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Q3UMW8

- CLN5_MOUSE

UniProt

Q3UMW8 - CLN5_MOUSE

Protein

Ceroid-lipofuscinosis neuronal protein 5 homolog

Gene

Cln5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. mannose binding Source: UniProtKB

    GO - Biological processi

    1. brain development Source: UniProtKB
    2. cell death Source: UniProtKB-KW
    3. glycosylation Source: UniProtKB
    4. lysosomal lumen acidification Source: UniProtKB
    5. lysosome organization Source: MGI
    6. neurogenesis Source: UniProtKB
    7. signal peptide processing Source: UniProtKB
    8. visual perception Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ceroid-lipofuscinosis neuronal protein 5 homolog
    Short name:
    Protein CLN5
    Gene namesi
    Name:Cln5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:2442253. Cln5.

    Subcellular locationi

    Lysosome By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. Golgi apparatus Source: UniProtKB
    3. integral component of membrane Source: UniProtKB
    4. lysosomal membrane Source: UniProtKB
    5. lysosome Source: UniProtKB
    6. perinuclear region of cytoplasm Source: UniProtKB
    7. vacuolar lumen Source: MGI

    Keywords - Cellular componenti

    Lysosome

    Pathology & Biotechi

    Keywords - Diseasei

    Neurodegeneration, Neuronal ceroid lipofuscinosis

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 341308Ceroid-lipofuscinosis neuronal protein 5 homologPRO_0000330471Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi238 – 2381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ3UMW8.
    PRIDEiQ3UMW8.

    PTM databases

    PhosphoSiteiQ3UMW8.

    Expressioni

    Gene expression databases

    BgeeiQ3UMW8.
    GenevestigatoriQ3UMW8.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3UMW8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CLN5 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45312.
    GeneTreeiENSGT00390000010065.
    HOGENOMiHOG000060233.
    HOVERGENiHBG005345.
    InParanoidiQ3UMW8.
    KOiK12390.
    OMAiKKIETNY.
    OrthoDBiEOG77DJ65.
    PhylomeDBiQ3UMW8.
    TreeFamiTF330864.

    Family and domain databases

    InterProiIPR026138. CLN5.
    [Graphical view]
    PANTHERiPTHR15380. PTHR15380. 1 hit.
    PfamiPF15014. CLN5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3UMW8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRGGPCGAH WRPALALALL GLATILGASP TSGQRWPVPY KRFSFRPKTD    50
    PYCQAKYTFC PTGSPIPVMK DNDVIEVLRL QAPIWEFKYG DLLGHFKLMH 100
    DAVGFRSTLT GKNYTIEWYE LFQLGNCTFP HLRPDKSAPF WCNQGAACFF 150
    EGIDDKHWKE NGTLSVVATI SGNTFNKVAE WVKQDNETGI YYETWTVRAG 200
    PGQGAQTWFE SYDCSNFVLR TYKKLAEFGT EFKKIETNYT KIFLYSGEPI 250
    YLGNETSIFG PKGNKTLALA IKKFYGPFRP YLSTKDFLMN FLKIFDTVII 300
    HRQFYLFYNF EYWFLPMKPP FVKITYEETP LPTRHTTFTD L 341
    Length:341
    Mass (Da):39,329
    Last modified:October 11, 2005 - v1
    Checksum:i1969A4003CAF0E4D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 83PCG → TRP in AAH25487. (PubMed:15489334)Curated
    Sequence conflicti42 – 421R → H in BAC27797. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK032293 mRNA. Translation: BAC27797.1.
    AK144635 mRNA. Translation: BAE25980.1.
    BC025487 mRNA. Translation: AAH25487.1.
    CCDSiCCDS27314.1.
    RefSeqiNP_001028414.1. NM_001033242.1.
    UniGeneiMm.295289.

    Genome annotation databases

    EnsembliENSMUST00000022721; ENSMUSP00000022721; ENSMUSG00000022125.
    GeneIDi211286.
    KEGGimmu:211286.
    UCSCiuc007uwg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK032293 mRNA. Translation: BAC27797.1 .
    AK144635 mRNA. Translation: BAE25980.1 .
    BC025487 mRNA. Translation: AAH25487.1 .
    CCDSi CCDS27314.1.
    RefSeqi NP_001028414.1. NM_001033242.1.
    UniGenei Mm.295289.

    3D structure databases

    ProteinModelPortali Q3UMW8.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q3UMW8.

    Proteomic databases

    PaxDbi Q3UMW8.
    PRIDEi Q3UMW8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022721 ; ENSMUSP00000022721 ; ENSMUSG00000022125 .
    GeneIDi 211286.
    KEGGi mmu:211286.
    UCSCi uc007uwg.1. mouse.

    Organism-specific databases

    CTDi 1203.
    MGIi MGI:2442253. Cln5.

    Phylogenomic databases

    eggNOGi NOG45312.
    GeneTreei ENSGT00390000010065.
    HOGENOMi HOG000060233.
    HOVERGENi HBG005345.
    InParanoidi Q3UMW8.
    KOi K12390.
    OMAi KKIETNY.
    OrthoDBi EOG77DJ65.
    PhylomeDBi Q3UMW8.
    TreeFami TF330864.

    Miscellaneous databases

    ChiTaRSi CLN5. mouse.
    NextBioi 373192.
    PROi Q3UMW8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3UMW8.
    Genevestigatori Q3UMW8.

    Family and domain databases

    InterProi IPR026138. CLN5.
    [Graphical view ]
    PANTHERi PTHR15380. PTHR15380. 1 hit.
    Pfami PF15014. CLN5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Lung and Olfactory bulb.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-341.
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiCLN5_MOUSE
    AccessioniPrimary (citable) accession number: Q3UMW8
    Secondary accession number(s): Q8C054, Q8R152
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3