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Protein

Spermatogenesis-associated protein 5

Gene

Spata5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in morphological and functional mitochondrial transformations during spermatogenesis.1 Publication

Miscellaneous

Aberrantly expressed at the malignant conversion stage in a clonal epidermal model of chemical carcinogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi394 – 401ATP 1Sequence analysis8
Nucleotide bindingi668 – 675ATP 2Sequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-associated protein 5
Alternative name(s):
Spermatogenesis-associated factor protein
Gene namesi
Name:Spata5
Synonyms:Spaf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1927170. Spata5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003305841 – 893Spermatogenesis-associated protein 5Add BLAST893

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei271PhosphothreonineCombined sources1
Modified residuei273PhosphoserineBy similarity1
Modified residuei278PhosphoserineBy similarity1
Cross-linki859Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ3UMC0.
MaxQBiQ3UMC0.
PaxDbiQ3UMC0.
PRIDEiQ3UMC0.

PTM databases

iPTMnetiQ3UMC0.
PhosphoSitePlusiQ3UMC0.

Expressioni

Tissue specificityi

Expressed in testis; with localization to spermatogonia and early spermatocytes in the basal compartment of the seminiferous tubules (at early stages of spermatogenesis). Very weak signals observed in spleen and skin.1 Publication

Gene expression databases

BgeeiENSMUSG00000027722.
ExpressionAtlasiQ3UMC0. baseline and differential.
GenevisibleiQ3UMC0. MM.

Interactioni

Protein-protein interaction databases

BioGridi208337. 1 interactor.
IntActiQ3UMC0. 1 interactor.
STRINGi10090.ENSMUSP00000103747.

Structurei

3D structure databases

ProteinModelPortaliQ3UMC0.
SMRiQ3UMC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family. AFG2 subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0730. Eukaryota.
COG0464. LUCA.
GeneTreeiENSGT00900000140994.
HOGENOMiHOG000223225.
HOVERGENiHBG108504.
InParanoidiQ3UMC0.
KOiK14575.
OMAiIRMGIQP.
OrthoDBiEOG091G03VY.
PhylomeDBiQ3UMC0.
TreeFamiTF314525.

Family and domain databases

Gene3Di3.10.330.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR009010. Asp_de-COase-like_dom_sf.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR029067. CDC48_domain_2-like_sf.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00004. AAA. 2 hits.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiView protein in PROSITE
PS00674. AAA. 2 hits.

Sequencei

Sequence statusi: Complete.

Q3UMC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKKNRKRQ KEGAEGASPS LSAAPSRSGT STPFAQPSPA APGMLVVTNF
60 70 80 90 100
LEKVDGKVPK TFQNSLVHLG LNTMKSANIC IGRPVLLTSL DGKQEVYTAW
110 120 130 140 150
PVAGFPGGKV GLSEMAQKNV GVRAGETIQV QPLLGAVLQA QEMDLALSDK
160 170 180 190 200
DKEINEEELT GCILRKLDGK IVLPGNFLYC TFYGRLCKLQ VLQVKGTDGT
210 220 230 240 250
TLGKLQSASG TDAQGMASEH SSMESSDVDL SFQLSQLDLK EPQSPSSQST
260 270 280 290 300
PCKPTNDRTV NKAGEVLLDV TQSPRDGSGL GLEESTGLKC SFDSSKEGNT
310 320 330 340 350
QPVSEEKLLK PASAGTKSNT DTFYFISSTT RINLRKICTN SKEQDSQFKV
360 370 380 390 400
TYDMIGGLNS QLKAIREIIE LPLKQPELFK SYGIPAPRGL LLYGPPGTGK
410 420 430 440 450
TMIARAVANE VGAYVSVING PEIISKFYGE TEARLRQIFA EATLRHPSII
460 470 480 490 500
FIDELDALCP KREGAQSEVE KRVVASLLTL MDGIGSEGSE GRVLVLGATN
510 520 530 540 550
RPQALDAALR RPGRFDKEIE IGIPNAQDRL DILQKLLRRV PHLLTKAELL
560 570 580 590 600
RLANNAHGYV GADLKALCNE AGLHALRRVL RKQPNLPDSK VAGMVKITLN
610 620 630 640 650
DFLQGMNDIR PSAMREVAID VPNVSWSDIG GLENIKLKLK QAVEWPLKHP
660 670 680 690 700
KSFNRMGIQP PKGVLLYGPP GCSKTMIAKA LANESGLNFL AIKGPELMNK
710 720 730 740 750
YVGESERAVR EIFRKARAVA PSIIFFDELD ALAVERGSSS GAGNVADRVL
760 770 780 790 800
AQLLTEMDGI EQLKNVTVLA ATNRPDRIDK ALMRPGRIDR IIYVPLPDAA
810 820 830 840 850
TRREILNLQF HSMPISNEVD LDELVLQTDT YSGAEIIAVC KEAALLALEE
860 870 880 890
NIKADCIMKR HFTQALSIVT PRIPESLRRF YEDYQEKSGL HTV
Length:893
Mass (Da):97,256
Last modified:April 29, 2008 - v2
Checksum:i1B5FF96EDC9B9596
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54Missing in AAD02481 (PubMed:10734318).Curated1
Sequence conflicti54Missing in CAM46306 (PubMed:19468303).Curated1
Sequence conflicti54Missing in CAM21041 (PubMed:19468303).Curated1
Sequence conflicti205L → P in AAD02481 (PubMed:10734318).Curated1
Sequence conflicti205L → P in BAE26178 (PubMed:16141072).Curated1
Sequence conflicti205L → P in CAM46305 (PubMed:19468303).Curated1
Sequence conflicti205L → P in CAM46306 (PubMed:19468303).Curated1
Sequence conflicti225S → N in AAD02481 (PubMed:10734318).Curated1
Sequence conflicti225S → N in CAM46305 (PubMed:19468303).Curated1
Sequence conflicti225S → N in CAM46306 (PubMed:19468303).Curated1
Sequence conflicti864Q → E in AAD02481 (PubMed:10734318).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049099 mRNA. Translation: AAD02481.1.
AK011111 mRNA. Translation: BAB27406.1.
AK144998 mRNA. Translation: BAE26178.1.
AL669927, AL627074 Genomic DNA. Translation: CAM21041.1.
AL669927, AL627074 Genomic DNA. Translation: CAM21042.1.
AL627074, AL669927 Genomic DNA. Translation: CAM25218.1.
AL627074, AL669927 Genomic DNA. Translation: CAM25219.1.
AL645968 Genomic DNA. Translation: CAM46305.1.
AL645968 Genomic DNA. Translation: CAM46306.1.
CCDSiCCDS50895.1.
RefSeqiNP_001156983.1. NM_001163511.2.
NP_001297402.1. NM_001310473.1.
NP_067318.2. NM_021343.3.
UniGeneiMm.172679.

Genome annotation databases

EnsembliENSMUST00000108112; ENSMUSP00000103747; ENSMUSG00000027722.
GeneIDi57815.
KEGGimmu:57815.
UCSCiuc008pav.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiSPAT5_MOUSE
AccessioniPrimary (citable) accession number: Q3UMC0
Secondary accession number(s): A2ACU2
, A3KG23, A3KG24, Q9CXZ7, Q9Z2K7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: November 22, 2017
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families