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Q3UMW8

- CLN5_MOUSE

UniProt

Q3UMW8 - CLN5_MOUSE

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Protein

Ceroid-lipofuscinosis neuronal protein 5 homolog

Gene
Cln5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. mannose binding Source: UniProtKB

GO - Biological processi

  1. brain development Source: UniProtKB
  2. cell death Source: UniProtKB-KW
  3. glycosylation Source: UniProtKB
  4. lysosomal lumen acidification Source: UniProtKB
  5. lysosome organization Source: MGI
  6. neurogenesis Source: UniProtKB
  7. signal peptide processing Source: UniProtKB
  8. visual perception Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ceroid-lipofuscinosis neuronal protein 5 homolog
Short name:
Protein CLN5
Gene namesi
Name:Cln5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:2442253. Cln5.

Subcellular locationi

Lysosome By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. Golgi apparatus Source: UniProtKB
  3. integral component of membrane Source: UniProtKB
  4. lysosomal membrane Source: UniProtKB
  5. lysosome Source: UniProtKB
  6. perinuclear region of cytoplasm Source: UniProtKB
  7. vacuolar lumen Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Keywords - Diseasei

Neurodegeneration, Neuronal ceroid lipofuscinosis

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333 Reviewed predictionAdd
BLAST
Chaini34 – 341308Ceroid-lipofuscinosis neuronal protein 5 homologPRO_0000330471Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi113 – 1131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi126 – 1261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi161 – 1611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi186 – 1861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi238 – 2381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi254 – 2541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi264 – 2641N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3UMW8.
PRIDEiQ3UMW8.

PTM databases

PhosphoSiteiQ3UMW8.

Expressioni

Gene expression databases

BgeeiQ3UMW8.
GenevestigatoriQ3UMW8.

Structurei

3D structure databases

ProteinModelPortaliQ3UMW8.

Family & Domainsi

Sequence similaritiesi

Belongs to the CLN5 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45312.
GeneTreeiENSGT00390000010065.
HOGENOMiHOG000060233.
HOVERGENiHBG005345.
InParanoidiQ3UMW8.
KOiK12390.
OMAiKKIETNY.
OrthoDBiEOG77DJ65.
PhylomeDBiQ3UMW8.
TreeFamiTF330864.

Family and domain databases

InterProiIPR026138. CLN5.
[Graphical view]
PANTHERiPTHR15380. PTHR15380. 1 hit.
PfamiPF15014. CLN5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UMW8-1 [UniParc]FASTAAdd to Basket

« Hide

MLRGGPCGAH WRPALALALL GLATILGASP TSGQRWPVPY KRFSFRPKTD    50
PYCQAKYTFC PTGSPIPVMK DNDVIEVLRL QAPIWEFKYG DLLGHFKLMH 100
DAVGFRSTLT GKNYTIEWYE LFQLGNCTFP HLRPDKSAPF WCNQGAACFF 150
EGIDDKHWKE NGTLSVVATI SGNTFNKVAE WVKQDNETGI YYETWTVRAG 200
PGQGAQTWFE SYDCSNFVLR TYKKLAEFGT EFKKIETNYT KIFLYSGEPI 250
YLGNETSIFG PKGNKTLALA IKKFYGPFRP YLSTKDFLMN FLKIFDTVII 300
HRQFYLFYNF EYWFLPMKPP FVKITYEETP LPTRHTTFTD L 341
Length:341
Mass (Da):39,329
Last modified:October 11, 2005 - v1
Checksum:i1969A4003CAF0E4D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 83PCG → TRP in AAH25487. 1 Publication
Sequence conflicti42 – 421R → H in BAC27797. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK032293 mRNA. Translation: BAC27797.1.
AK144635 mRNA. Translation: BAE25980.1.
BC025487 mRNA. Translation: AAH25487.1.
CCDSiCCDS27314.1.
RefSeqiNP_001028414.1. NM_001033242.1.
UniGeneiMm.295289.

Genome annotation databases

EnsembliENSMUST00000022721; ENSMUSP00000022721; ENSMUSG00000022125.
GeneIDi211286.
KEGGimmu:211286.
UCSCiuc007uwg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK032293 mRNA. Translation: BAC27797.1 .
AK144635 mRNA. Translation: BAE25980.1 .
BC025487 mRNA. Translation: AAH25487.1 .
CCDSi CCDS27314.1.
RefSeqi NP_001028414.1. NM_001033242.1.
UniGenei Mm.295289.

3D structure databases

ProteinModelPortali Q3UMW8.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q3UMW8.

Proteomic databases

PaxDbi Q3UMW8.
PRIDEi Q3UMW8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022721 ; ENSMUSP00000022721 ; ENSMUSG00000022125 .
GeneIDi 211286.
KEGGi mmu:211286.
UCSCi uc007uwg.1. mouse.

Organism-specific databases

CTDi 1203.
MGIi MGI:2442253. Cln5.

Phylogenomic databases

eggNOGi NOG45312.
GeneTreei ENSGT00390000010065.
HOGENOMi HOG000060233.
HOVERGENi HBG005345.
InParanoidi Q3UMW8.
KOi K12390.
OMAi KKIETNY.
OrthoDBi EOG77DJ65.
PhylomeDBi Q3UMW8.
TreeFami TF330864.

Miscellaneous databases

ChiTaRSi CLN5. mouse.
NextBioi 373192.
PROi Q3UMW8.
SOURCEi Search...

Gene expression databases

Bgeei Q3UMW8.
Genevestigatori Q3UMW8.

Family and domain databases

InterProi IPR026138. CLN5.
[Graphical view ]
PANTHERi PTHR15380. PTHR15380. 1 hit.
Pfami PF15014. CLN5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung and Olfactory bulb.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-341.
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiCLN5_MOUSE
AccessioniPrimary (citable) accession number: Q3UMW8
Secondary accession number(s): Q8C054, Q8R152
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 11, 2005
Last modified: July 9, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi