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Protein
Submitted name:

NAD-dependent protein deacetylase sirtuin-6

Gene

Sirt6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
NAD-dependent protein deacetylase sirtuin-6Imported
Gene namesi
Name:Sirt6Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1354161. Sirt6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSMUSG00000034748.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048971.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 234Deacetylase sirtuin-typeInterPro annotationAdd BLAST234

Phylogenomic databases

eggNOGiKOG1905. Eukaryota.
COG0846. LUCA.
GeneTreeiENSGT00530000063706.
HOGENOMiHOG000231240.
HOVERGENiHBG060028.

Family and domain databases

Gene3Di3.40.50.1220. 2 hits.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR003000. Sirtuin.
IPR026590. Ssirtuin_cat_dom.
[Graphical view]
PANTHERiPTHR11085. PTHR11085. 1 hit.
PfamiPF02146. SIR2. 2 hits.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
PROSITEiPS50305. SIRTUIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UKP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWQSSSVVFH TGAGISTASG IPDFRGPHGV WTMEERGLAP KFDTTFENAR
60 70 80 90 100
PSKTHMALVQ LERMGFLSFL VSQNVDGLHV RSGFPRDKLA ELHGNMFVEE
110 120 130 140 150
CPKCKTQYVR DTVVGTMGLK ATGRLCTVAK TRGLRACRGE LRDTILDWED
160 170 180 190 200
SLPDRDLMLA DEASRTADLS VTLGTSLQIR PSGNLPLATK RRGGRLVIVN
210 220 230 240 250
LQPTKHDRQA DLRIHGYVDE VMCRLMKHLG LEIPAWDGPC VLDKALPPLP
260 270 280 290
RPVALKAEPP VHLNGAVHVS YKSKPNSPIL HRPPKRVKTE AAPS
Length:294
Mass (Da):32,443
Last modified:October 11, 2005 - v1
Checksum:i3541FDBBFF16A7FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC153919 Genomic DNA. No translation available.
AK145929 mRNA. Translation: BAE26760.1.
RefSeqiNP_001156902.1. NM_001163430.1.
UniGeneiMm.131825.
Mm.25643.

Genome annotation databases

EnsembliENSMUST00000119324; ENSMUSP00000113953; ENSMUSG00000034748.
GeneIDi50721.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC153919 Genomic DNA. No translation available.
AK145929 mRNA. Translation: BAE26760.1.
RefSeqiNP_001156902.1. NM_001163430.1.
UniGeneiMm.131825.
Mm.25643.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048971.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000119324; ENSMUSP00000113953; ENSMUSG00000034748.
GeneIDi50721.

Organism-specific databases

CTDi51548.
MGIiMGI:1354161. Sirt6.

Phylogenomic databases

eggNOGiKOG1905. Eukaryota.
COG0846. LUCA.
GeneTreeiENSGT00530000063706.
HOGENOMiHOG000231240.
HOVERGENiHBG060028.

Miscellaneous databases

ChiTaRSiSirt6. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034748.

Family and domain databases

Gene3Di3.40.50.1220. 2 hits.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR003000. Sirtuin.
IPR026590. Ssirtuin_cat_dom.
[Graphical view]
PANTHERiPTHR11085. PTHR11085. 1 hit.
PfamiPF02146. SIR2. 2 hits.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
PROSITEiPS50305. SIRTUIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ3UKP1_MOUSE
AccessioniPrimary (citable) accession number: Q3UKP1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.