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Protein

Trifunctional purine biosynthetic protein adenosine-3

Gene

Gart

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation
ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase (Pfas)
  2. Trifunctional purine biosynthetic protein adenosine-3 (Gart), Trifunctional purine biosynthetic protein adenosine-3 (Gart)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Amidophosphoribosyltransferase (Ppat), Amidophosphoribosyltransferase (Ppat), Amidophosphoribosyltransferase (Ppat), Amidophosphoribosyltransferase (Ppat)
  2. Trifunctional purine biosynthetic protein adenosine-3 (Gart), Trifunctional purine biosynthetic protein adenosine-3 (Gart)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Trifunctional purine biosynthetic protein adenosine-3 (Gart), Trifunctional purine biosynthetic protein adenosine-3 (Gart)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotation
Biological processPurine biosynthesisUniRule annotation
LigandATP-bindingPROSITE-ProRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00125.
UPA00074; UER00126.
UPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Trifunctional purine biosynthetic protein adenosine-3UniRule annotation
Including the following 3 domains:
Phosphoribosylamine--glycine ligaseUniRule annotation (EC:6.3.4.13UniRule annotation)
Alternative name(s):
Glycinamide ribonucleotide synthetaseUniRule annotation
Short name:
GARSUniRule annotation
Phosphoribosylglycinamide synthetaseUniRule annotation
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
Short name:
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Phosphoribosylglycinamide formyltransferaseUniRule annotation (EC:2.1.2.2UniRule annotation)
Alternative name(s):
5'-phosphoribosylglycinamide transformylaseUniRule annotation
GAR transformylaseUniRule annotation
Short name:
GARTUniRule annotation
Gene namesi
Name:GartImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95654. Gart.

Subcellular locationi

PTM / Processingi

Proteomic databases

PaxDbiQ3UJP8.
PeptideAtlasiQ3UJP8.
PRIDEiQ3UJP8.

Structurei

3D structure databases

ProteinModelPortaliQ3UJP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini111 – 318ATP-graspInterPro annotationAdd BLAST208

Sequence similaritiesi

In the C-terminal section; belongs to the GART family.UniRule annotation
In the N-terminal section; belongs to the GARS family.UniRule annotation
In the central section; belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0237. Eukaryota.
KOG3076. Eukaryota.
COG0150. LUCA.
COG0151. LUCA.
COG0299. LUCA.
HOVERGENiHBG008333.

Family and domain databases

CDDicd08645. FMT_core_GART. 1 hit.
cd02196. PurM. 1 hit.
Gene3Di3.30.1330.10. 1 hit.
3.30.1490.20. 1 hit.
3.40.50.170. 1 hit.
3.90.600.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS. 1 hit.
MF_00138. GARS. 1 hit.
MF_01930. PurN. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR002376. Formyl_transf_N.
IPR036477. Formyl_transf_N_sf.
IPR004607. GART.
IPR001555. GART_AS.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR037123. PRibGlycinamide_synth_C_sf.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR010918. PurM-like_C_dom.
IPR036676. PurM-like_C_sf.
IPR016188. PurM-like_N.
IPR036921. PurM-like_N_sf.
IPR004733. PurM_cligase.
IPR011054. Rudment_hybrid_motif.
PANTHERiPTHR10520. PTHR10520. 1 hit.
PfamiView protein in Pfam
PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
PF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
SMARTiView protein in SMART
SM01210. GARS_C. 1 hit.
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
SSF53328. SSF53328. 1 hit.
SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00877. purD. 1 hit.
TIGR00878. purM. 1 hit.
TIGR00639. PurN. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
PS00373. GART. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3UJP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARVLVIGS GGREHTLAWK LAQSPQVKQV LVAPGNAGTA CAGKISNAAV
60 70 80 90 100
SVNDHSALAQ FCKDEKIELV VVGPEAPLAA GIVGDLTSAG VRCFGPTAQA
110 120 130 140 150
AQLESSKKFA KEFMDRHEIP TAQWRAFTNP EDACSFITSA NFPALVVKAS
160 170 180 190 200
GLAAGKGVIV AKSQAEACRA VQEIMQEKSF GAAGETVVVE EFLEGEEVSC
210 220 230 240 250
LCFTDGKTVA EMPPAQDHKR LLDGDEGPNT GGMGAYCPAP QVSKDLLVKI
260 270 280 290 300
KNTILQRAVD GMQQEGAPYT GILYAGIMLT KDGPKVLEFN CRFGDPECQV
310 320 330 340 350
ILPLLKSDLY EVMQSTLDGL LSASLPVWLE NHSAVTVVMA SKGYPGAYTK
360 370 380 390 400
GVEITGFPEA QALGLQVFHA GTALKDGKVV TSGGRVLTVT AVQENLMSAL
410 420 430 440 450
AEARKGLTAL KFEGAIYRKD IGFRAVAFLQ RPRGLTYKDS GVDIAAGNML
460 470 480 490 500
VKKIQPLAKA TSRPGCSVDL GGFAGLFDLK AAGLKDPLLA SGTDGVGTKL
510 520 530 540 550
KIAQLCNKHD SIGQDLAAMC VNDILAQGAE PLFFLDYFSC GKLDLSTTEA
560 570 580 590 600
VIAGIAAACQ QAGCALLGGE TAEMPNMYPP GEYDLAGFAV GAMERHQKLP
610 620 630 640 650
QLERITEGDA VIGVASSGLH SNGFSLVRKI VERSSLQYSS PAPGGCGDQT
660 670 680 690 700
LGDLLLTPTR IYSHSLLPII RSGRVKAFAH ITGGGLLENI PRVLPQKFGV
710 720 730 740 750
DLDASTWRVP KVFSWLQQEG ELSEEEMART FNCGIGAALV VSKDQAEQVL
760 770 780 790 800
HDVRRRQEEA WVIGSVVACP EDSPRVRVKN LIETIQTNGS LVANGFLKSN
810 820 830 840 850
FPVQQKKARV AVLISGTGSN LQALIDSTRD PKSSSHIVLV ISNKAAVAGL
860 870 880 890 900
DRAERAGIPT RVINHKLYKN RVEFDNAVDH VLEEFSVDIV CLAGFMRILS
910 920 930 940 950
GPFVRKWDGK MLNIHPSLLP SFKGSNAHEQ VLEAGVTITG CTVHFVAEDV
960 970 980 990 1000
DAGQIILQEA VPVRRGDTVA TLSERVKVAE HKIFPAALQL VASGAVQLRE
1010
DGKIHWAKEQ
Length:1,010
Mass (Da):107,471
Last modified:October 11, 2005 - v1
Checksum:i8641807A2BB082AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146355 mRNA. Translation: BAE27107.1.
UniGeneiMm.10281.
Mm.4505.

Similar proteinsi

Entry informationi

Entry nameiQ3UJP8_MOUSE
AccessioniPrimary (citable) accession number: Q3UJP8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: October 25, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Multifunctional enzymeUniRule annotation