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Protein

Conserved oligomeric Golgi complex subunit 7

Gene

Cog7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for normal Golgi function.By similarity

GO - Biological processi

  1. intracellular protein transport Source: MGI
  2. protein glycosylation Source: MGI
  3. protein localization to Golgi apparatus Source: MGI
  4. protein localization to organelle Source: MGI
  5. protein stabilization Source: MGI
  6. retrograde vesicle-mediated transport, Golgi to ER Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 7
Short name:
COG complex subunit 7
Alternative name(s):
Component of oligomeric Golgi complex 7
Gene namesi
Name:Cog7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2685013. Cog7.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: MGI
  2. Golgi membrane Source: UniProtKB-SubCell
  3. Golgi transport complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 770770Conserved oligomeric Golgi complex subunit 7PRO_0000320147Add
BLAST

Proteomic databases

MaxQBiQ3UM29.
PaxDbiQ3UM29.
PRIDEiQ3UM29.

PTM databases

PhosphoSiteiQ3UM29.

Expressioni

Gene expression databases

BgeeiQ3UM29.
CleanExiMM_COG7.
GenevestigatoriQ3UM29.

Interactioni

Subunit structurei

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ3UM29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COG7 family.Curated

Phylogenomic databases

eggNOGiNOG288194.
GeneTreeiENSGT00390000001260.
HOGENOMiHOG000007766.
HOVERGENiHBG020364.
InParanoidiQ3UM29.
OrthoDBiEOG78SQH8.
PhylomeDBiQ3UM29.
TreeFamiTF324498.

Family and domain databases

InterProiIPR019335. COG7.
[Graphical view]
PANTHERiPTHR21443. PTHR21443. 1 hit.
PfamiPF10191. COG7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UM29-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFSKFLADD FDVKDWINAA FRAGPKDGAA GKADGHAATL VMKLQLFIQE
60 70 80 90 100
VNHAVEETSL QALQNMPKVL RDVEALKQEA SFLKEQMILV KEDIKKFEQD
110 120 130 140 150
TSQSMQVLVE IDQVKSRMQL AAESLQEADK WSTLSADIEE TFKTQDIAVI
160 170 180 190 200
SAKLTGMQNS LMMLVDTPDY SEKCVHLEAL KNRLEALASP QIVAAFTSQS
210 220 230 240 250
VDQSKVFVKV FTEIDRMPQL LAYYYKCHKV QLLATWQELC QSDLPLDRQL
260 270 280 290 300
TGLYDALLGA WHTQTQWATQ VFKNPHEVVT VLLIQTLGAL VPSLPMCLSA
310 320 330 340 350
AVERAGPELE LTRLLEFYDT TAHFAKGLEM ALLPHLQDHN LVKVVELVDA
360 370 380 390 400
VYGPYKPFQL KYGDMEENNL LIQISAVPLE HGEVIDCVQE LSHSVHKLFG
410 420 430 440 450
LASAAVDRCA KFTNGLGTCG LLTALKSLFA KYVSHFTNAL QSIRKKCKLD
460 470 480 490 500
DIPPNSLFQE DWTAFQNSVR IIATCGELLR QCGDFEQQLA NRILSTAGKY
510 520 530 540 550
LSDSYSPRSL AGFQDSILTD KKSPAKNPWQ EYNYLQKDNP AEYASLMEIL
560 570 580 590 600
YTLKEKGSSN HNLLSASRTA LTRLNQQAHQ LAFDSVFLRI KQQLLLVSRM
610 620 630 640 650
DSWNTAGIGE TLTDDLPAFS LTPLEYISNI GQYIMSLPLN LEPFVTQEDS
660 670 680 690 700
ALELALHAGK LPFPPEQGDE LPELDNMADN WLGSIARATM QTYCDVILQI
710 720 730 740 750
PEVTPHSTKQ LATDIDYLIN VMDALGLQPS RTLQNIAALL KAKPEEYRQV
760 770
SKGLPRRLAA TVATMRGVNY
Length:770
Mass (Da):86,073
Last modified:October 11, 2005 - v1
Checksum:i2DDE4F0E0923AB38
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti195 – 1951A → S in BAE32768. (PubMed:16141072)Curated
Sequence conflicti301 – 3011A → G in BAE32768. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145163 mRNA. Translation: BAE26269.1.
AK154693 mRNA. Translation: BAE32768.1.
CCDSiCCDS21805.1.
RefSeqiNP_001028490.2. NM_001033318.3.
UniGeneiMm.442015.

Genome annotation databases

EnsembliENSMUST00000057576; ENSMUSP00000058990; ENSMUSG00000034951.
GeneIDi233824.
KEGGimmu:233824.
UCSCiuc009jnz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145163 mRNA. Translation: BAE26269.1.
AK154693 mRNA. Translation: BAE32768.1.
CCDSiCCDS21805.1.
RefSeqiNP_001028490.2. NM_001033318.3.
UniGeneiMm.442015.

3D structure databases

ProteinModelPortaliQ3UM29.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ3UM29.

Proteomic databases

MaxQBiQ3UM29.
PaxDbiQ3UM29.
PRIDEiQ3UM29.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057576; ENSMUSP00000058990; ENSMUSG00000034951.
GeneIDi233824.
KEGGimmu:233824.
UCSCiuc009jnz.1. mouse.

Organism-specific databases

CTDi91949.
MGIiMGI:2685013. Cog7.

Phylogenomic databases

eggNOGiNOG288194.
GeneTreeiENSGT00390000001260.
HOGENOMiHOG000007766.
HOVERGENiHBG020364.
InParanoidiQ3UM29.
OrthoDBiEOG78SQH8.
PhylomeDBiQ3UM29.
TreeFamiTF324498.

Miscellaneous databases

NextBioi381863.
PROiQ3UM29.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UM29.
CleanExiMM_COG7.
GenevestigatoriQ3UM29.

Family and domain databases

InterProiIPR019335. COG7.
[Graphical view]
PANTHERiPTHR21443. PTHR21443. 1 hit.
PfamiPF10191. COG7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Mammary gland.

Entry informationi

Entry nameiCOG7_MOUSE
AccessioniPrimary (citable) accession number: Q3UM29
Secondary accession number(s): Q3U3L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 11, 2005
Last modified: February 4, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.