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Q3ULB5

- PAK6_MOUSE

UniProt

Q3ULB5 - PAK6_MOUSE

Protein

Serine/threonine-protein kinase PAK 6

Gene

Pak6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei437 – 4371ATPPROSITE-ProRule annotation
    Active sitei527 – 5271Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi414 – 4229ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. learning Source: MGI
    2. locomotory behavior Source: MGI
    3. memory Source: MGI

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase PAK 6 (EC:2.7.11.1)
    Alternative name(s):
    p21-activated kinase 6
    Short name:
    PAK-6
    Gene namesi
    Name:Pak6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2679420. Pak6.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Cotranslocates into nucleus with AR in response to androgen induction.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 682682Serine/threonine-protein kinase PAK 6PRO_0000278117Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei561 – 5611Phosphoserine; by autocatalysisBy similarity

    Post-translational modificationi

    Autophosphorylated. Phosphorylated by MAP2K6/MAPKK6, leading to PAK6 activation By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ3ULB5.

    PTM databases

    PhosphoSiteiQ3ULB5.

    Expressioni

    Gene expression databases

    BgeeiQ3ULB5.
    CleanExiMM_PAK6.
    GenevestigatoriQ3ULB5.

    Interactioni

    Subunit structurei

    Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with the androgen receptor AR. Interacts with IQGAP1 and PPM1B By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ3ULB5.
    SMRiQ3ULB5. Positions 11-45, 386-675.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 2514CRIBPROSITE-ProRule annotationAdd
    BLAST
    Domaini408 – 659252Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni26 – 407382LinkerBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi4 – 85Poly-Lys

    Sequence similaritiesi

    Contains 1 CRIB domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00670000097939.
    HOGENOMiHOG000234205.
    HOVERGENiHBG108518.
    InParanoidiQ3ULB5.
    KOiK05735.
    OMAiVPWPEPQ.
    OrthoDBiEOG73804D.
    PhylomeDBiQ3ULB5.
    TreeFamiTF105352.

    Family and domain databases

    Gene3Di3.90.810.10. 1 hit.
    InterProiIPR000095. CRIB_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view]
    PfamiPF00786. PBD. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00285. PBD. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50108. CRIB. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3ULB5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFRKKKKKRP EISAPQNFQH RVHTSFDPKE GKFVGLPPQW QNILDTLRRP    50
    KPVVDPSRIT RVQLQPMKTV VRGSSVPTEG YISGLLNDIQ KLSVISSNTL 100
    RGRSPTSRRR AQSLGLLGDD QWAADPDMYL QSPQSEHTDP HGLYLSCNGG 150
    TPAGHRQVPW PEPQSPQALP NGMAAKAQSL GPAEFQGASQ RCLQQLGACL 200
    QSSPPGTSPP MATGRRGVKV AKHSSEEARP QSCLVGSAIG RPGGEGSPSP 250
    KNQESSLKHR LFRSMFLSTP ATGAASSSKP VPLPQNKPNS AFRPPQKDSS 300
    SNLVAKAQSL PSEQPMGTFS PLTTSDTSSP QKSLRTAPAA GPLPGRSSPA 350
    GSPRTRHAQI STSNLYLPQD PTVAKGALGG EDTGIVTHEQ FKAALRMVVD 400
    QGDPRLLLDS YVKIGEGSTG IVCLAREKHS GRQVAVKMMD LRKQQRRELL 450
    FNEVVIMRDY QHLNVVEMYK SYLVGEELWV LMEFLQGGAL TDIISQVRLN 500
    EEQIATVCEA VLQALAYLHA QGVIHRDIKS DSILLTLDGR VKLSDFGFCA 550
    QISKDVPKRK SLVGTPYWMA PEVISRSLYA TEVDIWSLGI MVIEMVDGEP 600
    PYFSDSPVQA MKRLRDSAPP KLKNSYKVSP VLRDFLDRML VREPQERATA 650
    QELLDHPFLL QTGLPECLVP LIQLYRKQTS TC 682
    Length:682
    Mass (Da):74,867
    Last modified:October 11, 2005 - v1
    Checksum:iF9D415D49A130C0C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti667 – 6671C → R in BAE34737. (PubMed:16141072)Curated
    Sequence conflicti667 – 6671C → R in BAE34725. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK145601 mRNA. Translation: BAE26534.1.
    AK158913 mRNA. Translation: BAE34725.1.
    AK158944 mRNA. Translation: BAE34737.1.
    AL845470 Genomic DNA. Translation: CAM17416.1.
    CCDSiCCDS16580.1.
    RefSeqiNP_001028426.2. NM_001033254.3.
    NP_001139326.1. NM_001145854.1.
    UniGeneiMm.241857.

    Genome annotation databases

    EnsembliENSMUST00000099557; ENSMUSP00000097153; ENSMUSG00000074923.
    ENSMUST00000110853; ENSMUSP00000106477; ENSMUSG00000074923.
    GeneIDi214230.
    KEGGimmu:214230.
    UCSCiuc008lsf.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK145601 mRNA. Translation: BAE26534.1 .
    AK158913 mRNA. Translation: BAE34725.1 .
    AK158944 mRNA. Translation: BAE34737.1 .
    AL845470 Genomic DNA. Translation: CAM17416.1 .
    CCDSi CCDS16580.1.
    RefSeqi NP_001028426.2. NM_001033254.3.
    NP_001139326.1. NM_001145854.1.
    UniGenei Mm.241857.

    3D structure databases

    ProteinModelPortali Q3ULB5.
    SMRi Q3ULB5. Positions 11-45, 386-675.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q3ULB5.

    Proteomic databases

    PRIDEi Q3ULB5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000099557 ; ENSMUSP00000097153 ; ENSMUSG00000074923 .
    ENSMUST00000110853 ; ENSMUSP00000106477 ; ENSMUSG00000074923 .
    GeneIDi 214230.
    KEGGi mmu:214230.
    UCSCi uc008lsf.2. mouse.

    Organism-specific databases

    CTDi 56924.
    MGIi MGI:2679420. Pak6.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00670000097939.
    HOGENOMi HOG000234205.
    HOVERGENi HBG108518.
    InParanoidi Q3ULB5.
    KOi K05735.
    OMAi VPWPEPQ.
    OrthoDBi EOG73804D.
    PhylomeDBi Q3ULB5.
    TreeFami TF105352.

    Miscellaneous databases

    NextBioi 374228.
    PROi Q3ULB5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3ULB5.
    CleanExi MM_PAK6.
    Genevestigatori Q3ULB5.

    Family and domain databases

    Gene3Di 3.90.810.10. 1 hit.
    InterProi IPR000095. CRIB_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view ]
    Pfami PF00786. PBD. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00285. PBD. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50108. CRIB. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Visual cortex.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiPAK6_MOUSE
    AccessioniPrimary (citable) accession number: Q3ULB5
    Secondary accession number(s): Q3TY26
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3