SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q3ULJ0

- GPD1L_MOUSE

UniProt

Q3ULJ0 - GPD1L_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glycerol-3-phosphate dehydrogenase 1-like protein

Gene
Gpd1l, Kiaa0089
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L By similarity.

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431NAD By similarity
Binding sitei99 – 991NAD By similarity
Binding sitei122 – 1221Substrate By similarity
Binding sitei155 – 1551NAD; via amide nitrogen By similarity
Active sitei206 – 2061Proton acceptor By similarity
Binding sitei271 – 2711NAD By similarity
Binding sitei298 – 2981NAD; via amide nitrogen By similarity
Binding sitei300 – 3001NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 176NAD By similarity

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro
  3. sodium channel regulator activity Source: Ensembl

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate catabolic process Source: InterPro
  3. NADH metabolic process Source: MGI
  4. negative regulation of peptidyl-serine phosphorylation Source: Ensembl
  5. negative regulation of protein kinase C signaling Source: Ensembl
  6. positive regulation of protein localization to cell surface Source: Ensembl
  7. positive regulation of sodium ion transport Source: Ensembl
  8. regulation of heart rate Source: Ensembl
  9. regulation of sodium ion transmembrane transporter activity Source: Ensembl
  10. regulation of ventricular cardiac muscle cell membrane depolarization Source: Ensembl
  11. ventricular cardiac muscle cell action potential Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_188640. Synthesis of PA.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase 1-like protein (EC:1.1.1.8)
Gene namesi
Name:Gpd1l
Synonyms:Kiaa0089
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1289257. Gpd1l.

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
  2. membrane Source: BHF-UCL
  3. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Glycerol-3-phosphate dehydrogenase 1-like proteinPRO_0000286512Add
BLAST

Proteomic databases

MaxQBiQ3ULJ0.
PaxDbiQ3ULJ0.
PRIDEiQ3ULJ0.

PTM databases

PhosphoSiteiQ3ULJ0.

Expressioni

Gene expression databases

ArrayExpressiQ3ULJ0.
BgeeiQ3ULJ0.
CleanExiMM_GPD1L.
GenevestigatoriQ3ULJ0.

Interactioni

Subunit structurei

Interacts with SCN5A By similarity.

Protein-protein interaction databases

IntActiQ3ULJ0. 1 interaction.
MINTiMINT-4113076.

Structurei

3D structure databases

ProteinModelPortaliQ3ULJ0.
SMRiQ3ULJ0. Positions 4-346.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni271 – 2722Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0240.
GeneTreeiENSGT00390000003114.
HOGENOMiHOG000246855.
HOVERGENiHBG003669.
InParanoidiQ3ULJ0.
KOiK00006.
OMAiKIFCKGQ.
OrthoDBiEOG7ZKSBS.
PhylomeDBiQ3ULJ0.
TreeFamiTF300836.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3ULJ0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAAPLKVCI VGSGNWGSAV AKIIGSNVKT LQKFSSTVKM WVFEETVNGR    50
KLTDIINNDH ENVKYLPGHK LPENVVAVPN LSEAVQDADL LVFVIPHQFI 100
HKICDEITGR VPEKALGITL IKGIDEGPDG LKLISDIIRE KMGIDISVLM 150
GANIASEVAA EKFCETTIGS KVMQNGLLFK ELLQTPNFRI TVVDDADTVE 200
LCGALKNIVA VGAGFCDGLR CGDNTKAAVI RLGLMEMIAF AKIFCKGQVS 250
TATFLESCGV ADLITTCYGG RNRRVAEAFA RTGKTIEELE KELLNGQKLQ 300
GPQTSAEVYR ILRQKGLLDK FPLFTAVYQI CYEGRPVTQM LSCLQSHPEH 350
I 351
Length:351
Mass (Da):38,226
Last modified:May 15, 2007 - v2
Checksum:iBE192D41F592E577
GO
Isoform 2 (identifier: Q3ULJ0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     321-351: Missing.

Note: No experimental confirmation available.

