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Protein

B9 domain-containing protein 2

Gene

B9d2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.2 Publications

GO - Molecular functioni

  • gamma-tubulin binding Source: UniProtKB

GO - Biological processi

  • cilium assembly Source: UniProtKB

Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-MMU-141444. Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
R-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2500257. Resolution of Sister Chromatid Cohesion.
R-MMU-5620912. Anchoring of the basal body to the plasma membrane.
R-MMU-5663220. RHO GTPases Activate Formins.
R-MMU-68877. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
B9 domain-containing protein 2
Alternative name(s):
Stumpy
Gene namesi
Name:B9d2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2387643. B9d2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice expressing reduced levels of the protein in the central nervous system and kidney develop perinatal triventricular hydrocephaly, polycystic kidney disease, lack functional intact cilia and die at the time of weaning.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003076751 – 175B9 domain-containing protein 2Add BLAST175

Proteomic databases

MaxQBiQ3UK10.
PaxDbiQ3UK10.
PeptideAtlasiQ3UK10.
PRIDEiQ3UK10.

Expressioni

Tissue specificityi

Highest expression in thymus and skeletal muscle. Also expressed in spleen, kidney, lung, heart, microglia and liver. Detected in brain (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000063439.
CleanExiMM_B9D2.
ExpressionAtlasiQ3UK10. baseline and differential.
GenevisibleiQ3UK10. MM.

Interactioni

Subunit structurei

Part of the tectonic-like complex (also named B9 complex). Interacts with TUBG1.3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • gamma-tubulin binding Source: UniProtKB

Protein-protein interaction databases

CORUMiQ3UK10.
DIPiDIP-29732N.
IntActiQ3UK10. 8 interactors.
STRINGi10090.ENSMUSP00000104040.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 118B9PROSITE-ProRule annotationAdd BLAST117

Sequence similaritiesi

Belongs to the B9D family.Curated

Phylogenomic databases

eggNOGiKOG4028. Eukaryota.
ENOG410ZQAW. LUCA.
GeneTreeiENSGT00530000063756.
HOGENOMiHOG000257718.
HOVERGENiHBG107102.
InParanoidiQ3UK10.
KOiK16745.
OMAiQVWHQDS.
OrthoDBiEOG091G0BGX.
PhylomeDBiQ3UK10.
TreeFamiTF314883.

Family and domain databases

InterProiView protein in InterPro
IPR010796. B9_dom.
PANTHERiPTHR12968. PTHR12968. 1 hit.
PfamiView protein in Pfam
PF07162. B9-C2. 1 hit.
PROSITEiView protein in PROSITE
PS51381. B9. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3UK10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVHVIGQI IGATGFSESS LFCKWGIHTG AAWKLLSGVR EGQTQVDTPQ
60 70 80 90 100
IGDMAYWSHP IDLHFATKGL QGWPRLHLQV WSQDSFGRCQ LAGYGFCHVP
110 120 130 140 150
SSPGTHQLDC PTWRPLGSWR EQLARAFVGG GPQLLHADTI YSGADRYRLH
160 170
TAAGGTVHLG IGLLLRHFDR YGVEC
Length:175
Mass (Da):19,250
Last modified:October 23, 2007 - v2
Checksum:iF36F5AA5636163D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti167H → N in BAE26994 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK141500 mRNA. Translation: BAE24704.1.
AK146227 mRNA. Translation: BAE26994.1.
BC028440 mRNA. Translation: AAH28440.1.
CCDSiCCDS20992.1.
RefSeqiNP_742160.1. NM_172148.1.
XP_006539917.1. XM_006539854.3.
UniGeneiMm.22849.

Genome annotation databases

EnsembliENSMUST00000108403; ENSMUSP00000104040; ENSMUSG00000063439.
ENSMUST00000205658; ENSMUSP00000146289; ENSMUSG00000063439.
GeneIDi232987.
KEGGimmu:232987.
UCSCiuc009fto.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiB9D2_MOUSE
AccessioniPrimary (citable) accession number: Q3UK10
Secondary accession number(s): Q8R045
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: September 27, 2017
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families