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Protein

Histone deacetylase

Gene

Hdac5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.UniRule annotation

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi689ZincUniRule annotation1
Metal bindingi691ZincUniRule annotation1
Metal bindingi697ZincUniRule annotation1
Metal bindingi774ZincUniRule annotation1
Active sitei826UniRule annotation1
Sitei999Contributes to catalysisUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation, RepressorUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
Name:Hdac5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1333784 Hdac5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000008855

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 156HDAC4_GlnInterPro annotationAdd BLAST89
Domaini697 – 1015Hist_deacetylInterPro annotationAdd BLAST319

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili118 – 169Sequence analysisAdd BLAST52
Coiled coili568 – 598Sequence analysisAdd BLAST31

Sequence similaritiesi

Belongs to the histone deacetylase family. HD type 2 subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1343 Eukaryota
COG0123 LUCA
GeneTreeiENSGT00530000062809
HOVERGENiHBG057100
KOiK11406
TreeFamiTF106174

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR024643 Hist_deacetylase_Gln_rich_N
IPR017320 Histone_deAcase_II_euk
IPR030703 Histone_deacetylase_5
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 1 hit
PTHR10625:SF57 PTHR10625:SF57, 1 hit
PfamiView protein in Pfam
PF12203 HDAC4_Gln, 1 hit
PF00850 Hist_deacetyl, 1 hit
PIRSFiPIRSF037911 HDAC_II_euk, 1 hit
PRINTSiPR01270 HDASUPER
SUPFAMiSSF52768 SSF52768, 1 hit

Sequencei

Sequence statusi: Complete.

Q3UJF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSPNESADG MSGREPSLEI LPRTPLHSIP VAVEVKPVLP GAMPSSMGGG
60 70 80 90 100
GGGSPSPVEL RGALAGPMDP ALREQQLQQE LLVLKQQQQL QKQLLFAEFQ
110 120 130 140 150
KQHDHLTRQH EVQLQKHLKQ QQEMLAAKRQ QELEQQRQRE QQRQEELEKQ
160 170 180 190 200
RLEQQLLILR NKEKSKESAI ASTEVKLRLQ EFLLSKSKEP TPGGLNHSLP
210 220 230 240 250
QHPKCWGAHH ASLDQSSPPQ SGPPGTPPSY KLPLLGPYDS RDDFPLRKTA
260 270 280 290 300
SEPNLKVRSR LKQKVAERRS SPLLRRKDGT VISTFKKRAV EITGTGPGVS
310 320 330 340 350
SVCNSAPGSG PSSPNSSHST IAENGFTGSV PNIPTEMIPQ HRALPLDSSP
360 370 380 390 400
NQFSLYTSPS LPNISLGLQA TVTVTNSHLT ASPKLSTQQE AERQALQSLR
410 420 430 440 450
QGGTLTGKFM STSSIPGCLL GVALEGDTSP HGHASLLQHV LLLEQARQQS
460 470 480 490 500
TLIAVPLHGQ SPLVTGERVA TSMRTVGKLP RHRPLSRTQS SPLPQSPQAL
510 520 530 540 550
QQLVMQQQHQ QFLEKQKQQQ MQLGKILTKT GELSRQPTTH PEETEEELTE
560 570 580 590 600
QQEALLGEGA LTIPREGSTE SESTQEDLEE EEEEEEEEEE DCIQVKDEDG
610 620 630 640 650
ESGPDEGPDL EESSAGYKKL FADAQQLQPL QVYQAPLSLA TVPHQALGRT
660 670 680 690 700
QSSPAAPGSM KSPTDQPTVV KHLFTTGVVY DTFMLKHQCM CGNTHVHPEH
710 720 730 740 750
AGRIQSIWSR LQETGLLGKC ERIRGRKATL DEIQTVHSEY HTLLYGTSPL
760 770 780 790 800
NRQKLDSKKL LGPISQKMYA MLPCGGIGVD SDTVWNEMHS SSAVRMAVGC
810 820 830 840 850
LVELAFKVAA GELKNGFAII RPPGHHAEES TAMGFCFFNS VAITAKLLQQ
860 870 880 890 900
KLSVGKVLIV DWDIHHGNGT QQAFYNDPSV LYISLHRYDN GNFFPGSGAP
910 920 930 940 950
EEVGGGPGVG YNVNVAWTGG VDPPIGDVEY LTAFRTVVMP IAQEFSPDVV
960 970 980 990 1000
LVSAGFDAVE GHLSPLGGYS VTARCFGHLT RQLMTLAGGR VVLALEGGHD
1010 1020 1030 1040 1050
LTAICDASEA CVSALLSVEL QPLDEAVLQQ KPSVNAVATL EKVIEIQSKH
1060 1070 1080 1090 1100
WSCVQRFAAG LGCSLREAQT GEKEEAETVS AMALLSVGAE QAQAVATQEH
1110
SPRPAEEPME QEPAL
Length:1,115
Mass (Da):121,219
Last modified:October 11, 2005 - v1
Checksum:iD46C999D156CAE96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954730 Genomic DNA No translation available.
AK146483 mRNA Translation: BAE27204.1
RefSeqiNP_001071164.1, NM_001077696.1
UniGeneiMm.22665

Genome annotation databases

EnsembliENSMUST00000107152; ENSMUSP00000102770; ENSMUSG00000008855
GeneIDi15184
KEGGimmu:15184
UCSCiuc007lqv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiQ3UJF1_MOUSE
AccessioniPrimary (citable) accession number: Q3UJF1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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