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Q3UMU9

- HDGR2_MOUSE

UniProt

Q3UMU9 - HDGR2_MOUSE

Protein

Hepatoma-derived growth factor-related protein 2

Gene

Hdgfrp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Associates with chromatin. Isoform 1 and isoform 3 bind to condensed chromatin in mitotic cells. Isoform 4 binds to non-condensed chromatin in the presence of HDGF.1 Publication

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. DNA binding Source: InterPro
    3. protein binding Source: IntAct

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hepatoma-derived growth factor-related protein 2
    Short name:
    HRP-2
    Gene namesi
    Name:Hdgfrp2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1194492. Hdgfrp2.

    Subcellular locationi

    Nucleus 1 Publication
    Note: Isoform 4 displays a punctate pattern and colocalizes with N-terminally processed HDFG.

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 669669Hepatoma-derived growth factor-related protein 2PRO_0000317644Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei366 – 3661Phosphoserine5 Publications
    Modified residuei367 – 3671Phosphoserine5 Publications
    Modified residuei450 – 4501Phosphoserine1 Publication
    Modified residuei635 – 6351Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ3UMU9.
    PaxDbiQ3UMU9.
    PRIDEiQ3UMU9.

    PTM databases

    PhosphoSiteiQ3UMU9.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.1 Publication

    Gene expression databases

    BgeeiQ3UMU9.
    CleanExiMM_HDGFRP2.
    GenevestigatoriQ3UMU9.

    Interactioni

    Subunit structurei

    Interacts with HDGF. Isoform 4 selectively interacts with HDGF (N-terminally processed form). Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3). Interacts with trimethylated 'Lys-79' of histone H3 (H3K79me3), but has higher affinity for H3K36me3 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HdgfP518594EBI-7627932,EBI-2943087

    Protein-protein interaction databases

    IntActiQ3UMU9. 3 interactions.
    MINTiMINT-4104792.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3UMU9.
    SMRiQ3UMU9. Positions 1-93, 466-535.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 6458PWWPPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili550 – 57526Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi142 – 271130Ser-richAdd
    BLAST
    Compositional biasi322 – 36342Arg-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the HDGF family.Curated
    Contains 1 PWWP domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG80217.
    GeneTreeiENSGT00530000063013.
    HOGENOMiHOG000230488.
    HOVERGENiHBG099722.
    InParanoidiQ3UMU9.
    OMAiSDHSGLK.
    OrthoDBiEOG7NKKMQ.
    PhylomeDBiQ3UMU9.
    TreeFamiTF105385.

    Family and domain databases

    Gene3Di1.20.930.10. 1 hit.
    InterProiIPR021567. LEDGF.
    IPR000313. PWWP_dom.
    IPR017923. TFIIS_N.
    [Graphical view]
    PfamiPF11467. LEDGF. 1 hit.
    PF00855. PWWP. 1 hit.
    [Graphical view]
    SMARTiSM00293. PWWP. 1 hit.
    [Graphical view]
    PROSITEiPS50812. PWWP. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3UMU9-1) [UniParc]FASTAAdd to Basket

