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Q3UJF0

- GPR55_MOUSE

UniProt

Q3UJF0 - GPR55_MOUSE

Protein

G-protein coupled receptor 55

Gene

Gpr55

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca2+ release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA By similarity. Putative cannabinoid receptor By similarity. May play a role in bone physiology by regulating osteoclast number and function By similarity. May be involved in hyperalgesia associated with inflammatory and neuropathic pain.By similarity1 Publication

    GO - Molecular functioni

    1. cannabinoid receptor activity Source: Ensembl

    GO - Biological processi

    1. activation of phospholipase C activity Source: UniProtKB
    2. bone resorption Source: Ensembl
    3. negative regulation of osteoclast differentiation Source: Ensembl
    4. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
    5. positive regulation of Rho protein signal transduction Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein coupled receptor 55
    Gene namesi
    Name:Gpr55
    Synonyms:Gm218
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2685064. Gpr55.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Mutant mice are resistant to mechanical hyperalgesia and have increased levels of anti-inflammatory cytokines.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 327327G-protein coupled receptor 55PRO_0000233978Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ3UJF0.

    PTM databases

    PhosphoSiteiQ3UJF0.

    Expressioni

    Gene expression databases

    CleanExiMM_GPR55.
    GenevestigatoriQ3UJF0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3UJF0.
    SMRiQ3UJF0. Positions 9-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2020ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini42 – 5716CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini79 – 9315ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini115 – 13622CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini158 – 17922ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini201 – 23939CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini261 – 27919ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini301 – 32727CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei94 – 11421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei137 – 15721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei180 – 20021Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei240 – 26021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei280 – 30021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG145477.
    GeneTreeiENSGT00730000110768.
    HOGENOMiHOG000013155.
    HOVERGENiHBG096388.
    InParanoidiQ3UJF0.
    KOiK08413.
    OMAiCFHNMSD.
    OrthoDBiEOG7327PC.
    TreeFamiTF335700.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR028334. GPR55.
    [Graphical view]
    PANTHERiPTHR24232:SF8. PTHR24232:SF8. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3UJF0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQPERDNCS FDSVDKLTRT LQLAVHIPTF LLGLVLNLLA IRGFSAFLKK    50
    RKLDYIATSI YMINLAVFDL LLVLSLPFKM VLPQVESPLP SFCTLVECLY 100
    FISMYGSVFT ICFISLDRFL AIQYPILASH LRSPRKTFGI CCIIWMLVWI 150
    GSIPIYTFHR EVERYKCFHN MSDVTWSASV FFPLEIFGFL LPMGIMGFCS 200
    YRSIHILLRR PDSTEDWVQQ RDTKGWVQKR ACIWTIATNL VIFVVSFLPV 250
    HLGFFLQYLV RNRFILDCRM KQGISLFLQL SLCFSNINCC LDVFCYYFVI 300
    KEFRMRIKAH RPSTIKLVNQ DTMVSRG 327
    Length:327
    Mass (Da):38,090
    Last modified:October 3, 2012 - v2
    Checksum:i4B33F94E3CCAEA1C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti226 – 2316WVQKRA → LGTKREP in BAE27205. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK146484 mRNA. Translation: BAE27205.1.
    AC102506 Genomic DNA. No translation available.
    AC107707 Genomic DNA. No translation available.
    CCDSiCCDS15115.1.
    RefSeqiNP_001028462.2. NM_001033290.2.
    XP_006529525.1. XM_006529462.1.
    XP_006529526.1. XM_006529463.1.
    UniGeneiMm.244158.

    Genome annotation databases

    EnsembliENSMUST00000086975; ENSMUSP00000084196; ENSMUSG00000049608.
    GeneIDi227326.
    KEGGimmu:227326.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK146484 mRNA. Translation: BAE27205.1 .
    AC102506 Genomic DNA. No translation available.
    AC107707 Genomic DNA. No translation available.
    CCDSi CCDS15115.1.
    RefSeqi NP_001028462.2. NM_001033290.2.
    XP_006529525.1. XM_006529462.1.
    XP_006529526.1. XM_006529463.1.
    UniGenei Mm.244158.

    3D structure databases

    ProteinModelPortali Q3UJF0.
    SMRi Q3UJF0. Positions 9-308.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 109.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q3UJF0.

    Proteomic databases

    PRIDEi Q3UJF0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000086975 ; ENSMUSP00000084196 ; ENSMUSG00000049608 .
    GeneIDi 227326.
    KEGGi mmu:227326.

    Organism-specific databases

    CTDi 9290.
    MGIi MGI:2685064. Gpr55.

    Phylogenomic databases

    eggNOGi NOG145477.
    GeneTreei ENSGT00730000110768.
    HOGENOMi HOG000013155.
    HOVERGENi HBG096388.
    InParanoidi Q3UJF0.
    KOi K08413.
    OMAi CFHNMSD.
    OrthoDBi EOG7327PC.
    TreeFami TF335700.

    Miscellaneous databases

    PROi Q3UJF0.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_GPR55.
    Genevestigatori Q3UJF0.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR028334. GPR55.
    [Graphical view ]
    PANTHERi PTHR24232:SF8. PTHR24232:SF8. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Amnion.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain."
      Staton P.C., Hatcher J.P., Walker D.J., Morrison A.D., Shapland E.M., Hughes J.P., Chong E., Mander P.K., Green P.J., Billinton A., Fulleylove M., Lancaster H.C., Smith J.C., Bailey L.T., Wise A., Brown A.J., Richardson J.C., Chessell I.P.
      Pain 139:225-236(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, FUNCTION.

    Entry informationi

    Entry nameiGPR55_MOUSE
    AccessioniPrimary (citable) accession number: Q3UJF0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The classification of this protein as a cannabinoid receptor remains a contentious issue due to conflicting pharmacological results.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3