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Q3UJD6

- UBP19_MOUSE

UniProt

Q3UJD6 - UBP19_MOUSE

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Protein
Ubiquitin carboxyl-terminal hydrolase 19
Gene
Usp19, Kiaa0891
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates By similarity. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing thier ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains By similarity. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei548 – 5481Nucleophile By similarity
Active sitei1207 – 12071Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri833 – 87543MYND-type
Add
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. ER-associated ubiquitin-dependent protein catabolic process Source: UniProtKB
  2. negative regulation of skeletal muscle tissue development Source: UniProtKB
  3. positive regulation of cell cycle process Source: UniProtKB
  4. protein deubiquitination Source: UniProtKB
  5. regulation of cellular response to hypoxia Source: UniProtKB
  6. regulation of protein stability Source: UniProtKB
  7. response to endoplasmic reticulum stress Source: UniProtKB
  8. skeletal muscle atrophy Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiC19.024.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 19 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 19
Ubiquitin thioesterase 19
Ubiquitin-specific-processing protease 19
Gene namesi
Name:Usp19
Synonyms:Kiaa0891
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1918722. Usp19.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 13331333Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1334 – 135421Helical; Reviewed prediction
Add
BLAST
Topological domaini1355 – 13606Lumenal Reviewed prediction

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. endoplasmic reticulum membrane Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13601360Ubiquitin carboxyl-terminal hydrolase 19
PRO_0000295157Add
BLAST

Proteomic databases

MaxQBiQ3UJD6.
PaxDbiQ3UJD6.
PRIDEiQ3UJD6.

PTM databases

PhosphoSiteiQ3UJD6.

Expressioni

Inductioni

Up-regulated by ESR1 in the presence of 17 beta-estradiol (E2).1 Publication

Gene expression databases

ArrayExpressiQ3UJD6.
BgeeiQ3UJD6.
CleanExiMM_USP19.
GenevestigatoriQ3UJD6.

Interactioni

Subunit structurei

Interacts with and stabilizes RNF123 By similarity. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Interacts with HIF1A (via N-terminus) By similarity.

Protein-protein interaction databases

BioGridi214730. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ3UJD6.
SMRiQ3UJD6. Positions 306-444, 536-719, 1038-1257.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 14090CS 1
Add
BLAST
Domaini322 – 424103CS 2
Add
BLAST
Domaini539 – 1256718USP
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi524 – 5307Poly-Glu

Sequence similaritiesi

Contains 2 CS domains.
Contains 1 USP domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiCOG5560.
GeneTreeiENSGT00670000097750.
HOGENOMiHOG000074206.
HOVERGENiHBG061889.
KOiK11847.
OMAiPQCKQHR.
PhylomeDBiQ3UJD6.
TreeFamiTF106276.

