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Protein

Protein phosphatase 1 regulatory subunit 7

Gene

Ppp1r7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of protein phosphatase 1.By similarity

GO - Biological processi

  • chromosome segregation Source: MGI
  • positive regulation of protein dephosphorylation Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 7
Alternative name(s):
Protein phosphatase 1 regulatory subunit 22
Gene namesi
Name:Ppp1r7
Synonyms:Sds22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1913635 Ppp1r7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002396142 – 361Protein phosphatase 1 regulatory subunit 7Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Modified residuei24PhosphoserineCombined sources1
Modified residuei27PhosphoserineCombined sources1
Modified residuei45PhosphoserineCombined sources1
Modified residuei48PhosphoserineBy similarity1
Modified residuei323PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ3UM45
MaxQBiQ3UM45
PaxDbiQ3UM45
PeptideAtlasiQ3UM45
PRIDEiQ3UM45

2D gel databases

REPRODUCTION-2DPAGEiQ3UM45

PTM databases

iPTMnetiQ3UM45
PhosphoSitePlusiQ3UM45

Expressioni

Tissue specificityi

Widely expressed with high level in testis. Expression increases during puberty. Expressed in spermatids and probably also in spermatozoa.1 Publication

Gene expression databases

BgeeiENSMUSG00000026275
ExpressionAtlasiQ3UM45 baseline and differential
GenevisibleiQ3UM45 MM

Interactioni

Subunit structurei

Interacts with PPP1CA, PPP1CB and PPP1CC/PPP1G.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Ppp1caP621373EBI-8318179,EBI-357187

Protein-protein interaction databases

BioGridi211432, 6 interactors
IntActiQ3UM45, 8 interactors
MINTiQ3UM45
STRINGi10090.ENSMUSP00000027494

Structurei

3D structure databases

ProteinModelPortaliQ3UM45
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati78 – 99LRR 1Add BLAST22
Repeati100 – 121LRR 2Add BLAST22
Repeati122 – 143LRR 3Add BLAST22
Repeati144 – 165LRR 4Add BLAST22
Repeati166 – 187LRR 5Add BLAST22
Repeati188 – 209LRR 6Add BLAST22
Repeati210 – 231LRR 7Add BLAST22
Repeati232 – 253LRR 8Add BLAST22
Repeati254 – 275LRR 9Add BLAST22
Repeati276 – 297LRR 10Add BLAST22
Repeati298 – 319LRR 11Add BLAST22
Domaini332 – 361LRRCTAdd BLAST30

Sequence similaritiesi

Belongs to the SDS22 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0531 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00900000140836
HOGENOMiHOG000211189
HOVERGENiHBG082161
InParanoidiQ3UM45
KOiK17550
OMAiLFLRWNL
OrthoDBiEOG091G0FWO
PhylomeDBiQ3UM45
TreeFamiTF105538

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR003603 U2A'_phosphoprotein32A_C
SMARTiView protein in SMART
SM00369 LRR_TYP, 7 hits
SM00446 LRRcap, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 12 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UM45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAERGAGQQ QSQEMMEVDR RVESEESGDE EGKKHGGGGI VANLSEQSLK
60 70 80 90 100
DGVDRGAEDP EEEHELAVDM ETINLDRDAE DVDLTHYRIG KIEGLEVLKK
110 120 130 140 150
VKSLCLRQNL IKCIENLEEL QSLRELDLYD NQIKKIENLE ALTELEVLDI
160 170 180 190 200
SFNMLRNIEG IDKLTQLKKL FLVNNKINKI ENISNLHQLQ MLELGSNRIR
210 220 230 240 250
AIENIDTLTN LESLFLGKNK ITKLQNLDAL TNLTVLSVQS NRLAKIEGLQ
260 270 280 290 300
SLVNLRELYL SNNGIEVIEG LENNNKLTML DIASNRIKKI ENISHLTELQ
310 320 330 340 350
EFWMNDNLLE SWSDLDELKG ARSLETVYLE RNPLQKDPQY RRKVMLALPS
360
VRQIDATYVR F
Length:361
Mass (Da):41,292
Last modified:June 13, 2006 - v2
Checksum:iA31206AFB3BD0F30
GO

Sequence cautioni

The sequence BAB26554 differs from that shown. Reason: Frameshift at position 255.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39G → S in BAE26253 (PubMed:16141072).Curated1
Sequence conflicti54D → E in BAE26253 (PubMed:16141072).Curated1
Sequence conflicti97V → L in BAE26253 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067129 Genomic DNA Translation: AAK08624.1
AF222867 mRNA Translation: AAK00624.1
AK009870 mRNA Translation: BAB26554.1 Frameshift.
AK145136 mRNA Translation: BAE26253.1
AK162517 mRNA Translation: BAE36954.1
BC013524 mRNA Translation: AAH13524.1
CCDSiCCDS15187.1
RefSeqiNP_075689.1, NM_023200.2
UniGeneiMm.88704

Genome annotation databases

EnsembliENSMUST00000027494; ENSMUSP00000027494; ENSMUSG00000026275
GeneIDi66385
KEGGimmu:66385
UCSCiuc007cdv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPP1R7_MOUSE
AccessioniPrimary (citable) accession number: Q3UM45
Secondary accession number(s): Q9CV31, Q9Z105
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: March 28, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health