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Protein

Decorin

Gene

Dcn

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May affect the rate of fibrils formation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
DecorinUniRule annotation
Alternative name(s):
Bone proteoglycan IIUniRule annotation
Gene namesi
Name:DcnImported
ORF Names:mCG_11308Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:94872 Dcn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrixUniRule annotation, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16UniRule annotationAdd BLAST16
ChainiPRO_501420583317 – 354DecorinUniRule annotationAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 55UniRule annotation
Disulfide bondi53 ↔ 62UniRule annotation
Disulfide bondi308 ↔ 341UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

MaxQBiQ3UKR1

Expressioni

Gene expression databases

BgeeiENSMUSG00000019929
ExpressionAtlasiQ3UKR1 baseline and differential

Interactioni

Subunit structurei

Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ3UKR1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 80LRRNTInterPro annotationAdd BLAST33

Sequence similaritiesi

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.UniRule annotation

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
HOVERGENiHBG016052
KOiK04660
OMAiPLGPVCP
OrthoDBiEOG091G044B

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR028549 Decorin
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR016352 SLRP_I_decor/aspor/byglycan
PANTHERiPTHR44053:SF2 PTHR44053:SF2, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
PF01462 LRRNT, 1 hit
PIRSFiPIRSF002490 SLRP_I, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 8 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 8 hits

Sequencei

Sequence statusi: Complete.

Q3UKR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKATLIFFLL AQVSWAGPFE QRGLFDFMLE DEASGIIPYD PDNPLISMCP
60 70 80 90 100
YRCQCHLRVV QCSDLGLDKV PWDFPPDTTL LDLQNNKITE IKEGAFKNLK
110 120 130 140 150
DLHTLILVNN KISKISPEAF KPLVKLERLY LSKNQLKELP EKMPRTLQEL
160 170 180 190 200
RVHENEITKL RKSDFNGLNN VLVIELGGNP LKNSGIENGA FQGLKSLSYI
210 220 230 240 250
RISDTNITAI PQGLPTSLTE VHLDGNKITK VDAPSLKGLI NLSKLGLSFN
260 270 280 290 300
SITVMENGSL ANVPHLRELH LDNNKLLRVP AGLAQHKYIQ VVYLHNNNIS
310 320 330 340 350
AVGQNDFCRA GHPSRKASYS AVSLYGNPVR YWEIFPNTFR CVYVRSAIQL

GNYK
Length:354
Mass (Da):39,809
Last modified:October 11, 2005 - v1
Checksum:iF05B5CC08DCABF6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC132521 mRNA Translation: AAI32522.1
BC138564 mRNA Translation: AAI38565.1
AK135287 mRNA Translation: BAE22476.1
AK145905 mRNA Translation: BAE26740.1
AK147020 mRNA Translation: BAE27613.1
CH466539 Genomic DNA Translation: EDL21628.1
RefSeqiNP_001177380.1, NM_001190451.2
NP_031859.1, NM_007833.6
UniGeneiMm.56769

Genome annotation databases

GeneIDi13179
KEGGimmu:13179

Similar proteinsi

Entry informationi

Entry nameiQ3UKR1_MOUSE
AccessioniPrimary (citable) accession number: Q3UKR1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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