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Protein

Carcinoembryonic antigen-related cell adhesion molecule 5

Gene

Ceacam5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 5
Alternative name(s):
Pregnancy-specific glycoprotein 30
Gene namesi
Name:Ceacam5
Synonyms:Psg30
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1920500 Ceacam5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000037850635 – 947Carcinoembryonic antigen-related cell adhesion molecule 5Add BLAST913

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi341N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi823N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi878 ↔ 926PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ3UKK2
PeptideAtlasiQ3UKK2
PRIDEiQ3UKK2

Expressioni

Gene expression databases

BgeeiENSMUSG00000008789

Structurei

3D structure databases

ProteinModelPortaliQ3UKK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 132Ig-like V-type 1Add BLAST98
Domaini166 – 259Ig-like V-type 2Add BLAST94
Domaini270 – 378Ig-like V-type 3Add BLAST109
Domaini392 – 498Ig-like V-type 4Add BLAST107
Domaini509 – 615Ig-like V-type 5Add BLAST107
Domaini642 – 733Ig-like V-type 6Add BLAST92
Domaini746 – 851Ig-like V-type 7Add BLAST106
Domaini859 – 943Ig-like V-type 8Add BLAST85

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410JAIP Eukaryota
ENOG41114FZ LUCA
GeneTreeiENSGT00760000119187
HOGENOMiHOG000233417
InParanoidiQ3UKK2
OrthoDBiEOG09070B7S
PhylomeDBiQ3UKK2
TreeFamiTF336859

Family and domain databases

Gene3Di2.60.40.10, 8 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF07686 V-set, 6 hits
SMARTiView protein in SMART
SM00409 IG, 8 hits
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 8 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UKK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEASSVLPCK WCTHLQGLLL TASFLTCCHL PTTAQITIEL EPPQVIEGEN
60 70 80 90 100
VLIRVNNLTE NLITLAWFRG MRIKSPQIGQ YTPATKVTVL GPGHSGRETL
110 120 130 140 150
YSNGSLQIYN VTQEDIGFYS LRIINKHAEI VSITSIYLNV YSSLWTCEHP
160 170 180 190 200
SPHAKLTIES VPPGISEGGS VLLLVKNLPQ NLLSLFWYKG VIAVKKFEIA
210 220 230 240 250
RHIKATNSSV PGPAHTGRET VFSNGSLLLQ EVMQSDTGFY TLRTMSTDLK
260 270 280 290 300
DEVAHVQLYM DTYLLTCYHP LQVKIESLPQ NVAVGKTVLL LVHNLPEDFQ
310 320 330 340 350
AFFWYKSAYR RDTYKIAEYK RAMDATILGS AYSSREFIYN NGSMLIIDVT
360 370 380 390 400
EDDAGYFLLE ILREDLKIEK AYIQLHVNSF VSNSKDSAST ARLSIESVPP
410 420 430 440 450
SIVEGGSVLL LVHNLPKNLQ SLFWYKGMIA EKKSELIQHI IATSSSLPGP
460 470 480 490 500
AHSGRETVYN NGSLLLQRVM QNDTQFYTLQ TMDTDLKYEV AHVQLQLDTS
510 520 530 540 550
LSTWYHPLQV KIESLPRNVA VGKSVLFLVH NFPEVFRAFS WYKPAYKSHT
560 570 580 590 600
SKIVEYHRFT DSATVGAAYR GIEVIFTNGS MVMIDVTEDD AGFYMLEILR
610 620 630 640 650
EDFKVEKAYV QLHVNSFVPN SKVSVSTARL SIESVPPSIV GGESVLLLVH
660 670 680 690 700
NLPKNLQSLF WYKGVIAEEK SELIQHIIAT SSSLPGPAHS GRETVYSNGS
710 720 730 740 750
LLLQRVMQND TGFYTLLTMS TDLKDEIAHV QLQLDTSTCC SLLTSDQLII
760 770 780 790 800
VPVPRNIAVG KSVLLLVCNV PKDVQTIFWY KSVYRTDIFK IAEYSRSMES
810 820 830 840 850
TIWGLAHSGK EMVYTNGSLL IQNVTEHDAG LYMLEILHKD YKLERAHVQV
860 870 880 890 900
HVNNPVSWPF VRVTDTTVRV QSSVVFTCFS ADPGVSIRWL FNKQSLQLTE
910 920 930 940
RMTLSPSKCQ LSIDPVWRED AGKYQCEVSN PVSSKSSLPV RLAVIEE
Length:947
Mass (Da):106,270
Last modified:October 11, 2005 - v1
Checksum:i3FE79EE7FC560029
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145976 mRNA Translation: BAE26799.1
CCDSiCCDS20863.1
RefSeqiNP_082756.1, NM_028480.2
UniGeneiMm.244138

Genome annotation databases

EnsembliENSMUST00000081907; ENSMUSP00000080582; ENSMUSG00000008789
GeneIDi73250
KEGGimmu:73250
UCSCiuc009fiz.1 mouse

Entry informationi

Entry nameiCEAM5_MOUSE
AccessioniPrimary (citable) accession number: Q3UKK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health