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Q3ULR1 (Q3ULR1_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
Gene names
Name:Bmp4 MGI 88180 EMBL EDL20710.1
ORF Names:mCG_4634 EMBL EDL20710.1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length408 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the TGF-beta family. RuleBase RU000354

Ontologies

Keywords
   Cellular componentSecreted SAAS SAAS001111
   Molecular functionGrowth factor SAAS SAAS001111 RuleBase RU000354
   PTMDisulfide bond SAAS SAAS001111
Gene Ontology (GO)
   Biological_processBMP signaling pathway

Inferred from direct assay PubMed 14623234PubMed 17472960. Source: MGI

BMP signaling pathway involved in heart induction

Inferred from electronic annotation. Source: Compara

BMP signaling pathway involved in nephric duct formation

Inferred from electronic annotation. Source: Compara

SMAD protein signal transduction

Inferred from direct assay PubMed 9420335. Source: MGI

activation of MAPKK activity

Inferred from electronic annotation. Source: Compara

angiogenesis

Inferred from mutant phenotype PubMed 15070745. Source: MGI

anterior/posterior axis specification

Inferred from genetic interaction PubMed 10964473. Source: MGI

blood vessel endothelial cell proliferation involved in sprouting angiogenesis

Inferred from electronic annotation. Source: Compara

branching involved in prostate gland morphogenesis

Inferred from mutant phenotype PubMed 11401393. Source: MGI

branching involved in ureteric bud morphogenesis

Inferred from genetic interaction PubMed 17522159. Source: MGI

bronchus development

Inferred from sequence orthology PubMed 8674409. Source: MGI

bud dilation involved in lung branching

Inferred from sequence orthology PubMed 8674409. Source: MGI

bud elongation involved in lung branching

Inferred from direct assay PubMed 18367557. Source: MGI

cellular response to growth factor stimulus

Inferred from direct assay PubMed 7848824. Source: MGI

cranial suture morphogenesis

Inferred from direct assay PubMed 9477322. Source: MGI

dorsal/ventral neural tube patterning

Inferred from direct assay PubMed 15218525. Source: MGI

embryonic cranial skeleton morphogenesis

Inferred from mutant phenotype PubMed 9268572. Source: MGI

embryonic digit morphogenesis

Inferred from genetic interaction PubMed 9268572. Source: MGI

embryonic hindlimb morphogenesis

Inferred from genetic interaction PubMed 10964473. Source: MGI

embryonic skeletal joint morphogenesis

Inferred from mutant phenotype PubMed 9664686. Source: MGI

epithelial cell proliferation involved in lung morphogenesis

Inferred from sequence orthology PubMed 8674409. Source: MGI

epithelial-mesenchymal cell signaling

Inferred from direct assay PubMed 8104708. Source: MGI

erythrocyte differentiation

Inferred from direct assay PubMed 15591122. Source: MGI

germ cell development

Inferred from mutant phenotype PubMed 15289457. Source: MGI

heart development

Inferred from mutant phenotype PubMed 12975322PubMed 15070745. Source: MGI

hematopoietic progenitor cell differentiation

Inferred from direct assay PubMed 7799920. Source: MGI

inner ear receptor cell differentiation

Inferred from genetic interaction PubMed 17555714. Source: MGI

intermediate mesodermal cell differentiation

Inferred from electronic annotation. Source: Compara

lens induction in camera-type eye

Inferred from mutant phenotype PubMed 9851982. Source: MGI

lung alveolus development

Inferred from sequence orthology PubMed 8674409. Source: MGI

lymphoid progenitor cell differentiation

Inferred from electronic annotation. Source: Compara

macrophage differentiation

Inferred from electronic annotation. Source: Compara

mammary gland formation

Inferred from mutant phenotype PubMed 17071745. Source: MGI

mesenchymal to epithelial transition involved in metanephros morphogenesis

Inferred from electronic annotation. Source: Compara

mesodermal cell fate determination

Inferred from mutant phenotype PubMed 7657163. Source: MGI

mesonephros development

Inferred from electronic annotation. Source: Compara

metanephros development

Inferred from direct assay PubMed 12631064. Source: MGI

monocyte differentiation

Inferred from electronic annotation. Source: Compara

negative regulation of MAP kinase activity

Inferred from electronic annotation. Source: Compara

negative regulation of T cell differentiation in thymus

