Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gap junction protein

Gene

Gjb2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction proteinUniRule annotation
Gene namesi
Name:Gjb2Imported
ORF Names:mCG_13733Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95720. Gjb2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 40HelicalSequence analysisAdd BLAST18
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei132 – 158HelicalSequence analysisAdd BLAST27
Transmembranei191 – 215HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Gap junctionUniRule annotationSAAS annotation, Membrane

PTM / Processingi

Proteomic databases

MaxQBiQ3UJE9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000046352.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.UniRule annotationSAAS annotation

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 75CNXInterPro annotationAdd BLAST34
Domaini146 – 213Connexin_CCCInterPro annotationAdd BLAST68

Sequence similaritiesi

Belongs to the connexin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IFM8. Eukaryota.
ENOG410Y7VN. LUCA.
HOVERGENiHBG009576.
KOiK07621.
OMAiVMYDGFA.
OrthoDBiEOG091G0FKH.

Family and domain databases

InterProiView protein in InterPro
IPR000500. Connexin.
IPR002268. Connexin26.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiView protein in Pfam
PF00029. Connexin. 1 hit.
PRINTSiPR00206. CONNEXIN.
PR01139. CONNEXINB2.
SMARTiView protein in SMART
SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
PROSITEiView protein in PROSITE
PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3UJE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWGTLQSIL GGVNKHSTSI GKIWLTVLFI FRIMILVVAA KEVWGDEQAD
60 70 80 90 100
FVCNTLQPGC KNVCYDHHFP ISHIRLWALQ LIMVSTPALL VAMHVAYRRH
110 120 130 140 150
EKKRKFMKGE IKNEFKDIEE IKTQKVRIEG SLWWTYTTSI FFRVIFEAVF
160 170 180 190 200
MYVFYIMYNG FFMQRLVKCN AWPCPNTVDC FISRPTEKTV FTVFMISVSG
210 220
ICILLNITEL CYLFVRYCSG KSKRPV
Length:226
Mass (Da):26,411
Last modified:October 11, 2005 - v1
Checksum:i0D8178F7A339E0B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133942 mRNA. Translation: BAE21940.1.
AK146485 mRNA. Translation: BAE27206.1.
AK160905 mRNA. Translation: BAE36083.1.
CH466535 Genomic DNA. Translation: EDL36180.1.
RefSeqiNP_032151.1. NM_008125.3.
UniGeneiMm.390683.

Genome annotation databases

GeneIDi14619.
KEGGimmu:14619.

Similar proteinsi

Entry informationi

Entry nameiQ3UJE9_MOUSE
AccessioniPrimary (citable) accession number: Q3UJE9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 22, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)