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Protein

Protein phosphatase 1 regulatory subunit 7

Gene

Ppp1r7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of protein phosphatase 1.By similarity

GO - Biological processi

  • chromosome segregation Source: MGI
  • positive regulation of protein dephosphorylation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 7
Alternative name(s):
Protein phosphatase 1 regulatory subunit 22
Gene namesi
Name:Ppp1r7
Synonyms:Sds22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1913635. Ppp1r7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 361360Protein phosphatase 1 regulatory subunit 7PRO_0000239614Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei12 – 121PhosphoserineBy similarity
Modified residuei24 – 241PhosphoserineCombined sources
Modified residuei27 – 271PhosphoserineCombined sources
Modified residuei45 – 451PhosphoserineCombined sources
Modified residuei48 – 481PhosphoserineBy similarity
Modified residuei323 – 3231PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ3UM45.
MaxQBiQ3UM45.
PaxDbiQ3UM45.
PRIDEiQ3UM45.

2D gel databases

REPRODUCTION-2DPAGEQ3UM45.

PTM databases

iPTMnetiQ3UM45.

Expressioni

Tissue specificityi

Widely expressed with high level in testis. Expression increases during puberty. Expressed in spermatids and probably also in spermatozoa.1 Publication

Gene expression databases

BgeeiQ3UM45.
ExpressionAtlasiQ3UM45. baseline and differential.
GenevisibleiQ3UM45. MM.

Interactioni

Subunit structurei

Interacts with PPP1CA, PPP1CB and PPP1CC/PPP1G.By similarity

Protein-protein interaction databases

BioGridi211432. 5 interactions.
IntActiQ3UM45. 6 interactions.
MINTiMINT-3292766.
STRINGi10090.ENSMUSP00000027494.

Structurei

3D structure databases

ProteinModelPortaliQ3UM45.
SMRiQ3UM45. Positions 39-360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati78 – 9922LRR 1Add
BLAST
Repeati100 – 12122LRR 2Add
BLAST
Repeati122 – 14322LRR 3Add
BLAST
Repeati144 – 16522LRR 4Add
BLAST
Repeati166 – 18722LRR 5Add
BLAST
Repeati188 – 20922LRR 6Add
BLAST
Repeati210 – 23122LRR 7Add
BLAST
Repeati232 – 25322LRR 8Add
BLAST
Repeati254 – 27522LRR 9Add
BLAST
Repeati276 – 29722LRR 10Add
BLAST
Repeati298 – 31922LRR 11Add
BLAST
Domaini332 – 36130LRRCTAdd
BLAST

Sequence similaritiesi

Belongs to the SDS22 family.Curated
Contains 11 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0531. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00730000110223.
HOGENOMiHOG000211189.
HOVERGENiHBG082161.
InParanoidiQ3UM45.
KOiK17550.
OMAiLEYNPLA.
OrthoDBiEOG72NRQW.
PhylomeDBiQ3UM45.
TreeFamiTF105538.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR003603. U2A'_phosphoprotein32A_C.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00446. LRRcap. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UM45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAERGAGQQ QSQEMMEVDR RVESEESGDE EGKKHGGGGI VANLSEQSLK
60 70 80 90 100
DGVDRGAEDP EEEHELAVDM ETINLDRDAE DVDLTHYRIG KIEGLEVLKK
110 120 130 140 150
VKSLCLRQNL IKCIENLEEL QSLRELDLYD NQIKKIENLE ALTELEVLDI
160 170 180 190 200
SFNMLRNIEG IDKLTQLKKL FLVNNKINKI ENISNLHQLQ MLELGSNRIR
210 220 230 240 250
AIENIDTLTN LESLFLGKNK ITKLQNLDAL TNLTVLSVQS NRLAKIEGLQ
260 270 280 290 300
SLVNLRELYL SNNGIEVIEG LENNNKLTML DIASNRIKKI ENISHLTELQ
310 320 330 340 350
EFWMNDNLLE SWSDLDELKG ARSLETVYLE RNPLQKDPQY RRKVMLALPS
360
VRQIDATYVR F
Length:361
Mass (Da):41,292
Last modified:June 13, 2006 - v2
Checksum:iA31206AFB3BD0F30
GO