Family and domain databases

Gene3Di2.60.40.790. 2 hits.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF04969. CS. 2 hits.
PF00443. UCH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 2 hits.
PROSITEiPS51203. CS. 2 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3UJD6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSAGASATGP RRGPPGLEEA TSKKKQKDRA NLESKDGDAR RVSLPRKEPT     50
KDELLLDWRQ SADEVIVKLR VGTGPVRLED VDAAFTDTDC VVRLPDGRQW 100
GGVFFAEIQS SCTKVQARKG GLLQLVLPKK VPLLTWPSLL KPLGTQELVP 150
GLQCQENGQE LSPIALEPGS EPRRAKQEAR NQKRAQGRGE VGSGAGPGTQ 200
AGPSAKRAVH LRRGPEGEGS MDGPGPQGDA PSFLSDSATQ VEAEEKLCAP 250
PMNTQTSLLS SEKSLALLTV EKTVSPRNDP VAPVMVQDRD PEPEQEDQVK 300
EEMALGADPT ALVEEPESMV NLAFVKNDSY EKGPDSVVVH VYVKEIRRDS 350
SRVLFREQDF TLIFQTRDGN FLRLHPGCGP HTIFRWQVKL RNLIEPEQCT 400
FCFTASRIDI CLRKRQSQRW GGLEAPATRG AVGGAKVAVP TGPTPLDSTP 450
PGGGPHPLTG QEEARAVEKE KPKARSEDSG LDGVVARTPL EHVAPKPDPH 500
LASPKPTCMV PPMPHSPVSG DSVEEDEEEE KKVCLPGFTG LVNLGNTCFM 550
NSVIQSLSNT RELRDFFHDR SFEAEINYNN PLGTGGRLAI GFAVLLRALW 600
KGTHQAFQPS KLKAIVASKA SQFTGYAQHD AQEFMAFLLD GLHEDLNRIQ 650
NKPYTETVDS DGRPDEVVAE EAWQRHKMRN DSFIVDLFQG QYKSKLVCPV 700
CAKVSITFDP FLYLPVPLPQ KQKVLPIFYF AREPHSKPIK FLVSVSKENS 750
SASEVLDSLS QSVHVKPENL RLAEVIKNRF HRVFLPSHSL DAVSPTDVLL 800
CFELLSPELA KERVVVLEVQ QRPQVPSIPI SKCAACQRKQ QSEEEKLKRC 850
TRCYRVGYCN QFCQKTHWPD HKGLCRPENI GYPFLVSVPA SRLTYARLAQ 900
LLEGYARYSV SVFQPPFQPG RMALESQSPG CTTLLSTSSL EAGDSEREPI 950
QPSELQLVTP VAEGDTGAHR VWPPADRGPV PSTSGLSSEM LASGPIEGCP 1000
LLAGERVSRP EAAVPGYQHS SESVNTHTPQ FFIYKIDASN REQRLEDKGE 1050
TPLELGDDCS LALVWRNNER LQEFVLVASK ELECAEDPGS AGEAARAGHF 1100
TLDQCLNLFT RPEVLAPEEA WYCPQCKQHR EASKQLLLWR LPNVLIVQLK 1150
RFSFRSFIWR DKINDLVEFP VRNLDLSKFC IGQKEEQLPS YDLYAVINHY 1200
GGMIGGHYTA CARLPNDRSS QRSDVGWRLF DDSTVTTVDE SQVVTRYAYV 1250
LFYRRRNSPV ERPPRASHSE HHPDLGPAAE AAASQASRIW QELEAEEEMV 1300
PEGPGPLGPW GPQDWVGPPP RGPTTPDEGC LRYFVLGTVA ALVALVLNVF 1350
YPLVSQSRWR 1360
Length:1,360
Mass (Da):150,549
Last modified:October 11, 2005 - v1
Checksum:iFE9C3020D2CD9AED
GO
Isoform 2 (identifier: Q3UJD6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1286-1340: ASRIWQELEA...LRYFVLGTVA → GLGPGQAPEV...PTYSNMEEVD
     1341-1360: Missing.

Show »
Length:1,323
Mass (Da):146,283
Checksum:i73E85AA9778738F7
GO

Sequence cautioni

The sequence BAC65678.4 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1286 – 134055ASRIW…LGTVA → GLGPGQAPEVAPTRTAPERF APPVDRPAPTYSNMEEVD in isoform 2.
VSP_026769Add
BLAST
Alternative sequencei1341 – 136020Missing in isoform 2.
VSP_026770Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti140 – 1401L → LK in BAE42739. 1 Publication
Sequence conflicti142 – 1421P → S in AAH60613. 1 Publication
Sequence conflicti430 – 4312Missing in BAE42739. 1 Publication
Sequence conflicti669 – 6691A → T in BAE42739. 1 Publication
Sequence conflicti1058 – 10581D → E in BAE42739. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122396 mRNA. Translation: BAC65678.4. Different initiation.
AK146504 mRNA. Translation: BAE27219.1.
AK160807 mRNA. Translation: BAE36025.1.
AK171942 mRNA. Translation: BAE42739.1.
BC046824 mRNA. Translation: AAH46824.1.
BC060613 mRNA. Translation: AAH60613.1.
CCDSiCCDS23529.1. [Q3UJD6-1]
CCDS52924.1. [Q3UJD6-2]
RefSeqiNP_001161843.1. NM_001168371.2.
NP_001161844.1. NM_001168372.2. [Q3UJD6-2]
NP_001161845.1. NM_001168373.2.
NP_082080.3. NM_027804.4. [Q3UJD6-1]
NP_663382.2. NM_145407.3.
UniGeneiMm.289706.

