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Q3UJF0

- GPR55_MOUSE

UniProt

Q3UJF0 - GPR55_MOUSE

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Protein

G-protein coupled receptor 55

Gene
Gpr55, Gm218
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca2+ release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA By similarity. Putative cannabinoid receptor By similarity. May play a role in bone physiology by regulating osteoclast number and function By similarity. May be involved in hyperalgesia associated with inflammatory and neuropathic pain.1 Publication

GO - Molecular functioni

  1. cannabinoid receptor activity Source: Ensembl

GO - Biological processi

  1. activation of phospholipase C activity Source: UniProtKB
  2. bone resorption Source: Ensembl
  3. negative regulation of osteoclast differentiation Source: Ensembl
  4. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  5. positive regulation of Rho protein signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 55
Gene namesi
Name:Gpr55
Synonyms:Gm218
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2685064. Gpr55.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020Extracellular Reviewed predictionAdd
BLAST
Transmembranei21 – 4121Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini42 – 5716Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei58 – 7821Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini79 – 9315Extracellular Reviewed predictionAdd
BLAST
Transmembranei94 – 11421Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini115 – 13622Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei137 – 15721Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini158 – 17922Extracellular Reviewed predictionAdd
BLAST
Transmembranei180 – 20021Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini201 – 23939Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei240 – 26021Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini261 – 27919Extracellular Reviewed predictionAdd
BLAST
Transmembranei280 – 30021Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini301 – 32727Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutant mice are resistant to mechanical hyperalgesia and have increased levels of anti-inflammatory cytokines.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327G-protein coupled receptor 55PRO_0000233978Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...) Reviewed prediction
Glycosylationi170 – 1701N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ3UJF0.

PTM databases

PhosphoSiteiQ3UJF0.

Expressioni

Gene expression databases

CleanExiMM_GPR55.
GenevestigatoriQ3UJF0.

Structurei

3D structure databases

ProteinModelPortaliQ3UJF0.
SMRiQ3UJF0. Positions 9-308.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG145477.
GeneTreeiENSGT00730000110768.
HOGENOMiHOG000013155.
HOVERGENiHBG096388.
InParanoidiQ3UJF0.
KOiK08413.
OMAiCFHNMSD.
OrthoDBiEOG7327PC.
TreeFamiTF335700.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028334. GPR55.
[Graphical view]
PANTHERiPTHR24232:SF8. PTHR24232:SF8. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UJF0-1 [UniParc]FASTAAdd to Basket

« Hide

MSQPERDNCS FDSVDKLTRT LQLAVHIPTF LLGLVLNLLA IRGFSAFLKK    50
RKLDYIATSI YMINLAVFDL LLVLSLPFKM VLPQVESPLP SFCTLVECLY 100
FISMYGSVFT ICFISLDRFL AIQYPILASH LRSPRKTFGI CCIIWMLVWI 150
GSIPIYTFHR EVERYKCFHN MSDVTWSASV FFPLEIFGFL LPMGIMGFCS 200
YRSIHILLRR PDSTEDWVQQ RDTKGWVQKR ACIWTIATNL VIFVVSFLPV 250
HLGFFLQYLV RNRFILDCRM KQGISLFLQL SLCFSNINCC LDVFCYYFVI 300
KEFRMRIKAH RPSTIKLVNQ DTMVSRG 327
Length:327
Mass (Da):38,090
Last modified:October 3, 2012 - v2
Checksum:i4B33F94E3CCAEA1C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti226 – 2316WVQKRA → LGTKREP in BAE27205. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK146484 mRNA. Translation: BAE27205.1.
AC102506 Genomic DNA. No translation available.
AC107707 Genomic DNA. No translation available.
CCDSiCCDS15115.1.
RefSeqiNP_001028462.2. NM_001033290.2.
XP_006529525.1. XM_006529462.1.
XP_006529526.1. XM_006529463.1.
UniGeneiMm.244158.

Genome annotation databases

EnsembliENSMUST00000086975; ENSMUSP00000084196; ENSMUSG00000049608.
GeneIDi227326.
KEGGimmu:227326.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK146484 mRNA. Translation: BAE27205.1 .
AC102506 Genomic DNA. No translation available.
AC107707 Genomic DNA. No translation available.
CCDSi CCDS15115.1.
RefSeqi NP_001028462.2. NM_001033290.2.
XP_006529525.1. XM_006529462.1.
XP_006529526.1. XM_006529463.1.
UniGenei Mm.244158.

3D structure databases

ProteinModelPortali Q3UJF0.
SMRi Q3UJF0. Positions 9-308.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 109.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q3UJF0.

Proteomic databases

PRIDEi Q3UJF0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000086975 ; ENSMUSP00000084196 ; ENSMUSG00000049608 .
GeneIDi 227326.
KEGGi mmu:227326.

Organism-specific databases

CTDi 9290.
MGIi MGI:2685064. Gpr55.

Phylogenomic databases

eggNOGi NOG145477.
GeneTreei ENSGT00730000110768.
HOGENOMi HOG000013155.
HOVERGENi HBG096388.
InParanoidi Q3UJF0.
KOi K08413.
OMAi CFHNMSD.
OrthoDBi EOG7327PC.
TreeFami TF335700.

Miscellaneous databases

PROi Q3UJF0.
SOURCEi Search...

Gene expression databases

CleanExi MM_GPR55.
Genevestigatori Q3UJF0.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028334. GPR55.
[Graphical view ]
PANTHERi PTHR24232:SF8. PTHR24232:SF8. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Amnion.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain."
    Staton P.C., Hatcher J.P., Walker D.J., Morrison A.D., Shapland E.M., Hughes J.P., Chong E., Mander P.K., Green P.J., Billinton A., Fulleylove M., Lancaster H.C., Smith J.C., Bailey L.T., Wise A., Brown A.J., Richardson J.C., Chessell I.P.
    Pain 139:225-236(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION.

Entry informationi

Entry nameiGPR55_MOUSE
AccessioniPrimary (citable) accession number: Q3UJF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The classification of this protein as a cannabinoid receptor remains a contentious issue due to conflicting pharmacological results.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi