Ppp1r12c

Functionⁱ

Regulates myosin phosphatase activity.By similarity

GO - Molecular functionⁱ

protein kinase binding Source: InterPro

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein phosphatase 1 regulatory subunit 12C Alternative name(s): Protein phosphatase 1 myosin-binding subunit of 85 kDa Short name: Protein phosphatase 1 myosin-binding subunit p85
Gene namesⁱ	Name:Ppp1r12cImported Synonyms:Mbs851 Publication
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:1924258. Ppp1r12c.

Subcellular locationⁱ

Cytoplasm
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:Q9BZL4 (PP12C_HUMAN)

Note:

Along actomyosin filaments and stress fibers.By similarity

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000315864	2 – 782	Protein phosphatase 1 regulatory subunit 12CAdd BLAST		781

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineBy similarity	1
Modified residueⁱ	403	PhosphoserineCombined sources	1
Modified residueⁱ	411	PhosphoserineBy similarity	1
Modified residueⁱ	431	PhosphoserineBy similarity	1
Modified residueⁱ	454	PhosphoserineBy similarity	1
Modified residueⁱ	509	PhosphoserineBy similarity	1
Modified residueⁱ	560	PhosphothreonineCombined sources	1
Modified residueⁱ	647	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylation at Thr-560 is essential for its interaction with PPP1CB.By similarity

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q3UMT1.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q3UMT1.
PaxDbⁱ	Q3UMT1.
PeptideAtlas More...PeptideAtlasⁱ	Q3UMT1.
PRIDEⁱ	Q3UMT1.

PTM databases

iPTMnetⁱ	Q3UMT1.
PhosphoSitePlusⁱ	Q3UMT1.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000019254.
ExpressionAtlasⁱ	Q3UMT1. baseline and differential.
Genevisibleⁱ	Q3UMT1. MM.

Interactionⁱ

Subunit structureⁱ

PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12C mediates binding to myosin. Interacts via its N-terminus with PPP1CB. Interacts with IL16. Interacts with the coiled-coil domain of MPRIP.1 Publication

GO - Molecular functionⁱ

protein kinase binding Source: InterPro

Complete GO annotation...

Protein-protein interaction databases

IntActⁱ	Q3UMT1. 1 interactor.
STRINGⁱ	10090.ENSMUSP00000013886.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3UMT1.
SMRⁱ	Q3UMT1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	104 – 133	ANK 1Sequence analysisAdd BLAST	30
Repeatⁱ	137 – 166	ANK 2Sequence analysisAdd BLAST	30
Repeatⁱ	230 – 259	ANK 3Sequence analysisAdd BLAST	30
Repeatⁱ	263 – 292	ANK 4Sequence analysisAdd BLAST	30

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	301 – 332	Sequence analysisAdd BLAST		32
Coiled coilⁱ	681 – 782	Sequence analysisAdd BLAST		102

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	8 – 96	Ala-richSequence analysisAdd BLAST		89

Keywords - Domainⁱ

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0505. Eukaryota. COG0666. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119141.
HOGENOMⁱ	HOG000290648.
HOVERGENⁱ	HBG104929.
InParanoidⁱ	Q3UMT1.
KEGG Orthology (KO) More...KOⁱ	K17457.
OMAⁱ	GPPIRDE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06U5.
TreeFamⁱ	TF105543.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204. ANK. 1 hit.
Gene3Dⁱ	1.25.40.20. 2 hits.
InterProⁱ	View protein in InterPro IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR031205. PPP1R12C. IPR031775. PRKG1_interact.
PANTHERⁱ	PTHR24179:SF32. PTHR24179:SF32. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796. Ank_2. 2 hits. PF15898. PRKG1_interact. 1 hit.
PRINTSⁱ	PR01415. ANKYRIN.
SMARTⁱ	View protein in SMART SM00248. ANK. 4 hits.
SUPFAMⁱ	SSF48403. SSF48403. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 4 hits.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q3UMT1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSGEDGPAAG PGAAAAAAAA RERRQEQLRQ WGARAGADPG PGERRARTVR 
        60         70         80         90        100
FERAAEFLAA CAGGDLDEAR LMLRAADPGP GSGAASDPAV PPPARAVLDS 
       110        120        130        140        150
TNADGISALH QACIDENLEV VRFLVEQGAT VNQADNEGWT PLHVAASCGY 
       160        170        180        190        200
LDIARYLLSH GANIAAVNSD GDLPLDLAES DAMEGLLKAE ITRRGVDVEA 
       210        220        230        240        250
AKRAEEELLL HDTRCWLNGG AMPEARHPRT GASALHVAAA KGYIEVMRLL 
       260        270        280        290        300
LQAGYDTELR DGDGWTPLHA AAHWGVEDAC RLLAEHGGGM DSLTHAGQRP 
       310        320        330        340        350
CDLADEDVMN LLEELAQKQE DLRNQKEGSQ GRGQESQVPS SSKHRRSSVC 
       360        370        380        390        400
RLSSREKISL QDLSKERRPG GAGGPPIGDE DEGGEASAEH PAVEPRALNG 
       410        420        430        440        450
VSSPVSSNPK SPVLPEEAPF SRRFGLQKTG STGALGPSER RATEGVLGLQ 
       460        470        480        490        500
RSASSSLLEK ASTQAREPRL ARITPTPAQK VPEPFTLYEA ATPPSLDHSV 
       510        520        530        540        550
PPSRREPGSI VKPNVLTASA APLADSRDRR RSYQMPVRDE ESESQRKARS 
       560        570        580        590        600
RLMRQSRRST QGVTLTDLKE AEKVAGKVPE PEQPALPSLD PSRRPRVPGV 
       610        620        630        640        650
ENAEGPAQRE APEGQGQGPQ AAREHRKAGH ERRGPAEGEE AGPAERSPEC 
       660        670        680        690        700
STVDGGSQVR RQHSQRDLVL ESKQEHEEPD GGFRKMYTEL RRENERLREA 
       710        720        730        740        750
LTETTLRLAQ LKVELERATQ RQERFAERPA LLELERFERR ALERKAAELE 
       760        770        780 
EELKALSDLR ADNQRLKDEN AALIRVISKL SK

