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Q3ULB5

- PAK6_MOUSE

UniProt

Q3ULB5 - PAK6_MOUSE

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Protein

Serine/threonine-protein kinase PAK 6

Gene

Pak6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD By similarity.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei437 – 4371ATPPROSITE-ProRule annotation
Active sitei527 – 5271Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi414 – 4229ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. learning Source: MGI
  2. locomotory behavior Source: MGI
  3. memory Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PAK 6 (EC:2.7.11.1)
Alternative name(s):
p21-activated kinase 6
Short name:
PAK-6
Gene namesi
Name:Pak6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2679420. Pak6.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Cotranslocates into nucleus with AR in response to androgen induction.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 682682Serine/threonine-protein kinase PAK 6PRO_0000278117Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei561 – 5611Phosphoserine; by autocatalysisBy similarity

Post-translational modificationi

Autophosphorylated. Phosphorylated by MAP2K6/MAPKK6, leading to PAK6 activation By similarity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3ULB5.
PRIDEiQ3ULB5.

PTM databases

PhosphoSiteiQ3ULB5.

Expressioni

Gene expression databases

BgeeiQ3ULB5.
CleanExiMM_PAK6.
GenevestigatoriQ3ULB5.

Interactioni

Subunit structurei

Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with the androgen receptor AR. Interacts with IQGAP1 and PPM1B By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ3ULB5.
SMRiQ3ULB5. Positions 11-45, 341-675.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 2514CRIBPROSITE-ProRule annotationAdd
BLAST
Domaini408 – 659252Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 407382LinkerBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 85Poly-Lys

Sequence similaritiesi

Contains 1 CRIB domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119176.
HOGENOMiHOG000234205.
HOVERGENiHBG108518.
InParanoidiQ3ULB5.
KOiK05735.
OMAiVPWPEPQ.
OrthoDBiEOG73804D.
PhylomeDBiQ3ULB5.
TreeFamiTF105352.

Family and domain databases

Gene3Di3.90.810.10. 1 hit.
InterProiIPR000095. CRIB_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view]
PfamiPF00786. PBD. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00285. PBD. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50108. CRIB. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3ULB5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFRKKKKKRP EISAPQNFQH RVHTSFDPKE GKFVGLPPQW QNILDTLRRP
60 70 80 90 100
KPVVDPSRIT RVQLQPMKTV VRGSSVPTEG YISGLLNDIQ KLSVISSNTL
110 120 130 140 150
RGRSPTSRRR AQSLGLLGDD QWAADPDMYL QSPQSEHTDP HGLYLSCNGG
160 170 180 190 200
TPAGHRQVPW PEPQSPQALP NGMAAKAQSL GPAEFQGASQ RCLQQLGACL
210 220 230 240 250
QSSPPGTSPP MATGRRGVKV AKHSSEEARP QSCLVGSAIG RPGGEGSPSP
260 270 280 290 300
KNQESSLKHR LFRSMFLSTP ATGAASSSKP VPLPQNKPNS AFRPPQKDSS
310 320 330 340 350
SNLVAKAQSL PSEQPMGTFS PLTTSDTSSP QKSLRTAPAA GPLPGRSSPA
360 370 380 390 400
GSPRTRHAQI STSNLYLPQD PTVAKGALGG EDTGIVTHEQ FKAALRMVVD
410 420 430 440 450
QGDPRLLLDS YVKIGEGSTG IVCLAREKHS GRQVAVKMMD LRKQQRRELL
460 470 480 490 500
FNEVVIMRDY QHLNVVEMYK SYLVGEELWV LMEFLQGGAL TDIISQVRLN
510 520 530 540 550
EEQIATVCEA VLQALAYLHA QGVIHRDIKS DSILLTLDGR VKLSDFGFCA
560 570 580 590 600
QISKDVPKRK SLVGTPYWMA PEVISRSLYA TEVDIWSLGI MVIEMVDGEP
610 620 630 640 650
PYFSDSPVQA MKRLRDSAPP KLKNSYKVSP VLRDFLDRML VREPQERATA
660 670 680
QELLDHPFLL QTGLPECLVP LIQLYRKQTS TC
Length:682
Mass (Da):74,867
Last modified:October 11, 2005 - v1
Checksum:iF9D415D49A130C0C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti667 – 6671C → R in BAE34737. (PubMed:16141072)Curated
Sequence conflicti667 – 6671C → R in BAE34725. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK145601 mRNA. Translation: BAE26534.1.
AK158913 mRNA. Translation: BAE34725.1.
AK158944 mRNA. Translation: BAE34737.1.
AL845470 Genomic DNA. Translation: CAM17416.1.
CCDSiCCDS16580.1.
RefSeqiNP_001028426.2. NM_001033254.3.
NP_001139326.1. NM_001145854.1.
UniGeneiMm.241857.

Genome annotation databases

EnsembliENSMUST00000099557; ENSMUSP00000097153; ENSMUSG00000074923.
ENSMUST00000110853; ENSMUSP00000106477; ENSMUSG00000074923.
GeneIDi214230.
KEGGimmu:214230.
UCSCiuc008lsf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK145601 mRNA. Translation: BAE26534.1 .
AK158913 mRNA. Translation: BAE34725.1 .
AK158944 mRNA. Translation: BAE34737.1 .
AL845470 Genomic DNA. Translation: CAM17416.1 .
CCDSi CCDS16580.1.
RefSeqi NP_001028426.2. NM_001033254.3.
NP_001139326.1. NM_001145854.1.
UniGenei Mm.241857.

3D structure databases

ProteinModelPortali Q3ULB5.
SMRi Q3ULB5. Positions 11-45, 341-675.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q3ULB5.

Proteomic databases

MaxQBi Q3ULB5.
PRIDEi Q3ULB5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000099557 ; ENSMUSP00000097153 ; ENSMUSG00000074923 .
ENSMUST00000110853 ; ENSMUSP00000106477 ; ENSMUSG00000074923 .
GeneIDi 214230.
KEGGi mmu:214230.
UCSCi uc008lsf.2. mouse.

Organism-specific databases

CTDi 56924.
MGIi MGI:2679420. Pak6.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000119176.
HOGENOMi HOG000234205.
HOVERGENi HBG108518.
InParanoidi Q3ULB5.
KOi K05735.
OMAi VPWPEPQ.
OrthoDBi EOG73804D.
PhylomeDBi Q3ULB5.
TreeFami TF105352.

Miscellaneous databases

NextBioi 374228.
PROi Q3ULB5.
SOURCEi Search...

Gene expression databases

Bgeei Q3ULB5.
CleanExi MM_PAK6.
Genevestigatori Q3ULB5.

Family and domain databases

Gene3Di 3.90.810.10. 1 hit.
InterProi IPR000095. CRIB_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view ]
Pfami PF00786. PBD. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00285. PBD. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50108. CRIB. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Visual cortex.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiPAK6_MOUSE
AccessioniPrimary (citable) accession number: Q3ULB5
Secondary accession number(s): Q3TY26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 11, 2005
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3