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Protein

Decorin

Gene

Dcn

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May affect the rate of fibrils formation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
DecorinUniRule annotation
Alternative name(s):
Bone proteoglycan IIUniRule annotation
Gene namesi
Name:DcnImported
ORF Names:mCG_11308Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:94872. Dcn.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrixUniRule annotation, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16UniRule annotationAdd BLAST16
ChainiPRO_501101780417 – 354DecorinUniRule annotationAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 55UniRule annotation
Disulfide bondi53 ↔ 62UniRule annotation
Disulfide bondi308 ↔ 341UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

MaxQBiQ3UKR1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000019929.

Interactioni

Subunit structurei

Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ3UKR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 80LRRNTInterPro annotationAdd BLAST33

Sequence similaritiesi

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.UniRule annotation

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
HOVERGENiHBG016052.
KOiK04660.
OMAiPLGPVCP.
OrthoDBiEOG091G044B.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR028549. Decorin.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR032675. LRR_dom_sf.
IPR000372. LRRNT.
IPR016352. SLRP_I_decor/aspor/byglycan.
PANTHERiPTHR44053:SF2. PTHR44053:SF2. 1 hit.
PfamiView protein in Pfam
PF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
PIRSFiPIRSF002490. SLRP_I. 1 hit.
SMARTiView protein in SMART
SM00369. LRR_TYP. 8 hits.
SM00013. LRRNT. 1 hit.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 8 hits.

Sequencei

Sequence statusi: Complete.

Q3UKR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKATLIFFLL AQVSWAGPFE QRGLFDFMLE DEASGIIPYD PDNPLISMCP
60 70 80 90 100
YRCQCHLRVV QCSDLGLDKV PWDFPPDTTL LDLQNNKITE IKEGAFKNLK
110 120 130 140 150
DLHTLILVNN KISKISPEAF KPLVKLERLY LSKNQLKELP EKMPRTLQEL
160 170 180 190 200
RVHENEITKL RKSDFNGLNN VLVIELGGNP LKNSGIENGA FQGLKSLSYI
210 220 230 240 250
RISDTNITAI PQGLPTSLTE VHLDGNKITK VDAPSLKGLI NLSKLGLSFN
260 270 280 290 300
SITVMENGSL ANVPHLRELH LDNNKLLRVP AGLAQHKYIQ VVYLHNNNIS
310 320 330 340 350
AVGQNDFCRA GHPSRKASYS AVSLYGNPVR YWEIFPNTFR CVYVRSAIQL

GNYK
Length:354
Mass (Da):39,809
Last modified:October 11, 2005 - v1
Checksum:iF05B5CC08DCABF6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC132521 mRNA. Translation: AAI32522.1.
BC138564 mRNA. Translation: AAI38565.1.
AK135287 mRNA. Translation: BAE22476.1.
AK145905 mRNA. Translation: BAE26740.1.
AK147020 mRNA. Translation: BAE27613.1.
CH466539 Genomic DNA. Translation: EDL21628.1.
RefSeqiNP_001177380.1. NM_001190451.2.
NP_031859.1. NM_007833.6.
UniGeneiMm.56769.

Genome annotation databases

GeneIDi13179.
KEGGimmu:13179.

Similar proteinsi

Entry informationi

Entry nameiQ3UKR1_MOUSE
AccessioniPrimary (citable) accession number: Q3UKR1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 22, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)