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Protein

Hepatoma-derived growth factor-related protein 2

Gene

Hdgfrp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cellular growth control, through the regulation of cyclin D1 expression (By similarity). Associates with chromatin. Isoform 1 and isoform 3 bind to condensed chromatin in mitotic cells. Isoform 4 binds to non-condensed chromatin in the presence of HDGF.By similarity1 Publication

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatoma-derived growth factor-related protein 2
Short name:
HRP-2
Gene namesi
Name:Hdgfrp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1194492. Hdgfrp2.

Subcellular locationi

  • Nucleus 1 Publication

  • Note: Isoform 4 displays a punctate pattern and colocalizes with N-terminally processed HDFG.

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003176441 – 669Hepatoma-derived growth factor-related protein 2Add BLAST669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei366PhosphoserineCombined sources1
Modified residuei367PhosphoserineCombined sources1
Modified residuei450PhosphoserineCombined sources1
Modified residuei454PhosphoserineBy similarity1
Modified residuei620PhosphoserineCombined sources1
Modified residuei628PhosphoserineCombined sources1
Modified residuei629PhosphoserineCombined sources1
Modified residuei635PhosphoserineCombined sources1
Modified residuei640PhosphoserineCombined sources1
Modified residuei659PhosphoserineCombined sources1
Modified residuei661PhosphoserineCombined sources1
Modified residuei669PhosphoserineCombined sources1
Isoform 4 (identifier: Q3UMU9-4)
Modified residuei567PhosphoserineCombined sources1
Isoform 2 (identifier: Q3UMU9-2)
Modified residuei619PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3UMU9.
MaxQBiQ3UMU9.
PaxDbiQ3UMU9.
PeptideAtlasiQ3UMU9.
PRIDEiQ3UMU9.

PTM databases

iPTMnetiQ3UMU9.
PhosphoSitePlusiQ3UMU9.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000002833.
CleanExiMM_HDGFRP2.
GenevisibleiQ3UMU9. MM.

Interactioni

Subunit structurei

Interacts with HDGF (PubMed:22212508). Isoform 4 selectively interacts with HDGF (N-terminally processed form). Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3). Interacts with trimethylated 'Lys-79' of histone H3 (H3K79me3), but has higher affinity for H3K36me3 (By similarity). Interacts with IWS1 (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HdgfP518594EBI-7627862,EBI-2943087

Protein-protein interaction databases

BioGridi200267. 1 interactor.
IntActiQ3UMU9. 3 interactors.
MINTiMINT-4104792.
STRINGi10090.ENSMUSP00000002911.

Structurei

3D structure databases

ProteinModelPortaliQ3UMU9.
SMRiQ3UMU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 64PWWPPROSITE-ProRule annotationAdd BLAST58

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili550 – 575Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi142 – 271Ser-richAdd BLAST130
Compositional biasi322 – 363Arg-richAdd BLAST42

Sequence similaritiesi

Belongs to the HDGF family.Curated
Contains 1 PWWP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1904. Eukaryota.
ENOG4111PJT. LUCA.
GeneTreeiENSGT00530000063013.
HOGENOMiHOG000230488.
HOVERGENiHBG099722.
InParanoidiQ3UMU9.
OMAiANKEVME.
OrthoDBiEOG091G045X.
PhylomeDBiQ3UMU9.
TreeFamiTF105385.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
InterProiIPR021567. LEDGF.
IPR000313. PWWP_dom.
IPR017923. TFIIS_N.
[Graphical view]
PfamiPF11467. LEDGF. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UMU9-1) [UniParc]FASTAAdd to basket
Also known as: Isoform a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPHAFKPGDL VFAKMKGYPH WPARIDDIAD GAVKPPPNKY PIFFFGTHET
60 70 80 90 100
AFLGPKDLFP YDKCKDKYGK PNKRKGFNEG LWEIQNNPHA SYSAPPPVSS
110 120 130 140 150
SDSEAPEADL GCGSDVDKDK ESRRVMTVTA VTTTATSDRM ESDSDSDKSS
160 170 180 190 200
DHSGLKRKTP VLKVSVSKRA RRASSDLDQA SVSPSEEDSE SPSESEKTSD
210 220 230 240 250
QDFTPEKKTA ARPPRRGPLG GRKKKKVPSA SDSDSKADSD GAKEEPVVTA
260 270 280 290 300
QPSPSSSSSS SSSSSSDSDV SVKKPPRGRK PAEKPPPKPR GRRPKPERPP
310 320 330 340 350
STSSSDSDSD SGEVDRISEW KRRDEERRRE LEARRRREQE EELRRLREQE
360 370 380 390 400
REEKERRKER AERGGSSGEE LEDEEPVKKR SRKARGRGTP SSSDSEPEGE
410 420 430 440 450
LGKEGKKLAK KSQLPGSESA RKPGQKEKRG RPDEKPRARP VKVERTRKRS
460 470 480 490 500
EGLSLERKGE KKKEPSVEER LQKLHSEIKF ALKVDNPDVR KCLSALEELG
510 520 530 540 550
TLQVTSQILQ KNTDVVATLK KIRRYKANKD VMAKAAEVYT RLKSRVLGPK
560 570 580 590 600
VEALQKVNKA GAEKERADNE KLEEQPGEQA PRELAEDEPS TDRSAPVNGE
610 620 630 640 650
ATSQKGENME DRAQEDGQDS EDGPRGGSSE ELHDSPRDNS DPAKPGNERQ
660
DHERTRLASE SANDDNEDS
Length:669
Mass (Da):74,291
Last modified:October 17, 2006 - v1
Checksum:i01228985D4616848
GO
Isoform 2 (identifier: Q3UMU9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     226-226: Missing.
     635-635: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:667
Mass (Da):74,075
Checksum:iE8B865571B20D78B
GO
Isoform 3 (identifier: Q3UMU9-3) [UniParc]FASTAAdd to basket
Also known as: Isoform b