Inferred from electronic annotation. Source: Compara

negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway

Inferred from electronic annotation. Source: Compara

negative regulation of branching involved in ureteric bud morphogenesis

Inferred from electronic annotation. Source: Compara

negative regulation of cell proliferation involved in heart morphogenesis

Inferred from electronic annotation. Source: Compara

negative regulation of chondrocyte differentiation

Inferred from direct assay PubMed 17481601. Source: MGI

negative regulation of epithelial cell proliferation

Inferred from mutant phenotype PubMed 11401393. Source: MGI

negative regulation of glomerular mesangial cell proliferation

Inferred from electronic annotation. Source: Compara

negative regulation of glomerulus development

Inferred from electronic annotation. Source: Compara

negative regulation of immature T cell proliferation in thymus

Inferred from electronic annotation. Source: Compara

negative regulation of mesenchymal cell proliferation involved in ureter development

Inferred from electronic annotation. Source: Compara

negative regulation of metanephric S-shaped body morphogenesis

Inferred from electronic annotation. Source: Compara

negative regulation of metanephric comma-shaped body morphogenesis

Inferred from electronic annotation. Source: Compara

negative regulation of mitosis

Inferred from electronic annotation. Source: Compara

negative regulation of myoblast differentiation

Inferred from electronic annotation. Source: Compara

negative regulation of prostatic bud formation

Inferred from direct assay PubMed 18393306. Source: MGI

negative regulation of striated muscle tissue development

Inferred from electronic annotation. Source: Compara

negative regulation of thymocyte apoptotic process

Inferred from electronic annotation. Source: Compara

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 9585504. Source: MGI

neural tube closure

Inferred from direct assay PubMed 19850029. Source: MGI

neuron fate commitment

Inferred from direct assay PubMed 17698011. Source: MGI

odontogenesis of dentin-containing tooth

Inferred from direct assay PubMed 15525533PubMed 16179481. Source: MGI

organ induction

Inferred from mutant phenotype PubMed 9806931. Source: MGI

osteoblast differentiation

Inferred from direct assay PubMed 15381701. Source: MGI

pituitary gland development

Inferred from mutant phenotype PubMed 9806931. Source: MGI

positive regulation of DNA-dependent DNA replication

Inferred from electronic annotation. Source: Compara

positive regulation of ERK1 and ERK2 cascade

Inferred from direct assay PubMed 18692041. Source: MGI

positive regulation of SMAD protein import into nucleus

Inferred from electronic annotation. Source: Compara

positive regulation of apoptotic process

Inferred from sequence orthology PubMed 9187146. Source: MGI

positive regulation of bone mineralization

Inferred from electronic annotation. Source: Compara

positive regulation of cardiac muscle fiber development

Inferred from electronic annotation. Source: Compara

positive regulation of cartilage development

Inferred from sequence orthology PubMed 3201241. Source: MGI

positive regulation of cell proliferation

Inferred from mutant phenotype PubMed 18692041. Source: MGI

positive regulation of collagen biosynthetic process

Inferred from electronic annotation. Source: Compara

positive regulation of endothelial cell migration

Inferred from electronic annotation. Source: Compara

positive regulation of endothelial cell proliferation

Inferred from electronic annotation. Source: Compara

positive regulation of kidney development

Inferred from electronic annotation. Source: Compara

positive regulation of neuron differentiation

Inferred from direct assay PubMed 9786991. Source: MGI

positive regulation of ossification

Inferred from direct assay PubMed 8358941. Source: MGI

positive regulation of pathway-restricted SMAD protein phosphorylation

Inferred from electronic annotation. Source: Compara

positive regulation of protein phosphorylation

Inferred from mutant phenotype PubMed 18692041. Source: MGI

positive regulation of smooth muscle cell proliferation

Inferred from electronic annotation. Source: Compara

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 10391928PubMed 18692041PubMed 18776146PubMed 8104708PubMed 8769660PubMed 8898217PubMed 9477322PubMed 9501024. Source: MGI

