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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6

Gene

Ndufb6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
Alternative name(s):
Complex I-B17
Short name:
CI-B17
NADH-ubiquinone oxidoreductase B17 subunit
Gene namesi
Name:Ndufb6
Synonyms:Gm137
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2684983. Ndufb6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei64 – 8623HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 128127NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6PRO_0000233980Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei24 – 241N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ3UIU2.
PaxDbiQ3UIU2.
PRIDEiQ3UIU2.

PTM databases

iPTMnetiQ3UIU2.
PhosphoSiteiQ3UIU2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000071014.
ExpressionAtlasiQ3UIU2. baseline and differential.
GenevisibleiQ3UIU2. MM.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

BioGridi230927. 1 interaction.
IntActiQ3UIU2. 1 interaction.
STRINGi10090.ENSMUSP00000092746.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB6 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4633. Eukaryota.
ENOG4111RT5. LUCA.
GeneTreeiENSGT00390000007535.
HOGENOMiHOG000231724.
HOVERGENiHBG006449.
InParanoidiQ3UIU2.
KOiK03962.
OMAiPAWIIHY.
OrthoDBiEOG091G0SHB.
PhylomeDBiQ3UIU2.
TreeFamiTF328587.

Family and domain databases

InterProiIPR019174. NADH_DH_b-subcmplx_su6.
[Graphical view]
PfamiPF09782. NDUF_B6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UIU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGYTPDEKL RLQQLRELRR RWLKDQELSP REPVLPPRRM WPLERFWDNF
60 70 80 90 100
LRDGAVWKNM VFKAYRSSLF AVSHVLIPMW FVHYYVKYHM ATKPYTIVSS
110 120
KPRIFPGDTI LETGEVIPPM RDFPDQHH
Length:128
Mass (Da):15,515
Last modified:January 23, 2007 - v3
Checksum:iC6E28FD41E455873
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146762 mRNA. Translation: BAE27414.1.
CCDSiCCDS18045.1.
RefSeqiNP_001028477.1. NM_001033305.3.
UniGeneiMm.1103.

Genome annotation databases

EnsembliENSMUST00000095128; ENSMUSP00000092746; ENSMUSG00000071014.
GeneIDi230075.
KEGGimmu:230075.
UCSCiuc008shk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146762 mRNA. Translation: BAE27414.1.
CCDSiCCDS18045.1.
RefSeqiNP_001028477.1. NM_001033305.3.
UniGeneiMm.1103.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230927. 1 interaction.
IntActiQ3UIU2. 1 interaction.
STRINGi10090.ENSMUSP00000092746.

PTM databases

iPTMnetiQ3UIU2.
PhosphoSiteiQ3UIU2.

Proteomic databases

MaxQBiQ3UIU2.
PaxDbiQ3UIU2.
PRIDEiQ3UIU2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095128; ENSMUSP00000092746; ENSMUSG00000071014.
GeneIDi230075.
KEGGimmu:230075.
UCSCiuc008shk.1. mouse.

Organism-specific databases

CTDi4712.
MGIiMGI:2684983. Ndufb6.

Phylogenomic databases

eggNOGiKOG4633. Eukaryota.
ENOG4111RT5. LUCA.
GeneTreeiENSGT00390000007535.
HOGENOMiHOG000231724.
HOVERGENiHBG006449.
InParanoidiQ3UIU2.
KOiK03962.
OMAiPAWIIHY.
OrthoDBiEOG091G0SHB.
PhylomeDBiQ3UIU2.
TreeFamiTF328587.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

PROiQ3UIU2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071014.
ExpressionAtlasiQ3UIU2. baseline and differential.
GenevisibleiQ3UIU2. MM.

Family and domain databases

InterProiIPR019174. NADH_DH_b-subcmplx_su6.
[Graphical view]
PfamiPF09782. NDUF_B6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDUB6_MOUSE
AccessioniPrimary (citable) accession number: Q3UIU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 85 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.