The sequence of this isoform differs from the canonical sequence as follows:
     224-225: KK → KKHPTGYACPQ

Show »
Length:678
Mass (Da):75,246
Checksum:i034861DA18787C49
GO
Isoform 4 (identifier: Q3UMU9-4) [UniParc]FASTAAdd to basket
Also known as: Isoform c

The sequence of this isoform differs from the canonical sequence as follows:
     66-118: Missing.
     635-635: Missing.

Show »
Length:615
Mass (Da):68,530
Checksum:i71CD1E3AEE4761EE
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04764866 – 118Missing in isoform 4. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_031117224 – 225KK → KKHPTGYACPQ in isoform 3. 2 Publications2
Alternative sequenceiVSP_031118226Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_031119635Missing in isoform 2 and isoform 4. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63850 mRNA. Translation: BAA22896.1.
FN687734 mRNA. Translation: CBK52221.2.
AK143616 mRNA. Translation: BAE25467.1.
AK144669 mRNA. Translation: BAE25999.1.
AK146813 mRNA. Translation: BAE27453.1.
AK146918 mRNA. Translation: BAE27530.1.
BC003741 mRNA. Translation: AAH03741.1.
CCDSiCCDS28894.1. [Q3UMU9-1]
PIRiJC5662.
RefSeqiNP_001291713.1. NM_001304784.2. [Q3UMU9-3]
NP_001291714.1. NM_001304785.2. [Q3UMU9-2]
NP_001317982.1. NM_001331053.1.
NP_032259.1. NM_008233.4. [Q3UMU9-1]
UniGeneiMm.12966.
Mm.279188.

Genome annotation databases

EnsembliENSMUST00000002911; ENSMUSP00000002911; ENSMUSG00000002833. [Q3UMU9-1]
GeneIDi15193.
KEGGimmu:15193.
UCSCiuc008dau.2. mouse. [Q3UMU9-1]
uc008dav.3. mouse. [Q3UMU9-2]
uc008daw.2. mouse. [Q3UMU9-3]
uc012avq.2. mouse. [Q3UMU9-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63850 mRNA. Translation: BAA22896.1.
FN687734 mRNA. Translation: CBK52221.2.
AK143616 mRNA. Translation: BAE25467.1.
AK144669 mRNA. Translation: BAE25999.1.
AK146813 mRNA. Translation: BAE27453.1.
AK146918 mRNA. Translation: BAE27530.1.
BC003741 mRNA. Translation: AAH03741.1.
CCDSiCCDS28894.1. [Q3UMU9-1]
PIRiJC5662.
RefSeqiNP_001291713.1. NM_001304784.2. [Q3UMU9-3]
NP_001291714.1. NM_001304785.2. [Q3UMU9-2]
NP_001317982.1. NM_001331053.1.
NP_032259.1. NM_008233.4. [Q3UMU9-1]
UniGeneiMm.12966.
Mm.279188.

3D structure databases

ProteinModelPortaliQ3UMU9.
SMRiQ3UMU9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200267. 1 interactor.
IntActiQ3UMU9. 3 interactors.
MINTiMINT-4104792.
STRINGi10090.ENSMUSP00000002911.

PTM databases

iPTMnetiQ3UMU9.
PhosphoSitePlusiQ3UMU9.

Proteomic databases

EPDiQ3UMU9.
MaxQBiQ3UMU9.
PaxDbiQ3UMU9.
PeptideAtlasiQ3UMU9.
PRIDEiQ3UMU9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002911; ENSMUSP00000002911; ENSMUSG00000002833. [Q3UMU9-1]
GeneIDi15193.
KEGGimmu:15193.
UCSCiuc008dau.2. mouse. [Q3UMU9-1]
uc008dav.3. mouse. [Q3UMU9-2]
uc008daw.2. mouse. [Q3UMU9-3]
uc012avq.2. mouse. [Q3UMU9-4]

Organism-specific databases

CTDi84717.
MGIiMGI:1194492. Hdgfrp2.

Phylogenomic databases

eggNOGiKOG1904. Eukaryota.
ENOG4111PJT. LUCA.
GeneTreeiENSGT00530000063013.
HOGENOMiHOG000230488.
HOVERGENiHBG099722.
InParanoidiQ3UMU9.
OMAiANKEVME.
OrthoDBiEOG091G045X.
PhylomeDBiQ3UMU9.
TreeFamiTF105385.

Miscellaneous databases

PROiQ3UMU9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002833.
CleanExiMM_HDGFRP2.
GenevisibleiQ3UMU9. MM.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
InterProiIPR021567. LEDGF.
IPR000313. PWWP_dom.
IPR017923. TFIIS_N.
[Graphical view]
PfamiPF11467. LEDGF. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHDGR2_MOUSE
AccessioniPrimary (citable) accession number: Q3UMU9
Secondary accession number(s): D6CHX5
, O35540, Q3UIH6, Q99L92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.