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Protein

Ceroid-lipofuscinosis neuronal protein 5 homolog

Gene

Cln5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. mannose binding Source: UniProtKB

GO - Biological processi

  1. brain development Source: UniProtKB
  2. glycosylation Source: UniProtKB
  3. lysosomal lumen acidification Source: UniProtKB
  4. lysosome organization Source: MGI
  5. neurogenesis Source: UniProtKB
  6. signal peptide processing Source: UniProtKB
  7. visual perception Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ceroid-lipofuscinosis neuronal protein 5 homolog
Short name:
Protein CLN5
Gene namesi
Name:Cln5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:2442253. Cln5.

Subcellular locationi

Lysosome By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. extracellular vesicular exosome Source: MGI
  3. Golgi apparatus Source: UniProtKB
  4. integral component of membrane Source: UniProtKB
  5. lysosomal membrane Source: UniProtKB
  6. lysosome Source: UniProtKB
  7. perinuclear region of cytoplasm Source: UniProtKB
  8. vacuolar lumen Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Keywords - Diseasei

Neurodegeneration, Neuronal ceroid lipofuscinosis

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Chaini34 – 341308Ceroid-lipofuscinosis neuronal protein 5 homologPRO_0000330471Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi238 – 2381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ3UMW8.
PaxDbiQ3UMW8.
PRIDEiQ3UMW8.

PTM databases

PhosphoSiteiQ3UMW8.

Expressioni

Gene expression databases

BgeeiQ3UMW8.
ExpressionAtlasiQ3UMW8. baseline and differential.
GenevestigatoriQ3UMW8.

Structurei

3D structure databases

ProteinModelPortaliQ3UMW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CLN5 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45312.
GeneTreeiENSGT00390000010065.
HOGENOMiHOG000060233.
HOVERGENiHBG005345.
InParanoidiQ3UMW8.
KOiK12390.
OMAiKKIETNY.
OrthoDBiEOG77DJ65.
PhylomeDBiQ3UMW8.
TreeFamiTF330864.

Family and domain databases

InterProiIPR026138. CLN5.
[Graphical view]
PANTHERiPTHR15380. PTHR15380. 1 hit.
PfamiPF15014. CLN5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UMW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRGGPCGAH WRPALALALL GLATILGASP TSGQRWPVPY KRFSFRPKTD
60 70 80 90 100
PYCQAKYTFC PTGSPIPVMK DNDVIEVLRL QAPIWEFKYG DLLGHFKLMH
110 120 130 140 150
DAVGFRSTLT GKNYTIEWYE LFQLGNCTFP HLRPDKSAPF WCNQGAACFF
160 170 180 190 200
EGIDDKHWKE NGTLSVVATI SGNTFNKVAE WVKQDNETGI YYETWTVRAG
210 220 230 240 250
PGQGAQTWFE SYDCSNFVLR TYKKLAEFGT EFKKIETNYT KIFLYSGEPI
260 270 280 290 300
YLGNETSIFG PKGNKTLALA IKKFYGPFRP YLSTKDFLMN FLKIFDTVII
310 320 330 340
HRQFYLFYNF EYWFLPMKPP FVKITYEETP LPTRHTTFTD L
Length:341
Mass (Da):39,329
Last modified:October 11, 2005 - v1
Checksum:i1969A4003CAF0E4D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 83PCG → TRP in AAH25487 (PubMed:15489334).Curated
Sequence conflicti42 – 421R → H in BAC27797 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032293 mRNA. Translation: BAC27797.1.
AK144635 mRNA. Translation: BAE25980.1.
BC025487 mRNA. Translation: AAH25487.1.
CCDSiCCDS27314.1.
RefSeqiNP_001028414.1. NM_001033242.1.
UniGeneiMm.295289.

Genome annotation databases

EnsembliENSMUST00000022721; ENSMUSP00000022721; ENSMUSG00000022125.
GeneIDi211286.
KEGGimmu:211286.
UCSCiuc007uwg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032293 mRNA. Translation: BAC27797.1.
AK144635 mRNA. Translation: BAE25980.1.
BC025487 mRNA. Translation: AAH25487.1.
CCDSiCCDS27314.1.
RefSeqiNP_001028414.1. NM_001033242.1.
UniGeneiMm.295289.

3D structure databases

ProteinModelPortaliQ3UMW8.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ3UMW8.

Proteomic databases

MaxQBiQ3UMW8.
PaxDbiQ3UMW8.
PRIDEiQ3UMW8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022721; ENSMUSP00000022721; ENSMUSG00000022125.
GeneIDi211286.
KEGGimmu:211286.
UCSCiuc007uwg.1. mouse.

Organism-specific databases

CTDi1203.
MGIiMGI:2442253. Cln5.

Phylogenomic databases

eggNOGiNOG45312.
GeneTreeiENSGT00390000010065.
HOGENOMiHOG000060233.
HOVERGENiHBG005345.
InParanoidiQ3UMW8.
KOiK12390.
OMAiKKIETNY.
OrthoDBiEOG77DJ65.
PhylomeDBiQ3UMW8.
TreeFamiTF330864.

Miscellaneous databases

ChiTaRSiCln5. mouse.
NextBioi373192.
PROiQ3UMW8.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UMW8.
ExpressionAtlasiQ3UMW8. baseline and differential.
GenevestigatoriQ3UMW8.

Family and domain databases

InterProiIPR026138. CLN5.
[Graphical view]
PANTHERiPTHR15380. PTHR15380. 1 hit.
PfamiPF15014. CLN5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung and Olfactory bulb.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-341.
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiCLN5_MOUSE
AccessioniPrimary (citable) accession number: Q3UMW8
Secondary accession number(s): Q8C054, Q8R152
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 11, 2005
Last modified: February 4, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.