UniProtKB - Q3UMY5 (EMAL4_MOUSE)
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Protein
Echinoderm microtubule-associated protein-like 4
Gene
Eml4
Organism
Mus musculus (Mouse)
Status
Functioni
May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.By similarity
GO - Molecular functioni
- microtubule binding Source: GO_Central
GO - Biological processi
Names & Taxonomyi
Protein namesi | Recommended name: Echinoderm microtubule-associated protein-like 4Short name: EMAP-4 |
Gene namesi | Name:Eml4 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1926048. Eml4. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000284392 | 1 – 988 | Echinoderm microtubule-associated protein-like 4Add BLAST | 988 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 7 | PhosphoserineBy similarity | 1 | |
Modified residuei | 13 | PhosphoserineBy similarity | 1 | |
Modified residuei | 16 | PhosphoserineBy similarity | 1 | |
Modified residuei | 61 | PhosphoserineBy similarity | 1 | |
Modified residuei | 79 | PhosphoserineCombined sources | 1 | |
Modified residuei | 96 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 144 | PhosphoserineCombined sources | 1 | |
Modified residuei | 146 | PhosphoserineCombined sources | 1 | |
Modified residuei | 171 | PhosphoserineBy similarity | 1 | |
Modified residuei | 200 | PhosphoserineBy similarity | 1 | |
Modified residuei | 201 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 237 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 248 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 906 | PhosphoserineBy similarity | 1 | |
Modified residuei | 908 | PhosphoserineCombined sources | 1 | |
Modified residuei | 914 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q3UMY5. |
MaxQBi | Q3UMY5. |
PaxDbi | Q3UMY5. |
PeptideAtlasi | Q3UMY5. |
PRIDEi | Q3UMY5. |
PTM databases
iPTMneti | Q3UMY5. |
PhosphoSitePlusi | Q3UMY5. |
Interactioni
GO - Molecular functioni
- microtubule binding Source: GO_Central
Protein-protein interaction databases
BioGridi | 219641. 1 interactor. |
STRINGi | 10090.ENSMUSP00000094528. |
Structurei
3D structure databases
ProteinModelPortali | Q3UMY5. |
SMRi | Q3UMY5. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 270 – 308 | WD 1Add BLAST | 39 | |
Repeati | 312 – 359 | WD 2Add BLAST | 48 | |
Repeati | 367 – 407 | WD 3Add BLAST | 41 | |
Repeati | 414 – 449 | WD 4Add BLAST | 36 | |
Repeati | 456 – 495 | WD 5Add BLAST | 40 | |
Repeati | 511 – 549 | WD 6Add BLAST | 39 | |
Repeati | 554 – 590 | WD 7Add BLAST | 37 | |
Repeati | 593 – 632 | WD 8Add BLAST | 40 | |
Repeati | 636 – 673 | WD 9Add BLAST | 38 | |
Repeati | 679 – 715 | WD 10Add BLAST | 37 | |
Repeati | 722 – 761 | WD 11Add BLAST | 40 | |
Repeati | 771 – 829 | WD 12Add BLAST | 59 | |
Repeati | 836 – 875 | WD 13Add BLAST | 40 |
Sequence similaritiesi
Belongs to the WD repeat EMAP family.Curated
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | ENOG410KDGE. Eukaryota. COG2319. LUCA. |
HOGENOMi | HOG000294061. |
HOVERGENi | HBG051470. |
InParanoidi | Q3UMY5. |
KOi | K15420. |
PhylomeDBi | Q3UMY5. |
Family and domain databases
Gene3Di | 2.130.10.10. 3 hits. |
InterProi | View protein in InterPro IPR005108. HELP. IPR011047. Quinoprotein_ADH-like_supfam. IPR015943. WD40/YVTN_repeat-like_dom_sf. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. IPR036322. WD40_repeat_dom_sf. |
Pfami | View protein in Pfam PF03451. HELP. 1 hit. PF00400. WD40. 5 hits. |
SMARTi | View protein in SMART SM00320. WD40. 9 hits. |
SUPFAMi | SSF50978. SSF50978. 1 hit. SSF50998. SSF50998. 1 hit. |
