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Protein

G-protein coupled receptor 55

Gene

Gpr55

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca2+ release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA (By similarity). Putative cannabinoid receptor (By similarity). May play a role in bone physiology by regulating osteoclast number and function (By similarity). May be involved in hyperalgesia associated with inflammatory and neuropathic pain.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_275529. Class A/1 (Rhodopsin-like receptors).
REACT_331048. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 55
Gene namesi
Name:Gpr55
Synonyms:Gm218
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2685064. Gpr55.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020ExtracellularSequence AnalysisAdd
BLAST
Transmembranei21 – 4121Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini42 – 5716CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei58 – 7821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini79 – 9315ExtracellularSequence AnalysisAdd
BLAST
Transmembranei94 – 11421Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini115 – 13622CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei137 – 15721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini158 – 17922ExtracellularSequence AnalysisAdd
BLAST
Transmembranei180 – 20021Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini201 – 23939CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini261 – 27919ExtracellularSequence AnalysisAdd
BLAST
Transmembranei280 – 30021Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini301 – 32727CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutant mice are resistant to mechanical hyperalgesia and have increased levels of anti-inflammatory cytokines.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327G-protein coupled receptor 55PRO_0000233978Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ3UJF0.

PTM databases

PhosphoSiteiQ3UJF0.

Expressioni

Gene expression databases

CleanExiMM_GPR55.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084196.

Structurei

3D structure databases

ProteinModelPortaliQ3UJF0.
SMRiQ3UJF0. Positions 9-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG145477.
GeneTreeiENSGT00730000110768.
HOGENOMiHOG000013155.
HOVERGENiHBG096388.
InParanoidiQ3UJF0.
KOiK08413.
OMAiCFHNMSD.
OrthoDBiEOG7327PC.
TreeFamiTF335700.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028334. GPR55.
[Graphical view]
PANTHERiPTHR24232:SF8. PTHR24232:SF8. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UJF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQPERDNCS FDSVDKLTRT LQLAVHIPTF LLGLVLNLLA IRGFSAFLKK
60 70 80 90 100
RKLDYIATSI YMINLAVFDL LLVLSLPFKM VLPQVESPLP SFCTLVECLY
110 120 130 140 150
FISMYGSVFT ICFISLDRFL AIQYPILASH LRSPRKTFGI CCIIWMLVWI
160 170 180 190 200
GSIPIYTFHR EVERYKCFHN MSDVTWSASV FFPLEIFGFL LPMGIMGFCS
210 220 230 240 250
YRSIHILLRR PDSTEDWVQQ RDTKGWVQKR ACIWTIATNL VIFVVSFLPV
260 270 280 290 300
HLGFFLQYLV RNRFILDCRM KQGISLFLQL SLCFSNINCC LDVFCYYFVI
310 320
KEFRMRIKAH RPSTIKLVNQ DTMVSRG
Length:327
Mass (Da):38,090
Last modified:October 3, 2012 - v2
Checksum:i4B33F94E3CCAEA1C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti226 – 2316WVQKRA → LGTKREP in BAE27205 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146484 mRNA. Translation: BAE27205.1.
AC102506 Genomic DNA. No translation available.
AC107707 Genomic DNA. No translation available.
CCDSiCCDS15115.1.
RefSeqiNP_001028462.2. NM_001033290.2.
XP_006529525.1. XM_006529462.2.
XP_006529526.1. XM_006529463.2.
UniGeneiMm.244158.

Genome annotation databases

EnsembliENSMUST00000086975; ENSMUSP00000084196; ENSMUSG00000049608.
GeneIDi227326.
KEGGimmu:227326.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146484 mRNA. Translation: BAE27205.1.
AC102506 Genomic DNA. No translation available.
AC107707 Genomic DNA. No translation available.
CCDSiCCDS15115.1.
RefSeqiNP_001028462.2. NM_001033290.2.
XP_006529525.1. XM_006529462.2.
XP_006529526.1. XM_006529463.2.
UniGeneiMm.244158.

3D structure databases

ProteinModelPortaliQ3UJF0.
SMRiQ3UJF0. Positions 9-308.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084196.

Chemistry

GuidetoPHARMACOLOGYi109.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ3UJF0.

Proteomic databases

PRIDEiQ3UJF0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000086975; ENSMUSP00000084196; ENSMUSG00000049608.
GeneIDi227326.
KEGGimmu:227326.

Organism-specific databases

CTDi9290.
MGIiMGI:2685064. Gpr55.

Phylogenomic databases

eggNOGiNOG145477.
GeneTreeiENSGT00730000110768.
HOGENOMiHOG000013155.
HOVERGENiHBG096388.
InParanoidiQ3UJF0.
KOiK08413.
OMAiCFHNMSD.
OrthoDBiEOG7327PC.
TreeFamiTF335700.

Enzyme and pathway databases

ReactomeiREACT_275529. Class A/1 (Rhodopsin-like receptors).
REACT_331048. G alpha (i) signalling events.

Miscellaneous databases

PROiQ3UJF0.
SOURCEiSearch...

Gene expression databases

CleanExiMM_GPR55.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028334. GPR55.
[Graphical view]
PANTHERiPTHR24232:SF8. PTHR24232:SF8. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Amnion.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain."
    Staton P.C., Hatcher J.P., Walker D.J., Morrison A.D., Shapland E.M., Hughes J.P., Chong E., Mander P.K., Green P.J., Billinton A., Fulleylove M., Lancaster H.C., Smith J.C., Bailey L.T., Wise A., Brown A.J., Richardson J.C., Chessell I.P.
    Pain 139:225-236(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION.

Entry informationi

Entry nameiGPR55_MOUSE
AccessioniPrimary (citable) accession number: Q3UJF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 3, 2012
Last modified: June 24, 2015
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The classification of this protein as a cannabinoid receptor remains a contentious issue due to conflicting pharmacological results.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.