Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Amine oxidase [flavin-containing]

Gene

Maoa

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues.UniRule annotation

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.UniRule annotation

Cofactori

FADUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidase [flavin-containing]UniRule annotation (EC:1.4.3.4UniRule annotation)
Alternative name(s):
Monoamine oxidaseUniRule annotation
Gene namesi
Name:MaoaImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96915. Maoa.

Subcellular locationi

  • Mitochondrion outer membrane UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membraneUniRule annotation

PTM / Processingi

Keywords - PTMi

AcetylationUniRule annotation

Proteomic databases

PaxDbiQ3UJ53.
PRIDEiQ3UJ53.

Expressioni

Gene expression databases

GenevisibleiQ3UJ53. MM.

Interactioni

Subunit structurei

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.UniRule annotation

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026013.

Structurei

3D structure databases

ProteinModelPortaliQ3UJ53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 460438Amino_oxidaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the flavin monoamine oxidase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0029. Eukaryota.
ENOG410XSNC. LUCA.
HOVERGENiHBG004255.
KOiK00274.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR023753. FAD/NAD-binding_dom.
IPR001613. Flavin_amine_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

Q3UJ53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDLEKPSIT GHMFDVVVIG GGISGLAAAK LLSEYKINVL VLEARDRVGG
60 70 80 90 100
RTYTVRNEHV KWVDVGGAYV GPTQNRILRL SKELGIETYK VNVNERLVQY
110 120 130 140 150
VKGKTYPFRG AFPPVWNPLA YLDYNNLWRT MDDMGKEIPV DAPWQARHAE
160 170 180 190 200
EWDKITMKDL IDKICWTKTA REFAYLFVNI NVTSEPHEVS ALWFLWYVRQ
210 220 230 240 250
CGGTSRIFSV TNGGQERKFV GGSGQISEQI MVLLGDKVKL SSPVTYIDQT
260 270 280 290 300
DDNVIIETLN HEHYECKYVI SAIPPVLTAK IHFKPELPPE RNQLIQRLPM
310 320 330 340 350
GAVIKCMVYY KEAFWKKKDY CGCMIIEDEE APISITLDDT KPDGSMPAIM
360 370 380 390 400
GFILARKAER LAKLHKDIRK RKICELYAKV LGSQEALSPV HYEEKNWCEE
410 420 430 440 450
QYSGGCYTAY FPPGIMTLYG RVIRQPVGRI YFAGTETATQ WSGYMEGAVE
460 470 480 490 500
AGERAAREVL NALGKVAKKD IWVQEPESKD VPALEITHTF LERNLPSVPG
510 520
LLKITGFSTS VALLCFVLYK FKQPQS
Length:526
Mass (Da):59,588
Last modified:October 11, 2005 - v1
Checksum:i56A13A20CC5893F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146612 mRNA. Translation: BAE27302.1.
RefSeqiNP_776101.3. NM_173740.3.
UniGeneiMm.21108.

Genome annotation databases

GeneIDi17161.
KEGGimmu:17161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146612 mRNA. Translation: BAE27302.1.
RefSeqiNP_776101.3. NM_173740.3.
UniGeneiMm.21108.

3D structure databases

ProteinModelPortaliQ3UJ53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026013.

Proteomic databases

PaxDbiQ3UJ53.
PRIDEiQ3UJ53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17161.
KEGGimmu:17161.

Organism-specific databases

CTDi4128.
MGIiMGI:96915. Maoa.

Phylogenomic databases

eggNOGiKOG0029. Eukaryota.
ENOG410XSNC. LUCA.
HOVERGENiHBG004255.
KOiK00274.

Miscellaneous databases

NextBioi291438.
SOURCEiSearch...

Gene expression databases

GenevisibleiQ3UJ53. MM.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR023753. FAD/NAD-binding_dom.
IPR001613. Flavin_amine_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeartImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeartImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeartImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeartImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeartImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeartImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeartImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeartImported.

Entry informationi

Entry nameiQ3UJ53_MOUSE
AccessioniPrimary (citable) accession number: Q3UJ53
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: March 16, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.