Q3UJD6 (UBP19_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 56.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Ubiquitin carboxyl-terminal hydrolase 19 EC=3.4.19.12 Alternative name(s): Deubiquitinating enzyme 19 Ubiquitin thiolesterase 19 Ubiquitin-specific-processing protease 19 | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 1360 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates By similarity. |
| Catalytic activity | Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). |
| Subunit structure | Interacts with and stabilizes RNF123 By similarity. |
| Subcellular location | Endoplasmic reticulum membrane; Single-pass membrane protein By similarity. |
| Post-translational modification | Phosphorylated upon DNA damage, probably by ATM or ATR By similarity. |
| Sequence similarities | Contains 2 CS domains. Contains 1 MYND-type zinc finger. |
| Sequence caution | The sequence BAC65678.4 differs from that shown. Reason: Erroneous initiation. |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q3UJD6-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q3UJD6-2) The sequence of this isoform differs from the canonical sequence as follows: 1286-1340: ASRIWQELEA...LRYFVLGTVA → GLGPGQAPEV...PTYSNMEEVD 1341-1360: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1360 | 1360 | Ubiquitin carboxyl-terminal hydrolase 19 | PRO_0000295157 | |||||
Regions | |||||||||
| Topological domain | 1 – 1333 | 1333 | Cytoplasmic Potential | ||||||
| Transmembrane | 1334 – 1354 | 21 | Helical; Potential | ||||||
| Topological domain | 1355 – 1360 | 6 | Lumenal Potential | ||||||
| Domain | 51 – 140 | 90 | CS 1 | ||||||
| Domain | 322 – 424 | 103 | CS 2 | ||||||
| Zinc finger | 833 – 875 | 43 | MYND-type | ||||||
| Compositional bias | 524 – 530 | 7 | Poly-Glu | ||||||
Sites | |||||||||
| Active site | 548 | 1 | Nucleophile By similarity | ||||||
| Active site | 1207 | 1 | Proton acceptor By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 1284 | 1 | Phosphoserine By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 1286 – 1340 | 55 | ASRIW…LGTVA → GLGPGQAPEVAPTRTAPERF APPVDRPAPTYSNMEEVD in isoform 2. | VSP_026769 | |||||
| Alternative sequence | 1341 – 1360 | 20 | Missing in isoform 2. | VSP_026770 | |||||
Experimental info | |||||||||
| Sequence conflict | 140 | 1 | L → LK in BAE42739. Ref.2 | ||||||
| Sequence conflict | 142 | 1 | P → S in AAH60613. Ref.3 | ||||||
| Sequence conflict | 430 – 431 | 2 | Missing in BAE42739. Ref.2 | ||||||
| Sequence conflict | 669 | 1 | A → T in BAE42739. Ref.2 | ||||||
| Sequence conflict | 1058 | 1 | D → E in BAE42739. Ref.2 | ||||||
Sequences
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References
| [1] | "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H. DNA Res. 10:35-48(2003) [PubMed: 12693553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Fetal brain. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: C57BL/6J and NOD. Tissue: Head, Kidney and Spleen. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 395-1360 (ISOFORM 2). Strain: C57BL/6. Tissue: Brain. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AK122396 mRNA. Translation: BAC65678.4. Different initiation. AK146504 mRNA. Translation: BAE27219.1. AK160807 mRNA. Translation: BAE36025.1. AK171942 mRNA. Translation: BAE42739.1. BC046824 mRNA. Translation: AAH46824.1. BC060613 mRNA. Translation: AAH60613.1. |
| IPI | IPI00420483. IPI00457619. |
| RefSeq | NP_001161843.1. NM_001168371.2. NP_001161844.1. NM_001168372.2. NP_001161845.1. NM_001168373.2. NP_082080.3. NM_027804.4. NP_663382.2. NM_145407.3. |
| UniGene | Mm.289706. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2GFO based on UniProtKB P40818. |
| ProteinModelPortal | Q3UJD6. |
| SMR | Q3UJD6. Positions 306-444, 532-722. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q3UJD6. |
Protein family/group databases | |
| MEROPS | C19.024. |
PTM databases | |
| PhosphoSite | Q3UJD6. |
Proteomic databases | |
| PRIDE | Q3UJD6. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000006854; ENSMUSP00000006854; ENSMUSG00000006676. ENSMUST00000085044; ENSMUSP00000082119; ENSMUSG00000006676. |
| GeneID | 71472. |
| KEGG | mmu:71472. |
| UCSC | uc009rpt.2. mouse. uc009rpu.2. mouse. |
Organism-specific databases | |
| CTD | 10869. |
| MGI | MGI:1918722. Usp19. |
| Rouge | Search... |
Phylogenomic databases | |
| eggNOG | roNOG11044. |
| GeneTree | ENSGT00600000084034. |
| HOVERGEN | HBG061889. |
| OrthoDB | EOG4NVZJG. |
| PhylomeDB | Q3UJD6. |
Gene expression databases | |
| ArrayExpress | Q3UJD6. |
| Bgee | Q3UJD6. |
| CleanEx | MM_USP19. |
| Genevestigator | Q3UJD6. |
Family and domain databases | |
| InterPro | IPR007052. CS-like_domain. IPR017447. CS_domain. IPR015054. DUF1872. IPR008978. HSP20-like_chaperone. IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. IPR002893. Znf_MYND. [Graphical view] |
| KO | K11847. |
| Pfam | PF04969. CS. 1 hit. PF08959. DUF1872. 1 hit. PF00443. UCH. 1 hit. PF01753. zf-MYND. 1 hit. [Graphical view] |
| SUPFAM | SSF49764. HSP20_chap. 2 hits. |
| PROSITE | PS51203. CS. 2 hits. PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. PS01360. ZF_MYND_1. 1 hit. PS50865. ZF_MYND_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 333851. |
| SOURCE | Search... |
Entry information
| Entry name | UBP19_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q3UJD6 Secondary accession number(s): Q3TAC9 Q80ZW5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with