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Protein

Structural maintenance of chromosomes protein

Gene

Smc2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Structural maintenance of chromosomes proteinUniRule annotation
Gene namesi
Name:Smc2Imported
Synonyms:Smc2l1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:106067. Smc2.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiQ3ULS2.
PeptideAtlasiQ3ULS2.
PRIDEiQ3ULS2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099979.

Structurei

3D structure databases

ProteinModelPortaliQ3ULS2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini520 – 640SMC_hingeInterPro annotationAdd BLAST121

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili246 – 294Sequence analysisAdd BLAST49
Coiled coili324 – 351Sequence analysisAdd BLAST28
Coiled coili402 – 502Sequence analysisAdd BLAST101
Coiled coili681 – 725Sequence analysisAdd BLAST45
Coiled coili738 – 874Sequence analysisAdd BLAST137
Coiled coili903 – 930Sequence analysisAdd BLAST28
Coiled coili984 – 1011Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the SMC family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0933. Eukaryota.
COG1196. LUCA.
HOGENOMiHOG000163792.
HOVERGENiHBG106605.
KOiK06674.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
InterProiIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR027120. Smc2.
IPR010935. SMC_hinge.
[Graphical view]
PANTHERiPTHR18937:SF9. PTHR18937:SF9. 1 hit.
PfamiPF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005719. SMC. 1 hit.
SMARTiSM00968. SMC_hinge. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF75553. SSF75553. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3ULS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYVKSIILEG FKSYAQRTEV NGFDPLFNAI TGLNGSGKSN ILDSICFLLG
60 70 80 90 100
ISNLSQVRAS NLQDLVYKNG QAGITKASVS ITFDNSDKKQ SPLGFVAHDE
110 120 130 140 150
ITVTRQVVIG GRNKYLINGV NANNTRVQDL FCSVGLNVNN PHFLIMQGRI
160 170 180 190 200
TKVLNMKPPE ILSMIEEAAG TRMYEYKKIA AQKTIEKKEA KLKEIKTILE
210 220 230 240 250
EEITPTIQKL KEERSSYLEY QKVMREIEHL SRLYIAYQFL RAEDTKERSA
260 270 280 290 300
GELKEMQDKI VNLQEVLSEN EKKIKALNCE IEELERRKDK ETGGKLKSLE
310 320 330 340 350
DACAEAQRVN TKSQSAFDLK KKNLASEETK RKELQNSMAE DSKALAAKEK
360 370 380 390 400
EVKKITDGLH GLQEASNKDA EALAAAQQHF NAVSAGLSSN EDGAEATLAG
410 420 430 440 450
QMIACKNDIS KAQTEAKQAQ MKLKHAQQEL KSKQAEVKKM DSGYKKDQDA
460 470 480 490 500
FEAVKKAKEK LETEMKKLNY EENKEEKLLE KHRQLSRDIN NLKGKHEALL
510 520 530 540 550
AKFPNLQFAY KDPEKNWNRN SVKGLVASLI NVKDNSTATA LEVVAGERLY
560 570 580 590 600
NVVVDTEVTA KKLLEKGELK RRYTIIPLNK ISARCIAPET LRVAQNLVGP
610 620 630 640 650
DNVHVALSLV DYKPELQKGM EFVFGTTFVC NNMDNAKKVA FDKRIMTRTV
660 670 680 690 700
TLGGDVFDPH GTLSGGARSQ AASILTKFQE VKDVQDELRT KENELRALEE
710 720 730 740 750
ELAGLKNVAE KYRQLKQQWE MKTEEGDLLQ TKLQQSSYHK QQEELDALKK
760 770 780 790 800
TIEESEETLK STKEIQKKAE EKYEALENKM KNAEAEREKE LKDAQKKLDC
810 820 830 840 850
AKTKADASSK KMKEKQQEVE AITLELEELK REHASNEQQL DAVNEAIKAY
860 870 880 890 900
EGQIEKMAAE VAKNKESVNK AQDELMKQKQ IITAQDNIIK DKCAEVAKHN
910 920 930 940 950
LQNNESQLKI KELDHSISKH KREADDAAAK VSKMLSDYDW INAEKHLFGQ
960 970 980 990 1000
PNSAYDFKTN NPKEAGQRLQ KLQEVKEKLG RNDNLRAMNV LTEAEERYND
1010 1020 1030 1040 1050
LMKKKRIVEN DKSKILATIE DLDQKKNQAL NIAWQKVNKD FGSIFSTLLP
1060 1070 1080 1090 1100
GANAMLAPPE GQTVLDGLEF KVALGNTWKE NLTELSGGQR SLVALSLILS
1110 1120 1130 1140 1150
MLLFKPAPIY ILDEVDAALD LSHTQNIGQM LRTHFTHSQF IVVSLKEGMF
1160 1170 1180 1190 1200
NNANVLFKTK FVDGVSTVAR FTQSQAGKIP KEAKLQRKRT QLSACQFRVQ
1210 1220 1230
TSHLDVFTHE LPRIWDPSCL YNNVNIIFIC NSF
Length:1,233
Mass (Da):139,292
Last modified:October 11, 2005 - v1
Checksum:i7A7DCEA12AD1804F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145341 mRNA. Translation: BAE26376.1.
RefSeqiNP_001288341.1. NM_001301412.1.
NP_032043.3. NM_008017.4.
UniGeneiMm.2999.

Genome annotation databases

GeneIDi14211.
KEGGimmu:14211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145341 mRNA. Translation: BAE26376.1.
RefSeqiNP_001288341.1. NM_001301412.1.
NP_032043.3. NM_008017.4.
UniGeneiMm.2999.

3D structure databases

ProteinModelPortaliQ3ULS2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099979.

Proteomic databases

PaxDbiQ3ULS2.
PeptideAtlasiQ3ULS2.
PRIDEiQ3ULS2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi14211.
KEGGimmu:14211.

Organism-specific databases

CTDi10592.
MGIiMGI:106067. Smc2.

Phylogenomic databases

eggNOGiKOG0933. Eukaryota.
COG1196. LUCA.
HOGENOMiHOG000163792.
HOVERGENiHBG106605.
KOiK06674.

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
InterProiIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR027120. Smc2.
IPR010935. SMC_hinge.
[Graphical view]
PANTHERiPTHR18937:SF9. PTHR18937:SF9. 1 hit.
PfamiPF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005719. SMC. 1 hit.
SMARTiSM00968. SMC_hinge. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF75553. SSF75553. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ3ULS2_MOUSE
AccessioniPrimary (citable) accession number: Q3ULS2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.