Sequence cautioni

The sequence BAB26554.1 differs from that shown. Reason: Frameshift at position 255. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391G → S in BAE26253 (PubMed:16141072).Curated
Sequence conflicti54 – 541D → E in BAE26253 (PubMed:16141072).Curated
Sequence conflicti97 – 971V → L in BAE26253 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067129 Genomic DNA. Translation: AAK08624.1.
AF222867 mRNA. Translation: AAK00624.1.
AK009870 mRNA. Translation: BAB26554.1. Frameshift.
AK145136 mRNA. Translation: BAE26253.1.
AK162517 mRNA. Translation: BAE36954.1.
BC013524 mRNA. Translation: AAH13524.1.
CCDSiCCDS15187.1.
RefSeqiNP_075689.1. NM_023200.2.
UniGeneiMm.88704.

Genome annotation databases

EnsembliENSMUST00000027494; ENSMUSP00000027494; ENSMUSG00000026275.
GeneIDi66385.
KEGGimmu:66385.
UCSCiuc007cdv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067129 Genomic DNA. Translation: AAK08624.1.
AF222867 mRNA. Translation: AAK00624.1.
AK009870 mRNA. Translation: BAB26554.1. Frameshift.
AK145136 mRNA. Translation: BAE26253.1.
AK162517 mRNA. Translation: BAE36954.1.
BC013524 mRNA. Translation: AAH13524.1.
CCDSiCCDS15187.1.
RefSeqiNP_075689.1. NM_023200.2.
UniGeneiMm.88704.

3D structure databases

ProteinModelPortaliQ3UM45.
SMRiQ3UM45. Positions 39-360.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211432. 5 interactions.
IntActiQ3UM45. 6 interactions.
MINTiMINT-3292766.
STRINGi10090.ENSMUSP00000027494.

PTM databases

iPTMnetiQ3UM45.

2D gel databases

REPRODUCTION-2DPAGEQ3UM45.

Proteomic databases

EPDiQ3UM45.
MaxQBiQ3UM45.
PaxDbiQ3UM45.
PRIDEiQ3UM45.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027494; ENSMUSP00000027494; ENSMUSG00000026275.
GeneIDi66385.
KEGGimmu:66385.
UCSCiuc007cdv.1. mouse.

Organism-specific databases

CTDi5510.
MGIiMGI:1913635. Ppp1r7.

Phylogenomic databases

eggNOGiKOG0531. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00730000110223.
HOGENOMiHOG000211189.
HOVERGENiHBG082161.
InParanoidiQ3UM45.
KOiK17550.
OMAiLEYNPLA.
OrthoDBiEOG72NRQW.
PhylomeDBiQ3UM45.
TreeFamiTF105538.

Miscellaneous databases

ChiTaRSiPpp1r7. mouse.
PROiQ3UM45.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UM45.
ExpressionAtlasiQ3UM45. baseline and differential.
GenevisibleiQ3UM45. MM.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR003603. U2A'_phosphoprotein32A_C.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00446. LRRcap. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and splice products of the human gene encoding sds22, a putative mitotic regulator of protein phosphatase-1."
    Ceulemans H., Van Eynde A., Perez-Callejon E., Beullens M., Stalmans W., Bollen M.
    Eur. J. Biochem. 262:36-42(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  2. "Cloning, genomic structure and splice products of the mouse PPP1R7 gene, encoding sds22, a putative mitotic regulator of protein phosphatase-1."
    Ceulemans H., Stalmans W., Bollen M.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/SvJ.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  5. Lubec G., Klug S., Yang J.W., Zigmond M.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 224-242 AND 246-256, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Brain and Hippocampus.
  6. Cited for: TISSUE SPECIFICITY.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24; SER-27; SER-45 AND SER-323, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiPP1R7_MOUSE
AccessioniPrimary (citable) accession number: Q3UM45
Secondary accession number(s): Q9CV31, Q9Z105
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: June 8, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.