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Protein

RING finger protein 10

Gene

Rnf10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression and myelin formation in Schwann cells.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri225 – 267RING-typePROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 10
Alternative name(s):
Sid 2705
Gene namesi
Name:Rnf10
Synonyms:Kiaa0262, Rie2, Sid2705
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1859162. Rnf10.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595861 – 804RING finger protein 10Add BLAST804

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphoserineBy similarity1
Modified residuei110PhosphoserineBy similarity1
Modified residuei128PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3UIW5.
MaxQBiQ3UIW5.
PaxDbiQ3UIW5.
PeptideAtlasiQ3UIW5.
PRIDEiQ3UIW5.

PTM databases

iPTMnetiQ3UIW5.
PhosphoSitePlusiQ3UIW5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000041740.
CleanExiMM_RNF10.
ExpressionAtlasiQ3UIW5. baseline and differential.
GenevisibleiQ3UIW5. MM.

Interactioni

Subunit structurei

Interacts with MEOX2.By similarity

Protein-protein interaction databases

BioGridi206133. 2 interactors.
IntActiQ3UIW5. 1 interactor.
STRINGi10090.ENSMUSP00000107725.

Structurei

3D structure databases

ProteinModelPortaliQ3UIW5.
SMRiQ3UIW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 111Ser-richAdd BLAST108
Compositional biasi387 – 390Poly-Gly4

Sequence similaritiesi

Belongs to the RNF10 family.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri225 – 267RING-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2164. Eukaryota.
ENOG410XTFS. LUCA.
GeneTreeiENSGT00390000001731.
HOGENOMiHOG000006763.
HOVERGENiHBG059523.
InParanoidiQ3UIW5.
TreeFamiTF323455.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UIW5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPQSSPSAAA TASDMDKNSG SNSSSASSGS SKGQQPPRSA SAGPAGESKP
60 70 80 90 100
KSDGKNSNGS KRYNRKREPS YPKNENFSNQ SRRSNSQKSK TFNKMPPQRG
110 120 130 140 150
GGSSKPFSSS SNGGRRDEVA EAQRAEFSPA QFSGPKKINL NHLLNFTFEP
160 170 180 190 200
RGQAGHFEGS GHGGWGKRNK WGHKPFNKEL FLQANCQFVV SEDQDYAAHF
210 220 230 240 250
ADPDTLVNWD FVEQVRICSH EVPSCPICLY PPTAAKITRC GHIFCWACIL
260 270 280 290 300
HYLSLSEKTW SKCPICYSSV HKKDLKSVVA TESRQYAVGD TITMQLMKRE
310 320 330 340 350
KGVLVALPKS KWVNVDHPIN LGDEQLSQYS KLLLASKEQV LHRVVLEEKG
360 370 380 390 400
ALEQQLAEEK HTPESCFIEA AIQEVKIREE ALSGVAGGGG EVTGVVAALE
410 420 430 440 450
HLVLMAPLAT ESAFQPRKGV LEYLSAFDDE AAQVCSLDPP GPLALPLVEE
460 470 480 490 500
EEAVSEPEAC EDAEVADDSL GEGTVGPEMS QEEPITKPGF TQLSSSPCYY
510 520 530 540 550
FYQAEDGQHM FLHPVNVRCL VREYGSLEQS PEKISATVVE IAGYSMSEDV
560 570 580 590 600
RQRHRYLSHL PLTCEFSICE LALQPPVVSK ETLEMFSDDI EKRKRQRQKK
610 620 630 640 650
AREERRRERR IEMEENKRQG RYPEVHIPLE NLQQFPAFNS YTCPSDSALG
660 670 680 690 700
PTSTEGHGAL SLSPLSRSPG SHADFLLTPL SPTASQGSPS FCVGSLEDDS
710 720 730 740 750
PFLSFAQMLR VGKAKADGWP KTAPKKDDNS LVPPAPVDSD GESDNSDRVP
760 770 780 790 800
VPSFQNSFSQ AIEAAFMKLD TPATSDPLSE DRGGKKRKRQ KQKLLFSTSV

VHTK
Length:804
Mass (Da):88,345
Last modified:October 31, 2006 - v2
Checksum:iA4E2231892D4F085
GO
Isoform 2 (identifier: Q3UIW5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-99: Missing.
     100-107: GGGSSKPF → MDKNSGSN
     780-780: Missing.

