330        340        350
SVVVLFNYEE RTQRHYLGHT DCVRCLAVHP DKIRIATGQI AGVDKDGRPL 
       360        370        380        390        400
QPHVRVWDSV SLTTLHVIGL GTFERGVGCL DFSKADSGVH LCVIDDSNEH 
       410        420        430        440        450
MLTVWDWQKK SKIAEIKTTN EVVLAVEFHP TDANTIITCG KSHIFFWTWS 
       460        470        480        490        500
GNSLTRKQGI FGKYEKPKFV QCLAFLGNGD VLTGDSGGVM LIWSKTMVEP 
       510        520        530        540        550
PPGKGPKGVY QINRQIKAHD GSVFTLCQMR NGMLLTGGGK DRKIILWDHD 
       560        570        580        590        600
LNLEREIEVP DQYGTIRAVA EGRAEQFLVG TSRNFILRGT FNDGFQIEVQ 
       610        620        630        640        650
GHRDELWGLA THPFKDLLLT CAQDRQVCMW NSVEHRLEWT RLVDEPGHCA 
       660        670        680        690        700
DFHPSGTVVA IGTHSGRWFV LDAETRDLVS IHTDGNEQLS VMRYSVDGTL 
       710        720        730        740        750
LAVGSHDNFI YLYTVLENGR KYSRYGKCTG HSSYITHLDW SPDNKHIMSN 
       760        770        780        790        800
SGDYEILYWD IENGCKLIRN RSDCKDIDWT TYTCVLGFQV FGVWPEGSDG 
       810        820        830        840        850
TDINALVRSH NRRVIAVADD FCKVHLFQYP CSKAKAPSHK YSAHSSHVTN 
       860        870        880        890        900
VSFTHNDSHL ISTGGKDMSI IQWKLVEKLP VPQNEVITDA SVTKTPASSS 
       910        920        930        940        950
ETARPSNSPP LPPSLPLTGT AEEESRMGSS PTLVENSLEQ IAEPSEEQSE 
       960        970        980 
WGSEDLGVVI DEEPASELSE TQGATELPEE ERGITPLC
Length:988
Mass (Da):110,027
Last modified:October 11, 2005 - v1
Checksum:i950336CFC1C178D5
GO
Isoform 2 (identifier: Q3UMY5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-171: Missing.
     223-233: Missing.

Note: No experimental confirmation available.
Show »
Length:919
Mass (Da):102,359
Checksum:iE60BB52B9525D4E4
GO
Isoform 3 (identifier: Q3UMY5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MDGFAGSL → MNRVSSDPVAIP
     114-171: Missing.

Note: No experimental confirmation available.
Show »
Length:934
Mass (Da):104,109
Checksum:i62D2D4042B771FB2
GO
Isoform 4 (identifier: Q3UMY5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-214: SGTEKKKEKP...ISKVIKNADK → R
     223-233: Missing.

Note: No experimental confirmation available.
Show »
Length:876
Mass (Da):97,563
Checksum:i4576D56445E59DAB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti603R → T in AAH67011 (PubMed:15489334).Curated1
Sequence conflicti603R → T in AAH66099 (PubMed:15489334).Curated1
Sequence conflicti603R → T in AAH79619 (PubMed:15489334).Curated1
Sequence conflicti603R → T in AAH65178 (PubMed:15489334).Curated1
Sequence conflicti603R → T in AAH70427 (PubMed:15489334).Curated1
Sequence conflicti804N → I in AAH67011 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0244841 – 8MDGFAGSL → MNRVSSDPVAIP in isoform 3. 1 Publication8
Alternative sequenceiVSP_024485113 – 214SGTEK…KNADK → R in isoform 4. 1 PublicationAdd BLAST102
Alternative sequenceiVSP_024486114 – 171Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_024487223 – 233Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144604 mRNA. Translation: BAE25963.1.
BC065178 mRNA. Translation: AAH65178.1.
BC066099 mRNA. Translation: AAH66099.1.
BC067011 mRNA. Translation: AAH67011.1.
BC070427 mRNA. Translation: AAH70427.1.
BC079619 mRNA. Translation: AAH79619.1.
CCDSiCCDS37708.1. [Q3UMY5-4]
CCDS50192.1. [Q3UMY5-1]
CCDS50193.1. [Q3UMY5-2]
RefSeqiNP_001107834.1. NM_001114362.1.
NP_001273496.1. NM_001286567.1.
NP_955760.3. NM_199466.3.
UniGeneiMm.295565.

Genome annotation databases

GeneIDi78798.
KEGGimmu:78798.
UCSCiuc008drx.2. mouse. [Q3UMY5-4]
uc008dry.2. mouse. [Q3UMY5-3]
uc008dsb.2. mouse. [Q3UMY5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiEMAL4_MOUSE
AccessioniPrimary (citable) accession number: Q3UMY5
Secondary accession number(s): Q6NS73
, Q6NXL8, Q6NZJ8, Q6P1A7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: October 11, 2005
Last modified: May 10, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families