PROSITEi | View protein in PROSITE PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 4 hits. PS50294. WD_REPEATS_REGION. 3 hits. |
s (4)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q3UMY5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MDGFAGSLDD SISAASTSDV QDRLSALESR VQQQEDEITV LKAALADVLR
60 70 80 90 100
RLAISEDHVA SVKKSMPSKG QPSLREAISM SCITNGSGIS RKQNHTSSVS
110 120 130 140 150
IARKETLSSA AKSGTEKKKE KPQGQREKKE DSHSNDQSPQ IRASPSPQPS
160 170 180 190 200
SQPLQINRQT PESKSSAPIK SIKRPPTAEK SHNSWENSDD SRNKLMKTVS
210 220 230 240 250
TSKLISKVIK NADKHKDVIV NQAKMSTREK NSQEGEYIKM FMRGRPITMF
260 270 280 290 300
IPSDVDNYDD IRTELPPEKL KLEWVYGYRG KDCRANVYLL PTGEIVYFIA
310 320 330 340 350
SVVVLFNYEE RTQRHYLGHT DCVRCLAVHP DKIRIATGQI AGVDKDGRPL
360 370 380 390 400
QPHVRVWDSV SLTTLHVIGL GTFERGVGCL DFSKADSGVH LCVIDDSNEH
410 420 430 440 450
MLTVWDWQKK SKIAEIKTTN EVVLAVEFHP TDANTIITCG KSHIFFWTWS
460 470 480 490 500
GNSLTRKQGI FGKYEKPKFV QCLAFLGNGD VLTGDSGGVM LIWSKTMVEP
510 520 530 540 550
PPGKGPKGVY QINRQIKAHD GSVFTLCQMR NGMLLTGGGK DRKIILWDHD
560 570 580 590 600
LNLEREIEVP DQYGTIRAVA EGRAEQFLVG TSRNFILRGT FNDGFQIEVQ
610 620 630 640 650
GHRDELWGLA THPFKDLLLT CAQDRQVCMW NSVEHRLEWT RLVDEPGHCA
660 670 680 690 700
DFHPSGTVVA IGTHSGRWFV LDAETRDLVS IHTDGNEQLS VMRYSVDGTL
710 720 730 740 750
LAVGSHDNFI YLYTVLENGR KYSRYGKCTG HSSYITHLDW SPDNKHIMSN
760 770 780 790 800
SGDYEILYWD IENGCKLIRN RSDCKDIDWT TYTCVLGFQV FGVWPEGSDG
810 820 830 840 850
TDINALVRSH NRRVIAVADD FCKVHLFQYP CSKAKAPSHK YSAHSSHVTN
860 870 880 890 900
VSFTHNDSHL ISTGGKDMSI IQWKLVEKLP VPQNEVITDA SVTKTPASSS
910 920 930 940 950
ETARPSNSPP LPPSLPLTGT AEEESRMGSS PTLVENSLEQ IAEPSEEQSE
960 970 980
WGSEDLGVVI DEEPASELSE TQGATELPEE ERGITPLC
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 603 | R → T in AAH67011 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 603 | R → T in AAH66099 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 603 | R → T in AAH79619 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 603 | R → T in AAH65178 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 603 | R → T in AAH70427 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 804 | N → I in AAH67011 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024484 | 1 – 8 | MDGFAGSL → MNRVSSDPVAIP in isoform 3. 1 Publication | 8 | |
Alternative sequenceiVSP_024485 | 113 – 214 | SGTEK…KNADK → R in isoform 4. 1 PublicationAdd BLAST | 102 | |
Alternative sequenceiVSP_024486 | 114 – 171 | Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST | 58 | |
Alternative sequenceiVSP_024487 | 223 – 233 | Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST | 11 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK144604 mRNA. Translation: BAE25963.1. BC065178 mRNA. Translation: AAH65178.1. BC066099 mRNA. Translation: AAH66099.1. BC067011 mRNA. Translation: AAH67011.1. BC070427 mRNA. Translation: AAH70427.1. BC079619 mRNA. Translation: AAH79619.1. |
CCDSi | CCDS37708.1. [Q3UMY5-4] CCDS50192.1. [Q3UMY5-1] CCDS50193.1. [Q3UMY5-2] |
RefSeqi | NP_001107834.1. NM_001114362.1. NP_001273496.1. NM_001286567.1. NP_955760.3. NM_199466.3. |
UniGenei | Mm.295565. |
Genome annotation databases
GeneIDi | 78798. |
KEGGi | mmu:78798. |
UCSCi | uc008drx.2. mouse. [Q3UMY5-4] uc008dry.2. mouse. [Q3UMY5-3] uc008dsb.2. mouse. [Q3UMY5-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | EMAL4_MOUSE | |
Accessioni | Q3UMY5Primary (citable) accession number: Q3UMY5 Secondary accession number(s): Q6NS73 Q6P1A7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 17, 2007 |
Last sequence update: | October 11, 2005 | |
Last modified: | March 28, 2018 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |