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Q3UMW8 (CLN5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ceroid-lipofuscinosis neuronal protein 5 homolog

Short name=Protein CLN5
Gene names
Name:Cln5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length341 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Lysosome By similarity.

Sequence similarities

Belongs to the CLN5 family.

Ontologies

Keywords
   Cellular componentLysosome
   DiseaseNeurodegeneration
Neuronal ceroid lipofuscinosis
   DomainSignal
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbrain development

Inferred from sequence or structural similarity. Source: UniProtKB

cell death

Inferred from electronic annotation. Source: UniProtKB-KW

glycosylation

Inferred from sequence or structural similarity. Source: UniProtKB

lysosomal lumen acidification

Inferred from sequence or structural similarity. Source: UniProtKB

lysosome organization

Inferred from mutant phenotype PubMed 15459177. Source: MGI

neurogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

signal peptide processing

Inferred from sequence or structural similarity. Source: UniProtKB

visual perception

Inferred from mutant phenotype PubMed 15459177. Source: MGI

   Cellular_componentGolgi apparatus

Inferred from sequence or structural similarity. Source: UniProtKB

endoplasmic reticulum

Inferred from sequence or structural similarity. Source: UniProtKB

integral component of membrane

Inferred from sequence or structural similarity. Source: UniProtKB

lysosomal membrane

Inferred from sequence or structural similarity. Source: UniProtKB

lysosome

Inferred from sequence or structural similarity. Source: UniProtKB

perinuclear region of cytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

vacuolar lumen

Inferred from direct assay PubMed 15207259. Source: MGI

   Molecular_functionmannose binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Potential
Chain34 – 341308Ceroid-lipofuscinosis neuronal protein 5 homolog
PRO_0000330471

Amino acid modifications

Glycosylation1131N-linked (GlcNAc...) Potential
Glycosylation1261N-linked (GlcNAc...) Potential
Glycosylation1611N-linked (GlcNAc...) Potential
Glycosylation1861N-linked (GlcNAc...) Potential
Glycosylation2381N-linked (GlcNAc...) Potential
Glycosylation2541N-linked (GlcNAc...) Potential
Glycosylation2641N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict6 – 83PCG → TRP in AAH25487. Ref.2
Sequence conflict421R → H in BAC27797. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q3UMW8 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 1969A4003CAF0E4D

FASTA34139,329
        10         20         30         40         50         60 
MLRGGPCGAH WRPALALALL GLATILGASP TSGQRWPVPY KRFSFRPKTD PYCQAKYTFC 

        70         80         90        100        110        120 
PTGSPIPVMK DNDVIEVLRL QAPIWEFKYG DLLGHFKLMH DAVGFRSTLT GKNYTIEWYE 

       130        140        150        160        170        180 
LFQLGNCTFP HLRPDKSAPF WCNQGAACFF EGIDDKHWKE NGTLSVVATI SGNTFNKVAE 

       190        200        210        220        230        240 
WVKQDNETGI YYETWTVRAG PGQGAQTWFE SYDCSNFVLR TYKKLAEFGT EFKKIETNYT 

       250        260        270        280        290        300 
KIFLYSGEPI YLGNETSIFG PKGNKTLALA IKKFYGPFRP YLSTKDFLMN FLKIFDTVII 

       310        320        330        340 
HRQFYLFYNF EYWFLPMKPP FVKITYEETP LPTRHTTFTD L 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Lung and Olfactory bulb.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-341.
Strain: FVB/N.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK032293 mRNA. Translation: BAC27797.1.
AK144635 mRNA. Translation: BAE25980.1.
BC025487 mRNA. Translation: AAH25487.1.
CCDSCCDS27314.1.
RefSeqNP_001028414.1. NM_001033242.1.
UniGeneMm.295289.

3D structure databases

ProteinModelPortalQ3UMW8.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ3UMW8.

Proteomic databases

PaxDbQ3UMW8.
PRIDEQ3UMW8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000022721; ENSMUSP00000022721; ENSMUSG00000022125.
GeneID211286.
KEGGmmu:211286.
UCSCuc007uwg.1. mouse.

Organism-specific databases

CTD1203.
MGIMGI:2442253. Cln5.

Phylogenomic databases

eggNOGNOG45312.
GeneTreeENSGT00390000010065.
HOGENOMHOG000060233.
HOVERGENHBG005345.
InParanoidQ3UMW8.
KOK12390.
OMAKKIETNY.
OrthoDBEOG77DJ65.
PhylomeDBQ3UMW8.
TreeFamTF330864.

Gene expression databases

BgeeQ3UMW8.
GenevestigatorQ3UMW8.

Family and domain databases

InterProIPR026138. CLN5.
[Graphical view]
PANTHERPTHR15380. PTHR15380. 1 hit.
PfamPF15014. CLN5. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCLN5. mouse.
NextBio373192.
PROQ3UMW8.
SOURCESearch...

Entry information

Entry nameCLN5_MOUSE
AccessionPrimary (citable) accession number: Q3UMW8
Secondary accession number(s): Q8C054, Q8R152
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 11, 2005
Last modified: July 9, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot