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Protein

Tax1-binding protein 1 homolog

Gene

Tax1bp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri750 – 779UBZ-type 1Add BLAST30
Zinc fingeri780 – 814UBZ-type 2Add BLAST35

GO - Molecular functioni

  • kinase binding Source: BHF-UCL
  • metal ion binding Source: UniProtKB-KW
  • ubiquitin binding Source: BHF-UCL

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • negative regulation of apoptotic process Source: Ensembl
  • negative regulation of NF-kappaB transcription factor activity Source: BHF-UCL

Keywordsi

Biological processApoptosis
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-5357905 Regulation of TNFR1 signaling
R-MMU-936440 Negative regulators of DDX58/IFIH1 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Tax1-binding protein 1 homolog
Gene namesi
Name:Tax1bp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1289308 Tax1bp1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002345551 – 814Tax1-binding protein 1 homologAdd BLAST814

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei124PhosphoserineCombined sources1
Modified residuei138PhosphoserineBy similarity1
Modified residuei225PhosphoserineBy similarity1
Modified residuei619Phosphoserine; by IKKABy similarityCurated1
Modified residuei632PhosphoserineCombined sources1
Modified residuei693Phosphoserine; by IKKACombined sources1

Post-translational modificationi

Phosphorylated in the C-terminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3UKC1
MaxQBiQ3UKC1
PaxDbiQ3UKC1
PeptideAtlasiQ3UKC1
PRIDEiQ3UKC1

PTM databases

iPTMnetiQ3UKC1
PhosphoSitePlusiQ3UKC1

Expressioni

Developmental stagei

Expressed at E11.5 and E12.5 in distal limb and genital bud.1 Publication

Gene expression databases

BgeeiENSMUSG00000004535
ExpressionAtlasiQ3UKC1 baseline and differential
GenevisibleiQ3UKC1 MM

Interactioni

Subunit structurei

Homooligomer. Interacts with TRAF6 in a IL-1-dependent manner. Interacts with STARD13 (By similarity). Interacts with TNFAIP3.By similarity1 Publication

GO - Molecular functioni

  • kinase binding Source: BHF-UCL
  • ubiquitin binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi206586, 11 interactors
IntActiQ3UKC1, 6 interactors
MINTiQ3UKC1
STRINGi10090.ENSMUSP00000079548

Structurei

3D structure databases

ProteinModelPortaliQ3UKC1
SMRiQ3UKC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni320 – 420OligomerizationBy similarityAdd BLAST101

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili144 – 623Sequence analysisAdd BLAST480

Domaini

The C-terminal UBZ-type zinc fingers function as ubiquitin-binding domains.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri750 – 779UBZ-type 1Add BLAST30
Zinc fingeri780 – 814UBZ-type 2Add BLAST35

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGMS Eukaryota
ENOG410XQDF LUCA
GeneTreeiENSGT00530000063216
HOGENOMiHOG000252947
HOVERGENiHBG053034
InParanoidiQ3UKC1
KOiK21347
OMAiERKMEGQ
OrthoDBiEOG091G01W2
PhylomeDBiQ3UKC1
TreeFamiTF329501

Family and domain databases

InterProiView protein in InterPro
IPR012852 CALCOCO1-like
PfamiView protein in Pfam
PF07888 CALCOCO1, 1 hit

Sequencei

Sequence statusi: Complete.

Q3UKC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSFQEVQLQ TSNFAHVIFQ NVAKSYLPNA HLECHYTLTP YIHPHSKDWV
60 70 80 90 100
GIFKVGWSTA RDYYTFLWSP MPEHYVEGST VNCVLAFQGY YLPNDDGEFY
110 120 130 140 150
QFCYVTHKGE IRGASTPFQF RAASPVEELL TMEDEGNSDM LVVTTKAGLL
160 170 180 190 200
ELKIEKTLKE KEELLKLIAV LEKETAQLRE QVGRMERELS QEKGRCEQLQ
210 220 230 240 250
AEQKGLLEVS QSLRVENEEF MKRYSDATAK VQQLEEDIVS VTHKAIEKET
260 270 280 290 300
DLDSLKDKLR KAQHEREQLE CQLQTEKDEK ELYKVHLKNT EIENTKLVSE
310 320 330 340 350
IQTLKNLDGN KESMITHFKE EISKLQSCLA DKENLYRALL LTTSNKEDTL
360 370 380 390 400
FLKEQLRKAE EQVQATRQEL IFLTKELSDA VNVRDKTMAD LHTARLENER
410 420 430 440 450
VKKQLADTLA ELQLHAVKKD QEKTDTLEHE LRREVEDLKL RLQMAADHYR
460 470 480 490 500
EKFKECQRLQ KQINKLSDQA ASTNSVFTKK MGSQQKVNDA SINTDPAAST
510 520 530 540 550
SASAVDVKPA ASCAETGFDM STKDHVCEMT KEIAEKIEKY NKCKQLLQDE
560 570 580 590 600
KTKCNKYAEE LAKMELKWKE QVKIAENVKL ELAEVEDNYK VQLAEKEKEI
610 620 630 640 650
NGLASYLENL SREKELTKSL EDQKGRKLEG QSPQQVSRCL NTCSEQNGLL
660 670 680 690 700
PPLSSAQPVL QYGNPYSAQE TRDGADGAFY PDEIQRPPVR VPSWEDNVVC
710 720 730 740 750
SQPARNLSRP DGLEDPEDSR EDENVPIPPD PANQHLRSHG AGFCFDSSFD
760 770 780 790 800
VHKKCPLCEL MFPPNYDQTK FEEHVESHWK VCPMCSEQFP PDYDQQGFER
810
HVQTHFDQNV LNFD
Length:814
Mass (Da):93,630
Last modified:May 16, 2006 - v2
Checksum:i828A1FC7D61A06B7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti328C → S in BAB23383 (PubMed:16141072).Curated1
Sequence conflicti368Q → P in BAB23383 (PubMed:16141072).Curated1
Sequence conflicti429H → Y in BAE26880 (PubMed:16141072).Curated1
Sequence conflicti658P → T in BAB23383 (PubMed:16141072).Curated1
Sequence conflicti751V → A in AAH14798 (PubMed:15489334).Curated1
Sequence conflicti764P → H in BAB25721 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004574 mRNA Translation: BAB23383.1
AK008528 mRNA Translation: BAB25721.1
AK146076 mRNA Translation: BAE26880.1
BC014798 mRNA Translation: AAH14798.1
CCDSiCCDS39490.1
RefSeqiNP_080092.2, NM_025816.3
XP_006506432.1, XM_006506369.3
UniGeneiMm.389757

Genome annotation databases

EnsembliENSMUST00000080723; ENSMUSP00000079548; ENSMUSG00000004535
GeneIDi52440
KEGGimmu:52440
UCSCiuc009byz.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTAXB1_MOUSE
AccessioniPrimary (citable) accession number: Q3UKC1
Secondary accession number(s): Q91YT6, Q9CVF0, Q9DC45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: March 28, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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