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Protein

B9 domain-containing protein 2

Gene

B9d2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.2 Publications

GO - Molecular functioni

  • gamma-tubulin binding Source: UniProtKB

GO - Biological processi

  • cilium assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2500257. Resolution of Sister Chromatid Cohesion.
R-MMU-5620912. Anchoring of the basal body to the plasma membrane.
R-MMU-5663220. RHO GTPases Activate Formins.
R-MMU-68877. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
B9 domain-containing protein 2
Alternative name(s):
Stumpy
Gene namesi
Name:B9d2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2387643. B9d2.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: MGI
  • ciliary basal body Source: MGI
  • cytoplasm Source: UniProtKB-KW
  • membrane Source: MGI
  • MKS complex Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice expressing reduced levels of the protein in the central nervous system and kidney develop perinatal triventricular hydrocephaly, polycystic kidney disease, lack functional intact cilia and die at the time of weaning.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 175175B9 domain-containing protein 2PRO_0000307675Add
BLAST

Proteomic databases

MaxQBiQ3UK10.
PaxDbiQ3UK10.
PeptideAtlasiQ3UK10.
PRIDEiQ3UK10.

Expressioni

Tissue specificityi

Highest expression in thymus and skeletal muscle. Also expressed in spleen, kidney, lung, heart, microglia and liver. Detected in brain (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000063439.
CleanExiMM_B9D2.
GenevisibleiQ3UK10. MM.

Interactioni

Subunit structurei

Part of the tectonic-like complex (also named B9 complex). Interacts with TUBG1.3 Publications

GO - Molecular functioni

  • gamma-tubulin binding Source: UniProtKB

Protein-protein interaction databases

DIPiDIP-29732N.
IntActiQ3UK10. 8 interactions.
STRINGi10090.ENSMUSP00000104040.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 118117B9PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the B9D family.Curated
Contains 1 B9 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4028. Eukaryota.
ENOG410ZQAW. LUCA.
GeneTreeiENSGT00530000063756.
HOGENOMiHOG000257718.
HOVERGENiHBG107102.
InParanoidiQ3UK10.
KOiK16745.
OMAiQVWHQDS.
OrthoDBiEOG091G0BGX.
PhylomeDBiQ3UK10.
TreeFamiTF314883.

Family and domain databases

InterProiIPR010796. B9_dom.
[Graphical view]
PfamiPF07162. B9-C2. 1 hit.
[Graphical view]
PROSITEiPS51381. B9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UK10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVHVIGQI IGATGFSESS LFCKWGIHTG AAWKLLSGVR EGQTQVDTPQ
60 70 80 90 100
IGDMAYWSHP IDLHFATKGL QGWPRLHLQV WSQDSFGRCQ LAGYGFCHVP
110 120 130 140 150
SSPGTHQLDC PTWRPLGSWR EQLARAFVGG GPQLLHADTI YSGADRYRLH
160 170
TAAGGTVHLG IGLLLRHFDR YGVEC
Length:175
Mass (Da):19,250
Last modified:October 23, 2007 - v2
Checksum:iF36F5AA5636163D1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti167 – 1671H → N in BAE26994 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK141500 mRNA. Translation: BAE24704.1.
AK146227 mRNA. Translation: BAE26994.1.
BC028440 mRNA. Translation: AAH28440.1.
CCDSiCCDS20992.1.
RefSeqiNP_742160.1. NM_172148.1.
XP_006539917.1. XM_006539854.2.
UniGeneiMm.22849.

Genome annotation databases

EnsembliENSMUST00000108403; ENSMUSP00000104040; ENSMUSG00000063439.
ENSMUST00000205658; ENSMUSP00000146289; ENSMUSG00000063439.
GeneIDi232987.
KEGGimmu:232987.
UCSCiuc009fto.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK141500 mRNA. Translation: BAE24704.1.
AK146227 mRNA. Translation: BAE26994.1.
BC028440 mRNA. Translation: AAH28440.1.
CCDSiCCDS20992.1.
RefSeqiNP_742160.1. NM_172148.1.
XP_006539917.1. XM_006539854.2.
UniGeneiMm.22849.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29732N.
IntActiQ3UK10. 8 interactions.
STRINGi10090.ENSMUSP00000104040.

Proteomic databases

MaxQBiQ3UK10.
PaxDbiQ3UK10.
PeptideAtlasiQ3UK10.
PRIDEiQ3UK10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108403; ENSMUSP00000104040; ENSMUSG00000063439.
ENSMUST00000205658; ENSMUSP00000146289; ENSMUSG00000063439.
GeneIDi232987.
KEGGimmu:232987.
UCSCiuc009fto.1. mouse.

Organism-specific databases

CTDi80776.
MGIiMGI:2387643. B9d2.

Phylogenomic databases

eggNOGiKOG4028. Eukaryota.
ENOG410ZQAW. LUCA.
GeneTreeiENSGT00530000063756.
HOGENOMiHOG000257718.
HOVERGENiHBG107102.
InParanoidiQ3UK10.
KOiK16745.
OMAiQVWHQDS.
OrthoDBiEOG091G0BGX.
PhylomeDBiQ3UK10.
TreeFamiTF314883.

Enzyme and pathway databases

ReactomeiR-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2500257. Resolution of Sister Chromatid Cohesion.
R-MMU-5620912. Anchoring of the basal body to the plasma membrane.
R-MMU-5663220. RHO GTPases Activate Formins.
R-MMU-68877. Mitotic Prometaphase.

Miscellaneous databases

PROiQ3UK10.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063439.
CleanExiMM_B9D2.
GenevisibleiQ3UK10. MM.

Family and domain databases

InterProiIPR010796. B9_dom.
[Graphical view]
PfamiPF07162. B9-C2. 1 hit.
[Graphical view]
PROSITEiPS51381. B9. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB9D2_MOUSE
AccessioniPrimary (citable) accession number: Q3UK10
Secondary accession number(s): Q8R045
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: September 7, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.