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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6

Gene

Ndufb6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
Alternative name(s):
Complex I-B17
Short name:
CI-B17
NADH-ubiquinone oxidoreductase B17 subunit
Gene namesi
Name:Ndufb6
Synonyms:Gm137
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2684983. Ndufb6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei64 – 86HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002339802 – 128NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei24N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ3UIU2.
PaxDbiQ3UIU2.
PRIDEiQ3UIU2.

PTM databases

iPTMnetiQ3UIU2.
PhosphoSitePlusiQ3UIU2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000071014.
ExpressionAtlasiQ3UIU2. baseline and differential.
GenevisibleiQ3UIU2. MM.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

BioGridi230927. 3 interactors.
CORUMiQ3UIU2.
IntActiQ3UIU2. 1 interactor.
STRINGi10090.ENSMUSP00000092746.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB6 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4633. Eukaryota.
ENOG4111RT5. LUCA.
GeneTreeiENSGT00390000007535.
HOGENOMiHOG000231724.
HOVERGENiHBG006449.
InParanoidiQ3UIU2.
KOiK03962.
OMAiPAWIIHY.
OrthoDBiEOG091G0SHB.
PhylomeDBiQ3UIU2.
TreeFamiTF328587.

Family and domain databases

InterProiView protein in InterPro
IPR019174. NADH_DH_b-subcmplx_su6.
PfamiView protein in Pfam
PF09782. NDUF_B6. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UIU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGYTPDEKL RLQQLRELRR RWLKDQELSP REPVLPPRRM WPLERFWDNF
60 70 80 90 100
LRDGAVWKNM VFKAYRSSLF AVSHVLIPMW FVHYYVKYHM ATKPYTIVSS
110 120
KPRIFPGDTI LETGEVIPPM RDFPDQHH
Length:128
Mass (Da):15,515
Last modified:January 23, 2007 - v3
Checksum:iC6E28FD41E455873
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146762 mRNA. Translation: BAE27414.1.
CCDSiCCDS18045.1.
RefSeqiNP_001028477.1. NM_001033305.3.
UniGeneiMm.1103.

Genome annotation databases

EnsembliENSMUST00000095128; ENSMUSP00000092746; ENSMUSG00000071014.
GeneIDi230075.
KEGGimmu:230075.
UCSCiuc008shk.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiNDUB6_MOUSE
AccessioniPrimary (citable) accession number: Q3UIU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 95 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families