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Q3UMU9

- HDGR2_MOUSE

UniProt

Q3UMU9 - HDGR2_MOUSE

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Protein
Hepatoma-derived growth factor-related protein 2
Gene
Hdgfrp2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Associates with chromatin. Isoform 1 and isoform 3 bind to condensed chromatin in mitotic cells. Isoform 4 binds to non-condensed chromatin in the presence of HDGF.1 Publication

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. chromatin binding Source: MGI
  3. protein binding Source: IntAct

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatoma-derived growth factor-related protein 2
Short name:
HRP-2
Gene namesi
Name:Hdgfrp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1194492. Hdgfrp2.

Subcellular locationi

Nucleus
Note: Isoform 4 displays a punctate pattern and colocalizes with N-terminally processed HDFG.1 Publication

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 669669Hepatoma-derived growth factor-related protein 2
PRO_0000317644Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei366 – 3661Phosphoserine5 Publications
Modified residuei367 – 3671Phosphoserine5 Publications
Modified residuei450 – 4501Phosphoserine1 Publication
Modified residuei635 – 6351Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3UMU9.
PaxDbiQ3UMU9.
PRIDEiQ3UMU9.

PTM databases

PhosphoSiteiQ3UMU9.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ3UMU9.
CleanExiMM_HDGFRP2.
GenevestigatoriQ3UMU9.

Interactioni

Subunit structurei

Interacts with HDGF. Isoform 4 selectively interacts with HDGF (N-terminally processed form). Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3). Interacts with trimethylated 'Lys-79' of histone H3 (H3K79me3), but has higher affinity for H3K36me3 By similarity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HdgfP518594EBI-7627961,EBI-2943087

Protein-protein interaction databases

IntActiQ3UMU9. 3 interactions.
MINTiMINT-4104792.

Structurei

3D structure databases

ProteinModelPortaliQ3UMU9.
SMRiQ3UMU9. Positions 1-93, 466-535.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 6458PWWP
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili550 – 57526 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi142 – 271130Ser-rich
Add
BLAST
Compositional biasi322 – 36342Arg-rich
Add
BLAST

Sequence similaritiesi

Belongs to the HDGF family.
Contains 1 PWWP domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG80217.
GeneTreeiENSGT00530000063013.
HOGENOMiHOG000230488.
HOVERGENiHBG099722.
InParanoidiQ3UMU9.
OMAiSDHSGLK.
OrthoDBiEOG7NKKMQ.
PhylomeDBiQ3UMU9.
TreeFamiTF105385.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
InterProiIPR021567. LEDGF.
IPR000313. PWWP_dom.
IPR017923. TFIIS_N.
[Graphical view]
PfamiPF11467. LEDGF. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3UMU9-1) [UniParc]FASTAAdd to Basket

Also known as: Isoform a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPHAFKPGDL VFAKMKGYPH WPARIDDIAD GAVKPPPNKY PIFFFGTHET    50
AFLGPKDLFP YDKCKDKYGK PNKRKGFNEG LWEIQNNPHA SYSAPPPVSS 100
SDSEAPEADL GCGSDVDKDK ESRRVMTVTA VTTTATSDRM ESDSDSDKSS 150
DHSGLKRKTP VLKVSVSKRA RRASSDLDQA SVSPSEEDSE SPSESEKTSD 200
QDFTPEKKTA ARPPRRGPLG GRKKKKVPSA SDSDSKADSD GAKEEPVVTA 250
QPSPSSSSSS SSSSSSDSDV SVKKPPRGRK PAEKPPPKPR GRRPKPERPP 300
STSSSDSDSD SGEVDRISEW KRRDEERRRE LEARRRREQE EELRRLREQE 350
REEKERRKER AERGGSSGEE LEDEEPVKKR SRKARGRGTP SSSDSEPEGE 400
LGKEGKKLAK KSQLPGSESA RKPGQKEKRG RPDEKPRARP VKVERTRKRS 450
EGLSLERKGE KKKEPSVEER LQKLHSEIKF ALKVDNPDVR KCLSALEELG 500
TLQVTSQILQ KNTDVVATLK KIRRYKANKD VMAKAAEVYT RLKSRVLGPK 550
VEALQKVNKA GAEKERADNE KLEEQPGEQA PRELAEDEPS TDRSAPVNGE 600
ATSQKGENME DRAQEDGQDS EDGPRGGSSE ELHDSPRDNS DPAKPGNERQ 650
DHERTRLASE SANDDNEDS 669
Length:669
Mass (Da):74,291
Last modified:October 17, 2006 - v1
Checksum:i01228985D4616848
GO
Isoform 2 (identifier: Q3UMU9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     226-226: Missing.
     635-635: Missing.

Note: No experimental confirmation available.

Show »
Length:667
Mass (Da):74,075
Checksum:iE8B865571B20D78B
GO
Isoform 3 (identifier: Q3UMU9-3) [UniParc]FASTAAdd to Basket

Also known as: Isoform b

The sequence of this isoform differs from the canonical sequence as follows:
     224-225: KK → KKHPTGYACPQ

Show »
Length:678
Mass (Da):75,246
Checksum:i034861DA18787C49
GO
Isoform 4 (identifier: Q3UMU9-4) [UniParc]FASTAAdd to Basket

Also known as: Isoform c

The sequence of this isoform differs from the canonical sequence as follows:
     66-118: Missing.
     635-635: Missing.

