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Protein

Myocardial zonula adherens protein

Gene

Myzap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in cellular signaling via Rho-related GTP-binding proteins and activation of transcription factor SRF. Targets TJP1 to cell junctions (By similarity). In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity).By similarity1 Publication

GO - Biological processi

  • intracellular signal transduction Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Myocardial zonula adherens protein
Gene namesi
Name:Myzap
Synonyms:Myozap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2142908. Myzap.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000032622617 – 466Myocardial zonula adherens proteinAdd BLAST450

Proteomic databases

MaxQBiQ3UIJ9.
PaxDbiQ3UIJ9.
PRIDEiQ3UIJ9.

PTM databases

iPTMnetiQ3UIJ9.
PhosphoSitePlusiQ3UIJ9.

Expressioni

Tissue specificityi

Detected in heart myocardium and lung.1 Publication

Developmental stagei

Detected in embryonic vasculature at 8 dpc. Detected in endocardium and the primitive ventricle at 9 dpc. First detected in myocardium at 11.5 dpc. Highly expressed in heart and lung at 15.5 dpc and in neonates, wherease expression in vasculature is no longer detectable.1 Publication

Gene expression databases

BgeeiENSMUSG00000041361.
ExpressionAtlasiQ3UIJ9. baseline and differential.
GenevisibleiQ3UIJ9. MM.

Interactioni

Subunit structurei

Interacts with DSP, MPRIP and TJP1/ZO1. Interaction with MPRIP inhibits the activation of transcription factor SRF. Interacts with GRIN1. Interacts with DYNLL1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091342.

Structurei

3D structure databases

ProteinModelPortaliQ3UIJ9.
SMRiQ3UIJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili95 – 137Sequence analysisAdd BLAST43
Coiled coili187 – 415Sequence analysisAdd BLAST229

Sequence similaritiesi

Belongs to the MYZAP family.Curated

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG410II7W. Eukaryota.
ENOG410ZUQB. LUCA.
GeneTreeiENSGT00530000063232.
HOGENOMiHOG000060195.
InParanoidiQ3UIJ9.
KOiK22031.
OrthoDBiEOG091G01MP.
PhylomeDBiQ3UIJ9.
TreeFamiTF331627.

Family and domain databases

InterProiView protein in InterPro
IPR028273. Myozap.
PANTHERiPTHR23171:SF2. PTHR23171:SF2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UIJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRSTSTVTL FSGGGAKSPG TPSRRANVCR LRLTVPPENP VPQQTEKKIE
60 70 80 90 100
RKDQPPELSN GESTKRLPQG VVYGVVRRSD PNQQKEMVVY GWSTNQLKEE
110 120 130 140 150
MNYIKDVRAT LEKVRKRMYG DYDEMRQKIR QLTQDLSVSH AQQDYLDSHI
160 170 180 190 200
QAQASALDSF NAMNAALASD SVGLQKTLVD VTLENSHIKD QIRHLQQTYE
210 220 230 240 250
ASMDKLREKQ RQLEAAQMEN QLLKMRVESS QEANAEVMRE MTRKLYSQYE
260 270 280 290 300
EKLQEAQRKH SAEKEVLLEE TNSFLKAIEE ANKKMEAAEL SLEEKDQKIG
310 320 330 340 350
ELDRLIERME KERHQLQLQL LEHETEMSGE MADSDKNRYQ QLEEASASLR
360 370 380 390 400
ERIRHLDDMV HCQQKKVKQM VEEIESLKKK VQQKQLLILQ LLEKISFLEG
410 420 430 440 450
ENNELQSRLD YLTETQPKTE VETREIGVGC DLLPSPTGRT REITMPSRSY
460
TPYTRVLELS SKKTLT
Length:466
Mass (Da):53,897
Last modified:October 11, 2005 - v1
Checksum:iFF6F99C1E486B717
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146889 mRNA. Translation: BAE27507.1.
CH466522 Genomic DNA. Translation: EDL26227.1.
BC139077 mRNA. Translation: AAI39078.1.
BC139078 mRNA. Translation: AAI39079.1.
CCDSiCCDS23327.1.
RefSeqiNP_001028380.1. NM_001033208.4.
UniGeneiMm.27585.

Genome annotation databases

EnsembliENSMUST00000093823; ENSMUSP00000091342; ENSMUSG00000041361.
GeneIDi102371.
KEGGimmu:102371.
UCSCiuc009qpa.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiMYZAP_MOUSE
AccessioniPrimary (citable) accession number: Q3UIJ9
Secondary accession number(s): B2RT00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 11, 2005
Last modified: October 25, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families