SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q3UJF1

- Q3UJF1_MOUSE

UniProt

Q3UJF1 - Q3UJF1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

Histone deacetylase 5

Gene
Hdac5
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. histone deacetylase activity Source: Ensembl
  2. protein binding Source: MGI
  3. transcription corepressor activity Source: MGI
  4. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. heart development Source: MGI
  2. multicellular organismal response to stress Source: MGI
  3. negative regulation of cell migration involved in sprouting angiogenesis Source: Ensembl
  4. negative regulation of myotube differentiation Source: Ensembl
  5. negative regulation of osteoblast differentiation Source: MGI
  6. negative regulation of transcription, DNA-templated Source: MGI
  7. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  8. osteoblast development Source: MGI
  9. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  10. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  11. regulation of protein binding Source: Ensembl
  12. regulation of skeletal muscle fiber development Source: MGI
  13. regulation of striated muscle cell differentiation Source: MGI
  14. response to cocaine Source: MGI
  15. response to drug Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotations

Enzyme and pathway databases

ReactomeiREACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

Names & Taxonomyi

Protein namesi
Submitted name:
Histone deacetylase 5Imported
Gene namesi
Name:Hdac5Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1333784. Hdac5.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. Golgi apparatus Source: Ensembl
  4. histone deacetylase complex Source: InterPro
  5. nuclear body Source: MGI
  6. nucleus Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ3UJF1.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000062809.
HOVERGENiHBG057100.
KOiK11406.
TreeFamiTF106174.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

Q3UJF1-1 [UniParc]FASTAAdd to Basket

« Hide

MNSPNESADG MSGREPSLEI LPRTPLHSIP VAVEVKPVLP GAMPSSMGGG     50
GGGSPSPVEL RGALAGPMDP ALREQQLQQE LLVLKQQQQL QKQLLFAEFQ 100
KQHDHLTRQH EVQLQKHLKQ QQEMLAAKRQ QELEQQRQRE QQRQEELEKQ 150
RLEQQLLILR NKEKSKESAI ASTEVKLRLQ EFLLSKSKEP TPGGLNHSLP 200
QHPKCWGAHH ASLDQSSPPQ SGPPGTPPSY KLPLLGPYDS RDDFPLRKTA 250
SEPNLKVRSR LKQKVAERRS SPLLRRKDGT VISTFKKRAV EITGTGPGVS 300
SVCNSAPGSG PSSPNSSHST IAENGFTGSV PNIPTEMIPQ HRALPLDSSP 350
NQFSLYTSPS LPNISLGLQA TVTVTNSHLT ASPKLSTQQE AERQALQSLR 400
QGGTLTGKFM STSSIPGCLL GVALEGDTSP HGHASLLQHV LLLEQARQQS 450
TLIAVPLHGQ SPLVTGERVA TSMRTVGKLP RHRPLSRTQS SPLPQSPQAL 500
QQLVMQQQHQ QFLEKQKQQQ MQLGKILTKT GELSRQPTTH PEETEEELTE 550
QQEALLGEGA LTIPREGSTE SESTQEDLEE EEEEEEEEEE DCIQVKDEDG 600
ESGPDEGPDL EESSAGYKKL FADAQQLQPL QVYQAPLSLA TVPHQALGRT 650
QSSPAAPGSM KSPTDQPTVV KHLFTTGVVY DTFMLKHQCM CGNTHVHPEH 700
AGRIQSIWSR LQETGLLGKC ERIRGRKATL DEIQTVHSEY HTLLYGTSPL 750
NRQKLDSKKL LGPISQKMYA MLPCGGIGVD SDTVWNEMHS SSAVRMAVGC 800
LVELAFKVAA GELKNGFAII RPPGHHAEES TAMGFCFFNS VAITAKLLQQ 850
KLSVGKVLIV DWDIHHGNGT QQAFYNDPSV LYISLHRYDN GNFFPGSGAP 900
EEVGGGPGVG YNVNVAWTGG VDPPIGDVEY LTAFRTVVMP IAQEFSPDVV 950
LVSAGFDAVE GHLSPLGGYS VTARCFGHLT RQLMTLAGGR VVLALEGGHD 1000
LTAICDASEA CVSALLSVEL QPLDEAVLQQ KPSVNAVATL EKVIEIQSKH 1050
WSCVQRFAAG LGCSLREAQT GEKEEAETVS AMALLSVGAE QAQAVATQEH 1100
SPRPAEEPME QEPAL 1115
Length:1,115
Mass (Da):121,219
Last modified:October 11, 2005 - v1
Checksum:iD46C999D156CAE96
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL954730 Genomic DNA. No translation available.
AK146483 mRNA. Translation: BAE27204.1.
RefSeqiNP_001071164.1. NM_001077696.1.
UniGeneiMm.22665.

Genome annotation databases

EnsembliENSMUST00000107152; ENSMUSP00000102770; ENSMUSG00000008855.
GeneIDi15184.
KEGGimmu:15184.
UCSCiuc007lqv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL954730 Genomic DNA. No translation available.
AK146483 mRNA. Translation: BAE27204.1 .
RefSeqi NP_001071164.1. NM_001077696.1.
UniGenei Mm.22665.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000107152 ; ENSMUSP00000102770 ; ENSMUSG00000008855 .
GeneIDi 15184.
KEGGi mmu:15184.
UCSCi uc007lqv.1. mouse.

Organism-specific databases

CTDi 10014.
MGIi MGI:1333784. Hdac5.

Phylogenomic databases

GeneTreei ENSGT00530000062809.
HOVERGENi HBG057100.
KOi K11406.
TreeFami TF106174.

Enzyme and pathway databases

Reactomei REACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

Miscellaneous databases

ChiTaRSi HDAC5. mouse.
NextBioi 287701.
SOURCEi Search...

Gene expression databases

Genevestigatori Q3UJF1.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037911. HDAC_II_euk. 1 hit.
PRINTSi PR01270. HDASUPER.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeartImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeartImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeartImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeartImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeartImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeartImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeartImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeartImported.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  10. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ3UJF1_MOUSE
AccessioniPrimary (citable) accession number: Q3UJF1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 3, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi