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Protein

BRISC and BRCA1-A complex member 1

Gene

Babam1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA repair, Mitosis, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
BRISC and BRCA1-A complex member 1
Alternative name(s):
Mediator of RAP80 interactions and targeting subunit of 40 kDa
New component of the BRCA1-A complex
Gene namesi
Name:Babam1
Synonyms:Merit40, Nba1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1915501. Babam1.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Localizes at sites of DNA damage at double-strand breaks (DSBs).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333BRISC and BRCA1-A complex member 1PRO_0000288459Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei8 – 81PhosphoserineBy similarity
Modified residuei33 – 331PhosphoserineBy similarity
Modified residuei53 – 531PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ3UI43.
MaxQBiQ3UI43.
PaxDbiQ3UI43.
PRIDEiQ3UI43.

PTM databases

iPTMnetiQ3UI43.
PhosphoSiteiQ3UI43.

Expressioni

Gene expression databases

BgeeiQ3UI43.
CleanExiMM_5430437P03RIK.
GenevisibleiQ3UI43. MM.

Interactioni

Subunit structurei

Component of the ARISC complex, at least composed of UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with FAM175A/Abraxas and BRE/BRCC45. Component of the BRISC complex, at least composed of FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002473.

Structurei

3D structure databases

ProteinModelPortaliQ3UI43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni99 – 302204VWFA-likeAdd
BLAST

Domaini

The VWFA-like region is similar to the VWFA domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes.By similarity

Sequence similaritiesi

Belongs to the BABAM1 family.Curated

Phylogenomic databases

eggNOGiENOG410IF7E. Eukaryota.
ENOG4111NFW. LUCA.
GeneTreeiENSGT00390000016934.
InParanoidiQ3UI43.
OMAiRPFQSHA.
OrthoDBiEOG7VB2FR.
PhylomeDBiQ3UI43.
TreeFamiTF329070.

Family and domain databases

InterProiIPR026126. BABAM1.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR15660. PTHR15660. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3UI43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVAEANSPT EEEEEEEEEG EETISEPRPH TRSNPEGAED RALGAQASVG
60 70 80 90 100
SRSEGEGEAA TADGGAASVP GAGPKPWQVP ASASEVQIRT PRVNCPEKVI
110 120 130 140 150
ICLDLSEEMS VPKLESFNGS RTNALNVSQK MVEMFVRTKH KIDKSHEFAL
160 170 180 190 200
VVVNDDSAWL SGLTSDPREL CSCLYDLETA SCSTFNLEGL FSLIQQKTEL
210 220 230 240 250
PVTENVQTIP PPYVVRTILV YSRPPCQPQF SLTEPMKKMF QCPYFFFDIV
260 270 280 290 300
YIHNGTEEKE EDMSWKDMFA FMGSLDTKGA SYKYEVALAG PALELHNCMA
310 320 330
KLLAHPLQRP CQTHASYSLL EEDEEAGEEE ATV
Length:333
Mass (Da):36,793
Last modified:October 11, 2005 - v1
Checksum:i5309BA609EA07FF8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231T → P in AAH05692 (PubMed:15489334).Curated
Sequence conflicti48 – 481S → N in AAH05692 (PubMed:15489334).Curated
Sequence conflicti120 – 1201S → T in BAC36785 (PubMed:16141072).Curated
Sequence conflicti315 – 3151A → S in AAH05692 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003366 mRNA. Translation: BAB22740.1.
AK077402 mRNA. Translation: BAC36785.1.
AK078265 mRNA. Translation: BAC37197.1.
AK147083 mRNA. Translation: BAE27663.1.
BC005692 mRNA. Translation: AAH05692.1.
CCDSiCCDS40381.1.
RefSeqiNP_080912.2. NM_026636.2.
UniGeneiMm.21749.

Genome annotation databases

EnsembliENSMUST00000002473; ENSMUSP00000002473; ENSMUSG00000031820.
GeneIDi68251.
KEGGimmu:68251.
UCSCiuc009mdb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003366 mRNA. Translation: BAB22740.1.
AK077402 mRNA. Translation: BAC36785.1.
AK078265 mRNA. Translation: BAC37197.1.
AK147083 mRNA. Translation: BAE27663.1.
BC005692 mRNA. Translation: AAH05692.1.
CCDSiCCDS40381.1.
RefSeqiNP_080912.2. NM_026636.2.
UniGeneiMm.21749.

3D structure databases

ProteinModelPortaliQ3UI43.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002473.

PTM databases

iPTMnetiQ3UI43.
PhosphoSiteiQ3UI43.

Proteomic databases

EPDiQ3UI43.
MaxQBiQ3UI43.
PaxDbiQ3UI43.
PRIDEiQ3UI43.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002473; ENSMUSP00000002473; ENSMUSG00000031820.
GeneIDi68251.
KEGGimmu:68251.
UCSCiuc009mdb.2. mouse.

Organism-specific databases

CTDi29086.
MGIiMGI:1915501. Babam1.

Phylogenomic databases

eggNOGiENOG410IF7E. Eukaryota.
ENOG4111NFW. LUCA.
GeneTreeiENSGT00390000016934.
InParanoidiQ3UI43.
OMAiRPFQSHA.
OrthoDBiEOG7VB2FR.
PhylomeDBiQ3UI43.
TreeFamiTF329070.

Miscellaneous databases

NextBioi326830.
PROiQ3UI43.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UI43.
CleanExiMM_5430437P03RIK.
GenevisibleiQ3UI43. MM.

Family and domain databases

InterProiIPR026126. BABAM1.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR15660. PTHR15660. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head, Heart and Olfactory bulb.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiBABA1_MOUSE
AccessioniPrimary (citable) accession number: Q3UI43
Secondary accession number(s): Q8C5Q8, Q99JU2, Q9CTJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2005
Last modified: April 13, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.