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Protein

Protein phosphatase 1 regulatory subunit 7

Gene

Ppp1r7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of protein phosphatase 1.By similarity

GO - Biological processi

  • chromosome segregation Source: MGI
  • positive regulation of protein dephosphorylation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 7
Alternative name(s):
Protein phosphatase 1 regulatory subunit 22
Gene namesi
Name:Ppp1r7
Synonyms:Sds22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1913635. Ppp1r7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002396142 – 361Protein phosphatase 1 regulatory subunit 7Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Modified residuei24PhosphoserineCombined sources1
Modified residuei27PhosphoserineCombined sources1
Modified residuei45PhosphoserineCombined sources1
Modified residuei48PhosphoserineBy similarity1
Modified residuei323PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ3UM45.
MaxQBiQ3UM45.
PaxDbiQ3UM45.
PeptideAtlasiQ3UM45.
PRIDEiQ3UM45.

2D gel databases

REPRODUCTION-2DPAGEQ3UM45.

PTM databases

iPTMnetiQ3UM45.
PhosphoSitePlusiQ3UM45.

Expressioni

Tissue specificityi

Widely expressed with high level in testis. Expression increases during puberty. Expressed in spermatids and probably also in spermatozoa.1 Publication

Gene expression databases

BgeeiENSMUSG00000026275.
ExpressionAtlasiQ3UM45. baseline and differential.
GenevisibleiQ3UM45. MM.

Interactioni

Subunit structurei

Interacts with PPP1CA, PPP1CB and PPP1CC/PPP1G.By similarity

Protein-protein interaction databases

BioGridi211432. 5 interactors.
IntActiQ3UM45. 6 interactors.
MINTiMINT-3292766.
STRINGi10090.ENSMUSP00000027494.

Structurei

3D structure databases

ProteinModelPortaliQ3UM45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati78 – 99LRR 1Add BLAST22
Repeati100 – 121LRR 2Add BLAST22
Repeati122 – 143LRR 3Add BLAST22
Repeati144 – 165LRR 4Add BLAST22
Repeati166 – 187LRR 5Add BLAST22
Repeati188 – 209LRR 6Add BLAST22
Repeati210 – 231LRR 7Add BLAST22
Repeati232 – 253LRR 8Add BLAST22
Repeati254 – 275LRR 9Add BLAST22
Repeati276 – 297LRR 10Add BLAST22
Repeati298 – 319LRR 11Add BLAST22
Domaini332 – 361LRRCTAdd BLAST30

Sequence similaritiesi

Belongs to the SDS22 family.Curated
Contains 11 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0531. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00730000110223.
HOGENOMiHOG000211189.
HOVERGENiHBG082161.
InParanoidiQ3UM45.
KOiK17550.
OMAiEELWLNH.
OrthoDBiEOG091G0FWO.
PhylomeDBiQ3UM45.
TreeFamiTF105538.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR003603. U2A'_phosphoprotein32A_C.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00446. LRRcap. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UM45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAERGAGQQ QSQEMMEVDR RVESEESGDE EGKKHGGGGI VANLSEQSLK
60 70 80 90 100
DGVDRGAEDP EEEHELAVDM ETINLDRDAE DVDLTHYRIG KIEGLEVLKK
110 120 130 140 150
VKSLCLRQNL IKCIENLEEL QSLRELDLYD NQIKKIENLE ALTELEVLDI
160 170 180 190 200
SFNMLRNIEG IDKLTQLKKL FLVNNKINKI ENISNLHQLQ MLELGSNRIR
210 220 230 240 250
AIENIDTLTN LESLFLGKNK ITKLQNLDAL TNLTVLSVQS NRLAKIEGLQ
260 270 280 290 300
SLVNLRELYL SNNGIEVIEG LENNNKLTML DIASNRIKKI ENISHLTELQ
310 320 330 340 350
EFWMNDNLLE SWSDLDELKG ARSLETVYLE RNPLQKDPQY RRKVMLALPS
360
VRQIDATYVR F
Length:361
Mass (Da):41,292
Last modified:June 13, 2006 - v2
Checksum:iA31206AFB3BD0F30
GO

Sequence cautioni

The sequence BAB26554 differs from that shown. Reason: Frameshift at position 255.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39G → S in BAE26253 (PubMed:16141072).Curated1
Sequence conflicti54D → E in BAE26253 (PubMed:16141072).Curated1
Sequence conflicti97V → L in BAE26253 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067129 Genomic DNA. Translation: AAK08624.1.
AF222867 mRNA. Translation: AAK00624.1.
AK009870 mRNA. Translation: BAB26554.1. Frameshift.
AK145136 mRNA. Translation: BAE26253.1.
AK162517 mRNA. Translation: BAE36954.1.
BC013524 mRNA. Translation: AAH13524.1.
CCDSiCCDS15187.1.
RefSeqiNP_075689.1. NM_023200.2.
UniGeneiMm.88704.

Genome annotation databases

EnsembliENSMUST00000027494; ENSMUSP00000027494; ENSMUSG00000026275.
GeneIDi66385.
KEGGimmu:66385.
UCSCiuc007cdv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067129 Genomic DNA. Translation: AAK08624.1.
AF222867 mRNA. Translation: AAK00624.1.
AK009870 mRNA. Translation: BAB26554.1. Frameshift.
AK145136 mRNA. Translation: BAE26253.1.
AK162517 mRNA. Translation: BAE36954.1.
BC013524 mRNA. Translation: AAH13524.1.
CCDSiCCDS15187.1.
RefSeqiNP_075689.1. NM_023200.2.
UniGeneiMm.88704.

3D structure databases

ProteinModelPortaliQ3UM45.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211432. 5 interactors.
IntActiQ3UM45. 6 interactors.
MINTiMINT-3292766.
STRINGi10090.ENSMUSP00000027494.

PTM databases

iPTMnetiQ3UM45.
PhosphoSitePlusiQ3UM45.

2D gel databases

REPRODUCTION-2DPAGEQ3UM45.

Proteomic databases

EPDiQ3UM45.
MaxQBiQ3UM45.
PaxDbiQ3UM45.
PeptideAtlasiQ3UM45.
PRIDEiQ3UM45.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027494; ENSMUSP00000027494; ENSMUSG00000026275.
GeneIDi66385.
KEGGimmu:66385.
UCSCiuc007cdv.1. mouse.

Organism-specific databases

CTDi5510.
MGIiMGI:1913635. Ppp1r7.

Phylogenomic databases

eggNOGiKOG0531. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00730000110223.
HOGENOMiHOG000211189.
HOVERGENiHBG082161.
InParanoidiQ3UM45.
KOiK17550.
OMAiEELWLNH.
OrthoDBiEOG091G0FWO.
PhylomeDBiQ3UM45.
TreeFamiTF105538.

Miscellaneous databases

ChiTaRSiPpp1r7. mouse.
PROiQ3UM45.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026275.
ExpressionAtlasiQ3UM45. baseline and differential.
GenevisibleiQ3UM45. MM.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR003603. U2A'_phosphoprotein32A_C.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00446. LRRcap. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPP1R7_MOUSE
AccessioniPrimary (citable) accession number: Q3UM45
Secondary accession number(s): Q9CV31, Q9Z105
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: November 2, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.