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Protein

G-protein coupled receptor 55

Gene

Gpr55

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca2+ release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA (By similarity). Putative cannabinoid receptor (By similarity). May play a role in bone physiology by regulating osteoclast number and function (By similarity). May be involved in hyperalgesia associated with inflammatory and neuropathic pain.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-373076. Class A/1 (Rhodopsin-like receptors).
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 55
Gene namesi
Name:Gpr55
Synonyms:Gm218
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2685064. Gpr55.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20ExtracellularSequence analysisAdd BLAST20
Transmembranei21 – 41Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini42 – 57CytoplasmicSequence analysisAdd BLAST16
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 93ExtracellularSequence analysisAdd BLAST15
Transmembranei94 – 114Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini115 – 136CytoplasmicSequence analysisAdd BLAST22
Transmembranei137 – 157Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini158 – 179ExtracellularSequence analysisAdd BLAST22
Transmembranei180 – 200Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini201 – 239CytoplasmicSequence analysisAdd BLAST39
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 279ExtracellularSequence analysisAdd BLAST19
Transmembranei280 – 300Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini301 – 327CytoplasmicSequence analysisAdd BLAST27

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutant mice are resistant to mechanical hyperalgesia and have increased levels of anti-inflammatory cytokines.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002339781 – 327G-protein coupled receptor 55Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1
Glycosylationi170N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3UJF0.
PRIDEiQ3UJF0.

PTM databases

iPTMnetiQ3UJF0.
PhosphoSitePlusiQ3UJF0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000049608.
CleanExiMM_GPR55.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084196.

Structurei

3D structure databases

ProteinModelPortaliQ3UJF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEJJ. Eukaryota.
ENOG4111H9D. LUCA.
GeneTreeiENSGT00730000110768.
HOGENOMiHOG000013155.
HOVERGENiHBG096388.
InParanoidiQ3UJF0.
KOiK08413.
OMAiCFHNMSD.
OrthoDBiEOG091G0CP3.
TreeFamiTF335700.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028334. GPR55.
[Graphical view]
PANTHERiPTHR24232:SF56. PTHR24232:SF56. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UJF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQPERDNCS FDSVDKLTRT LQLAVHIPTF LLGLVLNLLA IRGFSAFLKK
60 70 80 90 100
RKLDYIATSI YMINLAVFDL LLVLSLPFKM VLPQVESPLP SFCTLVECLY
110 120 130 140 150
FISMYGSVFT ICFISLDRFL AIQYPILASH LRSPRKTFGI CCIIWMLVWI
160 170 180 190 200
GSIPIYTFHR EVERYKCFHN MSDVTWSASV FFPLEIFGFL LPMGIMGFCS
210 220 230 240 250
YRSIHILLRR PDSTEDWVQQ RDTKGWVQKR ACIWTIATNL VIFVVSFLPV
260 270 280 290 300
HLGFFLQYLV RNRFILDCRM KQGISLFLQL SLCFSNINCC LDVFCYYFVI
310 320
KEFRMRIKAH RPSTIKLVNQ DTMVSRG
Length:327
Mass (Da):38,090
Last modified:October 3, 2012 - v2
Checksum:i4B33F94E3CCAEA1C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti226 – 231WVQKRA → LGTKREP in BAE27205 (PubMed:16141072).Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146484 mRNA. Translation: BAE27205.1.
AC102506 Genomic DNA. No translation available.
AC107707 Genomic DNA. No translation available.
CCDSiCCDS15115.1.
RefSeqiNP_001028462.2. NM_001033290.2.
XP_006529526.1. XM_006529463.3.
XP_017175826.1. XM_017320337.1.
UniGeneiMm.244158.
Mm.396343.
Mm.417775.

Genome annotation databases

EnsembliENSMUST00000086975; ENSMUSP00000084196; ENSMUSG00000049608.
GeneIDi227326.
KEGGimmu:227326.
UCSCiuc007buq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146484 mRNA. Translation: BAE27205.1.
AC102506 Genomic DNA. No translation available.
AC107707 Genomic DNA. No translation available.
CCDSiCCDS15115.1.
RefSeqiNP_001028462.2. NM_001033290.2.
XP_006529526.1. XM_006529463.3.
XP_017175826.1. XM_017320337.1.
UniGeneiMm.244158.
Mm.396343.
Mm.417775.

3D structure databases

ProteinModelPortaliQ3UJF0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084196.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ3UJF0.
PhosphoSitePlusiQ3UJF0.

Proteomic databases

PaxDbiQ3UJF0.
PRIDEiQ3UJF0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000086975; ENSMUSP00000084196; ENSMUSG00000049608.
GeneIDi227326.
KEGGimmu:227326.
UCSCiuc007buq.1. mouse.

Organism-specific databases

CTDi9290.
MGIiMGI:2685064. Gpr55.

Phylogenomic databases

eggNOGiENOG410IEJJ. Eukaryota.
ENOG4111H9D. LUCA.
GeneTreeiENSGT00730000110768.
HOGENOMiHOG000013155.
HOVERGENiHBG096388.
InParanoidiQ3UJF0.
KOiK08413.
OMAiCFHNMSD.
OrthoDBiEOG091G0CP3.
TreeFamiTF335700.

Enzyme and pathway databases

ReactomeiR-MMU-373076. Class A/1 (Rhodopsin-like receptors).
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ3UJF0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049608.
CleanExiMM_GPR55.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028334. GPR55.
[Graphical view]
PANTHERiPTHR24232:SF56. PTHR24232:SF56. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR55_MOUSE
AccessioniPrimary (citable) accession number: Q3UJF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 3, 2012
Last modified: November 30, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The classification of this protein as a cannabinoid receptor remains a contentious issue due to conflicting pharmacological results.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.