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Q3UJF1

- Q3UJF1_MOUSE

UniProt

Q3UJF1 - Q3UJF1_MOUSE

Protein
Submitted name:

Histone deacetylase 5

Gene

Hdac5

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. histone deacetylase activity Source: Ensembl
    2. protein binding Source: MGI
    3. transcription corepressor activity Source: MGI
    4. transcription regulatory region DNA binding Source: Ensembl

    GO - Biological processi

    1. heart development Source: MGI
    2. multicellular organismal response to stress Source: MGI
    3. negative regulation of cell migration involved in sprouting angiogenesis Source: Ensembl
    4. negative regulation of myotube differentiation Source: Ensembl
    5. negative regulation of osteoblast differentiation Source: MGI
    6. negative regulation of transcription, DNA-templated Source: MGI
    7. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    8. osteoblast development Source: MGI
    9. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    10. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    11. regulation of protein binding Source: Ensembl
    12. regulation of skeletal muscle fiber development Source: MGI
    13. regulation of striated muscle cell differentiation Source: MGI
    14. response to cocaine Source: MGI
    15. response to drug Source: Ensembl

    Keywords - Molecular functioni

    HydrolaseSAAS annotation

    Enzyme and pathway databases

    ReactomeiREACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Histone deacetylase 5Imported
    Gene namesi
    Name:Hdac5Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1333784. Hdac5.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytosol Source: MGI
    3. Golgi apparatus Source: Ensembl
    4. histone deacetylase complex Source: InterPro
    5. nuclear body Source: MGI
    6. nucleus Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ3UJF1.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00530000062809.
    HOVERGENiHBG057100.
    KOiK11406.
    TreeFamiTF106174.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    IPR024643. Hist_deacetylase_Gln_rich_N.
    IPR017320. Histone_deAcase_II_euk.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF12203. HDAC4_Gln. 1 hit.
    PF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
    PRINTSiPR01270. HDASUPER.

    Sequencei

    Sequence statusi: Complete.

    Q3UJF1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSPNESADG MSGREPSLEI LPRTPLHSIP VAVEVKPVLP GAMPSSMGGG     50
    GGGSPSPVEL RGALAGPMDP ALREQQLQQE LLVLKQQQQL QKQLLFAEFQ 100
    KQHDHLTRQH EVQLQKHLKQ QQEMLAAKRQ QELEQQRQRE QQRQEELEKQ 150
    RLEQQLLILR NKEKSKESAI ASTEVKLRLQ EFLLSKSKEP TPGGLNHSLP 200
    QHPKCWGAHH ASLDQSSPPQ SGPPGTPPSY KLPLLGPYDS RDDFPLRKTA 250
    SEPNLKVRSR LKQKVAERRS SPLLRRKDGT VISTFKKRAV EITGTGPGVS 300
    SVCNSAPGSG PSSPNSSHST IAENGFTGSV PNIPTEMIPQ HRALPLDSSP 350
    NQFSLYTSPS LPNISLGLQA TVTVTNSHLT ASPKLSTQQE AERQALQSLR 400
    QGGTLTGKFM STSSIPGCLL GVALEGDTSP HGHASLLQHV LLLEQARQQS 450
    TLIAVPLHGQ SPLVTGERVA TSMRTVGKLP RHRPLSRTQS SPLPQSPQAL 500
    QQLVMQQQHQ QFLEKQKQQQ MQLGKILTKT GELSRQPTTH PEETEEELTE 550
    QQEALLGEGA LTIPREGSTE SESTQEDLEE EEEEEEEEEE DCIQVKDEDG 600
    ESGPDEGPDL EESSAGYKKL FADAQQLQPL QVYQAPLSLA TVPHQALGRT 650
    QSSPAAPGSM KSPTDQPTVV KHLFTTGVVY DTFMLKHQCM CGNTHVHPEH 700
    AGRIQSIWSR LQETGLLGKC ERIRGRKATL DEIQTVHSEY HTLLYGTSPL 750
    NRQKLDSKKL LGPISQKMYA MLPCGGIGVD SDTVWNEMHS SSAVRMAVGC 800
    LVELAFKVAA GELKNGFAII RPPGHHAEES TAMGFCFFNS VAITAKLLQQ 850
    KLSVGKVLIV DWDIHHGNGT QQAFYNDPSV LYISLHRYDN GNFFPGSGAP 900
    EEVGGGPGVG YNVNVAWTGG VDPPIGDVEY LTAFRTVVMP IAQEFSPDVV 950
    LVSAGFDAVE GHLSPLGGYS VTARCFGHLT RQLMTLAGGR VVLALEGGHD 1000
    LTAICDASEA CVSALLSVEL QPLDEAVLQQ KPSVNAVATL EKVIEIQSKH 1050
    WSCVQRFAAG LGCSLREAQT GEKEEAETVS AMALLSVGAE QAQAVATQEH 1100
    SPRPAEEPME QEPAL 1115
    Length:1,115
    Mass (Da):121,219
    Last modified:October 11, 2005 - v1
    Checksum:iD46C999D156CAE96
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL954730 Genomic DNA. No translation available.
    AK146483 mRNA. Translation: BAE27204.1.
    RefSeqiNP_001071164.1. NM_001077696.1.
    UniGeneiMm.22665.

    Genome annotation databases

    EnsembliENSMUST00000107152; ENSMUSP00000102770; ENSMUSG00000008855.
    GeneIDi15184.
    KEGGimmu:15184.
    UCSCiuc007lqv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL954730 Genomic DNA. No translation available.
    AK146483 mRNA. Translation: BAE27204.1 .
    RefSeqi NP_001071164.1. NM_001077696.1.
    UniGenei Mm.22665.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000107152 ; ENSMUSP00000102770 ; ENSMUSG00000008855 .
    GeneIDi 15184.
    KEGGi mmu:15184.
    UCSCi uc007lqv.1. mouse.

    Organism-specific databases

    CTDi 10014.
    MGIi MGI:1333784. Hdac5.

    Phylogenomic databases

    GeneTreei ENSGT00530000062809.
    HOVERGENi HBG057100.
    KOi K11406.
    TreeFami TF106174.

    Enzyme and pathway databases

    Reactomei REACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

    Miscellaneous databases

    ChiTaRSi HDAC5. mouse.
    NextBioi 287701.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q3UJF1.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    IPR024643. Hist_deacetylase_Gln_rich_N.
    IPR017320. Histone_deAcase_II_euk.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF12203. HDAC4_Gln. 1 hit.
    PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037911. HDAC_II_euk. 1 hit.
    PRINTSi PR01270. HDASUPER.
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeartImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeartImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeartImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeartImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeartImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeartImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeartImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeartImported.
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    10. Ensembl
      Submitted (JUN-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ3UJF1_MOUSE
    AccessioniPrimary (citable) accession number: Q3UJF1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3