Genome annotation databases

EnsembliENSMUST00000006854; ENSMUSP00000006854; ENSMUSG00000006676. [Q3UJD6-1]
ENSMUST00000085044; ENSMUSP00000082119; ENSMUSG00000006676. [Q3UJD6-2]
GeneIDi71472.
KEGGimmu:71472.
UCSCiuc009rpt.2. mouse. [Q3UJD6-1]
uc009rpu.2. mouse. [Q3UJD6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122396 mRNA. Translation: BAC65678.4 . Different initiation.
AK146504 mRNA. Translation: BAE27219.1 .
AK160807 mRNA. Translation: BAE36025.1 .
AK171942 mRNA. Translation: BAE42739.1 .
BC046824 mRNA. Translation: AAH46824.1 .
BC060613 mRNA. Translation: AAH60613.1 .
CCDSi CCDS23529.1. [Q3UJD6-1 ]
CCDS52924.1. [Q3UJD6-2 ]
RefSeqi NP_001161843.1. NM_001168371.2.
NP_001161844.1. NM_001168372.2. [Q3UJD6-2 ]
NP_001161845.1. NM_001168373.2.
NP_082080.3. NM_027804.4. [Q3UJD6-1 ]
NP_663382.2. NM_145407.3.
UniGenei Mm.289706.

3D structure databases

ProteinModelPortali Q3UJD6.
SMRi Q3UJD6. Positions 306-444, 536-719, 1038-1257.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 214730. 1 interaction.

Protein family/group databases

MEROPSi C19.024.

PTM databases

PhosphoSitei Q3UJD6.

Proteomic databases

MaxQBi Q3UJD6.
PaxDbi Q3UJD6.
PRIDEi Q3UJD6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000006854 ; ENSMUSP00000006854 ; ENSMUSG00000006676 . [Q3UJD6-1 ]
ENSMUST00000085044 ; ENSMUSP00000082119 ; ENSMUSG00000006676 . [Q3UJD6-2 ]
GeneIDi 71472.
KEGGi mmu:71472.
UCSCi uc009rpt.2. mouse. [Q3UJD6-1 ]
uc009rpu.2. mouse. [Q3UJD6-2 ]

Organism-specific databases

CTDi 10869.
MGIi MGI:1918722. Usp19.
Rougei Search...

Phylogenomic databases

eggNOGi COG5560.
GeneTreei ENSGT00670000097750.
HOGENOMi HOG000074206.
HOVERGENi HBG061889.
KOi K11847.
OMAi PQCKQHR.
PhylomeDBi Q3UJD6.
TreeFami TF106276.

Miscellaneous databases

ChiTaRSi USP19. mouse.
NextBioi 333851.
PROi Q3UJD6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q3UJD6.
Bgeei Q3UJD6.
CleanExi MM_USP19.
Genevestigatori Q3UJD6.

Family and domain databases

Gene3Di 2.60.40.790. 2 hits.
InterProi IPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR002893. Znf_MYND.
[Graphical view ]
Pfami PF04969. CS. 2 hits.
PF00443. UCH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view ]
SUPFAMi SSF49764. SSF49764. 2 hits.
PROSITEi PS51203. CS. 2 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Fetal brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Head, Kidney and Spleen.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 395-1360 (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Brain.
  4. "17beta-estradiol represses myogenic differentiation by increasing ubiquitin-specific peptidase 19 through estrogen receptor alpha."
    Ogawa M., Yamaji R., Higashimura Y., Harada N., Ashida H., Nakano Y., Inui H.
    J. Biol. Chem. 286:41455-41465(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.

Entry informationi

Entry nameiUBP19_MOUSE
AccessioniPrimary (citable) accession number: Q3UJD6
Secondary accession number(s): Q3TAC9
, Q3TUE6, Q6P9T0, Q80TP5, Q80ZW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 11, 2005
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi