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Protein

Hepatocyte growth factor-regulated tyrosine kinase substrate

Gene

Hgs

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri160 – 220FYVE-typePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transportUniRule annotation, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-182971. EGFR downregulation.
R-MMU-432720. Lysosome Vesicle Biogenesis.
R-MMU-5689880. Ub-specific processing proteases.
R-MMU-6807004. Negative regulation of MET activity.
R-MMU-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-MMU-8856828. Clathrin-mediated endocytosis.
R-MMU-917729. Endosomal Sorting Complex Required For Transport (ESCRT).

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte growth factor-regulated tyrosine kinase substrateUniRule annotation
Gene namesi
Name:HgsImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:104681. Hgs.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, EndosomeUniRule annotation, MembraneUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000025793.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 143VHSInterPro annotationAdd BLAST129
Domaini160 – 220FYVE-typeInterPro annotationAdd BLAST61

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili469 – 511Sequence analysisAdd BLAST43

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri160 – 220FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1818. Eukaryota.
ENOG410XNRF. LUCA.
GeneTreeiENSGT00670000098022.
HOGENOMiHOG000044175.
HOVERGENiHBG062917.
KOiK12182.
OMAiKRMWYEQ.
OrthoDBiEOG091G06JJ.
TreeFamiTF314470.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR008942. ENTH_VHS.
IPR024641. HRS_helical.
IPR017073. Ubi-bd_Hrs_VPS27.
IPR003903. UIM_dom.
IPR002014. VHS_dom.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01363. FYVE. 1 hit.
PF12210. Hrs_helical. 1 hit.
PF00790. VHS. 1 hit.
PIRSFiPIRSF036956. Hrs_Vps27. 1 hit.
SMARTiView protein in SMART
SM00064. FYVE. 1 hit.
SM00288. VHS. 1 hit.
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiView protein in PROSITE
PS50330. UIM. 1 hit.
PS50179. VHS. 1 hit.
PS50178. ZF_FYVE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3UMA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRGSGTFER LLDKATSQLL LETDWESILQ ICDLIRQGDT QAKYAVNSIK
60 70 80 90 100
KKVNDKNPHV ALYALEVMES VVKNCGQTVH DEVANKQTME ELKELLKRQV
110 120 130 140 150
EVNVRNKILY LIQAWAHAFR NEPKYKVVQD TYQIMKVEGH VFPEFKESDA
160 170 180 190 200
MFAAERAPDW VDAEECHRCR VQFGVVTRKH HCRACGQIFC GKCSSKYSTI
210 220 230 240 250
PKFGIEKEVR VCEPCYEQLN KKAEGKASST TELPPEYLTS PLSQQSQLPP
260 270 280 290 300
KRDETALQEE EELQLALALS QSEAEEKERM RQKTTYTAHP KAEPTPLASS
310 320 330 340 350
APPAGSLYSS PVNSSAPLAE DIDPELARYL NRNYWEKKQE EARKSPTPSA
360 370 380 390 400
PVPLTEPAAQ PGEGHTAPNS MAEAPLPETD SQPITPCSGP FSEQYQNGES
410 420 430 440 450
EESHEQFLKA LQNAVSTFVN RMKSNHMRGR SITNDSAVLS LFQSINTMHP
460 470 480 490 500
QLLELLNQLD ERRLYYEGLQ DKLAQIRDAR GALSALREEH REKLRRAAEE
510 520 530 540 550
AERQRQIQLA QKLEIMRQKK QEYLEVQRQL AIQRLQEQEK ERQMRLEQQK
560 570 580 590 600
QTVQMRAQMP AFPLPYAQLQ AMPTAGGVLY QPSGPTSFPA TFSPAGSVEG
610 620 630 640 650
SPMHGVYMSQ PAPATGPYPS MPGTTADPSM VSAYMYPTGA PGAQAAPQAQ
660 670 680 690 700
AGPTTSPAYS SYQPTPTPGY QSVASQAPQS LPAISQPPQT SNIGYMGSQP
710 720 730 740 750
MSMGYQPYNM QNLMTALPGQ DASLPAQQPY IPGQQPLYQQ MAPSTGPPQQ
760 770
QPPVAQPAPT QGPPAQGSEA QLISFD
Length:776
Mass (Da):86,143
Last modified:October 11, 2005 - v1
Checksum:iE53FE4C5F39ECB49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL669855 Genomic DNA. No translation available.
AK145031 mRNA. Translation: BAE26195.1.
RefSeqiNP_001152800.1. NM_001159328.1.
NP_032270.3. NM_008244.3.
UniGeneiMm.7919.

Genome annotation databases

EnsembliENSMUST00000026900; ENSMUSP00000026900; ENSMUSG00000025793.
GeneIDi15239.
KEGGimmu:15239.
UCSCiuc007msz.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ3UMA3_MOUSE
AccessioniPrimary (citable) accession number: Q3UMA3
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 22, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported