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Protein

Regulator of microtubule dynamics protein 3

Gene

Rmdn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in cellular calcium homeostasis regulation (By similarity). May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processApoptosis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of microtubule dynamics protein 3
Short name:
RMD-3
Short name:
mRMD-3
Alternative name(s):
Protein FAM82A2
Protein FAM82C
Gene namesi
Name:Rmdn3
Synonyms:Fam82a2, Fam82c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1915059 Rmdn3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 35HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Microtubule, Mitochondrion, Mitochondrion outer membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002875111 – 470Regulator of microtubule dynamics protein 3Add BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44PhosphoserineBy similarity1
Modified residuei46PhosphoserineCombined sources1
Modified residuei50PhosphoserineCombined sources1
Modified residuei57PhosphoserineCombined sources1
Modified residuei183PhosphoserineBy similarity1
Modified residuei193PhosphoserineBy similarity1
Modified residuei212PhosphoserineCombined sources1
Modified residuei233PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3UJU9
MaxQBiQ3UJU9
PaxDbiQ3UJU9
PeptideAtlasiQ3UJU9
PRIDEiQ3UJU9

PTM databases

iPTMnetiQ3UJU9
PhosphoSitePlusiQ3UJU9

Expressioni

Gene expression databases

BgeeiENSMUSG00000070730
CleanExiMM_1200015F23RIK
ExpressionAtlasiQ3UJU9 baseline and differential
GenevisibleiQ3UJU9 MM

Interactioni

Subunit structurei

Interacts with PTPN2. Interacts with microtubules. Interacts with VAPB.By similarity

Protein-protein interaction databases

BioGridi212454, 77 interactors
IntActiQ3UJU9, 77 interactors
STRINGi10090.ENSMUSP00000092283

Structurei

3D structure databases

ProteinModelPortaliQ3UJU9
SMRiQ3UJU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili91 – 125Sequence analysisAdd BLAST35

Domaini

The transmembrane region is required for mitochondrial localization.By similarity

Sequence similaritiesi

Belongs to the RMDN family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFRV Eukaryota
ENOG41101S6 LUCA
GeneTreeiENSGT00530000063162
HOGENOMiHOG000015374
HOVERGENiHBG072518
InParanoidiQ3UJU9
OMAiEVRSHME
OrthoDBiEOG091G0F3V
PhylomeDBiQ3UJU9
TreeFamiTF315854

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR011990 TPR-like_helical_dom_sf
SUPFAMiSSF48452 SSF48452, 1 hit

Sequencei

Sequence statusi: Complete.

Q3UJU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLGALGGS RAGLGLLLGT AAGLGFLCVL YSQRWKRTQR HGRSHSLPNS
60 70 80 90 100
LDYAQASERG RQVTQFRAIP GEAGDAAILP SLSQEGQEKV LDRLDFVLTS
110 120 130 140 150
LMALRREVEE LQRSLQGLAG EIVGEVRSHI EENQRVARRR RFPFARERSD
160 170 180 190 200
STGSSSVYFT ASSGAALTDA ESEGGYTTAN AESDYERDSD KESGDAEDEV
210 220 230 240 250
SCETVRMGRK DSLDLDVEAA SSPAAAALEE DDSSGREDVQ LVLLQADELH
260 270 280 290 300
QGSKQDKREG FQLLLNNKLA YGSRQDFLWR LARAYSDMSD LTEEESGKKS
310 320 330 340 350
YALNGKEEAE AALKKGDESA ACHLWYAVLC GQLAEHEGIS KRIQSGFSFK
360 370 380 390 400
EHVDKAIELQ PEDPRGHFLL GRWCYQVSHL NWLEKKTATA LFESPLSATV
410 420 430 440 450
QDALQSFLKA EELQPGFSKA GRVYISKCYR ELGKNSEARK WMKLAQELPD
460 470
VTNEDSAFQK DLEELEVILG
Length:470
Mass (Da):52,029
Last modified:May 15, 2007 - v2
Checksum:iBA82C57843985A1B
GO

Sequence cautioni

The sequence AAH55754 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH61186 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence FAA00420 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti210K → R in BAE31902 (PubMed:16141072).Curated1
Sequence conflicti210K → R in BAE31937 (PubMed:16141072).Curated1
Sequence conflicti224A → S in AAH61186 (PubMed:15489334).Curated1
Sequence conflicti254K → E in BAE27056 (PubMed:16141072).Curated1
Sequence conflicti254K → E in AAH61186 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146299 mRNA Translation: BAE27056.1
AK151090 mRNA Translation: BAE30103.1
AK153369 mRNA Translation: BAE31937.1
AK153322 mRNA Translation: BAE31902.1
AL772264 Genomic DNA No translation available.
BC055754 mRNA Translation: AAH55754.1 Different initiation.
BC061186 mRNA Translation: AAH61186.1 Sequence problems.
BR000695 mRNA Translation: FAA00420.1 Different initiation.
CCDSiCCDS16591.1
RefSeqiNP_001028308.1, NM_001033136.3
UniGeneiMm.475909

Genome annotation databases

EnsembliENSMUST00000094695; ENSMUSP00000092283; ENSMUSG00000070730
GeneIDi67809
KEGGimmu:67809
UCSCiuc008lte.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRMD3_MOUSE
AccessioniPrimary (citable) accession number: Q3UJU9
Secondary accession number(s): A9UN03
, Q3U5Y8, Q3UB61, Q6P8M2, Q7TNF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: May 23, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health