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Protein

RING finger protein 10

Gene

Rnf10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression and myelin formation in Schwann cells.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri225 – 267RING-typePROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 10
Alternative name(s):
Sid 2705
Gene namesi
Name:Rnf10
Synonyms:Kiaa0262, Rie2, Sid2705
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1859162 Rnf10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595861 – 804RING finger protein 10Add BLAST804

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphoserineBy similarity1
Modified residuei110PhosphoserineBy similarity1
Modified residuei128PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3UIW5
MaxQBiQ3UIW5
PaxDbiQ3UIW5
PeptideAtlasiQ3UIW5
PRIDEiQ3UIW5

PTM databases

iPTMnetiQ3UIW5
PhosphoSitePlusiQ3UIW5

Expressioni

Gene expression databases

BgeeiENSMUSG00000041740
CleanExiMM_RNF10
ExpressionAtlasiQ3UIW5 baseline and differential
GenevisibleiQ3UIW5 MM

Interactioni

Subunit structurei

Interacts with MEOX2.By similarity

Protein-protein interaction databases

BioGridi206133, 2 interactors
IntActiQ3UIW5, 1 interactor
STRINGi10090.ENSMUSP00000107725

Structurei

3D structure databases

ProteinModelPortaliQ3UIW5
SMRiQ3UIW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 111Ser-richAdd BLAST108
Compositional biasi387 – 390Poly-Gly4

Sequence similaritiesi

Belongs to the RNF10 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri225 – 267RING-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2164 Eukaryota
ENOG410XTFS LUCA
GeneTreeiENSGT00390000001731
HOGENOMiHOG000006763
HOVERGENiHBG059523
InParanoidiQ3UIW5
TreeFamiTF323455

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UIW5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPQSSPSAAA TASDMDKNSG SNSSSASSGS SKGQQPPRSA SAGPAGESKP
60 70 80 90 100
KSDGKNSNGS KRYNRKREPS YPKNENFSNQ SRRSNSQKSK TFNKMPPQRG
110 120 130 140 150
GGSSKPFSSS SNGGRRDEVA EAQRAEFSPA QFSGPKKINL NHLLNFTFEP
160 170 180 190 200
RGQAGHFEGS GHGGWGKRNK WGHKPFNKEL FLQANCQFVV SEDQDYAAHF
210 220 230 240 250
ADPDTLVNWD FVEQVRICSH EVPSCPICLY PPTAAKITRC GHIFCWACIL
260 270 280 290 300
HYLSLSEKTW SKCPICYSSV HKKDLKSVVA TESRQYAVGD TITMQLMKRE
310 320 330 340 350
KGVLVALPKS KWVNVDHPIN LGDEQLSQYS KLLLASKEQV LHRVVLEEKG
360 370 380 390 400
ALEQQLAEEK HTPESCFIEA AIQEVKIREE ALSGVAGGGG EVTGVVAALE
410 420 430 440 450
HLVLMAPLAT ESAFQPRKGV LEYLSAFDDE AAQVCSLDPP GPLALPLVEE
460 470 480 490 500
EEAVSEPEAC EDAEVADDSL GEGTVGPEMS QEEPITKPGF TQLSSSPCYY
510 520 530 540 550
FYQAEDGQHM FLHPVNVRCL VREYGSLEQS PEKISATVVE IAGYSMSEDV
560 570 580 590 600
RQRHRYLSHL PLTCEFSICE LALQPPVVSK ETLEMFSDDI EKRKRQRQKK
610 620 630 640 650
AREERRRERR IEMEENKRQG RYPEVHIPLE NLQQFPAFNS YTCPSDSALG
660 670 680 690 700
PTSTEGHGAL SLSPLSRSPG SHADFLLTPL SPTASQGSPS FCVGSLEDDS
710 720 730 740 750
PFLSFAQMLR VGKAKADGWP KTAPKKDDNS LVPPAPVDSD GESDNSDRVP
760 770 780 790 800
VPSFQNSFSQ AIEAAFMKLD TPATSDPLSE DRGGKKRKRQ KQKLLFSTSV

VHTK
Length:804
Mass (Da):88,345
Last modified:October 31, 2006 - v2
Checksum:iA4E2231892D4F085
GO
Isoform 2 (identifier: Q3UIW5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-99: Missing.
     100-107: GGGSSKPF → MDKNSGSN
     780-780: Missing.

Note: No experimental confirmation available.
Show »
Length:704
Mass (Da):77,854
Checksum:iD9032170C40A2949
GO

Sequence cautioni

The sequence BAC97916 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti596 – 598QRQ → PTK in BAA84700 (PubMed:10697961).Curated3
Sequence conflicti660 – 661LS → YP in BAA84700 (PubMed:10697961).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0214791 – 99Missing in isoform 2. 1 PublicationAdd BLAST99
Alternative sequenceiVSP_021480100 – 107GGGSSKPF → MDKNSGSN in isoform 2. 1 Publication8
Alternative sequenceiVSP_021481780Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026621 mRNA Translation: BAA84700.1
AK129106 mRNA Translation: BAC97916.1 Different initiation.
AK146728 mRNA Translation: BAE27391.1
AK165617 mRNA Translation: BAE38297.1
AK168523 mRNA Translation: BAE40402.1
AK172065 mRNA Translation: BAE42807.1
BC010342 mRNA Translation: AAH10342.1
BC058527 mRNA Translation: AAH58527.1
CCDSiCCDS19584.1 [Q3UIW5-1]
RefSeqiNP_001289377.1, NM_001302448.1
NP_001289378.1, NM_001302449.1
NP_057907.2, NM_016698.2 [Q3UIW5-1]
UniGeneiMm.30051

Genome annotation databases

EnsembliENSMUST00000112096; ENSMUSP00000107725; ENSMUSG00000041740 [Q3UIW5-1]
GeneIDi50849
KEGGimmu:50849
UCSCiuc008zdl.2 mouse [Q3UIW5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRNF10_MOUSE
AccessioniPrimary (citable) accession number: Q3UIW5
Secondary accession number(s): Q6PDS8
, Q6ZQE8, Q91YZ9, Q9R0P0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: March 28, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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