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Protein

Carcinoembryonic antigen-related cell adhesion molecule 5

Gene

Ceacam5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling.By similarity

Enzyme and pathway databases

ReactomeiR-MMU-1566977. Fibronectin matrix formation.
R-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 5
Alternative name(s):
Pregnancy-specific glycoprotein 30
Gene namesi
Name:Ceacam5
Synonyms:Psg30
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1920500. Ceacam5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000037850635 – 947Carcinoembryonic antigen-related cell adhesion molecule 5Add BLAST913

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi103N-linked (GlcNAc...)Sequence analysis1
Glycosylationi110N-linked (GlcNAc...)Sequence analysis1
Glycosylationi207N-linked (GlcNAc...)Sequence analysis1
Glycosylationi341N-linked (GlcNAc...)Sequence analysis1
Glycosylationi823N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi878 ↔ 926PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ3UKK2.
PeptideAtlasiQ3UKK2.
PRIDEiQ3UKK2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000008789.

Structurei

3D structure databases

ProteinModelPortaliQ3UKK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 132Ig-like V-type 1Add BLAST98
Domaini166 – 259Ig-like V-type 2Add BLAST94
Domaini270 – 378Ig-like V-type 3Add BLAST109
Domaini392 – 498Ig-like V-type 4Add BLAST107
Domaini509 – 615Ig-like V-type 5Add BLAST107
Domaini642 – 733Ig-like V-type 6Add BLAST92
Domaini746 – 851Ig-like V-type 7Add BLAST106
Domaini859 – 943Ig-like V-type 8Add BLAST85

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410JAIP. Eukaryota.
ENOG41114FZ. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
InParanoidiQ3UKK2.
OrthoDBiEOG09070B7S.
PhylomeDBiQ3UKK2.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 8 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
PF07686. V-set. 6 hits.
[Graphical view]
SMARTiSM00409. IG. 8 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 8 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UKK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEASSVLPCK WCTHLQGLLL TASFLTCCHL PTTAQITIEL EPPQVIEGEN
60 70 80 90 100
VLIRVNNLTE NLITLAWFRG MRIKSPQIGQ YTPATKVTVL GPGHSGRETL
110 120 130 140 150
YSNGSLQIYN VTQEDIGFYS LRIINKHAEI VSITSIYLNV YSSLWTCEHP
160 170 180 190 200
SPHAKLTIES VPPGISEGGS VLLLVKNLPQ NLLSLFWYKG VIAVKKFEIA
210 220 230 240 250
RHIKATNSSV PGPAHTGRET VFSNGSLLLQ EVMQSDTGFY TLRTMSTDLK
260 270 280 290 300
DEVAHVQLYM DTYLLTCYHP LQVKIESLPQ NVAVGKTVLL LVHNLPEDFQ
310 320 330 340 350
AFFWYKSAYR RDTYKIAEYK RAMDATILGS AYSSREFIYN NGSMLIIDVT
360 370 380 390 400
EDDAGYFLLE ILREDLKIEK AYIQLHVNSF VSNSKDSAST ARLSIESVPP
410 420 430 440 450
SIVEGGSVLL LVHNLPKNLQ SLFWYKGMIA EKKSELIQHI IATSSSLPGP
460 470 480 490 500
AHSGRETVYN NGSLLLQRVM QNDTQFYTLQ TMDTDLKYEV AHVQLQLDTS
510 520 530 540 550
LSTWYHPLQV KIESLPRNVA VGKSVLFLVH NFPEVFRAFS WYKPAYKSHT
560 570 580 590 600
SKIVEYHRFT DSATVGAAYR GIEVIFTNGS MVMIDVTEDD AGFYMLEILR
610 620 630 640 650
EDFKVEKAYV QLHVNSFVPN SKVSVSTARL SIESVPPSIV GGESVLLLVH
660 670 680 690 700
NLPKNLQSLF WYKGVIAEEK SELIQHIIAT SSSLPGPAHS GRETVYSNGS
710 720 730 740 750
LLLQRVMQND TGFYTLLTMS TDLKDEIAHV QLQLDTSTCC SLLTSDQLII
760 770 780 790 800
VPVPRNIAVG KSVLLLVCNV PKDVQTIFWY KSVYRTDIFK IAEYSRSMES
810 820 830 840 850
TIWGLAHSGK EMVYTNGSLL IQNVTEHDAG LYMLEILHKD YKLERAHVQV
860 870 880 890 900
HVNNPVSWPF VRVTDTTVRV QSSVVFTCFS ADPGVSIRWL FNKQSLQLTE
910 920 930 940
RMTLSPSKCQ LSIDPVWRED AGKYQCEVSN PVSSKSSLPV RLAVIEE
Length:947
Mass (Da):106,270
Last modified:October 11, 2005 - v1
Checksum:i3FE79EE7FC560029
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145976 mRNA. Translation: BAE26799.1.
CCDSiCCDS20863.1.
RefSeqiNP_082756.1. NM_028480.2.
UniGeneiMm.244138.

Genome annotation databases

EnsembliENSMUST00000081907; ENSMUSP00000080582; ENSMUSG00000008789.
GeneIDi73250.
KEGGimmu:73250.
UCSCiuc009fiz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145976 mRNA. Translation: BAE26799.1.
CCDSiCCDS20863.1.
RefSeqiNP_082756.1. NM_028480.2.
UniGeneiMm.244138.

3D structure databases

ProteinModelPortaliQ3UKK2.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ3UKK2.
PeptideAtlasiQ3UKK2.
PRIDEiQ3UKK2.

Protocols and materials databases

DNASUi73250.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081907; ENSMUSP00000080582; ENSMUSG00000008789.
GeneIDi73250.
KEGGimmu:73250.
UCSCiuc009fiz.1. mouse.

Organism-specific databases

CTDi1048.
MGIiMGI:1920500. Ceacam5.

Phylogenomic databases

eggNOGiENOG410JAIP. Eukaryota.
ENOG41114FZ. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
InParanoidiQ3UKK2.
OrthoDBiEOG09070B7S.
PhylomeDBiQ3UKK2.
TreeFamiTF336859.

Enzyme and pathway databases

ReactomeiR-MMU-1566977. Fibronectin matrix formation.
R-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ3UKK2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000008789.

Family and domain databases

Gene3Di2.60.40.10. 8 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
PF07686. V-set. 6 hits.
[Graphical view]
SMARTiSM00409. IG. 8 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 8 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCEAM5_MOUSE
AccessioniPrimary (citable) accession number: Q3UKK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.