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Q3UJF1 (Q3UJF1_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Hdac5 Ensembl ENSMUSP00000102770 MGI 1333784
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1115 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Molecular functionHydrolase SAAS SAAS023801
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processheart development

Inferred from genetic interaction PubMed 15367668. Source: MGI

multicellular organismal response to stress

Inferred from mutant phenotype PubMed 17988634. Source: MGI

negative regulation of cell migration involved in sprouting angiogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of myotube differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of osteoblast differentiation

Inferred from mutant phenotype PubMed 15990875. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 10640276. Source: MGI

negative regulation of transcription, DNA-templated

Inferred from direct assay PubMed 16260608. Source: MGI

osteoblast development

Inferred from mutant phenotype PubMed 15990875. Source: MGI

positive regulation of sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

regulation of protein binding

Inferred from electronic annotation. Source: Ensembl

regulation of skeletal muscle fiber development

Inferred from genetic interaction PubMed 17786239. Source: MGI

regulation of striated muscle cell differentiation

Inferred from genetic interaction PubMed 17786239. Source: MGI

response to cocaine

Inferred from direct assay PubMed 17988634. Source: MGI

response to drug

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from direct assay PubMed 11081517. Source: MGI

cytosol

Inferred from direct assay PubMed 18198354PubMed 18332106. Source: MGI

histone deacetylase complex

Inferred from electronic annotation. Source: InterPro

nuclear body

Inferred from direct assay PubMed 11641275. Source: MGI

nucleus

Inferred from direct assay PubMed 11081517PubMed 18198354. Source: MGI

   Molecular_functionhistone deacetylase activity

Inferred from electronic annotation. Source: Ensembl

transcription corepressor activity

Inferred from direct assay PubMed 10640276. Source: MGI

transcription regulatory region DNA binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q3UJF1 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: D46C999D156CAE96

FASTA1,115121,219
        10         20         30         40         50         60 
MNSPNESADG MSGREPSLEI LPRTPLHSIP VAVEVKPVLP GAMPSSMGGG GGGSPSPVEL 

        70         80         90        100        110        120 
RGALAGPMDP ALREQQLQQE LLVLKQQQQL QKQLLFAEFQ KQHDHLTRQH EVQLQKHLKQ 

       130        140        150        160        170        180 
QQEMLAAKRQ QELEQQRQRE QQRQEELEKQ RLEQQLLILR NKEKSKESAI ASTEVKLRLQ 

       190        200        210        220        230        240 
EFLLSKSKEP TPGGLNHSLP QHPKCWGAHH ASLDQSSPPQ SGPPGTPPSY KLPLLGPYDS 

       250        260        270        280        290        300 
RDDFPLRKTA SEPNLKVRSR LKQKVAERRS SPLLRRKDGT VISTFKKRAV EITGTGPGVS 

       310        320        330        340        350        360 
SVCNSAPGSG PSSPNSSHST IAENGFTGSV PNIPTEMIPQ HRALPLDSSP NQFSLYTSPS 

       370        380        390        400        410        420 
LPNISLGLQA TVTVTNSHLT ASPKLSTQQE AERQALQSLR QGGTLTGKFM STSSIPGCLL 

       430        440        450        460        470        480 
GVALEGDTSP HGHASLLQHV LLLEQARQQS TLIAVPLHGQ SPLVTGERVA TSMRTVGKLP 

       490        500        510        520        530        540 
RHRPLSRTQS SPLPQSPQAL QQLVMQQQHQ QFLEKQKQQQ MQLGKILTKT GELSRQPTTH 

       550        560        570        580        590        600 
PEETEEELTE QQEALLGEGA LTIPREGSTE SESTQEDLEE EEEEEEEEEE DCIQVKDEDG 

       610        620        630        640        650        660 
ESGPDEGPDL EESSAGYKKL FADAQQLQPL QVYQAPLSLA TVPHQALGRT QSSPAAPGSM 

       670        680        690        700        710        720 
KSPTDQPTVV KHLFTTGVVY DTFMLKHQCM CGNTHVHPEH AGRIQSIWSR LQETGLLGKC 

       730        740        750        760        770        780 
ERIRGRKATL DEIQTVHSEY HTLLYGTSPL NRQKLDSKKL LGPISQKMYA MLPCGGIGVD 

       790        800        810        820        830        840 
SDTVWNEMHS SSAVRMAVGC LVELAFKVAA GELKNGFAII RPPGHHAEES TAMGFCFFNS 

       850        860        870        880        890        900 
VAITAKLLQQ KLSVGKVLIV DWDIHHGNGT QQAFYNDPSV LYISLHRYDN GNFFPGSGAP 

       910        920        930        940        950        960 
EEVGGGPGVG YNVNVAWTGG VDPPIGDVEY LTAFRTVVMP IAQEFSPDVV LVSAGFDAVE 

       970        980        990       1000       1010       1020 
GHLSPLGGYS VTARCFGHLT RQLMTLAGGR VVLALEGGHD LTAICDASEA CVSALLSVEL 

      1030       1040       1050       1060       1070       1080 
QPLDEAVLQQ KPSVNAVATL EKVIEIQSKH WSCVQRFAAG LGCSLREAQT GEKEEAETVS 

      1090       1100       1110 
AMALLSVGAE QAQAVATQEH SPRPAEEPME QEPAL 

« Hide

References

« Hide 'large scale' references
[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE27204.1.
Tissue: Heart EMBL BAE27204.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE27204.1.
Tissue: Heart EMBL BAE27204.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE27204.1.
Tissue: Heart EMBL BAE27204.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE27204.1.
Tissue: Heart EMBL BAE27204.1.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE27204.1.
Tissue: Heart EMBL BAE27204.1.
[6]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE27204.1.
Tissue: Heart EMBL BAE27204.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE27204.1.
Tissue: Heart EMBL BAE27204.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE27204.1.
Tissue: Heart EMBL BAE27204.1.
[9]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000102770.
[10]Ensembl
Submitted (JUN-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000102770.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL954730 Genomic DNA. No translation available.
AK146483 mRNA. Translation: BAE27204.1.
RefSeqNP_001071164.1. NM_001077696.1.
UniGeneMm.22665.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000107152; ENSMUSP00000102770; ENSMUSG00000008855.
GeneID15184.
KEGGmmu:15184.
UCSCuc007lqv.1. mouse.

Organism-specific databases

CTD10014.
MGIMGI:1333784. Hdac5.

Phylogenomic databases

GeneTreeENSGT00530000062809.
HOVERGENHBG057100.
KOK11406.
TreeFamTF106174.

Gene expression databases

GenevestigatorQ3UJF1.

Family and domain databases

Gene3D3.40.800.20. 1 hit.
InterProIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSPR01270. HDASUPER.
ProtoNetSearch...

Other

ChiTaRSHDAC5. mouse.
NextBio287701.
SOURCESearch...

Entry information

Entry nameQ3UJF1_MOUSE
AccessionPrimary (citable) accession number: Q3UJF1
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)