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Protein

WD40 repeat-containing protein SMU1

Gene

Smu1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
WD40 repeat-containing protein SMU1
Alternative name(s):
Smu-1 suppressor of mec-8 and unc-52 protein homolog
Cleaved into the following chain:
Gene namesi
Name:Smu1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1915546. Smu1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513WD40 repeat-containing protein SMU1PRO_0000237591Add
BLAST
Initiator methionineiRemoved; alternateBy similarity
Chaini2 – 513512WD40 repeat-containing protein SMU1, N-terminally processedPRO_0000424521Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei2 – 21N-acetylserine; in WD40 repeat-containing protein SMU1, N-terminally processedBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ3UKJ7.
MaxQBiQ3UKJ7.
PaxDbiQ3UKJ7.
PeptideAtlasiQ3UKJ7.
PRIDEiQ3UKJ7.

PTM databases

iPTMnetiQ3UKJ7.
PhosphoSiteiQ3UKJ7.

Expressioni

Developmental stagei

At 10.5 dpc expressed in otic vesicle.1 Publication

Gene expression databases

BgeeiENSMUSG00000028409.
GenevisibleiQ3UKJ7. MM.

Interactioni

Protein-protein interaction databases

BioGridi216611. 2 interactions.
IntActiQ3UKJ7. 4 interactions.
MINTiMINT-4129849.
STRINGi10090.ENSMUSP00000030117.

Structurei

3D structure databases

ProteinModelPortaliQ3UKJ7.
SMRiQ3UKJ7. Positions 1-511.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 3833LisHPROSITE-ProRule annotationAdd
BLAST
Domaini40 – 9253CTLHPROSITE-ProRule annotationAdd
BLAST
Repeati212 – 25342WD 1Add
BLAST
Repeati262 – 30342WD 2Add
BLAST
Repeati305 – 34642WD 3Add
BLAST
Repeati347 – 38640WD 4Add
BLAST
Repeati388 – 42639WD 5Add
BLAST
Repeati482 – 51332WD 6Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat SMU1 family.Curated
Contains 1 CTLH domain.PROSITE-ProRule annotation
Contains 1 LisH domain.PROSITE-ProRule annotation
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0275. Eukaryota.
ENOG410XP39. LUCA.
GeneTreeiENSGT00840000129769.
HOGENOMiHOG000264846.
HOVERGENiHBG079573.
InParanoidiQ3UKJ7.
KOiK13111.
OMAiYQADETF.
OrthoDBiEOG091G04XF.
PhylomeDBiQ3UKJ7.
TreeFamiTF313969.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR006595. CTLH_C.
IPR020472. G-protein_beta_WD-40_rep.
IPR006594. LisH.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00668. CTLH. 1 hit.
SM00667. LisH. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UKJ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSIEIESSDV IRLIMQYLKE NSLHRALATL QEETTVSLNT VDSIESFVAD
60 70 80 90 100
INSGHWDTVL QAIQSLKLPD KTLIDLYEQV VLELIELREL GAARSLLRQT
110 120 130 140 150
DPMIMLKQTQ PERYIHLENL LARSYFDPRE AYPDGSSKEK RRAAIAQALA
160 170 180 190 200
GEVSVVPPSR LMALLGQALK WQQHQGLLPP GMTIDLFRGK AAVKDVEEEK
210 220 230 240 250
FPTQLSRHIK FGQKSHVECA RFSPDGQYLV TGSVDGFIEV WNFTTGKIRK
260 270 280 290 300
DLKYQAQDNF MMMDDAVLCM CFSRDTEMLA TGAQDGKIKV WKIQSGQCLR
310 320 330 340 350
RFERAHSKGV TCLSFSKDSS QILSASFDQT IRIHGLKSGK TLKEFRGHSS
360 370 380 390 400
FVNEATFTQD GHYIISASSD GTVKIWNMKT TECSNTFKSL GSTAGTDITV
410 420 430 440 450
NSVILLPKNP EHFVVCNRSN TVVIMNMQGQ IVRSFSSGKR EGGDFVCCAL
460 470 480 490 500
SPRGEWIYCV GEDFVLYCFS TVTGKLERTL TVHEKDVIGI AHHPHQNLIA
510
TYSEDGLLKL WKP
Length:513
Mass (Da):57,544
Last modified:May 30, 2006 - v2
Checksum:iCB201E939DCCA188
GO
Isoform 2 (identifier: Q3UKJ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     333-513: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:332
Mass (Da):37,548
Checksum:i265EC5FBE851FFC0
GO