    Also known as: Isoform a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPHAFKPGDL VFAKMKGYPH WPARIDDIAD GAVKPPPNKY PIFFFGTHET    50
    AFLGPKDLFP YDKCKDKYGK PNKRKGFNEG LWEIQNNPHA SYSAPPPVSS 100
    SDSEAPEADL GCGSDVDKDK ESRRVMTVTA VTTTATSDRM ESDSDSDKSS 150
    DHSGLKRKTP VLKVSVSKRA RRASSDLDQA SVSPSEEDSE SPSESEKTSD 200
    QDFTPEKKTA ARPPRRGPLG GRKKKKVPSA SDSDSKADSD GAKEEPVVTA 250
    QPSPSSSSSS SSSSSSDSDV SVKKPPRGRK PAEKPPPKPR GRRPKPERPP 300
    STSSSDSDSD SGEVDRISEW KRRDEERRRE LEARRRREQE EELRRLREQE 350
    REEKERRKER AERGGSSGEE LEDEEPVKKR SRKARGRGTP SSSDSEPEGE 400
    LGKEGKKLAK KSQLPGSESA RKPGQKEKRG RPDEKPRARP VKVERTRKRS 450
    EGLSLERKGE KKKEPSVEER LQKLHSEIKF ALKVDNPDVR KCLSALEELG 500
    TLQVTSQILQ KNTDVVATLK KIRRYKANKD VMAKAAEVYT RLKSRVLGPK 550
    VEALQKVNKA GAEKERADNE KLEEQPGEQA PRELAEDEPS TDRSAPVNGE 600
    ATSQKGENME DRAQEDGQDS EDGPRGGSSE ELHDSPRDNS DPAKPGNERQ 650
    DHERTRLASE SANDDNEDS 669
    Length:669
    Mass (Da):74,291
    Last modified:October 17, 2006 - v1
    Checksum:i01228985D4616848
    GO
    Isoform 2 (identifier: Q3UMU9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         226-226: Missing.
         635-635: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:667
    Mass (Da):74,075
    Checksum:iE8B865571B20D78B
    GO
    Isoform 3 (identifier: Q3UMU9-3) [UniParc]FASTAAdd to Basket

    Also known as: Isoform b

    The sequence of this isoform differs from the canonical sequence as follows:
         224-225: KK → KKHPTGYACPQ

    Show »
    Length:678
    Mass (Da):75,246
    Checksum:i034861DA18787C49
    GO
    Isoform 4 (identifier: Q3UMU9-4) [UniParc]FASTAAdd to Basket

    Also known as: Isoform c

    The sequence of this isoform differs from the canonical sequence as follows:
         66-118: Missing.
         635-635: Missing.

    Show »
    Length:615
    Mass (Da):68,530
    Checksum:i71CD1E3AEE4761EE
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei66 – 11853Missing in isoform 4. 1 PublicationVSP_047648Add
    BLAST
    Alternative sequencei224 – 2252KK → KKHPTGYACPQ in isoform 3. 2 PublicationsVSP_031117
    Alternative sequencei226 – 2261Missing in isoform 2. 1 PublicationVSP_031118
    Alternative sequencei635 – 6351Missing in isoform 2 and isoform 4. 2 PublicationsVSP_031119

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D63850 mRNA. Translation: BAA22896.1.
    FN687734 mRNA. Translation: CBK52221.2.
    AK143616 mRNA. Translation: BAE25467.1.
    AK144669 mRNA. Translation: BAE25999.1.
    AK146813 mRNA. Translation: BAE27453.1.
    AK146918 mRNA. Translation: BAE27530.1.
    BC003741 mRNA. Translation: AAH03741.1.
    CCDSiCCDS28894.1. [Q3UMU9-1]
    PIRiJC5662.
    RefSeqiNP_032259.1. NM_008233.2. [Q3UMU9-1]
    XP_006523769.1. XM_006523706.1. [Q3UMU9-3]
    UniGeneiMm.279188.

    Genome annotation databases

    EnsembliENSMUST00000002911; ENSMUSP00000002911; ENSMUSG00000002833. [Q3UMU9-1]
    GeneIDi15193.
    KEGGimmu:15193.
    UCSCiuc008dau.1. mouse. [Q3UMU9-1]
    uc008dav.2. mouse. [Q3UMU9-2]
    uc008daw.1. mouse. [Q3UMU9-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D63850 mRNA. Translation: BAA22896.1 .
    FN687734 mRNA. Translation: CBK52221.2 .
    AK143616 mRNA. Translation: BAE25467.1 .
    AK144669 mRNA. Translation: BAE25999.1 .
    AK146813 mRNA. Translation: BAE27453.1 .
    AK146918 mRNA. Translation: BAE27530.1 .
    BC003741 mRNA. Translation: AAH03741.1 .
    CCDSi CCDS28894.1. [Q3UMU9-1 ]
    PIRi JC5662.
    RefSeqi NP_032259.1. NM_008233.2. [Q3UMU9-1 ]
    XP_006523769.1. XM_006523706.1. [Q3UMU9-3 ]
    UniGenei Mm.279188.