Show »
Length:615
Mass (Da):68,530
Checksum:i71CD1E3AEE4761EE
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei66 – 11853Missing in isoform 4.
VSP_047648Add
BLAST
Alternative sequencei224 – 2252KK → KKHPTGYACPQ in isoform 3.
VSP_031117
Alternative sequencei226 – 2261Missing in isoform 2.
VSP_031118
Alternative sequencei635 – 6351Missing in isoform 2 and isoform 4.
VSP_031119

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D63850 mRNA. Translation: BAA22896.1.
FN687734 mRNA. Translation: CBK52221.2.
AK143616 mRNA. Translation: BAE25467.1.
AK144669 mRNA. Translation: BAE25999.1.
AK146813 mRNA. Translation: BAE27453.1.
AK146918 mRNA. Translation: BAE27530.1.
BC003741 mRNA. Translation: AAH03741.1.
CCDSiCCDS28894.1. [Q3UMU9-1]
PIRiJC5662.
RefSeqiNP_032259.1. NM_008233.2. [Q3UMU9-1]
XP_006523769.1. XM_006523706.1. [Q3UMU9-3]
UniGeneiMm.279188.

Genome annotation databases

EnsembliENSMUST00000002911; ENSMUSP00000002911; ENSMUSG00000002833. [Q3UMU9-1]
GeneIDi15193.
KEGGimmu:15193.
UCSCiuc008dau.1. mouse. [Q3UMU9-1]
uc008dav.2. mouse. [Q3UMU9-2]
uc008daw.1. mouse. [Q3UMU9-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D63850 mRNA. Translation: BAA22896.1 .
FN687734 mRNA. Translation: CBK52221.2 .
AK143616 mRNA. Translation: BAE25467.1 .
AK144669 mRNA. Translation: BAE25999.1 .
AK146813 mRNA. Translation: BAE27453.1 .
AK146918 mRNA. Translation: BAE27530.1 .
BC003741 mRNA. Translation: AAH03741.1 .
CCDSi CCDS28894.1. [Q3UMU9-1 ]
PIRi JC5662.
RefSeqi NP_032259.1. NM_008233.2. [Q3UMU9-1 ]
XP_006523769.1. XM_006523706.1. [Q3UMU9-3 ]
UniGenei Mm.279188.

3D structure databases

ProteinModelPortali Q3UMU9.
SMRi Q3UMU9. Positions 1-93, 466-535.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q3UMU9. 3 interactions.
MINTi MINT-4104792.

PTM databases

PhosphoSitei Q3UMU9.

Proteomic databases

MaxQBi Q3UMU9.
PaxDbi Q3UMU9.
PRIDEi Q3UMU9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000002911 ; ENSMUSP00000002911 ; ENSMUSG00000002833 . [Q3UMU9-1 ]
GeneIDi 15193.
KEGGi mmu:15193.
UCSCi uc008dau.1. mouse. [Q3UMU9-1 ]
uc008dav.2. mouse. [Q3UMU9-2 ]
uc008daw.1. mouse. [Q3UMU9-3 ]

Organism-specific databases

CTDi 84717.
MGIi MGI:1194492. Hdgfrp2.

Phylogenomic databases

eggNOGi NOG80217.
GeneTreei ENSGT00530000063013.
HOGENOMi HOG000230488.
HOVERGENi HBG099722.
InParanoidi Q3UMU9.
OMAi SDHSGLK.
OrthoDBi EOG7NKKMQ.
PhylomeDBi Q3UMU9.
TreeFami TF105385.

Miscellaneous databases

NextBioi 287723.
PROi Q3UMU9.
SOURCEi Search...

Gene expression databases

Bgeei Q3UMU9.
CleanExi MM_HDGFRP2.
Genevestigatori Q3UMU9.

Family and domain databases

Gene3Di 1.20.930.10. 1 hit.
InterProi IPR021567. LEDGF.
IPR000313. PWWP_dom.
IPR017923. TFIIS_N.
[Graphical view ]
Pfami PF11467. LEDGF. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view ]
SMARTi SM00293. PWWP. 1 hit.
[Graphical view ]
PROSITEi PS50812. PWWP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Hepatoma-derived growth factor belongs to a gene family in mice showing significant homology in the amino terminus."
    Izumoto Y., Kuroda T., Harada H., Kishimoto T., Nakamura H.
    Biochem. Biophys. Res. Commun. 238:26-32(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: BALB/c.
    Tissue: Testis.
  2. "Interaction of HRP-2 isoforms with HDGF: chromatin binding of a specific heteromer."
    Thakar K., Votteler I., Kelkar D., Shidore T., Gupta S., Kelm S., Dietz F.
    FEBS J. 279:737-751(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), ALTERNATIVE SPLICING, FUNCTION, INTERACTION WITH HDGF, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Strain: C57BL/6J.
    Tissue: Heart, Lung and Spleen.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: FVB/N.
    Tissue: Mammary tumor.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-366 AND SER-367, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  6. "A differential phosphoproteomic analysis of retinoic acid-treated P19 cells."
    Smith J.C., Duchesne M.A., Tozzi P., Ethier M., Figeys D.
    J. Proteome Res. 6:3174-3186(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-366 AND SER-367, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Teratocarcinoma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-366; SER-367; SER-450 AND SER-635, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  8. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-366 AND SER-367, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-366 AND SER-367, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiHDGR2_MOUSE
AccessioniPrimary (citable) accession number: Q3UMU9
Secondary accession number(s): D6CHX5
, O35540, Q3UIH6, Q99L92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 17, 2006
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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