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Protein

Protein phosphatase 1 regulatory subunit 12C

Gene

Ppp1r12c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates myosin phosphatase activity.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 12C
Alternative name(s):
Protein phosphatase 1 myosin-binding subunit of 85 kDa
Short name:
Protein phosphatase 1 myosin-binding subunit p85
Gene namesi
Name:Ppp1r12cImported
Synonyms:Mbs851 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1924258. Ppp1r12c.

Subcellular locationi

  • Cytoplasm By similarity

  • Note: Along actomyosin filaments and stress fibers.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003158642 – 782Protein phosphatase 1 regulatory subunit 12CAdd BLAST781

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei403PhosphoserineCombined sources1
Modified residuei411PhosphoserineBy similarity1
Modified residuei431PhosphoserineBy similarity1
Modified residuei454PhosphoserineBy similarity1
Modified residuei509PhosphoserineBy similarity1
Modified residuei560PhosphothreonineCombined sources1
Modified residuei647PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation at Thr-560 is essential for its interaction with PPP1CB.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ3UMT1.
MaxQBiQ3UMT1.
PaxDbiQ3UMT1.
PeptideAtlasiQ3UMT1.
PRIDEiQ3UMT1.

PTM databases

iPTMnetiQ3UMT1.
PhosphoSitePlusiQ3UMT1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000019254.
ExpressionAtlasiQ3UMT1. baseline and differential.
GenevisibleiQ3UMT1. MM.

Interactioni

Subunit structurei

PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12C mediates binding to myosin. Interacts via its N-terminus with PPP1CB. Interacts with IL16. Interacts with the coiled-coil domain of MPRIP.1 Publication

Protein-protein interaction databases

IntActiQ3UMT1. 1 interactor.
STRINGi10090.ENSMUSP00000013886.

Structurei

3D structure databases

ProteinModelPortaliQ3UMT1.
SMRiQ3UMT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati104 – 133ANK 1Sequence analysisAdd BLAST30
Repeati137 – 166ANK 2Sequence analysisAdd BLAST30
Repeati230 – 259ANK 3Sequence analysisAdd BLAST30
Repeati263 – 292ANK 4Sequence analysisAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili301 – 332Sequence analysisAdd BLAST32
Coiled coili681 – 782Sequence analysisAdd BLAST102

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi8 – 96Ala-richSequence analysisAdd BLAST89

Sequence similaritiesi

Contains 4 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0505. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00760000119141.
HOGENOMiHOG000290648.
HOVERGENiHBG104929.
InParanoidiQ3UMT1.
KOiK17457.
OMAiPERRMAE.
OrthoDBiEOG091G06U5.
TreeFamiTF105543.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR031205. PPP1R12C.
IPR031775. PRKG1_interact.
[Graphical view]
PANTHERiPTHR24179:SF27. PTHR24179:SF27. 2 hits.
PfamiPF12796. Ank_2. 2 hits.
PF15898. PRKG1_interact. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UMT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGEDGPAAG PGAAAAAAAA RERRQEQLRQ WGARAGADPG PGERRARTVR
60 70 80 90 100
FERAAEFLAA CAGGDLDEAR LMLRAADPGP GSGAASDPAV PPPARAVLDS
110 120 130 140 150
TNADGISALH QACIDENLEV VRFLVEQGAT VNQADNEGWT PLHVAASCGY
160 170 180 190 200
LDIARYLLSH GANIAAVNSD GDLPLDLAES DAMEGLLKAE ITRRGVDVEA
210 220 230 240 250
AKRAEEELLL HDTRCWLNGG AMPEARHPRT GASALHVAAA KGYIEVMRLL
260 270 280 290 300
LQAGYDTELR DGDGWTPLHA AAHWGVEDAC RLLAEHGGGM DSLTHAGQRP
310 320 330 340 350
CDLADEDVMN LLEELAQKQE DLRNQKEGSQ GRGQESQVPS SSKHRRSSVC
360 370 380 390 400
RLSSREKISL QDLSKERRPG GAGGPPIGDE DEGGEASAEH PAVEPRALNG
410 420 430 440 450
VSSPVSSNPK SPVLPEEAPF SRRFGLQKTG STGALGPSER RATEGVLGLQ
460 470 480 490 500
RSASSSLLEK ASTQAREPRL ARITPTPAQK VPEPFTLYEA ATPPSLDHSV
510 520 530 540 550
PPSRREPGSI VKPNVLTASA APLADSRDRR RSYQMPVRDE ESESQRKARS
560 570 580 590 600
RLMRQSRRST QGVTLTDLKE AEKVAGKVPE PEQPALPSLD PSRRPRVPGV
610 620 630 640 650
ENAEGPAQRE APEGQGQGPQ AAREHRKAGH ERRGPAEGEE AGPAERSPEC
660 670 680 690 700
STVDGGSQVR RQHSQRDLVL ESKQEHEEPD GGFRKMYTEL RRENERLREA
710 720 730 740 750
LTETTLRLAQ LKVELERATQ RQERFAERPA LLELERFERR ALERKAAELE
760 770 780
EELKALSDLR ADNQRLKDEN AALIRVISKL SK
Length:782
Mass (Da):84,685
Last modified:October 11, 2005 - v1
Checksum:i83C2708E36BFBD7B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30Q → R in BAB27215 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010836 mRNA. Translation: BAB27215.1.
AK144691 mRNA. Translation: BAE26017.1.
CCDSiCCDS39735.1.
RefSeqiNP_084110.2. NM_029834.3.
UniGeneiMm.360391.

Genome annotation databases

EnsembliENSMUST00000013886; ENSMUSP00000013886; ENSMUSG00000019254.
GeneIDi232807.
KEGGimmu:232807.
UCSCiuc009exq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010836 mRNA. Translation: BAB27215.1.
AK144691 mRNA. Translation: BAE26017.1.
CCDSiCCDS39735.1.
RefSeqiNP_084110.2. NM_029834.3.
UniGeneiMm.360391.

3D structure databases

ProteinModelPortaliQ3UMT1.
SMRiQ3UMT1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3UMT1. 1 interactor.
STRINGi10090.ENSMUSP00000013886.

PTM databases

iPTMnetiQ3UMT1.
PhosphoSitePlusiQ3UMT1.

Proteomic databases

EPDiQ3UMT1.
MaxQBiQ3UMT1.
PaxDbiQ3UMT1.
PeptideAtlasiQ3UMT1.
PRIDEiQ3UMT1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000013886; ENSMUSP00000013886; ENSMUSG00000019254.
GeneIDi232807.
KEGGimmu:232807.
UCSCiuc009exq.1. mouse.

Organism-specific databases

CTDi54776.
MGIiMGI:1924258. Ppp1r12c.

Phylogenomic databases

eggNOGiKOG0505. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00760000119141.
HOGENOMiHOG000290648.
HOVERGENiHBG104929.
InParanoidiQ3UMT1.
KOiK17457.
OMAiPERRMAE.
OrthoDBiEOG091G06U5.
TreeFamiTF105543.

Miscellaneous databases

PROiQ3UMT1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019254.
ExpressionAtlasiQ3UMT1. baseline and differential.
GenevisibleiQ3UMT1. MM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR031205. PPP1R12C.
IPR031775. PRKG1_interact.
[Graphical view]
PANTHERiPTHR24179:SF27. PTHR24179:SF27. 2 hits.
PfamiPF12796. Ank_2. 2 hits.
PF15898. PRKG1_interact. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPP12C_MOUSE
AccessioniPrimary (citable) accession number: Q3UMT1
Secondary accession number(s): Q9CWD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.