Note: No experimental confirmation available.
Show »
Length:704
Mass (Da):77,854
Checksum:iD9032170C40A2949
GO

Sequence cautioni

The sequence BAC97916 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti596 – 598QRQ → PTK in BAA84700 (PubMed:10697961).Curated3
Sequence conflicti660 – 661LS → YP in BAA84700 (PubMed:10697961).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0214791 – 99Missing in isoform 2. 1 PublicationAdd BLAST99
Alternative sequenceiVSP_021480100 – 107GGGSSKPF → MDKNSGSN in isoform 2. 1 Publication8
Alternative sequenceiVSP_021481780Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026621 mRNA. Translation: BAA84700.1.
AK129106 mRNA. Translation: BAC97916.1. Different initiation.
AK146728 mRNA. Translation: BAE27391.1.
AK165617 mRNA. Translation: BAE38297.1.
AK168523 mRNA. Translation: BAE40402.1.
AK172065 mRNA. Translation: BAE42807.1.
BC010342 mRNA. Translation: AAH10342.1.
BC058527 mRNA. Translation: AAH58527.1.
CCDSiCCDS19584.1. [Q3UIW5-1]
RefSeqiNP_001289377.1. NM_001302448.1.
NP_001289378.1. NM_001302449.1.
NP_057907.2. NM_016698.2. [Q3UIW5-1]
UniGeneiMm.30051.

Genome annotation databases

EnsembliENSMUST00000112096; ENSMUSP00000107725; ENSMUSG00000041740. [Q3UIW5-1]
GeneIDi50849.
KEGGimmu:50849.
UCSCiuc008zdl.2. mouse. [Q3UIW5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026621 mRNA. Translation: BAA84700.1.
AK129106 mRNA. Translation: BAC97916.1. Different initiation.
AK146728 mRNA. Translation: BAE27391.1.
AK165617 mRNA. Translation: BAE38297.1.
AK168523 mRNA. Translation: BAE40402.1.
AK172065 mRNA. Translation: BAE42807.1.
BC010342 mRNA. Translation: AAH10342.1.
BC058527 mRNA. Translation: AAH58527.1.
CCDSiCCDS19584.1. [Q3UIW5-1]
RefSeqiNP_001289377.1. NM_001302448.1.
NP_001289378.1. NM_001302449.1.
NP_057907.2. NM_016698.2. [Q3UIW5-1]
UniGeneiMm.30051.

3D structure databases

ProteinModelPortaliQ3UIW5.
SMRiQ3UIW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206133. 2 interactors.
IntActiQ3UIW5. 1 interactor.
STRINGi10090.ENSMUSP00000107725.

PTM databases

iPTMnetiQ3UIW5.
PhosphoSitePlusiQ3UIW5.

Proteomic databases

EPDiQ3UIW5.
MaxQBiQ3UIW5.
PaxDbiQ3UIW5.
PeptideAtlasiQ3UIW5.
PRIDEiQ3UIW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112096; ENSMUSP00000107725; ENSMUSG00000041740. [Q3UIW5-1]
GeneIDi50849.
KEGGimmu:50849.
UCSCiuc008zdl.2. mouse. [Q3UIW5-1]

Organism-specific databases

CTDi9921.
MGIiMGI:1859162. Rnf10.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2164. Eukaryota.
ENOG410XTFS. LUCA.
GeneTreeiENSGT00390000001731.
HOGENOMiHOG000006763.
HOVERGENiHBG059523.
InParanoidiQ3UIW5.
TreeFamiTF323455.

Miscellaneous databases

ChiTaRSiRnf10. mouse.
PROiQ3UIW5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041740.
CleanExiMM_RNF10.
ExpressionAtlasiQ3UIW5. baseline and differential.
GenevisibleiQ3UIW5. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRNF10_MOUSE
AccessioniPrimary (citable) accession number: Q3UIW5
Secondary accession number(s): Q6PDS8
, Q6ZQE8, Q91YZ9, Q9R0P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 2, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.