Sequence cautioni

Isoform 2 : The sequence BAC25322 differs from that shown. Reason: Frameshift at position 242. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491A → V in BAE26804 (PubMed:16141072).Curated
Sequence conflicti346 – 3461R → L in BAB22820 (PubMed:16141072).Curated
Sequence conflicti452 – 4521P → L in BAA96656 (Ref. 1) Curated
Sequence conflicti466 – 4661L → F in BAA96656 (Ref. 1) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei333 – 513181Missing in isoform 2. 1 PublicationVSP_018593Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB044414 mRNA. Translation: BAA96656.1.
AK003493 mRNA. Translation: BAB22820.1.
AK011140 mRNA. Translation: BAC25322.1. Frameshift.
AK145982 mRNA. Translation: BAE26804.1.
AK159635 mRNA. Translation: BAE35249.1.
AK168813 mRNA. Translation: BAE40640.1.
BC057446 mRNA. Translation: AAH57446.1.
CCDSiCCDS18050.1. [Q3UKJ7-1]
RefSeqiNP_067510.3. NM_021535.4. [Q3UKJ7-1]
UniGeneiMm.289929.

Genome annotation databases

EnsembliENSMUST00000030117; ENSMUSP00000030117; ENSMUSG00000028409. [Q3UKJ7-1]
GeneIDi74255.
KEGGimmu:74255.
UCSCiuc008shu.2. mouse. [Q3UKJ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB044414 mRNA. Translation: BAA96656.1.
AK003493 mRNA. Translation: BAB22820.1.
AK011140 mRNA. Translation: BAC25322.1. Frameshift.
AK145982 mRNA. Translation: BAE26804.1.
AK159635 mRNA. Translation: BAE35249.1.
AK168813 mRNA. Translation: BAE40640.1.
BC057446 mRNA. Translation: AAH57446.1.
CCDSiCCDS18050.1. [Q3UKJ7-1]
RefSeqiNP_067510.3. NM_021535.4. [Q3UKJ7-1]
UniGeneiMm.289929.

3D structure databases

ProteinModelPortaliQ3UKJ7.
SMRiQ3UKJ7. Positions 1-511.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216611. 2 interactions.
IntActiQ3UKJ7. 4 interactions.
MINTiMINT-4129849.
STRINGi10090.ENSMUSP00000030117.

PTM databases

iPTMnetiQ3UKJ7.
PhosphoSiteiQ3UKJ7.

Proteomic databases

EPDiQ3UKJ7.
MaxQBiQ3UKJ7.
PaxDbiQ3UKJ7.
PeptideAtlasiQ3UKJ7.
PRIDEiQ3UKJ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030117; ENSMUSP00000030117; ENSMUSG00000028409. [Q3UKJ7-1]
GeneIDi74255.
KEGGimmu:74255.
UCSCiuc008shu.2. mouse. [Q3UKJ7-1]

Organism-specific databases

CTDi55234.
MGIiMGI:1915546. Smu1.

Phylogenomic databases

eggNOGiKOG0275. Eukaryota.
ENOG410XP39. LUCA.
GeneTreeiENSGT00840000129769.
HOGENOMiHOG000264846.
HOVERGENiHBG079573.
InParanoidiQ3UKJ7.
KOiK13111.
OMAiYQADETF.
OrthoDBiEOG091G04XF.
PhylomeDBiQ3UKJ7.
TreeFamiTF313969.

Miscellaneous databases

PROiQ3UKJ7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028409.
GenevisibleiQ3UKJ7. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR006595. CTLH_C.
IPR020472. G-protein_beta_WD-40_rep.
IPR006594. LisH.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00668. CTLH. 1 hit.
SM00667. LisH. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSMU1_MOUSE
AccessioniPrimary (citable) accession number: Q3UKJ7
Secondary accession number(s): Q6PFR6
, Q8BMY4, Q9D1I8, Q9JJ70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: September 7, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.