    3D structure databases

    ProteinModelPortali Q3UMU9.
    SMRi Q3UMU9. Positions 1-93, 466-535.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q3UMU9. 3 interactions.
    MINTi MINT-4104792.

    PTM databases

    PhosphoSitei Q3UMU9.

    Proteomic databases

    MaxQBi Q3UMU9.
    PaxDbi Q3UMU9.
    PRIDEi Q3UMU9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000002911 ; ENSMUSP00000002911 ; ENSMUSG00000002833 . [Q3UMU9-1 ]
    GeneIDi 15193.
    KEGGi mmu:15193.
    UCSCi uc008dau.1. mouse. [Q3UMU9-1 ]
    uc008dav.2. mouse. [Q3UMU9-2 ]
    uc008daw.1. mouse. [Q3UMU9-3 ]

    Organism-specific databases

    CTDi 84717.
    MGIi MGI:1194492. Hdgfrp2.

    Phylogenomic databases

    eggNOGi NOG80217.
    GeneTreei ENSGT00530000063013.
    HOGENOMi HOG000230488.
    HOVERGENi HBG099722.
    InParanoidi Q3UMU9.
    OMAi SDHSGLK.
    OrthoDBi EOG7NKKMQ.
    PhylomeDBi Q3UMU9.
    TreeFami TF105385.

    Miscellaneous databases

    NextBioi 287723.
    PROi Q3UMU9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3UMU9.
    CleanExi MM_HDGFRP2.
    Genevestigatori Q3UMU9.

    Family and domain databases

    Gene3Di 1.20.930.10. 1 hit.
    InterProi IPR021567. LEDGF.
    IPR000313. PWWP_dom.
    IPR017923. TFIIS_N.
    [Graphical view ]
    Pfami PF11467. LEDGF. 1 hit.
    PF00855. PWWP. 1 hit.
    [Graphical view ]
    SMARTi SM00293. PWWP. 1 hit.
    [Graphical view ]
    PROSITEi PS50812. PWWP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hepatoma-derived growth factor belongs to a gene family in mice showing significant homology in the amino terminus."
      Izumoto Y., Kuroda T., Harada H., Kishimoto T., Nakamura H.
      Biochem. Biophys. Res. Commun. 238:26-32(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: BALB/c.
      Tissue: Testis.
    2. "Interaction of HRP-2 isoforms with HDGF: chromatin binding of a specific heteromer."
      Thakar K., Votteler I., Kelkar D., Shidore T., Gupta S., Kelm S., Dietz F.
      FEBS J. 279:737-751(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), ALTERNATIVE SPLICING, FUNCTION, INTERACTION WITH HDGF, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: BALB/c.
      Tissue: Brain.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Strain: C57BL/6J.
      Tissue: Heart, Lung and Spleen.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: FVB/N.
      Tissue: Mammary tumor.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-366 AND SER-367, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.
    6. "A differential phosphoproteomic analysis of retinoic acid-treated P19 cells."
      Smith J.C., Duchesne M.A., Tozzi P., Ethier M., Figeys D.
      J. Proteome Res. 6:3174-3186(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-366 AND SER-367, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Teratocarcinoma.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-366; SER-367; SER-450 AND SER-635, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    8. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-366 AND SER-367, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-366 AND SER-367, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiHDGR2_MOUSE
    AccessioniPrimary (citable) accession number: Q3UMU9
    Secondary accession number(s): D6CHX5
    , O35540, Q3UIH6, Q99L92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3