Length:782

Mass (Da):84,685

Last modified:October 11, 2005 - v1

Checksum:ⁱ83C2708E36BFBD7B

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	30	Q → R in BAB27215 (PubMed:16141072).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK010836 mRNA. Translation: BAB27215.1. AK144691 mRNA. Translation: BAE26017.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS39735.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_084110.2. NM_029834.3.
UniGeneⁱ	Mm.360391.

Genome annotation databases

Ensemblⁱ	ENSMUST00000013886; ENSMUSP00000013886; ENSMUSG00000019254.
GeneIDⁱ	232807.
KEGGⁱ	mmu:232807.
UCSC genome browser More...UCSCⁱ	uc009exq.1. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK010836 mRNA. Translation: BAB27215.1. AK144691 mRNA. Translation: BAE26017.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS39735.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_084110.2. NM_029834.3.
UniGeneⁱ	Mm.360391.

3D structure databases

ProteinModelPortalⁱ	Q3UMT1.
SMRⁱ	Q3UMT1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q3UMT1. 1 interactor.
STRINGⁱ	10090.ENSMUSP00000013886.

PTM databases

iPTMnetⁱ	Q3UMT1.
PhosphoSitePlusⁱ	Q3UMT1.

Proteomic databases

EPDⁱ	Q3UMT1.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q3UMT1.
PaxDbⁱ	Q3UMT1.
PeptideAtlas More...PeptideAtlasⁱ	Q3UMT1.
PRIDEⁱ	Q3UMT1.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000013886; ENSMUSP00000013886; ENSMUSG00000019254.
GeneIDⁱ	232807.
KEGGⁱ	mmu:232807.
UCSC genome browser More...UCSCⁱ	uc009exq.1. mouse.

Organism-specific databases

CTDⁱ	54776.
MGIⁱ	MGI:1924258. Ppp1r12c.

Phylogenomic databases

eggNOGⁱ	KOG0505. Eukaryota. COG0666. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119141.
HOGENOMⁱ	HOG000290648.
HOVERGENⁱ	HBG104929.
InParanoidⁱ	Q3UMT1.
KEGG Orthology (KO) More...KOⁱ	K17457.
OMAⁱ	GPPIRDE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06U5.
TreeFamⁱ	TF105543.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q3UMT1.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000019254.
ExpressionAtlasⁱ	Q3UMT1. baseline and differential.
Genevisibleⁱ	Q3UMT1. MM.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204. ANK. 1 hit.
Gene3Dⁱ	1.25.40.20. 2 hits.
InterProⁱ	View protein in InterPro IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR031205. PPP1R12C. IPR031775. PRKG1_interact.
PANTHERⁱ	PTHR24179:SF32. PTHR24179:SF32. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796. Ank_2. 2 hits. PF15898. PRKG1_interact. 1 hit.
PRINTSⁱ	PR01415. ANKYRIN.
SMARTⁱ	View protein in SMART SM00248. ANK. 4 hits.
SUPFAMⁱ	SSF48403. SSF48403. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 4 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PP12C_MOUSE
Accessionⁱ	Q3UMT1Primary (citable) accession number: Q3UMT1 Secondary accession number(s): Q9CWD5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	October 11, 2005
	Last modified:	July 5, 2017
	This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3UMT1 (PP12C_MOUSE)

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Protein phosphatase 1 regulatory subunit 12C

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