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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6

Gene

Ndufb6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
Alternative name(s):
Complex I-B17
Short name:
CI-B17
NADH-ubiquinone oxidoreductase B17 subunit
Gene namesi
Name:Ndufb6
Synonyms:Gm137
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2684983. Ndufb6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei64 – 8623HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 128127NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6PRO_0000233980Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei24 – 241N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ3UIU2.
MaxQBiQ3UIU2.
PaxDbiQ3UIU2.
PRIDEiQ3UIU2.

PTM databases

iPTMnetiQ3UIU2.
PhosphoSiteiQ3UIU2.

Expressioni

Gene expression databases

BgeeiQ3UIU2.
ExpressionAtlasiQ3UIU2. baseline and differential.
GenevisibleiQ3UIU2. MM.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

BioGridi230927. 1 interaction.
IntActiQ3UIU2. 1 interaction.
STRINGi10090.ENSMUSP00000092746.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB6 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4633. Eukaryota.
ENOG4111RT5. LUCA.
GeneTreeiENSGT00390000007535.
HOGENOMiHOG000231724.
HOVERGENiHBG006449.
InParanoidiQ3UIU2.
KOiK03962.
OMAiPAWIIHY.
OrthoDBiEOG7ZWD40.
PhylomeDBiQ3UIU2.
TreeFamiTF328587.

Family and domain databases

InterProiIPR019174. NADH_DH_b-subcmplx_su6.
[Graphical view]
PfamiPF09782. NDUF_B6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UIU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGYTPDEKL RLQQLRELRR RWLKDQELSP REPVLPPRRM WPLERFWDNF
60 70 80 90 100
LRDGAVWKNM VFKAYRSSLF AVSHVLIPMW FVHYYVKYHM ATKPYTIVSS
110 120
KPRIFPGDTI LETGEVIPPM RDFPDQHH
Length:128
Mass (Da):15,515
Last modified:January 23, 2007 - v3
Checksum:iC6E28FD41E455873
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146762 mRNA. Translation: BAE27414.1.
CCDSiCCDS18045.1.
RefSeqiNP_001028477.1. NM_001033305.3.
UniGeneiMm.1103.

Genome annotation databases

EnsembliENSMUST00000095128; ENSMUSP00000092746; ENSMUSG00000071014.
GeneIDi230075.
KEGGimmu:230075.
UCSCiuc008shk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146762 mRNA. Translation: BAE27414.1.
CCDSiCCDS18045.1.
RefSeqiNP_001028477.1. NM_001033305.3.
UniGeneiMm.1103.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230927. 1 interaction.
IntActiQ3UIU2. 1 interaction.
STRINGi10090.ENSMUSP00000092746.

PTM databases

iPTMnetiQ3UIU2.
PhosphoSiteiQ3UIU2.

Proteomic databases

EPDiQ3UIU2.
MaxQBiQ3UIU2.
PaxDbiQ3UIU2.
PRIDEiQ3UIU2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095128; ENSMUSP00000092746; ENSMUSG00000071014.
GeneIDi230075.
KEGGimmu:230075.
UCSCiuc008shk.1. mouse.

Organism-specific databases

CTDi4712.
MGIiMGI:2684983. Ndufb6.

Phylogenomic databases

eggNOGiKOG4633. Eukaryota.
ENOG4111RT5. LUCA.
GeneTreeiENSGT00390000007535.
HOGENOMiHOG000231724.
HOVERGENiHBG006449.
InParanoidiQ3UIU2.
KOiK03962.
OMAiPAWIIHY.
OrthoDBiEOG7ZWD40.
PhylomeDBiQ3UIU2.
TreeFamiTF328587.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

PROiQ3UIU2.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UIU2.
ExpressionAtlasiQ3UIU2. baseline and differential.
GenevisibleiQ3UIU2. MM.

Family and domain databases

InterProiIPR019174. NADH_DH_b-subcmplx_su6.
[Graphical view]
PfamiPF09782. NDUF_B6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Amnion.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas and Testis.
  3. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-24, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiNDUB6_MOUSE
AccessioniPrimary (citable) accession number: Q3UIU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.