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Q3UJF1

- Q3UJF1_MOUSE

UniProt

Q3UJF1 - Q3UJF1_MOUSE

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Protein

Histone deacetylase

Gene

Hdac5

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.UniRule annotation

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi689 – 6891ZincUniRule annotation
Metal bindingi691 – 6911ZincUniRule annotation
Metal bindingi697 – 6971ZincUniRule annotation
Metal bindingi774 – 7741ZincUniRule annotation
Active sitei826 – 8261UniRule annotation

GO - Molecular functioni

  1. histone deacetylase activity Source: InterPro
  2. transcription corepressor activity Source: MGI
  3. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. heart development Source: MGI
  2. multicellular organismal response to stress Source: MGI
  3. negative regulation of cell migration involved in sprouting angiogenesis Source: Ensembl
  4. negative regulation of myotube differentiation Source: Ensembl
  5. negative regulation of osteoblast differentiation Source: MGI
  6. negative regulation of transcription, DNA-templated Source: MGI
  7. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  8. osteoblast development Source: MGI
  9. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  10. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  11. regulation of protein binding Source: Ensembl
  12. regulation of skeletal muscle fiber development Source: MGI
  13. regulation of striated muscle cell differentiation Source: MGI
  14. response to cocaine Source: MGI
  15. response to drug Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation, RepressorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
Name:Hdac5Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1333784. Hdac5.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. Golgi apparatus Source: Ensembl
  4. histone deacetylase complex Source: InterPro
  5. nuclear body Source: MGI
  6. nucleus Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ3UJF1.

Family & Domainsi

Sequence similaritiesi

Belongs to the histone deacetylase family. HD type 2 subfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000062809.
HOVERGENiHBG057100.
KOiK11406.
TreeFamiTF106174.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

Q3UJF1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSPNESADG MSGREPSLEI LPRTPLHSIP VAVEVKPVLP GAMPSSMGGG
60 70 80 90 100
GGGSPSPVEL RGALAGPMDP ALREQQLQQE LLVLKQQQQL QKQLLFAEFQ
110 120 130 140 150
KQHDHLTRQH EVQLQKHLKQ QQEMLAAKRQ QELEQQRQRE QQRQEELEKQ
160 170 180 190 200
RLEQQLLILR NKEKSKESAI ASTEVKLRLQ EFLLSKSKEP TPGGLNHSLP
210 220 230 240 250
QHPKCWGAHH ASLDQSSPPQ SGPPGTPPSY KLPLLGPYDS RDDFPLRKTA
260 270 280 290 300
SEPNLKVRSR LKQKVAERRS SPLLRRKDGT VISTFKKRAV EITGTGPGVS
310 320 330 340 350
SVCNSAPGSG PSSPNSSHST IAENGFTGSV PNIPTEMIPQ HRALPLDSSP
360 370 380 390 400
NQFSLYTSPS LPNISLGLQA TVTVTNSHLT ASPKLSTQQE AERQALQSLR
410 420 430 440 450
QGGTLTGKFM STSSIPGCLL GVALEGDTSP HGHASLLQHV LLLEQARQQS
460 470 480 490 500
TLIAVPLHGQ SPLVTGERVA TSMRTVGKLP RHRPLSRTQS SPLPQSPQAL
510 520 530 540 550
QQLVMQQQHQ QFLEKQKQQQ MQLGKILTKT GELSRQPTTH PEETEEELTE
560 570 580 590 600
QQEALLGEGA LTIPREGSTE SESTQEDLEE EEEEEEEEEE DCIQVKDEDG
610 620 630 640 650
ESGPDEGPDL EESSAGYKKL FADAQQLQPL QVYQAPLSLA TVPHQALGRT
660 670 680 690 700
QSSPAAPGSM KSPTDQPTVV KHLFTTGVVY DTFMLKHQCM CGNTHVHPEH
710 720 730 740 750
AGRIQSIWSR LQETGLLGKC ERIRGRKATL DEIQTVHSEY HTLLYGTSPL
760 770 780 790 800
NRQKLDSKKL LGPISQKMYA MLPCGGIGVD SDTVWNEMHS SSAVRMAVGC
810 820 830 840 850
LVELAFKVAA GELKNGFAII RPPGHHAEES TAMGFCFFNS VAITAKLLQQ
860 870 880 890 900
KLSVGKVLIV DWDIHHGNGT QQAFYNDPSV LYISLHRYDN GNFFPGSGAP
910 920 930 940 950
EEVGGGPGVG YNVNVAWTGG VDPPIGDVEY LTAFRTVVMP IAQEFSPDVV
960 970 980 990 1000
LVSAGFDAVE GHLSPLGGYS VTARCFGHLT RQLMTLAGGR VVLALEGGHD
1010 1020 1030 1040 1050
LTAICDASEA CVSALLSVEL QPLDEAVLQQ KPSVNAVATL EKVIEIQSKH
1060 1070 1080 1090 1100
WSCVQRFAAG LGCSLREAQT GEKEEAETVS AMALLSVGAE QAQAVATQEH
1110
SPRPAEEPME QEPAL
Length:1,115
Mass (Da):121,219
Last modified:October 11, 2005 - v1
Checksum:iD46C999D156CAE96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954730 Genomic DNA. No translation available.
AK146483 mRNA. Translation: BAE27204.1.
RefSeqiNP_001071164.1. NM_001077696.1.
UniGeneiMm.22665.

Genome annotation databases

EnsembliENSMUST00000107152; ENSMUSP00000102770; ENSMUSG00000008855.
GeneIDi15184.
KEGGimmu:15184.
UCSCiuc007lqv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954730 Genomic DNA. No translation available.
AK146483 mRNA. Translation: BAE27204.1 .
RefSeqi NP_001071164.1. NM_001077696.1.
UniGenei Mm.22665.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000107152 ; ENSMUSP00000102770 ; ENSMUSG00000008855 .
GeneIDi 15184.
KEGGi mmu:15184.
UCSCi uc007lqv.1. mouse.

Organism-specific databases

CTDi 10014.
MGIi MGI:1333784. Hdac5.

Phylogenomic databases

GeneTreei ENSGT00530000062809.
HOVERGENi HBG057100.
KOi K11406.
TreeFami TF106174.

Enzyme and pathway databases

Reactomei REACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

Miscellaneous databases

ChiTaRSi Hdac5. mouse.
NextBioi 287701.
SOURCEi Search...

Gene expression databases

Genevestigatori Q3UJF1.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037911. HDAC_II_euk. 1 hit.
PRINTSi PR01270. HDASUPER.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeartImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeartImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeartImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeartImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeartImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeartImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeartImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeartImported.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  10. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ3UJF1_MOUSE
AccessioniPrimary (citable) accession number: Q3UJF1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 26, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3