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Protein

Eukaryotic translation initiation factor 3 subunit A

Gene

Eif3a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factorSAAS annotation

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit ASAAS annotation
Gene namesi
Name:Eif3aImported
Synonyms:Eif3s10Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95301. Eif3a.

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiQ3UM46.
PeptideAtlasiQ3UM46.
PRIDEiQ3UM46.

Expressioni

Gene expression databases

GenevisibleiQ3UM46. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025955.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini426 – 50681PCIInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili558 – 63477Sequence analysisAdd
BLAST
Coiled coili667 – 73771Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the eIF-3 subunit A family.SAAS annotation
Contains PCI domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2072. Eukaryota.
ENOG410XQ37. LUCA.
HOVERGENiHBG006128.
KOiK03254.

Family and domain databases

HAMAPiMF_03000. eIF3a.
InterProiIPR027512. EIF3A.
IPR000717. PCI_dom.
[Graphical view]
PANTHERiPTHR14005:SF0. PTHR14005:SF0. 1 hit.
PfamiPF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3UM46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAYFQRPEN ALKRANEFLE VGKKQPALDV LYDVMKSKKH RTWQKIHEPI
60 70 80 90 100
MLKYLELCVD LRKSHLAKEG LYQYKNICQQ VNIKSLEDVV RAYLKLAEEK
110 120 130 140 150
TEAAKEESQQ MVLDIEDLDN IQTPESVLLS AVSGEDTQDR TDRLLLTPWV
160 170 180 190 200
KFLWESYRQC LDLLRNNSRV ERLYHDIAQQ AFKFCLQYTR KAEFRKLCDN
210 220 230 240 250
LRMHLSQIQR HHNQSTAINL NNPESQSMHL ETRLVQLDSA ISMELWQEAF
260 270 280 290 300
KAVEDIHGLF SLSKKPPKPQ LMANYYNKVS TVFWKSGNAL FHASTLHRLY
310 320 330 340 350
HLSREMRKNL TQEEMQRMST RVLLATLSIP ITPERTDIAR LLDMDGIIVE
360 370 380 390 400
KQRRLATLLG LQAPPTRIGL INDMVRFSVL QYVVPEVKDL YNWLEVEFNP
410 420 430 440 450
LKLCERVTKV LNWVREQPEK EPELQQYVPQ LQNNTILRLL QQVAQIYQSI
460 470 480 490 500
EFSRLTSLVP FVDAFQLERA IVDAARHCDL QVRIDHTSRT LSFGSDLNYA
510 520 530 540 550
TREDAPVGPH LQSMPSEQIR NQLTAMSSVL AKALEVIRPA HILQEKEEQH
560 570 580 590 600
QLAVNAYLKN SRKEHQRILA RRQTIEERKE RLESLNIQRE KEELEQREAE
610 620 630 640 650
LQKVRKAEEE RLRQEAKERE KERILQEHEQ IKKKTVRERL EQIKKTELGA
660 670 680 690 700
KAFKDIDIED LEELDPDFIM AKQVEQLEKE KKELQERLKN QEKKIDYFER
710 720 730
AKREEELREY QERVKKLEEV ERKKRQRELE IEERERR
Length:737
Mass (Da):87,518
Last modified:October 11, 2005 - v1
Checksum:i29D92B38CDB91C39
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei737 – 7371Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145132 mRNA. Translation: BAE26252.1.
RefSeqiNP_034253.3. NM_010123.3.
UniGeneiMm.2238.
Mm.482533.

Genome annotation databases

GeneIDi13669.
KEGGimmu:13669.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145132 mRNA. Translation: BAE26252.1.
RefSeqiNP_034253.3. NM_010123.3.
UniGeneiMm.2238.
Mm.482533.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025955.

Proteomic databases

PaxDbiQ3UM46.
PeptideAtlasiQ3UM46.
PRIDEiQ3UM46.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13669.
KEGGimmu:13669.

Organism-specific databases

CTDi8661.
MGIiMGI:95301. Eif3a.

Phylogenomic databases

eggNOGiKOG2072. Eukaryota.
ENOG410XQ37. LUCA.
HOVERGENiHBG006128.
KOiK03254.

Miscellaneous databases

ChiTaRSiEif3a. mouse.
SOURCEiSearch...

Gene expression databases

GenevisibleiQ3UM46. MM.

Family and domain databases

HAMAPiMF_03000. eIF3a.
InterProiIPR027512. EIF3A.
IPR000717. PCI_dom.
[Graphical view]
PANTHERiPTHR14005:SF0. PTHR14005:SF0. 1 hit.
PfamiPF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.

Entry informationi

Entry nameiQ3UM46_MOUSE
AccessioniPrimary (citable) accession number: Q3UM46
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.