Show »
Length:320
Mass (Da):34,634
Checksum:i690C96D09F52BC54
GO

Sequence cautioni

The sequence AAH37729.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAD32164.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei321 – 35131Missing in isoform 2. VSP_025062Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261S → G in BAC36001. 1 Publication
Sequence conflicti179 – 1791F → S in BAC36001. 1 Publication
Sequence conflicti202 – 2021C → W in BAC36001. 1 Publication
Sequence conflicti212 – 2121G → V in BAC36001. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK172886 mRNA. Translation: BAD32164.1. Different initiation.
AK050572 mRNA. Translation: BAC34327.1.
AK075845 mRNA. Translation: BAC36001.1.
AK145475 mRNA. Translation: BAE26458.1.
BC037729 mRNA. Translation: AAH37729.1. Different initiation.
CCDSiCCDS23598.1. [Q3ULJ0-1]
RefSeqiNP_780589.3. NM_175380.5. [Q3ULJ0-1]
UniGeneiMm.38198.

Genome annotation databases

EnsembliENSMUST00000084853; ENSMUSP00000081913; ENSMUSG00000050627. [Q3ULJ0-2]
ENSMUST00000146623; ENSMUSP00000117509; ENSMUSG00000050627. [Q3ULJ0-1]
GeneIDi333433.
KEGGimmu:333433.
UCSCiuc009ryj.2. mouse. [Q3ULJ0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK172886 mRNA. Translation: BAD32164.1 . Different initiation.
AK050572 mRNA. Translation: BAC34327.1 .
AK075845 mRNA. Translation: BAC36001.1 .
AK145475 mRNA. Translation: BAE26458.1 .
BC037729 mRNA. Translation: AAH37729.1 . Different initiation.
CCDSi CCDS23598.1. [Q3ULJ0-1 ]
RefSeqi NP_780589.3. NM_175380.5. [Q3ULJ0-1 ]
UniGenei Mm.38198.

3D structure databases

ProteinModelPortali Q3ULJ0.
SMRi Q3ULJ0. Positions 4-346.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q3ULJ0. 1 interaction.
MINTi MINT-4113076.

PTM databases

PhosphoSitei Q3ULJ0.

Proteomic databases

MaxQBi Q3ULJ0.
PaxDbi Q3ULJ0.
PRIDEi Q3ULJ0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000084853 ; ENSMUSP00000081913 ; ENSMUSG00000050627 . [Q3ULJ0-2 ]
ENSMUST00000146623 ; ENSMUSP00000117509 ; ENSMUSG00000050627 . [Q3ULJ0-1 ]
GeneIDi 333433.
KEGGi mmu:333433.
UCSCi uc009ryj.2. mouse. [Q3ULJ0-1 ]

Organism-specific databases

CTDi 23171.
MGIi MGI:1289257. Gpd1l.
Rougei Search...

Phylogenomic databases

eggNOGi COG0240.
GeneTreei ENSGT00390000003114.
HOGENOMi HOG000246855.
HOVERGENi HBG003669.
InParanoidi Q3ULJ0.
KOi K00006.
OMAi KIFCKGQ.
OrthoDBi EOG7ZKSBS.
PhylomeDBi Q3ULJ0.
TreeFami TF300836.

Enzyme and pathway databases

Reactomei REACT_188640. Synthesis of PA.

Miscellaneous databases

NextBioi 399982.
PROi Q3ULJ0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q3ULJ0.
Bgeei Q3ULJ0.
CleanExi MM_GPD1L.
Genevestigatori Q3ULJ0.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11728. PTHR11728. 1 hit.
Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSi PR00077. GPDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Fetal brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Stomach and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye.
  4. Lubec G., Klug S.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 207-220, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hippocampus.

Entry informationi

Entry nameiGPD1L_MOUSE
AccessioniPrimary (citable) accession number: Q3ULJ0
Secondary accession number(s): Q6A0D2
, Q8BVZ7, Q8BWM5, Q8CFN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: September 3, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi