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Protein

Glycerol-3-phosphate dehydrogenase 1-like protein

Gene

Gpd1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.By similarity

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei43NADBy similarity1
Binding sitei99NADBy similarity1
Binding sitei122SubstrateBy similarity1
Binding sitei155NAD; via amide nitrogenBy similarity1
Active sitei206Proton acceptorBy similarity1
Binding sitei271NADBy similarity1
Binding sitei298NAD; via amide nitrogenBy similarity1
Binding sitei300NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 17NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiR-MMU-1483166. Synthesis of PA.
R-MMU-75109. Triglyceride Biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase 1-like protein (EC:1.1.1.8)
Gene namesi
Name:Gpd1l
Synonyms:Kiaa0089
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1289257. Gpd1l.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002865121 – 351Glycerol-3-phosphate dehydrogenase 1-like proteinAdd BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei156PhosphoserineBy similarity1
Modified residuei291N6-succinyllysineBy similarity1
Modified residuei328PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3ULJ0.
PaxDbiQ3ULJ0.
PeptideAtlasiQ3ULJ0.
PRIDEiQ3ULJ0.

PTM databases

iPTMnetiQ3ULJ0.
PhosphoSitePlusiQ3ULJ0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000050627.
CleanExiMM_GPD1L.
ExpressionAtlasiQ3ULJ0. baseline and differential.
GenevisibleiQ3ULJ0. MM.

Interactioni

Subunit structurei

Interacts with SCN5A.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ3ULJ0. 1 interactor.
MINTiMINT-4113076.
STRINGi10090.ENSMUSP00000117509.

Structurei

3D structure databases

ProteinModelPortaliQ3ULJ0.
SMRiQ3ULJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni271 – 272Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2711. Eukaryota.
COG0240. LUCA.
GeneTreeiENSGT00390000003114.
HOGENOMiHOG000246855.
HOVERGENiHBG003669.
InParanoidiQ3ULJ0.
KOiK00006.
OMAiLFSEWIG.
OrthoDBiEOG091G0DO6.
PhylomeDBiQ3ULJ0.
TreeFamiTF300836.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3ULJ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAPLKVCI VGSGNWGSAV AKIIGSNVKT LQKFSSTVKM WVFEETVNGR
60 70 80 90 100
KLTDIINNDH ENVKYLPGHK LPENVVAVPN LSEAVQDADL LVFVIPHQFI
110 120 130 140 150
HKICDEITGR VPEKALGITL IKGIDEGPDG LKLISDIIRE KMGIDISVLM
160 170 180 190 200
GANIASEVAA EKFCETTIGS KVMQNGLLFK ELLQTPNFRI TVVDDADTVE
210 220 230 240 250
LCGALKNIVA VGAGFCDGLR CGDNTKAAVI RLGLMEMIAF AKIFCKGQVS
260 270 280 290 300
TATFLESCGV ADLITTCYGG RNRRVAEAFA RTGKTIEELE KELLNGQKLQ
310 320 330 340 350
GPQTSAEVYR ILRQKGLLDK FPLFTAVYQI CYEGRPVTQM LSCLQSHPEH

I
Length:351
Mass (Da):38,226
Last modified:May 15, 2007 - v2
Checksum:iBE192D41F592E577
GO
Isoform 2 (identifier: Q3ULJ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     321-351: Missing.

Note: No experimental confirmation available.
Show »
Length:320
Mass (Da):34,634
Checksum:i690C96D09F52BC54
GO

Sequence cautioni

The sequence AAH37729 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD32164 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26S → G in BAC36001 (PubMed:16141072).Curated1
Sequence conflicti179F → S in BAC36001 (PubMed:16141072).Curated1
Sequence conflicti202C → W in BAC36001 (PubMed:16141072).Curated1
Sequence conflicti212G → V in BAC36001 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025062321 – 351Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172886 mRNA. Translation: BAD32164.1. Different initiation.
AK050572 mRNA. Translation: BAC34327.1.
AK075845 mRNA. Translation: BAC36001.1.
AK145475 mRNA. Translation: BAE26458.1.
BC037729 mRNA. Translation: AAH37729.1. Different initiation.
CCDSiCCDS23598.1. [Q3ULJ0-1]
RefSeqiNP_780589.3. NM_175380.5. [Q3ULJ0-1]
UniGeneiMm.38198.

Genome annotation databases

EnsembliENSMUST00000084853; ENSMUSP00000081913; ENSMUSG00000050627. [Q3ULJ0-2]
ENSMUST00000146623; ENSMUSP00000117509; ENSMUSG00000050627. [Q3ULJ0-1]
GeneIDi333433.
KEGGimmu:333433.
UCSCiuc009ryj.2. mouse. [Q3ULJ0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172886 mRNA. Translation: BAD32164.1. Different initiation.
AK050572 mRNA. Translation: BAC34327.1.
AK075845 mRNA. Translation: BAC36001.1.
AK145475 mRNA. Translation: BAE26458.1.
BC037729 mRNA. Translation: AAH37729.1. Different initiation.
CCDSiCCDS23598.1. [Q3ULJ0-1]
RefSeqiNP_780589.3. NM_175380.5. [Q3ULJ0-1]
UniGeneiMm.38198.

3D structure databases

ProteinModelPortaliQ3ULJ0.
SMRiQ3ULJ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3ULJ0. 1 interactor.
MINTiMINT-4113076.
STRINGi10090.ENSMUSP00000117509.

PTM databases

iPTMnetiQ3ULJ0.
PhosphoSitePlusiQ3ULJ0.

Proteomic databases

MaxQBiQ3ULJ0.
PaxDbiQ3ULJ0.
PeptideAtlasiQ3ULJ0.
PRIDEiQ3ULJ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084853; ENSMUSP00000081913; ENSMUSG00000050627. [Q3ULJ0-2]
ENSMUST00000146623; ENSMUSP00000117509; ENSMUSG00000050627. [Q3ULJ0-1]
GeneIDi333433.
KEGGimmu:333433.
UCSCiuc009ryj.2. mouse. [Q3ULJ0-1]

Organism-specific databases

CTDi23171.
MGIiMGI:1289257. Gpd1l.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2711. Eukaryota.
COG0240. LUCA.
GeneTreeiENSGT00390000003114.
HOGENOMiHOG000246855.
HOVERGENiHBG003669.
InParanoidiQ3ULJ0.
KOiK00006.
OMAiLFSEWIG.
OrthoDBiEOG091G0DO6.
PhylomeDBiQ3ULJ0.
TreeFamiTF300836.

Enzyme and pathway databases

ReactomeiR-MMU-1483166. Synthesis of PA.
R-MMU-75109. Triglyceride Biosynthesis.

Miscellaneous databases

PROiQ3ULJ0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050627.
CleanExiMM_GPD1L.
ExpressionAtlasiQ3ULJ0. baseline and differential.
GenevisibleiQ3ULJ0. MM.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGPD1L_MOUSE
AccessioniPrimary (citable) accession number: Q3ULJ0
Secondary accession number(s): Q6A0D2
, Q8BVZ7, Q8BWM5, Q8CFN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 2, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.