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Protein

H/ACA ribonucleoprotein complex non-core subunit NAF1

Gene

Naf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • box H/ACA snoRNP assembly Source: BHF-UCL
  • positive regulation of telomerase activity Source: MGI
  • positive regulation of telomere maintenance via telomere lengthening Source: MGI
  • ribosome biogenesis Source: UniProtKB
  • RNA stabilization Source: BHF-UCL
  • snoRNA guided rRNA pseudouridine synthesis Source: BHF-UCL
  • telomerase holoenzyme complex assembly Source: MGI
  • telomerase RNA stabilization Source: MGI

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processRibosome biogenesis, rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
H/ACA ribonucleoprotein complex non-core subunit NAF1
Gene namesi
Name:Naf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2682306 Naf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003156381 – 489H/ACA ribonucleoprotein complex non-core subunit NAF1Add BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei308PhosphoserineCombined sources1
Cross-linki331Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ3UMQ8
MaxQBiQ3UMQ8
PRIDEiQ3UMQ8

PTM databases

iPTMnetiQ3UMQ8
PhosphoSitePlusiQ3UMQ8

Expressioni

Gene expression databases

CleanExiMM_NAF1

Interactioni

Subunit structurei

During assembly of the complex, component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs) which contains NOLA2/NHP2, NOLA3/NOP10, NAF1 and DKC1/NOLA4. Interacts directly with DKC1/NOLA4 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ3UMQ8
SMRiQ3UMQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi25 – 105Pro-richAdd BLAST81
Compositional biasi110 – 141Ser-richAdd BLAST32
Compositional biasi409 – 477Pro-richAdd BLAST69

Sequence similaritiesi

Belongs to the NAF1 family.Curated

Phylogenomic databases

HOGENOMiHOG000214085
HOVERGENiHBG108169
InParanoidiQ3UMQ8
KOiK14763
PhylomeDBiQ3UMQ8

Family and domain databases

Gene3Di2.40.10.230, 1 hit
InterProiView protein in InterPro
IPR038664 Gar1/Naf1_Cbf5-bd_sf
IPR007504 H/ACA_rnp_Gar1/Naf1
IPR009000 Transl_B-barrel_sf
PfamiView protein in Pfam
PF04410 Gar1, 1 hit
SUPFAMiSSF50447 SSF50447, 1 hit

Sequencei

Sequence statusi: Complete.

Q3UMQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVVEAAAQL QTLKFGGSGQ GSAAPQPPED RREAPPPGVQ PPPPAPSGRP
60 70 80 90 100
PPPPAPSSDP GGRPPPPPAP NWDAGGRPPP PPAPNSDPPP GGAWVTGRNA
110 120 130 140 150
AEPPPVLQAS DSSDSDSDSE TDSDSSSSSS SSSSSSSSCV SFPPVLSDGD
160 170 180 190 200
EDFQLEKENK NFPLKTKDEL LLNELPSVEE LTVILPEDIA LKPLGKVSSI
210 220 230 240 250
IEQLVIIESV TNIPPVNEDT VIFKSDRQAA GKIFEIFGPV AHPFYVLRFN
260 270 280 290 300
SSDHIESKGI KINDTMYFAP SMKDFTQYIF TEKLKQDRGS DASWKNDQEP
310 320 330 340 350
PPEVLDFSDD EKEKEAKQRK KSQIQGRKKL KSELNESGED FGEVHENWNA
360 370 380 390 400
YSSSEHSKGY HHREFSRGFA RGRYSRRSHG RPPPQQYYNS DHMASQESLG
410 420 430 440 450
FTPQRQDNPV MPHYPFPPPM FDMHNFPLPP PPPPPPPPPP SMGWAAPSMA
460 470 480
SHPVLNLPYS MPPPPLPPPP PPPPPSPGEN NSSHFGPYF
Length:489
Mass (Da):53,246
Last modified:January 15, 2008 - v2
Checksum:i2E752F90632375E8
GO

Sequence cautioni

The sequence BAE26040 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116731 Genomic DNA No translation available.
AK144735 mRNA Translation: BAE26040.1 Different initiation.
BC027148 mRNA Translation: AAH27148.1
RefSeqiNP_001157036.1, NM_001163564.1
UniGeneiMm.334561

Genome annotation databases

GeneIDi234344
KEGGimmu:234344

Similar proteinsi

Entry informationi

Entry nameiNAF1_MOUSE
AccessioniPrimary (citable) accession number: Q3UMQ8
Secondary accession number(s): Q8R2W2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: June 20, 2018
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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