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Protein

Phospholipase A2

Gene

Pla2g4a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolasePROSITE-ProRule annotation
Biological processLipid degradationPROSITE-ProRule annotation, Lipid metabolism
LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase A2UniRule annotation (EC:3.1.1.4UniRule annotation)
Gene namesi
Name:Pla2g4aImported
ORF Names:mCG_125138Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1195256. Pla2g4a.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

MaxQBiQ3UMQ1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000056220.
ExpressionAtlasiQ3UMQ1. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070868.

Structurei

3D structure databases

SMRiQ3UMQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 106C2InterPro annotationAdd BLAST102
Domaini140 – 739PLA2cInterPro annotationAdd BLAST600

Domaini

The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca2+.UniRule annotation

Phylogenomic databases

eggNOGiKOG1012. Eukaryota.
KOG1325. Eukaryota.
ENOG410XR72. LUCA.
HOVERGENiHBG053479.
KOiK16342.
OMAiRFSMALC.
OrthoDBiEOG091G0276.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiView protein in InterPro
IPR016035. Acyl_Trfase/lysoPLipase.
IPR000008. C2_dom.
IPR002642. LysoPLipase_cat_dom.
PfamiView protein in Pfam
PF00168. C2. 1 hit.
PF01735. PLA2_B. 1 hit.
SMARTiView protein in SMART
SM00239. C2. 1 hit.
SM00022. PLAc. 1 hit.
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF52151. SSF52151. 1 hit.
PROSITEiView protein in PROSITE
PS50004. C2. 1 hit.
PS51210. PLA2C. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3UMQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFIDPYQHI IVEHQYSHKF TVVVLRATKV TKGTFGDMLD TPDPYVELFI
60 70 80 90 100
STTPDSRKRT RHFNNDINPV WNETFEFILD PNQENVLEIT LMDANYVMDE
110 120 130 140 150
TLGTATFPVS SMKVGEKKEV PFIFNQVTEM ILEMSLEVCS CPDLRFSMAL
160 170 180 190 200
CDQEKTFRQQ RKENIKENMK KLLGPKKSEG LYSTRDVPVV AILGSGGGFR
210 220 230 240 250
AMVGFSGVMK ALYESGILDC ATYIAGLSGS TWYMSTLYSH PDFPEKGPEE
260 270 280 290 300
INEELMKNVS HNPLLLLTPQ KVKRYVESLW KKKSSGQPVT FTDIFGMLIG
310 320 330 340 350
ETLIQNRMSM TLSSLKEKVN AARCPLPLFT CLHVKPDVSE LMFADWVEFS
360 370 380 390 400
PYEIGMAKYG TFMAPDLFGS KFFMGTVVKK YEENPLHFLM GVWGSAFSIL
410 420 430 440 450
FNRVLGVSGS QNKGSTMEEE LENITAKHIV SNDSSDSDDE AQGPKGTENE
460 470 480 490 500
EAEKEYQSDN QASWVHRMLM ALVSDSALFN TREGRAGKVH NFMLGLNLNT
510 520 530 540 550
SYPLSPLRDF SSQDSFDDEL DAAVADPDEF ERIYEPLDVK SKKIHVVDSG
560 570 580 590 600
LTFNLPYPLI LRPQRGVDLI ISFDFSARPS DTSPPFKELL LAEKWAKMNK
610 620 630 640 650
LPFPKIDPYV FDREGLKECY VFKPKNPDVE KDCPTIIHFV LANINFRKYK
660 670 680 690 700
APGVLRETKE EKEIADFDIF DDPESPFSTF NFQYPNQAFK RLHDLMYFNT
710 720 730 740
LNNIDVIKDA IVESIEYRRQ NPSRCSVSLS NVEARKFFNK EFLSKPTV
Length:748
Mass (Da):85,222
Last modified:October 11, 2005 - v1
Checksum:i49D12BBB2911492A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144750 mRNA. Translation: BAE26047.1.
CH466520 Genomic DNA. Translation: EDL39489.1.
RefSeqiNP_032895.1. NM_008869.4.
UniGeneiMm.4186.

Genome annotation databases

GeneIDi18783.
KEGGimmu:18783.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144750 mRNA. Translation: BAE26047.1.
CH466520 Genomic DNA. Translation: EDL39489.1.
RefSeqiNP_032895.1. NM_008869.4.
UniGeneiMm.4186.

3D structure databases

SMRiQ3UMQ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070868.

Proteomic databases

MaxQBiQ3UMQ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi18783.
KEGGimmu:18783.

Organism-specific databases

CTDi5321.
MGIiMGI:1195256. Pla2g4a.

Phylogenomic databases

eggNOGiKOG1012. Eukaryota.
KOG1325. Eukaryota.
ENOG410XR72. LUCA.
HOVERGENiHBG053479.
KOiK16342.
OMAiRFSMALC.
OrthoDBiEOG091G0276.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056220.
ExpressionAtlasiQ3UMQ1. baseline and differential.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiView protein in InterPro
IPR016035. Acyl_Trfase/lysoPLipase.
IPR000008. C2_dom.
IPR002642. LysoPLipase_cat_dom.
PfamiView protein in Pfam
PF00168. C2. 1 hit.
PF01735. PLA2_B. 1 hit.
SMARTiView protein in SMART
SM00239. C2. 1 hit.
SM00022. PLAc. 1 hit.
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF52151. SSF52151. 1 hit.
PROSITEiView protein in PROSITE
PS50004. C2. 1 hit.
PS51210. PLA2C. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ3UMQ1_MOUSE
AccessioniPrimary (citable) accession number: Q3UMQ1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: March 15, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.