post-embryonic development

Inferred from mutant phenotype PubMed 9268572. Source: MGI

protein localization to nucleus

Inferred from electronic annotation. Source: Compara

pulmonary artery endothelial tube morphogenesis

Inferred from electronic annotation. Source: Compara

regulation of branching involved in prostate gland morphogenesis

Inferred from mutant phenotype PubMed 15772937. Source: MGI

regulation of odontogenesis of dentin-containing tooth

Inferred from genetic interaction PubMed 9244299. Source: MGI

regulation of smooth muscle cell differentiation

Inferred from direct assay PubMed 17881493. Source: MGI

regulation of smooth muscle cell proliferation

Inferred from direct assay PubMed 15800000. Source: MGI

renal system process

Inferred from mutant phenotype PubMed 9268572. Source: MGI

secondary heart field specification

Inferred from electronic annotation. Source: Compara

smooth muscle cell differentiation

Inferred from direct assay PubMed 16546160. Source: MGI

smoothened signaling pathway

Inferred from electronic annotation. Source: Compara

specification of organ position

Inferred from mutant phenotype PubMed 17071745. Source: MGI

specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway

Inferred from electronic annotation. Source: Compara

steroid hormone mediated signaling pathway

Inferred from electronic annotation. Source: Compara

telencephalon regionalization

Inferred from direct assay PubMed 16855091. Source: MGI

trachea formation

Inferred from mutant phenotype PubMed 18692041. Source: MGI

type B pancreatic cell development

Inferred from electronic annotation. Source: Compara

   Cellular_componentextracellular space

Inferred from direct assay PubMed 17481601. Source: MGI

   Molecular_functionBMP receptor binding

Inferred from sequence orthology PubMed 7811286. Source: MGI

chemoattractant activity

Inferred from electronic annotation. Source: Compara

heparin binding

Inferred from direct assay PubMed 15381701. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q3ULR1 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 35053D844624EF9D

FASTA40846,497
        10         20         30         40         50         60 
MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS HELLRDFEAT 

        70         80         90        100        110        120 
LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEEQS QGTGLEYPER PASRANTVRS 

       130        140        150        160        170        180 
FHHEEHLENI PGTSESSAFR FLFNLSSIPE NEVISSAELR LFREQVDQGP DWEQGFHRIN 

       190        200        210        220        230        240 
IYEVMKPPAE MVPGHLITRL LDTRLVHHNV TRWETFDVSP AVLRWTREKQ PNYGLAIEVT 

       250        260        270        280        290        300 
HLHQTRTHQG QHVRISRSLP QGSGDWAQLR PLLVTFGHDG RGHTLTRRRA KRSPKHHPQR 

       310        320        330        340        350        360 
SRKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN STNHAIVQTL 

       370        380        390        400 
VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM VVEGCGCR 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE26387.1.
Tissue: Cecum EMBL BAE23027.1 and Whole body EMBL BAE26387.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE26387.1.
Tissue: Cecum EMBL BAE23027.1 and Whole body EMBL BAE26387.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE26387.1.
Tissue: Cecum EMBL BAE23027.1 and Whole body EMBL BAE26387.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE26387.1.
Tissue: Cecum EMBL BAE23027.1 and Whole body EMBL BAE26387.1.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE26387.1.
Tissue: Cecum EMBL BAE23027.1 and Whole body EMBL BAE26387.1.
[6]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL20710.1.
[7]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE26387.1.
Tissue: Cecum EMBL BAE23027.1 and Whole body EMBL BAE26387.1.
[8]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE26387.1.
Tissue: Cecum EMBL BAE23027.1 and Whole body EMBL BAE26387.1.
[9]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE26387.1.
Tissue: Cecum EMBL BAE23027.1 and Whole body EMBL BAE26387.1.
[10]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL20710.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK136527 mRNA. Translation: BAE23027.1.
AK145359 mRNA. Translation: BAE26387.1.
CH466605 Genomic DNA. Translation: EDL20710.1.
CH466605 Genomic DNA. Translation: EDL20712.1.
IPIIPI00761842.
RefSeqNP_031580.2. NM_007554.2.
UniGeneMm.6813.

3D structure databases

SMRQ3ULR1. Positions 307-408.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID12159.
KEGGmmu:12159.
UCSCuc007thd.1. mouse.

Organism-specific databases

CTD652.
MGIMGI:88180. Bmp4.

Phylogenomic databases

GeneTreeENSGT00690000101685.
HOVERGENHBG004860.
InParanoidQ3ULR1.
KOK04662.
OMAQGFHRIN.

Gene expression databases

GenevestigatorQ3ULR1.

Family and domain databases

InterProIPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio280503.
SOURCESearch...

Entry information

Entry nameQ3ULR1_MOUSE
AccessionPrimary (citable) accession number: Q3ULR1
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 3, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)