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Protein

GTP-binding protein 2

Gene

Gtpbp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi179 – 1868GTPBy similarity
Nucleotide bindingi260 – 2645GTPBy similarity
Nucleotide bindingi316 – 3194GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: MGI
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein 2
Alternative name(s):
GTP-binding-like protein 2
Gene namesi
Name:Gtpbp2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1860138. Gtpbp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 602602GTP-binding protein 2PRO_0000248501Add
BLAST

Proteomic databases

EPDiQ3UJK4.
MaxQBiQ3UJK4.
PaxDbiQ3UJK4.
PRIDEiQ3UJK4.

PTM databases

PhosphoSiteiQ3UJK4.

Expressioni

Tissue specificityi

Predominantly expressed in thymus, spleen, and testis. Expressed at lower levels in brain, heart, lung, kidney, and skeletal muscle. In testis, specifically expressed in spermatocytes and round spermatids.1 Publication

Inductioni

Up-regulated in thioglycolate-elicited mouse peritoneal macrophages.1 Publication

Gene expression databases

BgeeiQ3UJK4.
CleanExiMM_GTPBP2.
ExpressionAtlasiQ3UJK4. baseline and differential.
GenevisibleiQ3UJK4. MM.

Interactioni

Protein-protein interaction databases

DIPiDIP-61685N.
STRINGi10090.ENSMUSP00000024748.

Structurei

3D structure databases

ProteinModelPortaliQ3UJK4.
SMRiQ3UJK4. Positions 173-569.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini170 – 398229tr-type GPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily.PROSITE-ProRule annotation
Contains 1 tr-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0463. Eukaryota.
COG5258. LUCA.
GeneTreeiENSGT00730000110829.
HOGENOMiHOG000176635.
HOVERGENiHBG004471.
InParanoidiQ3UJK4.
OrthoDBiEOG70KGPM.
PhylomeDBiQ3UJK4.
TreeFamiTF350446.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UJK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSRVSELFG GCCRPGGGPA MGGNLKARGA GGSSSCGGPK GKKKNGRNRG
60 70 80 90 100
GKANNPPYLP PEAEDGNIEY KLKLVNPSQY RFEHLVTQMK WRLQEGRGEA
110 120 130 140 150
VYQIGVEDNG LLVGLAEEEM RASLKTLHRM AEKVGADITV LREREVDYDS
160 170 180 190 200
DVPRKITEVL VRKVPDNQQF LDLRVAVLGN VDSGKSTLLG VLTQGELDNG
210 220 230 240 250
RGRARLNLFR HLHEIQSGRT SSISFEILGF NSKGEVVNYS DSRTAEEICE
260 270 280 290 300
SSSKMITFID LAGHHKYLHT TIFGLTSYCP DCALLLVSAN TGIAGTTREH
310 320 330 340 350
LGLALALKVP FFIVVSKVDL CAKTTVERTV RQLERVLKQP GCHKVPMLVT
360 370 380 390 400
SEDDAVTAAQ QFAQSPNVTP IFTLSSVSGE SLDLLKVFLN ILPPLTNSKE
410 420 430 440 450
QEELMQQLTE FQVDEIYTVP EVGTVVGGTL SSGICREGDQ LVVGPTDDGC
460 470 480 490 500
FLELRVCSIQ RNRSACRVLR AGQAATLALG DFDRALLRKG MVMVSPEMNP
510 520 530 540 550
TICSVFEAEI VLLFHATTFR RGFQVTVHVG NVRQTAVVEK IHAKDKLRTG
560 570 580 590 600
EKAVVRFRFL KHPEYLKVGA KLLFREGVTK GIGHVTDVQA ITAGEAQATM

GF
Length:602
Mass (Da):65,754
Last modified:October 11, 2005 - v1
Checksum:i018D8BBB4F05151D
GO

Sequence cautioni

The sequence AAF78885.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH49089.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH51958.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB12430.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti215 – 2151I → V in BAB12430 (PubMed:11054535).Curated
Sequence conflicti394 – 3941P → S in BAB12430 (PubMed:11054535).Curated
Sequence conflicti428 – 4281Missing in BAB12430 (PubMed:11054535).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF168991 mRNA. Translation: AAF78885.1. Different initiation.
AK146415 mRNA. Translation: BAE27151.1.
BC049089 mRNA. Translation: AAH49089.1. Different initiation.
BC051958 mRNA. Translation: AAH51958.1. Different initiation.
AB024573 mRNA. Translation: BAB12430.1. Different initiation.
CCDSiCCDS50122.1.
PIRiJC7285.
RefSeqiNP_001139451.1. NM_001145979.1.
NP_062527.2. NM_019581.3.
UniGeneiMm.22147.

Genome annotation databases

EnsembliENSMUST00000024748; ENSMUSP00000024748; ENSMUSG00000023952.
GeneIDi56055.
KEGGimmu:56055.
UCSCiuc008crw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF168991 mRNA. Translation: AAF78885.1. Different initiation.
AK146415 mRNA. Translation: BAE27151.1.
BC049089 mRNA. Translation: AAH49089.1. Different initiation.
BC051958 mRNA. Translation: AAH51958.1. Different initiation.
AB024573 mRNA. Translation: BAB12430.1. Different initiation.
CCDSiCCDS50122.1.
PIRiJC7285.
RefSeqiNP_001139451.1. NM_001145979.1.
NP_062527.2. NM_019581.3.
UniGeneiMm.22147.

3D structure databases

ProteinModelPortaliQ3UJK4.
SMRiQ3UJK4. Positions 173-569.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61685N.
STRINGi10090.ENSMUSP00000024748.

PTM databases

PhosphoSiteiQ3UJK4.

Proteomic databases

EPDiQ3UJK4.
MaxQBiQ3UJK4.
PaxDbiQ3UJK4.
PRIDEiQ3UJK4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024748; ENSMUSP00000024748; ENSMUSG00000023952.
GeneIDi56055.
KEGGimmu:56055.
UCSCiuc008crw.2. mouse.

Organism-specific databases

CTDi54676.
MGIiMGI:1860138. Gtpbp2.

Phylogenomic databases

eggNOGiKOG0463. Eukaryota.
COG5258. LUCA.
GeneTreeiENSGT00730000110829.
HOGENOMiHOG000176635.
HOVERGENiHBG004471.
InParanoidiQ3UJK4.
OrthoDBiEOG70KGPM.
PhylomeDBiQ3UJK4.
TreeFamiTF350446.

Miscellaneous databases

NextBioi311836.
PROiQ3UJK4.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UJK4.
CleanExiMM_GTPBP2.
ExpressionAtlasiQ3UJK4. baseline and differential.
GenevisibleiQ3UJK4. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse and human GTPBP2, newly identified members of the GP-1 family of GTPase."
    Kudo H., Senju S., Mitsuya H., Nishimura Y.
    Biochem. Biophys. Res. Commun. 272:456-465(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
    Tissue: BrainImported.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: DBA/2JImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: BrainImported.
  4. "Cloning, expression analysis, and chromosomal mapping of GTPBP2, a novel member of the G protein family."
    Watanabe M., Yoshida K., Hida M., Kato H., Uchida K., Yamaguchi R., Tateyama S., Sugano S.
    Gene 256:51-58(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 86-602, TISSUE SPECIFICITY.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen.

Entry informationi

Entry nameiGTPB2_MOUSE
AccessioniPrimary (citable) accession number: Q3UJK4
Secondary accession number(s): Q9EST7, Q9JIX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 11, 2005
Last modified: May 11, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.