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Protein

RNA polymerase II elongation factor ELL2

Gene

Ell2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (By similarity). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression.By similarity2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-6807505. RNA polymerase II transcribes snRNA genes.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II elongation factor ELL2
Gene namesi
Name:Ell2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2183438. Ell2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 639639RNA polymerase II elongation factor ELL2PRO_0000322974Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei501 – 5011PhosphoserineCombined sources
Modified residuei579 – 5791PhosphoserineBy similarity

Post-translational modificationi

Ubiquitinated by SIAH1, leading to its degradation by the proteaseome. Interaction with AFF4 stabilizeS ELL2 and prevent ELL2 ubiquitination (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ3UKU1.
PaxDbiQ3UKU1.
PRIDEiQ3UKU1.

PTM databases

iPTMnetiQ3UKU1.
PhosphoSiteiQ3UKU1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000001542.
CleanExiMM_ELL2.
GenevisibleiQ3UKU1. MM.

Interactioni

Subunit structurei

Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2. Interacts with AFF4; the interaction is direct and leads to stabilize ELL2 and prevent ELL2 ubiquitination. Interacts with EAF1 and EAF2 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ3UKU1. 1 interaction.
STRINGi10090.ENSMUSP00000001583.

Structurei

3D structure databases

ProteinModelPortaliQ3UKU1.
SMRiQ3UKU1. Positions 200-292, 527-634.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ELL/occludin family.Curated

Phylogenomic databases

eggNOGiKOG4796. Eukaryota.
ENOG410ZNGU. LUCA.
GeneTreeiENSGT00550000074378.
HOGENOMiHOG000112356.
HOVERGENiHBG005578.
InParanoidiQ3UKU1.
KOiK15183.
OMAiTIRKTHS.
OrthoDBiEOG091G043D.
TreeFamiTF326161.

Family and domain databases

InterProiIPR031176. ELL/occludin.
IPR031179. ELL2.
IPR019464. ELL_N.
IPR010844. Occludin_ELL.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR23288. PTHR23288. 1 hit.
PTHR23288:SF8. PTHR23288:SF8. 1 hit.
PfamiPF10390. ELL. 1 hit.
PF07303. Occludin_ELL. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3UKU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGGAAGLR EEQRYGLACG RLGQDNITVL HVKLTETAIR ALETYQSHKN
60 70 80 90 100
LIPFRPSIQF QGLQGLMKIP KNDPFNEVQN FNFYLSNVGR DNPQGSFDCI
110 120 130 140 150
QQTLSSSGAS QLNCLGFIQD KITVCATNDS YQMTRERMTQ AEEESRNRST
160 170 180 190 200
KVIKPGGPYV GKRVQIRKAP QAISDTVPER KRSTPMNPAN TIRKMHSGNS
210 220 230 240 250
VSQRPYRDRV IHLLALKAYK KPELLARLQK DGVNQKDKNS LGAILQQVAN
260 270 280 290 300
LNPKDLSYTL KDYVFKELQR DWPGYSETDR QTLDLVLSRK LNPSQNASTS
310 320 330 340 350
RSESPLCSSK DAASSPQKRP LDSDFIDPLM NKKARISHLT NRVPPTLNGY
360 370 380 390 400
LNPTSEKSCA GLLPPPAAAA IPTLSPLPST HLPVSNPPQT VNSNSNSPST
410 420 430 440 450
PEGLGTQDLP VDSFSQNGSI FEDQQEKYTS RTCLETLPPS SALLKCPKPM
460 470 480 490 500
EEEHPVSHKK SKKKSKKHKE KDQIKKLDIE TMEEKEEDLQ REETAKLSNA
510 520 530 540 550
SPNPNEGVKE GCTASMEPSS ALELPDYLIK YIAIVSYEQR QNYKDDFNAE
560 570 580 590 600
YDEYRALHAR METVARRFIK LDAQRKRLSP GSKEYQNVHE EVLQEYQKIK
610 620 630
QSSPNYHEEK YRCEYLHNKL AHIKRLIGEF DQQQAESWH
Length:639
Mass (Da):72,125
Last modified:July 27, 2011 - v2
Checksum:iD97846C943AC12FB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti286 – 2861V → E in BAE26710 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145868 mRNA. Translation: BAE26710.1.
CT025556 Genomic DNA. No translation available.
CCDSiCCDS36734.1.
RefSeqiNP_620403.2. NM_138953.2.
UniGeneiMm.21288.

Genome annotation databases

EnsembliENSMUST00000001583; ENSMUSP00000001583; ENSMUSG00000001542.
GeneIDi192657.
KEGGimmu:192657.
UCSCiuc007rfu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145868 mRNA. Translation: BAE26710.1.
CT025556 Genomic DNA. No translation available.
CCDSiCCDS36734.1.
RefSeqiNP_620403.2. NM_138953.2.
UniGeneiMm.21288.

3D structure databases

ProteinModelPortaliQ3UKU1.
SMRiQ3UKU1. Positions 200-292, 527-634.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3UKU1. 1 interaction.
STRINGi10090.ENSMUSP00000001583.

PTM databases

iPTMnetiQ3UKU1.
PhosphoSiteiQ3UKU1.

Proteomic databases

MaxQBiQ3UKU1.
PaxDbiQ3UKU1.
PRIDEiQ3UKU1.

Protocols and materials databases

DNASUi192657.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001583; ENSMUSP00000001583; ENSMUSG00000001542.
GeneIDi192657.
KEGGimmu:192657.
UCSCiuc007rfu.1. mouse.

Organism-specific databases

CTDi22936.
MGIiMGI:2183438. Ell2.

Phylogenomic databases

eggNOGiKOG4796. Eukaryota.
ENOG410ZNGU. LUCA.
GeneTreeiENSGT00550000074378.
HOGENOMiHOG000112356.
HOVERGENiHBG005578.
InParanoidiQ3UKU1.
KOiK15183.
OMAiTIRKTHS.
OrthoDBiEOG091G043D.
TreeFamiTF326161.

Enzyme and pathway databases

ReactomeiR-MMU-6807505. RNA polymerase II transcribes snRNA genes.

Miscellaneous databases

ChiTaRSiEll2. mouse.
PROiQ3UKU1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001542.
CleanExiMM_ELL2.
GenevisibleiQ3UKU1. MM.

Family and domain databases

InterProiIPR031176. ELL/occludin.
IPR031179. ELL2.
IPR019464. ELL_N.
IPR010844. Occludin_ELL.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR23288. PTHR23288. 1 hit.
PTHR23288:SF8. PTHR23288:SF8. 1 hit.
PfamiPF10390. ELL. 1 hit.
PF07303. Occludin_ELL. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiELL2_MOUSE
AccessioniPrimary (citable) accession number: Q3UKU1
Secondary accession number(s): E9QPE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.